Non-alcoholic fatty liver disease and dyslipidemia: An update
Abstract
Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic steatohepatitis, NASH), and in some cases to cirrhosis and hepatocellular carcinoma. Inflammation, oxidative stress and insulin resistance are involved in NAFLD development and progression. NAFLD has been associated with several cardiovascular (CV) risk factors including obesity, dyslipidemia, hyperglycemia, hypertension and smoking. NAFLD is also characterized by atherogenic dyslipidemia, postprandial lipemia and high-density lipoprotein (HDL) dysfunction. Most importantly, NAFLD patients have an increased risk for both liver and CV disease (CVD) morbidity and mortality. In this narrative review, the associations between NAFLD, dyslipidemia and vascular disease in NAFLD patients are discussed. NAFLD treatment is also reviewed with a focus on lipid-lowering drugs. Finally, future perspectives in terms of both NAFLD diagnostic biomarkers and therapeutic targets are considered.
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Obesity is linked to dysregulation of lipid metabolism, which may result in abnormal levels of blood lipids, ectopic lipid deposition and associated metabolic diseases such as non-alcoholic liver disease and atherosclerosis.
“Obesity is linked to dysregulation of lipid metabolism, which may result in abnormal levels of blood lipids, ectopic lipid deposition and associated metabolic diseases such as non-alcoholic liver disease (NAFLD) [8] and atherosclerosis [9].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [8]
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- Authors
- Katsiki, N., Mikhailidis, D. P., & Mantzoros, C. S.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- The Royal Free Hospital (GB)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Mikhailidis, Dimitri P.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 65
- Issue
- 8
- Pages
- 1109-1123
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2364200298
- Semantic Scholar
- 9882759994aaa113ed6e5e69154906a01b106c59
- Cited by
- 564
- References
- 16
- Citations by year
- 2026: 25 · 2025: 63 · 2024: 88 · 2023: 82 · 2022: 78 · 2021: 63 · 2020: 37 · 2019: 44 · 2018: 38 · 2017: 28 · 2016: 15
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, dyslipidemia, atherogenic dyslipidemia, postprandial lipemia, HDL dysfunction, cardiovascular risk, liver fibrosis, insulin resistance, oxidative stress, lipid-lowering drugs, diagnostic biomarkers, therapeutic target
- MeSH terms
- Humans, Insulin Resistance, Liver, Oxidative Stress, Disease Progression, Dyslipidemias, Non-alcoholic Fatty Liver Disease
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