Regulation of exosome release from mammary epithelial and breast cancer cells – A new regulatory pathway

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766

Exosomes: composition, biogenesis and function

Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature Reviews Immunology · doi:10.1038/nri855 · Cited by 5,346

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

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Rab27a and Rab27b control different steps of the exosome secretion pathway

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Shedding microvesicles: artefacts no more

Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,429

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

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Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

Rabinowits, G., Gerçel-Taylor, C., Day, J. M., Taylor, D. D., & Kloecker, G. H. (2009) · Clinical Lung Cancer · doi:10.3816/clc.2009.n.006 · Cited by 1,262

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Lee, Y., EL Andaloussi, S., & Wood, M. J. A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds317 · Cited by 938

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

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Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

Webber, J., Steadman, R., Mason, M. D., Tabi, Z., & Clayton, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1722 · Cited by 852

The Biogenesis and Functions of Exosomes

Stoorvogel, W., Kleijmeer, M. J., Geuze, H. J., & Raposo, G. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30502.x · Cited by 847

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

Kosaka, N., Iguchi, H., Hagiwara, K., Yoshioka, Y., Takeshita, F., & Ochiya, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446831 · Cited by 771

Interaction and uptake of exosomes by ovarian cancer cells

Escrevente, C., Keller, S., Altevogt, P., & Costa, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-108 · Cited by 666

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

Bobrie, A., Krumeich, S., Reyal, F., Recchi, C., Moita, L. F., Seabra, M. C., Ostrowski, M., & Théry, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0925 · Cited by 645

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 595

Extracellular vesicle sizing and enumeration by nanoparticle tracking analysis

Gardiner, C., Ferreira, Y. J., Dragovic, R. A., Redman, C. W. G., & Sargent, I. L. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.19671 · Cited by 584

Tumour-released exosomes and their implications in cancer immunity

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Exosome removal as a therapeutic adjuvant in cancer

Marleau, A. M., Chen, C.-S., Joyce, J. A., & Tullis, R. H. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-134 · Cited by 411

Itinerant exosomes: emerging roles in cell and tissue polarity

Lakkaraju, A., & Rodriguez-Boulan, E. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.03.002 · Cited by 391

Proteomics Analysis of Bladder Cancer Exosomes

Welton, J. L., Khanna, S., Giles, P. J., Brennan, P., Brewis, I. A., Staffurth, J., Mason, M. D., & Clayton, A. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m000063-mcp201 · Cited by 387

Current Protocols in Cell Biology

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Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells

Soo, C. Y., Song, Y., Zheng, Y., Campbell, E. C., Riches, A. C., Gunn‐Moore, F., & Powis, S. J. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03569.x · Cited by 348

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

Thompson, C. A., Purushothaman, A., Ramani, V. C., Vlodavsky, I., & Sanderson, R. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c112.444562 · Cited by 322

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models

Suetsugu, A., Honma, K., Saji, S., Moriwaki, H., Ochiya, T., & Hoffman, R. M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.007 · Cited by 317

Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T‐lymphocyte responses and antitumour immunity

Hao, S., Bai, O., Li, F., Yuan, J., Laferte, S., & Xiang, J. (2007) · Immunology · doi:10.1111/j.1365-2567.2006.02483.x · Cited by 248

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

O’Brien, K., Rani, S., Corcoran, C., Wallace, R., Hughes, L., Friel, A. M., McDonnell, S., Crown, J., Radomski, M. W., & O’Driscoll, L. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.01.017 · Cited by 239

Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines

CHIBA, M., KIMURA, M., & ASARI, S. (2012) · Oncology Reports · doi:10.3892/or.2012.1967 · Cited by 235

Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients

Gercel-Taylor, C., Atay, S., Tullis, R. H., Kesimer, M., & Taylor, D. D. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.06.004 · Cited by 232

Circulating MicroRNA Signatures of Tumor-Derived Exosomes for Early Diagnosis of Non–Small-Cell Lung Cancer

Rosell, R., Wei, J., & Tarón, M. (2009) · Clinical Lung Cancer · doi:10.3816/clc.2009.n.001 · Cited by 133

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

Zheng, Y. H., Campbell, E. C., Lucocq, J. M., Riches, A., & Powis, S. J. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.10.006 · Cited by 82

Novel gene rearrangements in transformed breast cells identified by high-resolution breakpoint analysis of chromosomal aberrations

Unger, K., Wienberg, J., Riches, A., Hieber, L., Walch, A. K., Brown, A., O’Brien, P. C., Briscoe, C., Gray, L., Rodríguez, E., et al. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0065 · Cited by 41

Targeting cancer stem cell pathways for cancer therapy

Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0110-5 · Cited by 1,906

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Mashouri, L., Yousefi, H., Aref, A. R., Ahadi, A. M., Molaei, F., & Alahari, S. K. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,363

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Fang, T., Lv, H., Lv, G., Li, T., Wang, C., Han, Q., Yu, L., Su, B., Guo, L., Huang, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02583-0 · Cited by 995

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

Minciacchi, V. R., Freeman, M. R., & Di Vizio, D. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.02.010 · Cited by 963

Advances in Hypoxia-Inducible Factor Biology

Choudhry, H., & Harris, A. L. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.005 · Cited by 868