Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies

Effects of Desipramine, Amitriptyline, and Fluoxetine on Pain in Diabetic Neuropathy

Max, M. B., Lynch, S. A., Muir, J., Shoaf, S. E., Smoller, B., & Dubner, R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205073261904 · Cited by 1,117

Chemotherapy-induced peripheral neuropathy

Quasthoff, S., & Hartung, H. P. (2002) · Journal of Neurology · doi:10.1007/pl00007853 · Cited by 966

Chemotherapy‐induced neuropathy

Windebank, A. J., & Grisold, W. (2008) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2008.00156.x · Cited by 613

Neuroprotective Effect of Reduced Glutathione on Oxaliplatin-Based Chemotherapy in Advanced Colorectal Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial

Cascinu, S., Catalano, V., Cordella, L., Labianca, R., Giordani, P., Baldelli, A. M., Beretta, G. D., Ubiali, E., & Catalano, G. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.07.061 · Cited by 421

Taxol: the first of the taxanes, an important new class of antitumor agents.

Rowinsky, E. K., Onetto-Pothier, N., Canetta, R. M., & Arbuck, S. G. (1992) · PubMed · Cited by 389

Efficacy of gabapentin in the management of chemotherapy‐induced peripheral neuropathy: A phase 3 randomized, double‐blind, placebo‐controlled, crossover trial (N00C3)

Rao, R. D., Michalak, J. C., Sloan, J. A., Loprinzi, C. L., Soori, G. S., Nikcevich, D. A., Warner, D. O., Novotny, P., Kutteh, L. A., Wong, G. Y., et al. (2007) · Cancer · doi:10.1002/cncr.23008 · Cited by 360

The Cancer Journals

Lorde, A. (2025) · Feminist Studies · doi:10.4324/9781003341567-53 · Cited by 351

Prevention of Oxaliplatin-Related Neurotoxicity by Calcium and Magnesium Infusions

Gamelin, L., Boisdron‐Celle, M., Delva, R., Guerin‐Meyer, V., Ifrah, N., Morel, A., & Gamelin, E. C. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0666 · Cited by 346

Neuroprotective Effect of Vitamin E Supplementation in Patients Treated With Cisplatin Chemotherapy

Pace, A., Savarese, A., Picardo, M., Maresca, V., Pacetti, U., Del Monte, G., Biroccio, A., Leonetti, C., Jandolo, B., Cognetti, F., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.139 · Cited by 307

Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells

Peters, C. M., Jimenez-Andrade, J. M., Jonas, B. M., Sevcik, M. A., Koewler, N. J., Ghilardi, J. R., Wong, G. Y., & Mantyh, P. W. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.07.022 · Cited by 288

Prevention of Cisplatin Neurotoxicity with an ACTH(4–9) Analogue in Patients with Ovarian Cancer

van der Hoop, R. G., Vecht, C. J., van der Burg, M. E. L., Elderson, A., Boogerd, W., Heimans, J. J., Vries, E. P., van Houwelingen, J. C., Jennekens, F. G. I., Gispen, W. H., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001113220204 · Cited by 287

2002 Update of Recommendations for the Use of Chemotherapy and Radiotherapy Protectants: Clinical Practice Guidelines of the American Society of Clinical Oncology

Schuchter, L. M., Hensley, M. L., Meropol, N. J., & Winer, E. P. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.04.178 · Cited by 262

Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients

Bairati, I., Meyer, F., Gélinas, M., Fortin, A., Nabid, A., Brochet, F., Mercier, J.-P., Têtu, B., Harel, F., Abdous, B., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.514 · Cited by 261

Antioxidants and Cancer Therapy: A Systematic Review

Ladas, E. J., Jacobson, J. S., Kennedy, D. D., Teel, K., Fleischauer, A., & Kelly, K. M. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.03.086 · Cited by 260

Phase III evaluation of nortriptyline for alleviation of symptoms of cis-platinum-induced peripheral neuropathy

Hammack, J. E., Michalak, J. C., Loprinzi, C. L., Sloan, J. A., Novotny, P. J., Soori, G. S., Tirona, M. T., Rowland, K. M., Stella, P. J., & Johnson, J. A. (2002) · Pain · doi:10.1016/s0304-3959(02)00047-7 · Cited by 231

Amitriptyline in the Treatment of Chemotherapy-Induced Neuropathic Symptoms

Kautio, A.-L., Haanpää, M., Saarto, T., & Kalso, E. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2007.02.043 · Cited by 213

Vitamin E for prophylaxis against chemotherapy-induced neuropathy: A randomized controlled trial

Argyriou, A. A., Chroni, E., Koutras, A., Ellul, J., Papapetropoulos, S., Katsoulas, G., Iconomou, G., & Kalofonos, H. P. (2005) · Neurology · doi:10.1212/01.wnl.0000148609.35718.7d · Cited by 209

Oral Glutamine Is Effective for Preventing Oxaliplatin-Induced Neuropathy in Colorectal Cancer Patients

Wang, W.-S., Lin, J.-K., Lin, T.-C., Chen, W.-S., Jiang, J., Wang, H.-S., Chiou, T.-J., Liu, H., Yen, C., & Chen, P. (2007) · The Oncologist · doi:10.1634/theoncologist.12-3-312 · Cited by 207

Neurologic complications of chemotherapy agents

Kannarkat, G., Lasher, E. E., & Schiff, D. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3282f1a06e · Cited by 200

Phase I and pharmacodynamic study of taxol in refractory acute leukemias.

