The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy
Open accessAbstract
Background: Chemotherapeutic agents produce dose-limiting peripheral neuropathy through mechanisms that remain poorly understood. We previously showed that AM1710, a cannabilactone 2 agonist, produces antinociception without producing central nervous system (CNS)-associated side effects. The present study was conducted to examine the antinociceptive effect of AM1710 in rodent models of neuropathic pain evoked by diverse chemotherapeutic agents (cisplatin and paclitaxel). A secondary objective was to investigate the potential contribution of alpha-chemokine receptor (CXCR4) signaling to both chemotherapy-induced neuropathy and CB 2 agonist efficacy. Results: AM1710 (0.1, 1 or 5 mg/kg i.p.) suppressed the maintenance of mechanical and cold allodynia in the cisplatin and paclitaxel models. Anti-allodynic effects of AM1710 were blocked by the CB 2 antagonist AM630 (3 mg/kg i.p.), but not the CB 1 antagonist AM251 (3 mg/kg i.p.), consistent with a CB 2-mediated effect. By contrast, blockade of CXCR4 signaling with its receptor antagonist AMD3100 (10 mg/kg i.p.) failed to attenuate mechanical or cold hypersensitivity induced by either cisplatin or paclitaxel. Moreover, blockade of CXCR4 signaling failed to alter the anti-allodynic effects of AM1710 in the paclitaxel model, further suggesting distinct mechanisms of action. Conclusions: Our results indicate that activation of cannabinoid CB 2 receptors by AM1710 suppresses both mechanical and cold allodynia in two distinct models of chemotherapy-induced neuropathic pain. By contrast, CXCR4 signaling does not contribute to the maintenance of chemotherapy-induced established neuropathy or efficacy of AM1710. Our studies suggest that CB 2 receptors represent a promising therapeutic target for the treatment of toxic neuropathies produced by cisplatin and paclitaxel chemotherapeutic agents.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AM1710 suppressed the maintenance of mechanical and cold allodynia in the cisplatin model through a CB2 receptor mechanism of action, with no evidence of CB1 receptor involvement.
“Conversely, AM1710 suppressed the maintenance of mechanical and cold allodynia in the cisplatin model through a CB 2 receptor mechanism of action, with no evidence of CB 1 receptor involvement (Deng et al, 2012).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Deng et al, 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762 · see citing works
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344 · see citing works
Identification and Functional Characterization of Brainstem Cannabinoid CB<sub>2</sub>Receptors
Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., et al. (2005) · Science · doi:10.1126/science.1115740 · Cited by 1,470 · see citing works
Self-citationBehavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
Yoon, C., Wook, Y. Y., Na, H. S., Ho, K. S., & Mo, C. J. (1994) · Pain · doi:10.1016/0304-3959(94)90023-x · Cited by 868 · see citing works
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793 · see citing works
Clinical toxicities encountered with paclitaxel (Taxol).
Rowinsky, E. K., Eisenhauer, E. A., Chaudhry, V., Sg, A., & Rc, D. (1993) · PubMed · Cited by 692 · see citing works
The Role of N-Methyl-d-Aspartate (NMDA) Receptors in Pain: A Review
Petrenko, A. B., Yamakura, T., Baba, H., & Shimoji, K. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000081061.12235.55 · Cited by 672 · see citing works
Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies
Wolf, S. L., Barton, D. L., Kottschade, L. A., Grothey, A. F., & Loprinzi, C. L. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.04.018 · Cited by 632 · see citing works
Chemokines, neuronal–glial interactions, and central processing of neuropathic pain
Gao, Y., & Ji, R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.002 · Cited by 629 · see citing works
Chemotherapy‐induced neuropathy
Windebank, A. J., & Grisold, W. (2008) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2008.00156.x · Cited by 613 · see citing works
HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor
Hanus, L. O., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R., & Fride, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14228 · Cited by 574 · see citing works
Flatters, S. J. L., & Bennett, G. J. (2006) · Pain · doi:10.1016/j.pain.2006.01.037 · Cited by 536 · see citing works
Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834309100 · Cited by 491 · see citing works
Self-citationA painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001) · Pain · doi:10.1016/s0304-3959(01)00363-3 · Cited by 476 · see citing works
The Endocannabinoid System and Pain
Guindon, J., & Hohmann, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789824660 · Cited by 476 · see citing works
Self-citationEmerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works
Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works
Self-citationKajander, K. C., & Bennett, G. J. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.3.734 · Cited by 372 · see citing works
Peripheral sensory neuropathy and cisplatin chemotherapy
Roelofs, R. I., Hrushesky, W. J. M., Rogin, J. B., & Rosenberg, L. (1984) · Neurology · doi:10.1212/wnl.34.7.934 · Cited by 369 · see citing works
Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy
Jaggi, A. S., & Singh, N. (2011) · Toxicology · doi:10.1016/j.tox.2011.10.019 · Cited by 357 · see citing works
Taxol produces a predominantly sensory neuropathy
Lipton, R. B., Apfel, S. C., Dutcher, J. P., Rosenberg, R., Kaplan, J., Berger, A., Einzig, A. I., Wiernik, P. H., & Schaumburg, H. H. (1989) · Neurology · doi:10.1212/wnl.39.3.368 · Cited by 317 · see citing works
Siau, C., Xiao, W. H., & BENNETT, G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.05.007 · Cited by 302 · see citing works
Wu, G., Ringkamp, M., Murinson, B. B., Pogatzki, E. M., Hartke, T. V., Weerahandi, H. M., Campbell, J. N., Griffin, J. W., & Meyer, R. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07746.2002 · Cited by 279 · see citing works
Zheng, H., Xiao, W. H., & Bennett, G. J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.016 · Cited by 273 · see citing works
Chemotherapy-Induced Peripheral Neuropathy: Prevention and Treatment
Pachman, D. R., Barton, D. L., Watson, J. C., & Loprinzi, C. L. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.115 · Cited by 269 · see citing works
Alessandri‐Haber, N., Dina, O. A., Joseph, E. K., Reichling, D. B., & Levine, J. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4497-07.2008 · Cited by 226 · see citing works
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
Anand, P., Whiteside, G. T., Fowler, C. J., & Hohmann, A. G. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.003 · Cited by 217 · see citing works
Self-citationCao, L., & DeLeo, J. A. (2008) · European Journal of Immunology · doi:10.1002/eji.200737485 · Cited by 212 · see citing works
Zhang, H.-J., Yoon, S.-Y., Zhang, H.-M., & Dougherty, P. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.12.002 · Cited by 211 · see citing works
Melli, G., Taiana, M. M., Camozzi, F., Triolo, D., Podini, P., Quattrini, A., Taroni, F., & Lauria, G. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.08.013 · Cited by 202 · see citing works
Goodnough, L. T., Saito, H., Manni, A., Jones, P. K., & Pearson, O. H. (1984) · Cancer · doi:10.1002/1097-0142(19841001)54:7 · Cited by 200 · see citing works
Ta, L. E., Bieber, A. J., Carlton, S. M., Loprinzi, C. L., Low, P. A., & Windebank, A. J. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-15 · Cited by 193 · see citing works
Xiao, W. H., & Bennett, G. J. (2007) · Pain · doi:10.1016/j.pain.2007.06.001 · Cited by 174 · see citing works
Dina, O. A., Chen, X., Reichling, D. B., & Levine, J. D. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00425-0 · Cited by 167 · see citing works
Anand, U., Otto, W. R., Sanchez-Herrera, D., Facer, P., Yiangou, Y., Korchev, Y., Birch, R., Benham, C., Bountra, C., Chessell, I. P., et al. (2008) · Pain · doi:10.1016/j.pain.2008.06.007 · Cited by 166 · see citing works
An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections
Authier, N. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00003-7 · Cited by 165 · see citing works
Elmes, S. J. R., Jhaveri, M. D., Smart, D., Kendall, D. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03690.x · Cited by 160 · see citing works
Sagar, D. R., Kelly, S., Millns, P. J., O'Shaughnessey, C. T., Kendall, D. A., & Chapman, V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04206.x · Cited by 154 · see citing works
Xiao, W. H., Zheng, H., Zheng, F. Y., Nuydens, R., Meert, T. F., & Bennett, G. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.010 · Cited by 154 · see citing works
