Cited by 181Sexual Differentiation and DisordersAdrenal Hormones and DisordersHormonal Regulation and Hypertension

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Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia

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Turcu, Adina F., Auchus, Richard J.·2015·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2015.02.002PMC PMC4506691

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Abstract

Adrenal steroidogenesis is a dynamic process, reliant on de novo synthesis from cholesterol, under the stimulation of ACTH and other regulators. The syntheses of mineralocorticoids (primarily aldosterone), glucocorticoids (primarily cortisol), and adrenal androgens (primarily dehydroepiandrosterone and its sulfate) occur in separate adrenal cortical zones, each expressing specific enzymes. Congenital adrenal hyperplasia (CAH) encompasses a group of autosomal-recessive enzymatic defects in cortisol biosynthesis. 21-Hydroxylase (21OHD) deficiency accounts for more than 90% of CAH cases and, when milder or nonclassic forms are included, 21OHD is one of the most common genetic diseases.

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11-Oxygenated androgens in health and disease
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Authors: Turcu, A. F., & Auchus, R. J.
Affiliations: University of Michigan (US)
Corresponding author: Auchus, Richard J.
ORCID: Turcu, Adina F.
Auchus, Richard J.
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2015-06
Volume: 44
Issue: 2
Pages: 275-296
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2015.02.002
PMC: PMC4506691
OpenAlex: W1958109677
Cited by: 177
References: 155
Citations by year: 2026: 14 · 2025: 15 · 2024: 20 · 2023: 19 · 2022: 23 · 2021: 12 · 2020: 17 · 2019: 19 · 2018: 18 · 2017: 8 · 2016: 10 · 2015: 1
FWCI: 1.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (F32DK103461)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: adrenal steroidogenesis, congenital adrenal hyperplasia, 21-hydroxylase deficiency, aldosterone, cortisol, dehydroepiandrosterone, adrenal androgens, mineralocorticoids, glucocorticoids, ACTH, cholesterol
MeSH terms: Adrenal Cortex Neoplasms, Adrenal Hyperplasia, Congenital, Aldosterone, Androgens, Dehydroepiandrosterone, Glucocorticoids, Humans, Hydrocortisone, Mineralocorticoids, Risk Factors, Myelolipoma, Adrenocortical Adenoma, Dehydroepiandrosterone Sulfate, Hormone Replacement Therapy

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Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia

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