Cited by 419Gout, Hyperuricemia, Uric AcidDiet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic Diseases

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Uric acid in metabolic syndrome: From an innocent bystander to a central player

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Kanbay, Mehmet, Jensen, Thomas, Solak, Yalcin, Le, Myphuong, Roncal-Jimenez, Carlos, Rivard, Chris, Lanaspa, Miguel A., Nakagawa, Takahiko, Johnson, Richard J.·2016·European Journal of Internal Medicine

DOI 10.1016/j.ejim.2015.11.026PMC PMC4826346

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Abstract

Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease. Several experimental and clinical studies support a role for uric acid as a contributory causal factor in these conditions. Here we discuss some of the major mechanisms linking uric acid to metabolic and cardiovascular diseases. At this time the key to understanding the importance of uric acid in these diseases will be the conduct of large clinical trials in which the effect of lowering uric acid on hard clinical outcomes is assessed. Elevated uric acid may turn out to be one of the more important remediable risk factors for metabolic and cardiovascular diseases.

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Authors: Kanbay, M., Jensen, T., Solak, Y., Le, M., Roncal-Jimenez, C., Rivard, C., Lanaspa, M. A., Nakagawa, T., & Johnson, R. J.
Affiliations: Koç University (TR)
Kyoto University (JP)
Denver VA Medical Center (US)
Corresponding author: Kanbay, Mehmet
ORCID: Kanbay, Mehmet
Le, Myphuong
Rivard, Chris
Lanaspa, Miguel A.
Nakagawa, Takahiko
Johnson, Richard J.
Venue: European Journal of Internal Medicine
Publisher: Elsevier BV
Published: 2016-04
Volume: 29
Pages: 3-8
ISSN: 0953-6205 (ISSN-L)
DOI: 10.1016/j.ejim.2015.11.026
PMC: PMC4826346
OpenAlex: W2215784195
Cited by: 419
References: 116
Citations by year: 2026: 38 · 2025: 42 · 2024: 27 · 2023: 44 · 2022: 51 · 2021: 37 · 2020: 56 · 2019: 34 · 2018: 42 · 2017: 24 · 2016: 22
FWCI: 4.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R03DK105041, K01DK095930)
Topics: Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: uric acid, metabolic syndrome, hypertension, diabetes mellitus, non-alcoholic fatty liver disease, chronic kidney disease, cardiovascular disease, purine metabolism, hyperuricemia, urate-lowering therapy, cardiovascular risk factors
MeSH terms: Diabetes Mellitus, Humans, Hypertension, Risk Factors, Uric Acid, Metabolic Syndrome, Hyperuricemia, Renal Insufficiency, Chronic, Non-alcoholic Fatty Liver Disease

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