Long-term LDR exposure may induce cognitive impairments: a possible association through targeting gut microbiota-gut-brain axis
Open accessAbstract
Environmental and occupational low-dose radiation (LDR) exposure may be harmful for health but the previous reports regarding effect of LDR on cognition are contradictory. Here we investigated the effect of long-term LDR exposure on cognition. In this study, male Balb/c mice' cognitive functions were tested at 15 weeks after being exposed to 0.5 Gy LDR in 10 fractions at each dose of 0.05 Gy. The results demonstrated that long-term LDR exposure increases escape latency and the time spent in finding exits in mice compared with non LDR exposure. Meanwhile, the inflammation-related proteins including NFκB and p38 also increased. Lipopolysaccharide (LPS) increased and short-chain fatty acid (SCFA) levels decreased following long term LDR exposure. Treatment with microbiota-derived LPS and SCFAs reversed these effects in mice. Furthermore, the gut barrier integrity was damaged in a time-dependent manner with the decreased expression of intestinal epithelial-related biomarkers such as ZO-1 and occludin. Mechanistically, long after exposure to LDR, increased LPS levels may cause cognitive impairment through the regulation of Akt/mTOR signaling in the mouse hippocampus. These findings provide new insight into the clinical applications of LDR and suggest that the gut microbiota-plasma LPS and SCFAs-brain axis may underlie long-term LDR-induced cognition effects.
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Mice exposed to environmental low-dose radiation show long-term impairments in cognitive function, hippocampal synaptic ultrastructure, and signaling through the Akt/mTOR pathway.
“Guo et al. showed that mice exposed to environmental low-dose radiation demonstrated long-term impairments in cognitive function, hippocampal synaptic ultrastructure, and signaling through the Akt/mTOR pathway (519).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [519]
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Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
- Authors
- Guo, P., Lei, M., Hu, S., Xu, Z., Zhou, Y., Zhou, P., & Huang, R.
- Affiliations
- Central South University (CN)
- Corresponding author
- Huang, Ruixue
- Venue
- Ecotoxicology and Environmental Safety
- Publisher
- Elsevier BV
- Published
- 2023-01
- Volume
- 249
- Pages
- 114351
- ISSN
- 0147-6513 (ISSN-L)
- OpenAlex
- W4311305956
- Cited by
- 8
- References
- 53
- Citations by year
- 2026: 4 · 2025: 1 · 2023: 3
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Ecotoxicology and Environmental Safety (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82073486)
- Central South University
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Keywords
- low-dose radiation, long-term radiation exposure, cognitive impairment, gut microbiota, gut-brain axis, lipopolysaccharide, short-chain fatty acids, intestinal barrier integrity, NF-κB, p38 MAPK, Akt/mTOR signaling, hippocampus, radiation neurotoxicity
- MeSH terms
- Radiation Exposure, Gastrointestinal Microbiome, Brain-Gut Axis, Animals, Dose-Response Relationship, Radiation, Lipopolysaccharides, Male, Mice, Inbred C57BL, Radiation Injuries, Mice, Cognitive Dysfunction
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