Cited by 103Effects and risks of endocrine disrupting chemicalsEnvironmental Toxicology and EcotoxicologyToxic Organic Pollutants Impact

Hormonal activity, cytotoxicity and developmental toxicity of UV filters

Balázs, Adrienn, Krifaton, Csilla, Orosz, Ivett, Szoboszlay, Sándor, Kovács, Róbert, Csenki, Zsolt, Urbányi, Béla, Kriszt, Balázs·2016·Ecotoxicology and Environmental Safety

Abstract

Ultraviolet (UV) filters are commonly used compounds in personal care products and polymer based materials, as they can absorb solar energy in the UVA and UVB spectrum. However, they are able to bind to hormone receptors and have several and different types of hormonal activities determined by in vitro assays. One of the aims of this work was to measure the hormonal and cytotoxic activities of four frequently used UV filters using bioluminescence based yeast test organisms. Using Saccharomyces cerevisiae BLYES and BLYAS strains allowed the rapid and reliable detection of agonist and antagonist hormonal activities, whereas BLYR strain served to measure cytotoxicity. Results confirmed that all tested UV filters show multiple hormonal activities. Cytotoxicity is detected only in the case of benzophenone-3. Research data on the toxic effects of benzophenone-3, especially on aquatic organisms are scarce, so further investigations were carried out regarding its cytotoxic and teratogenic effects on bacteria and zebrafish (Danio rerio) embryos, respectively. Results revealed the cytotoxicity of benzophenone-3 not only to yeasts but to bacteria, as well as its ability to influence zebrafish embryo hatching and development.

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Crossref · 10.1016/j.ecoenv.2016.04.037

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  • UV filters have endocrine disrupting effects including estrogenic, androgenic, and thyroid activities, as well as cytotoxicity, behavioural changes, and neurotoxicity.

    “Estrogenic, androgenic, and thyroid activities are included in the endocrine disrupting effects of UV filters [77], but other inherent effects have been reported, namely cytotoxicity [78], behavioural changes [79], and neurotoxicity [80].”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [78]

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Authors
Balázs, A., Krifaton, C., Orosz, I., Szoboszlay, S., Kovács, R., Csenki, Z., Urbányi, B., & Kriszt, B.
Affiliations
Magyar Agrár- és Élettudományi Egyetem (HU)
Corresponding author
Krifaton, Csilla
Venue
Ecotoxicology and Environmental Safety
Publisher
Elsevier BV
Published
2016-09
Volume
131
Pages
45-53
ISSN
0147-6513 (ISSN-L)
OpenAlex
W2403022207
Cited by
103
References
49
Citations by year
2026: 8 · 2025: 12 · 2024: 6 · 2023: 14 · 2022: 15 · 2021: 16 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 3 · 2016: 4
FWCI
4.83
Type
journal article
Language
en
Open access
closed
Locations
  • Ecotoxicology and Environmental Safety (publishedVersion)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
Funders
Magyar Tudományos Akadémia
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
UV filters, hormone action, endocrine disruptors, cytotoxicity, developmental toxicity, benzophenone-3, Saccharomyces cerevisiae, zebrafish embryos, bacterial cytotoxicity, teratogenicity, personal care products, polymer additives
MeSH terms
Animals, Benzophenones, Embryo, Nonmammalian, Hormone Antagonists, Saccharomyces cerevisiae, Sunscreening Agents, Zebrafish, Embryonic Development, Aquatic Organisms

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