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Co-exposure to fluoride and arsenic disrupts intestinal flora balance and induces testicular autophagy in offspring rats

Liu, Penghui, Li, Ran, Tian, Xiaolin, Zhao, Yannan, Li, Meng, Wang, Meng, Ying, Xiaodong, Yuan, Jiyu, Xie, Jiaxin, Yan, Xiaoting, Lyu, Yi, Wei, Cailing, Qiu, Yulan, Tian, Fengjie, Zhao, Qian, Yan, Xiaoyan·2021·Ecotoxicology and Environmental Safety
DOI 10.1016/j.ecoenv.2021.112506
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Image 1
CC-BY-NC-ND · From the PDF
Fig. 1 HE staining results of testicular tissue of offspring rats (40 × ). Control group (a), F exposure group (b), As exposure group (c), and F and As co-exposure group (d). Spg: spermatogonia; Spc: spermatocytes; Sp: spermatozoa.
Fig. 1 HE staining results of testicular tissue of offspring rats (40 × ). Control group (a), F exposure group (b), As exposure group (c), and F and As co-exposure group (d). Spg: spermatogonia; Spc: spermatocytes; Sp: spermatozoa.CC-BY-NC-ND · From the PDF
Image 3
CC-BY-NC-ND · From the PDF
Fig. 3 Correlations between intestinal flora composition at genus level and serum hormone levels. The highlighted black box indicates a significant dif­ ference correlation ( P ＜ 0.05).
Fig. 3 Correlations between intestinal flora composition at genus level and serum hormone levels. The highlighted black box indicates a significant dif­ ference correlation ( P ＜ 0.05).CC-BY-NC-ND · From the PDF
Fig. 4 The relative mRNA and protein expressions of Beclin1, LC3 and p62. Asterisk indicates significant difference compared to the control group (* P < 0.05, ** P < 0.01).
Fig. 4 The relative mRNA and protein expressions of Beclin1, LC3 and p62. Asterisk indicates significant difference compared to the control group (* P < 0.05, ** P < 0.01).CC-BY-NC-ND · From the PDF
Fig. 5 Representative image of autophagosome in rat testis tissue. Control group (a), F exposure group (b), As exposure group (c), and F and As co-exposure group (d). The yellow arrow shows the autophagic vacuole. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 5 Representative image of autophagosome in rat testis tissue. Control group (a), F exposure group (b), As exposure group (c), and F and As co-exposure group (d). The yellow arrow shows the autophagic vacuole. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)CC-BY-NC-ND · From the PDF
Fig. 6 Correlations between intestinal flora composition at genus level and autophagy-related gene levels. The highlighted yellow box indicates a significant dif­ ference correlation ( P ＜ 0.05). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 6 Correlations between intestinal flora composition at genus level and autophagy-related gene levels. The highlighted yellow box indicates a significant dif­ ference correlation ( P ＜ 0.05). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)CC-BY-NC-ND · From the PDF
Fig. 7 Interaction between F and As on the mRNA and protein experiment of LC3, Beclin 1 and p62.
Fig. 7 Interaction between F and As on the mRNA and protein experiment of LC3, Beclin 1 and p62.CC-BY-NC-ND · From the PDF

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Citations

Cites

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Metadata

Authors
Liu, P., Li, R., Tian, X., Zhao, Y., Li, M., Wang, M., Ying, X., Yuan, J., Xie, J., Yan, X., Lyu, Y., Wei, C., Qiu, Y., Tian, F., Zhao, Q., & Yan, X.
Venue
Ecotoxicology and Environmental Safety
Publisher
Elsevier BV
Published
2021-10
Volume
222
Pages
112506
ISSN
0147-6513
DOI
10.1016/j.ecoenv.2021.112506
Cited by
40
References
2
Language
en
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