Uric acid in metabolic syndrome: From an innocent bystander to a central player
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Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease. Several experimental and clinical studies support a role for uric acid as a contributory causal factor in these conditions. Here we discuss some of the major mechanisms linking uric acid to metabolic and cardiovascular diseases. At this time the key to understanding the importance of uric acid in these diseases will be the conduct of large clinical trials in which the effect of lowering uric acid on hard clinical outcomes is assessed. Elevated uric acid may turn out to be one of the more important remediable risk factors for metabolic and cardiovascular diseases.
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Excessive fructose consumption can promote uric acid synthesis by inducing degradation of ATP to AMP, a substrate for uric acid production.
“Many studies have confirmed that excessive fructose consumption can promote uric acid synthesis by inducing degradation ATP to AMP, a substrate for uric acid production.109 110 111”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [111]
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- Authors
- Kanbay, M., Jensen, T., Solak, Y., Le, M., Roncal-Jimenez, C., Rivard, C., Lanaspa, M. A., Nakagawa, T., & Johnson, R. J.
- Affiliations
- Koç University (TR)
- Kyoto University (JP)
- Denver VA Medical Center (US)
- Corresponding author
- Kanbay, Mehmet
- Venue
- European Journal of Internal Medicine
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 29
- Pages
- 3-8
- ISSN
- 0953-6205 (ISSN-L)
- PMC
- PMC4826346
- OpenAlex
- W2215784195
- Cited by
- 419
- References
- 116
- Citations by year
- 2026: 38 · 2025: 42 · 2024: 27 · 2023: 44 · 2022: 51 · 2021: 37 · 2020: 56 · 2019: 34 · 2018: 42 · 2017: 24 · 2016: 22 · 2015: 1
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R03DK105041, K01DK095930)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- uric acid, metabolic syndrome, hypertension, diabetes mellitus, non-alcoholic fatty liver disease, chronic kidney disease, cardiovascular disease, purine metabolism, hyperuricemia, urate-lowering therapy, cardiovascular risk factors
- MeSH terms
- Diabetes Mellitus, Humans, Hypertension, Risk Factors, Uric Acid, Metabolic Syndrome, Hyperuricemia, Renal Insufficiency, Chronic, Non-alcoholic Fatty Liver Disease
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