Bhangoo, S. K., Ren, D., Miller, R. J., Chan, D., Ripsch, M. S., Weiß, C., McGinnis, C., & White, F. A. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.003 · Cited by 150 · see citing works
Self-citationRahn, E. J., Makriyannis, A., & Hohmann, A. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707333 · Cited by 146 · see citing works
Self-citationCannabinoid Type-1 Receptor Reduces Pain and Neurotoxicity Produced by Chemotherapy
Khasabova, I. A., Khasabov, S., Paz, J., Harding-Rose, C., Simone, D. A., & Seybold, V. S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0403-12.2012 · Cited by 129 · see citing works
Animal Models of Chemotherapy-Evoked Painful Peripheral Neuropathies
Authier, N., Balayssac, D., Marchand, F., Ling, B., Zangarelli, A., Descoeur, J., Coudoré, F., Bourinet, E., & Eschalier, A. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.003 · Cited by 120 · see citing works
Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes
Ghosh, S. T., Preet, A., Groopman, J. E., & Ganju, R. K. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.01.005 · Cited by 120 · see citing works
Nociceptor Hyper-Responsiveness during Vincristine-Induced Painful Peripheral Neuropathy in the Rat
Tanner, K. D., Reichling, D. B., & Levine, J. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06480.1998 · Cited by 119 · see citing works
Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141994 · Cited by 116 · see citing works
Self-citationCXC Chemokine Receptor 4 Expression and Function in Human Astroglioma Cells
Oh, J., Drabik, K., Kutsch, O., Choi, C., Tousson, A., & Benveniste, E. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2695 · Cited by 114 · see citing works
Nackley, A. G., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00886.2003 · Cited by 111 · see citing works
Self-citationChemotherapy-Induced Neuropathy
Cavaletti, G., Alberti, P., Frigeni, B., Piatti, M., & Susani, E. L. (2010) · Current Treatment Options in Neurology · doi:10.1007/s11940-010-0108-3 · Cited by 110 · see citing works
Cannabis and Its Derivatives: Review of Medical Use
Leung, L. (2011) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2011.04.100280 · Cited by 102 · see citing works
Chemotherapy-evoked Painful Peripheral Neuropathy
Polomano, R. C., & Bennett, G. J. (2001) · Pain Medicine · doi:10.1046/j.1526-4637.2001.002001008.x · Cited by 100 · see citing works
Burgos, E., Gómez‐Nicola, D., Pascual, D., Martı́n, M. I., Nieto‐Sampedro, M., & Goicoechea, C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.008 · Cited by 99 · see citing works
Wilkerson, J. L., Gentry, K. R., Dengler, E. C., Wallace, J. A., Kerwin, A. A., Armijo, L. M., Kuhn, M. N., Thakur, G. A., Makriyannis, A., & Milligan, E. D. (2012) · Pain · doi:10.1016/j.pain.2012.02.015 · Cited by 99 · see citing works
Self-citationNasser, M. W., Qamri, Z., Deol, Y. S., Smith, D. L., Shilo, K., Zou, X., & Ganju, R. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023901 · Cited by 96 · see citing works
Neurologic complications of cancer therapy
Plotkin, S. R., & Wen, P. Y. (2003) · Neurologic Clinics · doi:10.1016/s0733-8619(02)00034-8 · Cited by 94 · see citing works
CXCR4 signaling mediates morphine-induced tactile hyperalgesia
Wilson, N. M., Jung, H., Ripsch, M. S., Miller, R. J., & White, F. A. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.014 · Cited by 94 · see citing works
Self-citationIncreased Chemokine Signaling in a Model of HIV1-Associated Peripheral Neuropathy
Bhangoo, S. K., Ripsch, M. S., Buchanan, D. J., Miller, R. J., & White, F. A. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-48 · Cited by 94 · see citing works
Self-citationCannabilactones: A Novel Class of CB2 Selective Agonists with Peripheral Analgesic Activity
Khanolkar, A. D., Lu, D., Ibrahim, M. M., Richard I. Duclos, Jr., Thakur, G. A., Malan, T. P., Porreca, F., Vijayabaskar, V., Tian, X., George, C. F., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070441u · Cited by 93 · see citing works
Self-citationDomain-restricted expression of two glutamic acid decarboxylase genes in midgestation mouse embryos
Katarova, Z., Sekerkov�, G., Prodan, S., Mugnaini, E., & Szab�, G. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000904)424:4 · Cited by 91 · see citing works
Cannabinoid CB2 Receptor-Mediated Anti-nociception in Models of Acute and Chronic Pain
Jhaveri, M. D., Sagar, D. R., Elmes, S. J. R., Kendall, D. A., & Chapman, V. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8007-7 · Cited by 89 · see citing works