Rowinsky, E. K., Burke, P. J., Karp, J. E., Tucker, R. W., Ettinger, D. S., & Donehower, R. C. (1989) · PubMed · Cited by 196

Efficacy of lamotrigine in the management of chemotherapy‐induced peripheral neuropathy: A phase 3 randomized, double‐blind, placebo‐controlled trial, N01C3

Rao, R. D., Flynn, P. J., Sloan, J. A., Wong, G. Y., Novotny, P., Johnson, D. B., Gross, H. M., Renno, S. I., Nashawaty, M., & Loprinzi, C. L. (2008) · Cancer · doi:10.1002/cncr.23482 · Cited by 193

Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: Results of a double-blind, randomised trial

Smyth, J. F., Bowman, A., Perren, T., Wilkinson, P., Prescott, R. J., Quinn, K. J., & Tedeschi, M. (1997) · Annals of Oncology · doi:10.1023/a:1008211226339 · Cited by 178

Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial.

Cascinu, S., Cordella, L., Ferro, E. D., Fronzoni, M., & Catalano, G. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.1.26 · Cited by 158

Protective effect of alpha‐tocopherol in head and neck cancer radiation‐induced mucositis: A double‐blind randomized trial

Ferreira, P. R. F., Fleck, J. F., Diehl, A. S., Barletta, D. V., Braga‐Filho, A., Barletta, A., & Ilha, L. A. (2004) · Head & Neck · doi:10.1002/hed.10382 · Cited by 156

Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-l-carnitine

Bianchi, G., Vitali, G., Caraceni, A. T., Ravaglia, S., Capri, G., Cundari, S., Zanna, C., & Gianni, L. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.04.028 · Cited by 152

Gabapentin for Neuropathic Pain: Systematic Review of Controlled and Uncontrolled Literature

Mellegers, M. A., Furlan, A. D., & Mailis, A. (2001) · Clinical Journal of Pain · doi:10.1097/00002508-200112000-00002 · Cited by 151

Reduction of paclitaxel-induced peripheral neuropathy with glutamine.

Vahdat, L. T., Papadopoulos, K. P., Lange, D., Leuin, S. C., Kaufman, E. A., Donovan, D., Frederick, D., Bagiella, E., Tiersten, A., NICHOLS, G. L., et al. (2001) · PubMed · Cited by 149

Topical 2% Amitriptyline and 1% Ketamine in Neuropathic Pain Syndromes

Lynch, M. E., Clark, A. J., Sawynok, J., & Sullivan, M. J. L. (2005) · Anesthesiology · doi:10.1097/00000542-200507000-00021 · Cited by 144

A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results

Argyriou, A. A., Chroni, E., Koutras, A. K., Iconomou, G., Papapetropoulos, S., Polychronopoulos, P., & Kalofonos, H. P. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-006-0072-3 · Cited by 138

Topical Amitriptyline and Ketamine in Neuropathic Pain Syndromes: An Open-Label Study

Lynch, M. E., Clark, A. J., Sawynok, J., & Sullivan, M. J. L. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.04.008 · Cited by 133

A Pilot Study Examining Topical Amitriptyline, Ketamine, and a Combination of Both in the Treatment of Neuropathic Pain

Lynch, M. E., Clark, A. J., & Sawynok, J. (2003) · Clinical Journal of Pain · doi:10.1097/00002508-200309000-00007 · Cited by 122

N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: preliminary data

Lin, P., Lee, M.-Y., Wang, W.-S., Yen, C., Chao, T., Hsiao, L., Yang, M., Chen, P., Lin, K., & Chiou, T.-J. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-006-0018-9 · Cited by 112

Cisplatin neuropathy: clinical course and neurophysiological findings

LoMonaco, M., Milone, M., Batocchi, A. P., Padua, L., Restuccia, D., & Tonali, P. A. (1992) · Journal of Neurology · doi:10.1007/bf00839140 · Cited by 109

The Paclitaxel Acute Pain Syndrome: Sensitization of Nociceptors as the Putative Mechanism

Loprinzi, C. L., Maddocks‐Christianson, K., Wolf, S. L., Rao, R. D., Dyck, P. J. B., Mantyh, P. W., & Dyck, P. J. B. (2007) · The Cancer Journal · doi:10.1097/ppo.0b013e31815a999b · Cited by 108

A Randomized, Double-Blinded, Placebo-Controlled Phase II Trial of Recombinant Human Leukemia Inhibitory Factor (rhuLIF, Emfilermin, AM424) to Prevent Chemotherapy-Induced Peripheral Neuropathy

Davis, I. D., Kiers, L., MacGregor, L., Quinn, M. A., Arezzo, J. C., Green, M., Rosenthal, M. A., Chia, M. M., Michael, M., Bartley, P., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1655 · Cited by 96

Overview of Taxol safety.

