Toxicity, Uptake Kinetics and Behavior Assessment in Zebrafish Embryos Following Exposure to Perfluorooctanesulphonicacid (PFOS)

Huang, Haihua; Huang, Changjiang; Wang, Lijun; Ye, Xiaowei; Bai, Chenglian; Simonich, Michael T.; Tanguay, Robert L.; Dong, Qiaoxiang

doi:10.1016/j.aquatox.2010.02.003

Cited by 283Per- and polyfluoroalkyl substances researchEnvironmental Toxicology and EcotoxicologyToxic Organic Pollutants Impact

Toxicity, Uptake Kinetics and Behavior Assessment in Zebrafish Embryos Following Exposure to Perfluorooctanesulphonicacid (PFOS)

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Huang, Haihua, Huang, Changjiang, Wang, Lijun, Ye, Xiaowei, Bai, Chenglian, Simonich, Michael T., Tanguay, Robert L., Dong, Qiaoxiang·2010·Aquatic Toxicology

DOI 10.1016/j.aquatox.2010.02.003PMC PMC4028132

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Abstract

Perfluorooctanesulphonicacid (PFOS), a persistent organic contaminant, has been widely detected in the environment, wildlife and humans, but few studies have assessed its effect on aquatic organisms. The present study evaluated the effect of PFOS on zebrafish embryos. Zebrafish embryos exhibited developmental toxicity of bent spine, uninflated swim bladder, decreased heart rate and affected spontaneous movement after exposure to various PFOS concentrations (0-8mg/L) from 6 to 120h post-fertilization (hpf). The LC(50) at 120hpf was 2.20mg/L and the EC(50) at 120hpf was 1.12mg/L. Continuous exposure to PFOS from 1 to 121hpf resulted in a steady accumulation with no evidence of elimination. PFOS induced cell death at 24hpf was consistently found in the brain, eye, and tail region of embryos. PFOS exposure induced lesions in the muscle fibers with histological examination. Behavior assessment of PFOS in zebrafish embryos elevated the basal rate of swimming after 4 days of exposure, and larvae exposed to PFOS (0.25-4mg/L) for only 1h at 6dpf swam faster with increasing PFOS concentration. Embryos/larvae exposed to 8mg/L PFOS for 24h periods from 1 to 121hpf showed the highest incidence of malformations in the 97-121hpf window. This is the first study to define uptake kinetics and to focus on behavioral consequences following PFOS exposure in zebrafish. Our results further the understanding of the toxicity of PFOS to aquatic organisms and suggest the need for additional research to identify the mode of PFOS toxicity.

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Several studies assessing PFOS exposure in larval zebrafish reported increased swimming speed or hyperactivity in PFOS-exposed adults.
“Several studies assessing PFOS exposure in larval zebrafish reported increased swimming speed or hyperactivity in PFOS-exposed adults (Huang et al., 2010; Chen et al., 2013; Gaballah et al., 2020).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Huang et al., 2010
Section 3.6 reports increased swimming speed in PFOS-exposed zebrafish larvae at 5–6 days post-fertilization. The paper does not report this behavioral finding in PFOS-exposed adults, so the adult portion of the attributed claim is unsupported. (LLM, conf=0.92)
Experimental — accuracy not yet measured
While studies on PFAS exposure in adult animals have not reported altered motor activity, several compounds have been shown to elicit developmental impairment of motor activity in mice, rats, and zebrafish.
“While studies on PFAS exposure in adult animals have not reported altered motor activity, several compounds have been shown to elicit developmental impairment of motor activity in mice, rats, and zebrafish (Johansson et al., 2008; Butenhoff et al., 2009b; Huang et al., 2010; Wang M. et al., 2011; Chen et al., 2013; Spulber et al., 2014; Hallgren et al., 2015; Goulding et al., 2017; Guo et al., 201”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Huang et al., 2010

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“Several studies assessing PFOS exposure in larval zebrafish reported increased swimming speed or hyperactivity in PFOSexposed adults (Huang et al., 2010; Chen et al., 2013; Gaballah et al., 2020).”
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Authors: Huang, H., Huang, C., Wang, L., Ye, X., Bai, C., Simonich, M. T., Tanguay, R. L., & Dong, Q.
Affiliations: Wenzhou Medical University (CN)
Oregon State University (US)
Corresponding author: Huang, Haihua
Huang, Changjiang
Dong, Qiaoxiang
ORCID: Huang, Haihua
Huang, Changjiang
Wang, Lijun
Simonich, Michael T.
Tanguay, Robert L.
Dong, Qiaoxiang
Venue: Aquatic Toxicology
Publisher: Elsevier BV
Published: 2010-06
Volume: 98
Issue: 2
Pages: 139-147
ISSN: 0166-445X (ISSN-L)
DOI: 10.1016/j.aquatox.2010.02.003
PMC: PMC4028132
OpenAlex: W2066635393
Cited by: 283
References: 49
Citations by year: 2026: 14 · 2025: 21 · 2024: 12 · 2023: 23 · 2022: 28 · 2021: 19 · 2020: 23 · 2019: 23 · 2018: 10 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 21 · 2012: 19
FWCI: 15.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Aquatic Toxicology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Wenzhou Municipal People's Government
National Institutes of Health
U.S. Public Health Service (P30 00210)
National Institute of Environmental Health Sciences (P30ES000210)
Science and Technology Department of Zhejiang Province
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: PFOS, zebrafish embryos, developmental toxicity, uptake kinetics, persistent organic pollutants, swimming behavior, malformations, cell death, LC50, EC50, aquatic toxicity
MeSH terms: Animals, Behavior, Animal, Dose-Response Relationship, Drug, Embryo, Nonmammalian, Fertilization, Fluorocarbons, Heart Rate, Kinetics, Larva, Water Pollutants, Chemical, Zebrafish, Alkanesulfonic Acids

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Toxicity, Uptake Kinetics and Behavior Assessment in Zebrafish Embryos Following Exposure to Perfluorooctanesulphonicacid (PFOS)

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