Naguib, M., Diaz, P., Xu, J. J., Astruc‐Diaz, F., Craig, S., Vivas‐Mejia, P., & Brown, D. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.340 · Cited by 82 · see citing works
Dubový, P., Klusáková, I., Svíženská, I. H., & Brázda, V. (2010) · Histochemistry and Cell Biology · doi:10.1007/s00418-010-0675-0 · Cited by 81 · see citing works
Naguib, M., Xu, J. J., Diaz, P., Brown, D. L., Cogdell, D. E., Bie, B., Hu, J., Craig, S. L., & Hittelman, W. N. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31824b0191 · Cited by 76 · see citing works
Carozzi, V., Chiorazzi, A., Canta, A., Lapidus, R. G., Slusher, B. S., Wozniak, K. M., & Cavaletti, G. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9114-1 · Cited by 67 · see citing works
Rahn, E. J., Thakur, G. A., Wood, J. A. T., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.024 · Cited by 57 · see citing works
Self-citationPascual, D., Goicoechea, C., Burgos, E., & Martín, M. I. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.02.009 · Cited by 52 · see citing works
Xu, J. J., Diaz, P., Astruc‐Diaz, F., Craig, S. L., Muñoz, E., & Naguib, M. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181e0cdaf · Cited by 51 · see citing works
Benamar, K., Geller, E. B., & Adler, M. W. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.135053 · Cited by 30 · see citing works
Neurologic complications of cancer therapy
Uhm, J. H., & Yung, W. K. A. (1999) · Current Treatment Options in Neurology · doi:10.1007/s11940-996-0006-x · Cited by 28 · see citing works
Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain
Guindon, J., Desroches, J., Dani, M., & Beaulieu, P. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.060 · Cited by 24 · see citing works
Self-citationBenamar, K., Yondorf, M. Z., Geller, E. B., Eisenstein, T. K., & Adler, M. W. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00285.x · Cited by 23 · see citing works
Ye, S., Istfan, N. W., Driscoll, D. F., & Bistrian, B. R. (1992) · Cancer · doi:10.1002/1097-0142(19920101)69:1 · Cited by 19 · see citing works
A cannabinoid pharmacotherapy for chemotherapy-evoked painful peripheral neuropathy
Hohmann, A. G. (2005) · Pain · doi:10.1016/j.pain.2005.07.007 · Cited by 10 · see citing works
Self-citationElmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4
Flagged first, then by citations
Cited by
Sorted by citations
Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain
Sisignano, M., Baron, R., Scholich, K., & Geißlinger, G. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.211 · Cited by 340 · see citing works
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
Ward, S. J., McAllister, S. D., Kawamura, R., Murase, R., Neelakantan, H., & Walker, E. A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12439 · Cited by 277 · see citing works
Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)
Han, F. Y., & Smith, M. T. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00156 · Cited by 273 · see citing works
Lynch, M. E., Cesar-Rittenberg, P., & Hohmann, A. G. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.02.018 · Cited by 266 · see citing works
Self-citationCytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management
Vanderwall, A. G., & Milligan, E. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03009 · Cited by 219 · see citing works
Deng, L., Guindon, J., Cornett, B., Makriyannis, A., Mackie, K., & Hohmann, A. G. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.009 · Cited by 200 · see citing works
Self-citationFumagalli, G., Monza, L., Cavaletti, G., Rigolio, R., & Meregalli, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.626687 · Cited by 183 · see citing works
Guindon, J., Lai, Y., Takacs, S. M., Bradshaw, H. B., & Hohmann, A. G. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.013 · Cited by 160 · see citing works
Self-citationKing, K. M., Myers, A. M., Soroka‐Monzo, A. J., Tuma, R. F., Tallarida, R. J., Walker, E. A., & Ward, S. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13887 · Cited by 156 · see citing works
Slivicki, R. A., Xu, Z., Kulkarni, P. M., Pertwee, R. G., Mackie, K., Thakur, G. A., & Hohmann, A. G. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.032 · Cited by 136 · see citing works
Self-citationAntiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice
Segat, G. C., Manjavachi, M. N., Matias, D. O., Passos, G. F., Freitas, C. S., da Costa, R., & Calixto, J. Β. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.015 · Cited by 113 · see citing works
Lin, X., Dhopeshwarkar, A., Huibregtse, M. E., Mackie, K., & Hohmann, A. G. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.109355 · Cited by 91 · see citing works
Self-citationOpportunities for cannabis in supportive care in cancer
Kleckner, A., Kleckner, I., Kamen, C., Tejani, M., Janelsins, M., Morrow, G., & Peppone, L. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919866362 · Cited by 78 · see citing works
Xu, T., Zhang, X., Ouyang, H., Li, Z., Liu, C., Huang, Z., Xu, J., Wei, J., Nie, B., Ma, C., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000805 · Cited by 87 · see citing works
Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research
Leitzelar, B. N., & Koltyn, K. F. (2021) · Sports Medicine - Open · doi:10.1186/s40798-021-00307-9 · Cited by 84 · see citing works
Khasabova, I. A., Khasabov, S. G., Olson, J. K., Uhelski, M. L., Kim, A. H., Albino-Ramírez, A. M., Wagner, C. L., Seybold, V. S., & Simone, D. A. (2018) · Pain · doi:10.1097/j.pain.0000000000001448 · Cited by 72 · see citing works
Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain
Blanton, H. L., Brelsfoard, J., Deturk, N., Pruitt, K., Narasimhan, M., Morgan, D. J., & Guindon, J. (2019) · Drugs · doi:10.1007/s40265-019-01132-x · Cited by 70 · see citing works
Self-citationLi, A.-L., Lin, X., Dhopeshwarkar, A., Thomaz, A. C., Carey, L. M., Liu, Y., Nikas, S. P., Makriyannis, A., Mackie, K., & Hohmann, A. G. (2018) · Molecular Pharmacology · doi:10.1124/mol.118.113233 · Cited by 69 · see citing works
Self-citationRahn, E. J., Deng, L., Thakur, G. A., Vemuri, K. V., Zvonok, A. M., Lai, Y. Y., Makriyannis, A., & Hohmann, A. G. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-27 · Cited by 65 · see citing works
Self-citationKulkarni, P. M., Kulkarni, A., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan‐Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01303 · Cited by 64 · see citing works
Self-citationDeng, L., Cornett, B., Mackie, K., & Hohmann, A. G. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.098483 · Cited by 60 · see citing works
Self-citationMulpuri, Y., Marty, V. N., Munier, J. J., Mackie, K., Schmidt, B. L., Seltzman, H. H., & Spigelman, I. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.002 · Cited by 62 · see citing works
Makriyannis, A. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500220s · Cited by 61 · see citing works
Self-citationJiang, M., Huizenga, M. C. W., Wirt, J. L., Pálóczi, J., Amedi, A., van den Berg, R. J. B. H. N., Benz, J., Collin, L., Deng, H., Di, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43606-3 · Cited by 59 · see citing works
Self-citationPaclitaxel Induces Acute Pain via Directly Activating Toll like Receptor 4
Yan, X., Maixner, D. W., Yadav, R., Gao, M., Li, P., Bartlett, M. G., & Weng, H. (2015) · Molecular Pain · doi:10.1186/s12990-015-0005-6 · Cited by 53 · see citing works
Hossain, M. Z., Ando, H., Unno, S., & Kitagawa, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041423 · Cited by 52 · see citing works
JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy
Khasabova, I. A., Yao, X., Paz, J., Lewandowski, C. T., Lindberg, A. E., Coicou, L., Burlakova, N., Simone, D. A., & Seybold, V. S. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.09.008 · Cited by 50 · see citing works
Ma, Y.-C., Kang, Z.-B., Shi, Y., Ji, W.-Y., Zhou, W., & Wei, N. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2305089 · Cited by 47 · see citing works
Ferris, C. F., Nodine, S., Pottala, T., Cai, X., Knox, T. M., Fofana, F. H., Kim, S. J., Kulkarni, P. P., Crystal, J. D., & Hohmann, A. G. (2019) · Neurobiology of Pain · doi:10.1016/j.ynpai.2019.100034 · Cited by 47 · see citing works
Self-citationKim, H. K., Hwang, S.-H., & Abdi, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00532 · Cited by 46 · see citing works
Jiang, L., Zhang, Q., Ren, H., Ma, S., Lu, C., Liu, B., Liu, J., Liang, J., Li, M., & Zhu, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124994 · Cited by 45 · see citing works
Slivicki, R. A., Saberi, S. A., Iyer, V., Vemuri, K. V., Makriyannis, A., & Hohmann, A. G. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.252288 · Cited by 45 · see citing works
Self-citationPittman, S. K., Gracias, N. G., Vasko, M. R., & Fehrenbacher, J. C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.011 · Cited by 44 · see citing works
