The DOI matches its Crossref record; 114 of the 116 references it cites were found in a registry or an index.
Uric acid in metabolic syndrome: From an innocent bystander to a central player
Open accessAbstract
Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non-alcoholic fatty liver disease, and chronic kidney disease. Several experimental and clinical studies support a role for uric acid as a contributory causal factor in these conditions. Here we discuss some of the major mechanisms linking uric acid to metabolic and cardiovascular diseases. At this time the key to understanding the importance of uric acid in these diseases will be the conduct of large clinical trials in which the effect of lowering uric acid on hard clinical outcomes is assessed. Elevated uric acid may turn out to be one of the more important remediable risk factors for metabolic and cardiovascular diseases.
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“Many studies have confirmed that excessive fructose consumption can promote uric acid synthesis by inducing degradation ATP to AMP, a substrate for uric acid production.109 110 111”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [111]
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Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
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2 of the 116 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
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Vallon, V., & Thomson, S. C. (2017) · Diabetologia · doi:10.1007/s00125-016-4157-3 · Cited by 635
Non-alcoholic fatty liver disease and dyslipidemia: An update
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Physiological functions and pathogenic potential of uric acid: A review
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The tubular hypothesis of nephron filtration and diabetic kidney disease
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Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
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Metadata
- Authors
- Kanbay, M., Jensen, T., Solak, Y., Le, M., Roncal-Jimenez, C., Rivard, C., Lanaspa, M. A., Nakagawa, T., & Johnson, R. J.
- Affiliations
- Koç University (TR)
- Kyoto University (JP)
- Denver VA Medical Center (US)
- Corresponding author
- Kanbay, Mehmet
- Venue
- European Journal of Internal Medicine
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 29
- Pages
- 3-8
- ISSN
- 0953-6205 (ISSN-L)
- PMC
- PMC4826346
- OpenAlex
- W2215784195
- Cited by
- 419
- References
- 116
- Citations by year
- 2026: 38 · 2025: 42 · 2024: 27 · 2023: 44 · 2022: 51 · 2021: 37 · 2020: 56 · 2019: 34 · 2018: 42 · 2017: 24 · 2016: 22
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R03DK105041, K01DK095930)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- uric acid, metabolic syndrome, hypertension, diabetes mellitus, non-alcoholic fatty liver disease, chronic kidney disease, cardiovascular disease, purine metabolism, hyperuricemia, urate-lowering therapy, cardiovascular risk factors
- MeSH terms
- Diabetes Mellitus, Humans, Hypertension, Risk Factors, Uric Acid, Metabolic Syndrome, Hyperuricemia, Renal Insufficiency, Chronic, Non-alcoholic Fatty Liver Disease
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