Structured assessment of hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage in 1242 patients: the German interdisciplinary database

Schneider, Harald J.; Schneider, Manfred; Kreitschmann-Andermahr, Ilonka; Tuschy, Ulrich; Wallaschofski, Henri; Fleck, Steffen; Faust, Michael; Renner, Caroline I.E.; Kopczak, Anna; Saller, Bernhard; Buchfelder, Michael; Jordan, Martina; Stalla, Günter K.

doi:10.1089/neu.2011.1887

Cited by 92Pituitary Gland Disorders and TreatmentsAdrenal Hormones and DisordersTraumatic Brain Injury and Neurovascular Disturbances

Structured assessment of hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage in 1242 patients: the German interdisciplinary database

Schneider, Harald J., Schneider, Manfred, Kreitschmann-Andermahr, Ilonka, Tuschy, Ulrich, Wallaschofski, Henri, Fleck, Steffen, Faust, Michael, Renner, Caroline I.E. +5 more·2011·Journal of Neurotrauma

DOI 10.1089/neu.2011.1887

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Abstract

Clinical studies have demonstrated that traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) are frequent causes of long-term disturbances of hypothalamo-pituitary function. This study aimed to assess the prevalence and associated factors of post-traumatic hypopituitarism in a large national registry of patients with TBI and SAH. Data were collected from 14 centers in Germany and Austria treating patients for TBI or SAH and performing endocrine assessments. Data were collected using a structured, internet-based study sheet, obtaining information on clinical, radiological, and hormonal parameters. A total of 1242 patients (825 TBI, age 43.5±19.7 years; 417 SAH, age 49.7±11.8 years) were included. We studied the prevalence of hypopituitarism reported based on different definitions of laboratory values and stimulation tests. Stimulation tests for the corticotropic and somatotropic axes were performed in 26% and 22% of the patients, respectively. The prevalence of hypopituitarism in the chronic phase (at least 5 months after the event) by laboratory values, physician diagnoses, and stimulation tests, was 35%, 36%, and 70%, respectively. Hypopituitarism was less common in the acute phase. According to the frequency of endocrine dysfunction, pituitary hormone secretion was impaired in the following sequence: ACTH, LH/FSH, GH, and TSH. TBI patients with abnormal stimulation tests had suffered from more severe TBI than patients with normal stimulation tests. In conclusion, our data confirm that hypopituitarism is a common complication of TBI and SAH. It is possible that patients with a higher likelihood of hypopituitarism were selected for endocrine stimulation tests.

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In most studies, no significant associations between TBI severity according to postresuscitation GCS and hypopituitarism in the chronic phase have been reported.
“In most studies, no significant associations between TBI severity according to postresuscitation GCS and hypopituitarism in the chronic phase have been reported (15, 23, 24, 27, 29, 181, 231-233), whereas others have demonstrated that hypopituitarism was more frequent in patients with more severe TBI (18,30,154).”
From Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015) · cites this paper as [233]

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Authors: Schneider, H. J., Schneider, M., Kreitschmann-Andermahr, I., Tuschy, U., Wallaschofski, H., Fleck, S., Faust, M., Renner, C. I. E., Kopczak, A., Saller, B., Buchfelder, M., Jordan, M., & Stalla, G. K.
Affiliations: Ludwig-Maximilians-Universität München (DE)
Schön Klinik Bad Aibling (DE)
Department of Neurosurgery, RWTH Hospital Aachen, Aachen, Germany.
Helios Klinikum Erfurt (DE)
Universität Greifswald (DE)
University Hospital Cologne (DE)
Neurologisches Rehabilitationszentrum Leipzig (DE)
Pfizer (United Kingdom) (GB)
Universitätsklinikum Erlangen (DE)
ClinSupport GmbH, Erlangen, Germany.
Max Planck Institute of Psychiatry (DE)
Corresponding author: Schneider, Harald J.
ORCID: Fleck, Steffen
Renner, Caroline I.E.
Kopczak, Anna
Buchfelder, Michael
Stalla, Günter K.
Venue: Journal of Neurotrauma
Publisher: SAGE Publications
Published: 2011-09
Volume: 28
Issue: 9
Pages: 1693-1698
ISSN: 0897-7151 (ISSN-L)
1557-9042
DOI: 10.1089/neu.2011.1887
OpenAlex: W1981285941
Cited by: 92
References: 27
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 17 · 2014: 9 · 2013: 5 · 2012: 14
FWCI: 7.57
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Journal of Neurotrauma (publishedVersion)
PubMed (publishedVersion)
Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Pfizer
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: hypopituitarism, traumatic brain injury, aneurysmal subarachnoid hemorrhage, hypothalamic-pituitary dysfunction, prevalence, ACTH deficiency, growth hormone deficiency, TSH deficiency, pituitary stimulation test, endocrine assessment
MeSH terms: Adult, Aged, Brain Injuries, Female, Germany, Humans, Hypopituitarism, Male, Middle Aged, Pituitary Gland, Subarachnoid Hemorrhage, Prevalence, Databases, Factual

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Structured assessment of hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage in 1242 patients: the German interdisciplinary database

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