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Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia
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Adrenal steroidogenesis is a dynamic process, reliant on de novo synthesis from cholesterol, under the stimulation of ACTH and other regulators. The syntheses of mineralocorticoids (primarily aldosterone), glucocorticoids (primarily cortisol), and adrenal androgens (primarily dehydroepiandrosterone and its sulfate) occur in separate adrenal cortical zones, each expressing specific enzymes. Congenital adrenal hyperplasia (CAH) encompasses a group of autosomal-recessive enzymatic defects in cortisol biosynthesis. 21-Hydroxylase (21OHD) deficiency accounts for more than 90% of CAH cases and, when milder or nonclassic forms are included, 21OHD is one of the most common genetic diseases.
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“Adrenal androgen biosynthesis takes place in the zona reticularis and proceeds via the classical Δ5 pathway (Miller and Auchus, 2011, Turcu and Auchus, 2015) as depicted in Fig. 2.”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Turcu and Auchus, 2015
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“Adrenal androgen biosynthesis takes place in the zona reticularis and proceeds via the classical Δ5 pathway (Miller and Auchus, 2011, Turcu and Auchus, 2015) as depicted in Fig. 2.”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Turcu and Auchus, 2015
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Metadata
- Authors
- Turcu, A. F., & Auchus, R. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Auchus, Richard J.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 44
- Issue
- 2
- Pages
- 275-296
- ISSN
- 0889-8529 (ISSN-L)
- PMC
- PMC4506691
- OpenAlex
- W1958109677
- Cited by
- 177
- References
- 155
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 20 · 2023: 19 · 2022: 23 · 2021: 12 · 2020: 17 · 2019: 19 · 2018: 18 · 2017: 8 · 2016: 10 · 2015: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK103461)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- adrenal steroidogenesis, congenital adrenal hyperplasia, 21-hydroxylase deficiency, aldosterone, cortisol, dehydroepiandrosterone, adrenal androgens, mineralocorticoids, glucocorticoids, ACTH, cholesterol
- MeSH terms
- Adrenal Cortex Neoplasms, Adrenal Hyperplasia, Congenital, Aldosterone, Androgens, Dehydroepiandrosterone, Glucocorticoids, Humans, Hydrocortisone, Mineralocorticoids, Risk Factors, Myelolipoma, Adrenocortical Adenoma, Dehydroepiandrosterone Sulfate, Hormone Replacement Therapy
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