Onetto-Pothier, N., Canetta, R. M., Winograd, B., Catane, R., Dougan, M., Grechko, J., Burroughs, J., & Rozencweig, M. (1993) · PubMed · Cited by 92

Chemotherapy Alonevs.Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer

Pathak, A., Bhutani, M., Guleria, R., Bal, S., Mohan, A., Mohanti, B. K., Sharma, A., Pathak, R., Bhardwaj, N. K., Prasad, K. N., et al. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719438 · Cited by 90

Limited Access Trial Using Amifostine for Protection Against Cisplatin- and Three-Hour Paclitaxel–Induced Neurotoxicity: A Phase II Study of the Gynecologic Oncology Group

Moore, D. H., Donnelly, J. P., McGuire, W. P., Almadrones, L., Cella, D. F., Herzog, T. J., & Waggoner, S. E. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.086 · Cited by 80

Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat

Jiménez‐Andrade, J. M., Peters, C. M., Mejia, N. A., Ghilardi, J. R., Kuskowski, M. A., & Mantyh, P. W. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.043 · Cited by 78

Topical Ketamine Gel: Possible Role in Treating Neuropathic Pain: Table 1

Gammaitoni, A. R., Gallagher, R. M., & Welz-Bosna, M. (2000) · Pain Medicine · doi:10.1046/j.1526-4637.2000.00006.x · Cited by 78

Neuroprotection with amifostine in the first-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapy—a double-blind, placebo-controlled, randomized phase II study from the Arbeitsgemeinschaft Gynäkologische Onkologoie (AGO) Ovarian Cancer Study Group

Hilpert, F., Stähle, A., Tomé, O., et al. (2005) · Supportive Care in Cancer · doi:10.1007/s00520-005-0782-y · Cited by 70

Use of Low-Dose Oral Prednisone to Prevent Paclitaxel-Induced Arthralgias and Myalgias

Markman, M. M., KENNEDY, A. W., Webster, K. D., Kulp, B., Peterson, G., & Belinson, J. L. (1999) · Gynecologic Oncology · doi:10.1006/gyno.1998.5226 · Cited by 48

Glutamine does not prevent paclitaxel-associated myalgias and arthralgias.

Jacobson, S. D., Loprinzi, C. L., Sloan, J. A., Wilke, J. L., Novotny, P. J., Okuno, S. H., Jatoi, A., & Moynihan, T. J. (2003) · PubMed · Cited by 42

Neuromuscular toxicities of paclitaxel 210 mg m-2 by 3-hour infusion

Kunitoh, H., Saijo, N., Furuse, K., Noda, K., & Ogawa, M. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.278 · Cited by 33

Topical analgesics

Lockhart, E. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.02.294 · Cited by 33

Endogenous Glutamate Levels Regulate Nerve Growth Factor mRNA Expression in the Rat Dentate Gyrus

Gwag, B. J., Sessler, F. M., Robine, V., & Springer, J. E. (1997) · Molecules and Cells · doi:10.1016/s1016-8478(23)13316-4 · Cited by 27

American Cancer Society Colorectal Cancer Survivorship Care Guidelines

El‐Shami, K., Oeffinger, K. C., Erb, N. L., Willis, A., Bretsch, J. K., Pratt‐Chapman, M. L., Cannady, R. S., Wong, S. L., Rose, J., Barbour, A. L., et al. (2015) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21286 · Cited by 475

Cisplatin in the modern era: The backbone of first-line chemotherapy for non-small cell lung cancer

Fennell, D. A., Summers, Y., Cadranel, J., Benepal, T., Christoph, D. C., Lal, R., Das, M., Maxwell, F., Visseren-Grul, C., & Ferry, D. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.01.003 · Cited by 382

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy

Zhang, H., Li, Y., de Carvalho-Barbosa, M., Kavelaars, A., Heijnen, C. J., Albrecht, P. J., & Dougherty, P. M. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.02.011 · Cited by 365

Effects of exercise on cancer patients suffering chemotherapy-induced peripheral neuropathy undergoing treatment: a systematic review

Duregon, F., Vendramin, B., Bullo, V., Gobbo, S., Cugusi, L., Di Blasio, A., Neunhaeuserer, D., Zaccaria, M., Bergamin, M., & Ermolao, A. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.11.002 · Cited by 196

The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Deng, L., Guindon, J., Vemuri, V. K., Thakur, G. A., White, F. A., Makriyannis, A., & Hohmann, A. G. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-71 · Cited by 94