Neuro-immune interactions in paclitaxel-induced peripheral neuropathy
Vermeer, C. J. C., Hiensch, A. E., Cleenewerk, L., May, A. M., & Eijkelkamp, N. (2021) · Acta Oncologica · doi:10.1080/0284186x.2021.1954241 · Cited by 39 · see citing works
Laprairie, R. B., Kulkarni, A., Kulkarni, P. M., Hurst, D. P., Lynch, D. L., Reggio, P. H., Janero, D. R., Pertwee, R. G., Stevenson, L., Kelly, M. E. M., et al. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00041 · Cited by 39 · see citing works
Self-citationNent, E., Nozaki, C., Schmöle, A., Otte, D. M., & Zimmer, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-43858-4 · Cited by 37 · see citing works
Masocha, W. (2018) · Pain Research and Management · doi:10.1155/2018/5234943 · Cited by 37 · see citing works
Carey, L. M., Lee, W.-H., Gutierrez, T., Kulkarni, P. M., Thakur, G. A., Lai, Y. Y., & Hohmann, A. G. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.055 · Cited by 33 · see citing works
Self-citationWu, B.-Y., Liu, C., Su, Y., Chen, S., Chen, Y., & Tsai, M.-Y. (2018) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2018.11.022 · Cited by 33 · see citing works
Kuai, C.-P., Ju, L., Hu, P.-P., & Huang, F. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500214 · Cited by 32 · see citing works
Pantouli, F., Grim, T. W., Schmid, C. L., Acevedo‐Canabal, A., Kennedy, N. M., Cameron, M. D., Bannister, T. D., & Bohn, L. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108439 · Cited by 31 · see citing works
Henderson, A. N., Nealon, C. M., Davis, B. J., Yuill, M. B., Sepúlveda, D. E., Blanton, H. L., Piscura, M. K., Zee, M. L., Haskins, C. P., Marcus, D. J., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107847 · Cited by 32 · see citing works
Self-citationPanoz‐Brown, D., Carey, L. M., Smith, A. E., Gentry, M., Sluka, C. M., Corbin, H. E., Wu, J.-E., Hohmann, A. G., & Crystal, J. D. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.08.001 · Cited by 30 · see citing works
Self-citationHenderson, A. N., Crawford, L. C., Sepúlveda, D. E., Hale, D. E., Lesperance, J., & Morgan, D. J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.684115 · Cited by 30 · see citing works
The CB2 cannabinoid receptor as a therapeutic target in the central nervous system
Cabañero, D., Martín‐García, E., & Maldonado, R. J. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1971196 · Cited by 29 · see citing works
Warren, W. G., Osborn, M., Tsantoulas, C., David-Pereira, A., Cohn, D., Duffy, P., Ruston, L., Johnson, C. T., Bradshaw, H. B., Kaczocha, M., et al. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.01.335 · Cited by 26 · see citing works
Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists
Dhopeshwarkar, A., Murataeva, N., Makriyannis, A., Straiker, A. J., & Mackie, K. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.236539 · Cited by 26 · see citing works
Self-citationAnalgesic Effects Mediated by Muscarinic Receptors: Mechanisms and Pharmacological Approaches
Angelis, F. D., & Tata, A. M. (2016) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524916666160302103033 · Cited by 25 · see citing works
Parvathy, S. S., & Masocha, W. (2015) · Scientific Reports · doi:10.1038/srep10541 · Cited by 25 · see citing works
Alkislar, I., Miller, A. R., Hohmann, A. G., Sadaka, A. H., Cai, X., Kulkarni, P., & Ferris, C. F. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.11.015 · Cited by 24 · see citing works
Self-citationRaup‐Konsavage, W. M., Sepúlveda, D. E., Wang, J., Dokholyan, N. V., Vrana, K. E., & Graziane, N. (2023) · Biomedicines · doi:10.3390/biomedicines12010083 · Cited by 24 · see citing works
Deng, L., Lee, W.-H., Xu, Z., Makriyannis, A., & Hohmann, A. G. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.10.007 · Cited by 23 · see citing works
Self-citationEffects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model
Hsu, S., Yao, C., Hsu, Y., Lin, J., Chen, Y., & Chen, Y.-S. (2017) · Scientific Reports · doi:10.1038/srep42280 · Cited by 23 · see citing works
Update on cannabis and cannabinoids for cancer pain
Chung, M. J., Kim, H. K., & Abdi, S. (2020) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000934 · Cited by 24 · see citing works
Slivicki, R. A., Ali, Y., Lu, H., & Hohmann, A. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147620 · Cited by 21 · see citing works
Self-citationUntapped endocannabinoid pharmacological targets: Pipe dream or pipeline?
