Cited by 390Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsPesticide Exposure and Toxicity

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Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection

Singh, Manjinder, Kaur, Maninder, Kukreja, Hitesh, Chugh, Rajan, Silakari, Om, Singh, Dhandeep·2013·European Journal of Medicinal Chemistry

DOI 10.1016/j.ejmech.2013.09.050

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Abstract

Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs has moved from a potent poison (Sarin, Soman) in war times to the potent medicine (physostigmine) in peaceful times. Natural anti-AChE includes carbamates, glycoalkaloids, anatoxins derived from green algae; synthetic anti-AChE includes highly poisonous organophosphates used as nerve gases and insecticides. Recently, the role of anti-AChE was reassessed from neurotoxins to neuron-protective in the diseases characterized by impaired acetylcholine-mediated neurotransmission like Alzheimer's disease (AD). So, the AChE has been proven to be the most viable therapeutic target for the symptomatic treatment of AD. This review article gives a spectrum of strategies to design AChE inhibitors used in the Alzheimer therapy.

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Authors: Singh, M., Kaur, M., Kukreja, H., Chugh, R., Silakari, O., & Singh, D.
Affiliations: Panjab University (IN)
Corresponding author: Singh, Dhandeep
ORCID: Singh, Manjinder
Kaur, Maninder
Silakari, Om
Singh, Dhandeep
Venue: European Journal of Medicinal Chemistry
Publisher: Elsevier BV
Published: 2013-12
Volume: 70
Pages: 165-188
ISSN: 0223-5234 (ISSN-L)
DOI: 10.1016/j.ejmech.2013.09.050
OpenAlex: W1994264985
Cited by: 364
References: 210
Citations by year: 2026: 12 · 2025: 30 · 2024: 31 · 2023: 34 · 2022: 35 · 2021: 29 · 2020: 32 · 2019: 36 · 2018: 30 · 2017: 31 · 2016: 21 · 2015: 23 · 2014: 17 · 2013: 1
FWCI: 2.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Keywords: acetylcholinesterase inhibitors, Alzheimer's disease, acetylcholinesterase, cholinergic neurotransmission, organophosphorus nerve agents, carbamate insecticides, physostigmine, glycoalkaloids, anatoxin, neuroprotection, drug design strategies, alpha/beta hydrolase superfamily
MeSH terms: Acetylcholinesterase, Alzheimer Disease, Animals, Cholinesterase Inhibitors, Humans, Drug Design, Molecular Structure

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Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection

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