Wilkerson, J. L., Bilbrey, J. A., Felix, J. S., Makriyannis, A., & McMahon, L. R. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173192 · Cited by 20 · see citing works
Self-citationEffect of Xylopic Acid on Paclitaxel-induced Neuropathic pain in rats
Ameyaw, E., Boampong, J., Kukuia, K. K. E., Amoateng, P., Obese, E., Osei-Sarpong, C., & Woode, E. (2014) · Journal of Medical and Biomedical Sciences · doi:10.4314/jmbs.v2i4.2 · Cited by 20 · see citing works
Yu, Z., Liu, T., Zhao, Y., Huang, Y., & Gao, Y. (2014) · Tumor Biology · doi:10.1007/s13277-014-1607-8 · Cited by 17 · see citing works
Wilkerson, J. L., Alberti, L. B., Kerwin, A. A., Ledent, C. A., Thakur, G. A., Makriyannis, A., & Milligan, E. D. (2020) · Brain and Behavior · doi:10.1002/brb3.1850 · Cited by 16 · see citing works
Self-citationAmoateng, P., Adjei, S., Osei‐Safo, D., Ameyaw, E. O., Ahedor, B., N’guessan, B. B., & Nyarko, A. K. (2015) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2014-0084 · Cited by 16 · see citing works
Rukh, L., Ali, G., Ullah, R., Islam, N. U., & Shahid, M. M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173481 · Cited by 16 · see citing works
Guenther, K. G., Wirt, J. L., Oliva, I., Saberi, S. A., Crystal, J. D., & Hohmann, A. G. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110257 · Cited by 15 · see citing works
Self-citationRamer, R., & Hinz, B. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108851 · Cited by 15 · see citing works
Agnes, J. P., dos Santos, B., das Neves, R. N., Luciano, V. M. M., Benvenutti, L., Goldoni, F. C., Schran, R. G., Santin, J. R., Quintão, N. L. M., & Zanotto‐Filho, A. (2023) · Antioxidants · doi:10.3390/antiox12101893 · Cited by 14 · see citing works
Dönertaş, B., Ünel, Ç. Ç., & Erol, K. (2018) · Journal of Experimental Pharmacology · doi:10.2147/jep.s162059 · Cited by 14 · see citing works
Shannonhouse, J. L., Bernabucci, M., Gómez, R. S., Son, H., Zhang, Y., Ai, C.-H., Ishida, H., & Kim, Y. S. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1064-21.2022 · Cited by 13 · see citing works
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
Guenther, K. G., & Hohmann, A. G. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70116 · Cited by 12 · see citing works
Self-citationGorzo, A., Havasi, A. D., Spînu, Ș., Oprea, A. L., Burz, C. C., & Sur, D. G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175036 · Cited by 13 · see citing works
Liu, C., Ma, M., Wen, C., Zaman, R. U., & Olatunji, O. J. (2021) · All Life · doi:10.1080/26895293.2021.1927204 · Cited by 12 · see citing works
Campeau, L., Füllhase, C., Sawada, N., Gratzke, C., Hedlund, P., Howlett, A. C., & Andersson, K. (2013) · Neurourology and Urodynamics · doi:10.1002/nau.22454 · Cited by 9 · see citing works
Eroglu, E., Ünel, Ç. Ç., HARMANCI, N., Erol, K., Arı, N. S., & Özatik, O. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126909 · Cited by 8 · see citing works
Becker, G., Atuati, S. F., & Oliveira, S. M. (2024) · Cancers · doi:10.3390/cancers16030580 · Cited by 8 · see citing works
Thompson, J. M., Blanton, H. L., Pietrzak, A., Little, W., Sherfey, C., & Guindon, J. (2019) · Molecular Pain · doi:10.1177/1744806919874192 · Cited by 8 · see citing works
Self-citationKim, L., Nan, G., Kim, H. Y., Cha, M., & Lee, B. H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117515 · Cited by 7 · see citing works
Marino, C. D., Llorente‐Berzal, A., Diego, A. M., Bella, A., Boullon, L., Berrocoso, E., Roche, M., & Finn, D. P. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1505980 · Cited by 7 · see citing works
Vera, G., López‐Gómez, L., Girón, R., Martı́n, M. I., Nurgali, K., Abalo, R., & Uranga, J. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914430 · Cited by 6 · see citing works
Cunha, M., Tavares, I., & Costa‐Pereira, J. T. (2024) · Brain Sciences · doi:10.3390/brainsci14070659 · Cited by 6 · see citing works
Drummond, I. S. A., Oliveira, J. D. D., Niella, R. V., Silva, Á. J. C., de Oliveira, I. S., de Souza, S. S., Marques, C. S. D. C., Corrêa, J. M. X., Silva, J. F., & de Lavor, M. S. L. (2024) · Animals · doi:10.3390/ani14131941 · Cited by 6 · see citing works
Warren, W. G., Osborn, M., David-Pereira, A., Tsantoulas, C., Xue, W., Yates, A., & O’Sullivan, S. E. (2024) · European Journal of Pain · doi:10.1002/ejp.4718 · Cited by 5 · see citing works
Modulation of Pain by Endocannabinoids in the Periphery
Uhelski, M. L., Khasabova, I. A., & Simone, D. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.79673 · Cited by 5 · see citing works
MMG22 Potently Blocks Hyperalgesia in Cisplatin-treated Mice
Cataldo, G., Lunzer, M. M., Akgün, E., Wong, H. L., Portoghese, P. S., & Simone, D. A. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.02.006 · Cited by 4 · see citing works
Altaf, N., Rehman, N. U., Karim, N., Khan, I., Halim, S. A., Alotaibi, B. S., Hamad, R. S., Batiha, G. E., Tayyeb, J. Z., Turkistani, A. A., et al. (2024) · Neurochemical Research · doi:10.1007/s11064-023-04078-5 · Cited by 4 · see citing works
Karim, N., Khan, I., Abdelhalim, A., Halim, S. A., Khan, A., Altaf, N., Ahmad, W., Ghaffar, R., & Al‐Harrasi, A. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-02021-x · Cited by 3 · see citing works
Cannabinoids to Fight Chemotherapy-Induced Adverse Effects
Bagüés, A., Benítez, D., & Abalo, R. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_350-2 · Cited by 1 · see citing works
Muscarinic agonists in the treatment of neuropathic pain: a novel finding
Deng, L., & Guindon, J. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12123 · Cited by 1 · see citing works
Self-citationMMG22 Potently Blocks Hyperalgesia in Cisplatin-Treated MicePreprint
Cataldo, G., Lunzer, M. M., Akgün, E., Wong, H. L., Portoghese, P. S., & Simone, D. A. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4192510 · Cited by 1 · see citing works
Cannabinoids: clearing the smoke on pain, inflammation and neurodegeneration
Downer, E. J., & Finn, D. P. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12642
Kurochkina, N. A. (2019) · Springer eBooks · doi:10.1007/978-981-13-6601-7_5
Cannabinoids to Fight Chemotherapy-Induced Adverse Effects
Bagüés, A., Benítez, D., & Abalo, R. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_350-1
Jesus, C. H. A., Reddy, G. R., Sizemore, E. F., Wirt, J. L., Sen, S., Yu, R. C., Takeuchi, T., Schwimmer, L. J., & Hohmann, A. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.26.690750
Self-citationCannabinoids to Fight Chemotherapy-Induced Adverse Effects
Bagüés, A., Benítez, D., & Abalo, R. (2025) · Springer eBooks · doi:10.1007/978-3-032-00775-9_350
Zia, B., Meeran, M. F. N., Sharma, C., Mirza, S., & Ojha, S. K. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178646
- Authors
- Deng, L., Guindon, J., Vemuri, V. K., Thakur, G. A., White, F. A., Makriyannis, A., & Hohmann, A. G.
- Affiliations
- Indiana University Bloomington (US)
- Center for Drug Discovery, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA
- Northeastern University (US)
- Indiana University School of Medicine (US)
- Corresponding author
- Hohmann, Andrea G
- Venue
- Molecular Pain
- Publisher
- SAGE Publications
- Published
- 2012-01-01
- Volume
- 8
- Pages
- 71-71
- ISSN
- 1744-8069 (ISSN-L)
- PMC
- PMC3502129
- OpenAlex
- W2097659456
- Cited by
- 94
- References
- 74
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 1
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Pain (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by)
- Funders
- National Institute on Drug Abuse (DA3801, DA 9158, R01DA026040, DA028200, R01DA021644, RC1DA028200, P01DA009158, DA021644, DA026040)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Keywords
- chemotherapy-induced peripheral neuropathy, CB2 receptor, cisplatin, paclitaxel, mechanical allodynia, cold allodynia, CXCR4 signaling, neuropathic pain, antinociception, AM630, AMD3100, CB1 receptor
- MeSH terms
- Cyclams, Animals, Benzylamines, Chromones, Cisplatin, Disease Models, Animal, Heterocyclic Compounds, Hyperalgesia, Indoles, Male, Peripheral Nervous System Diseases, Piperidines, Pyrazoles, Time Factors, Signal Transduction, Treatment Outcome, Rats, Sprague-Dawley, Paclitaxel, Receptors, CXCR4, Receptor, Cannabinoid, CB2, Rats, Cryopyrin-Associated Periodic Syndromes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review