The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications
Abstract
The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are members of the nuclear receptor super-family, acting as ligand-inducible transcription factors and play crucial roles in glucose and lipid metabolism. These are a well-known receptor for diabetic therapy, not only influence the cardiovascular systems but are also expressed in many human solid tumors. For atherosclerosis, inflammation, and hypertension, the PPARs are considered as important therapeutic targets. Furthermore, it has been suggested that careful designing of partial agonists for PPARs, may show improvement with the side effects and also increase the therapeutic value for different diseases as cancer, inflammation and cardiovascular etc. This review summaries structural features of PPAR receptors, illustrates the method of PPAR modulator design, then analyzes recent dual- and pan-agonist with different therapeutic outcomes of the receptor to be used as a target for drugs in future. The advances in PPARs antagonists, their classification and structure-activity relationship are also summarized.
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Cites
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Cited by
The role of lipid metabolic reprogramming in tumor microenvironment
Yang, K., Wang, X., Song, C., He, Z., Wang, R., Xu, Y., Jiang, G., Wan, Y., Mei, J., & Mao, W. (2023) · Theranostics · doi:10.7150/thno.82920 · Cited by 270
Shao, F., Wang, X., Wu, H., Wu, Q., & Zhang, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.825086 · Cited by 250
Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target
Chen, J., Liu, Q., He, J., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.958790 · Cited by 164
Iannotti, F. A., & Vitale, R. M. (2021) · Cells · doi:10.3390/cells10030586 · Cited by 130
Yuxin, L., Chen, L., Xiaoxia, L., Yue, L., Junjie, L., Youzhu, L., Huiliang, Z., & Qicai, L. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6612796 · Cited by 51
“PPARs are members of the nuclear receptor superfamily and have three subtypes, PPARα, PPARβ/δ, and PPARγ, which have the properties of anti-inflammation, anti-TLR4 inflammatory response pathway, and anti-NF-κB [35, 36].”
Background
Metadata
- Authors
- Mirza, A. Z., Althagafi, I. I., & Shamshad, H.
- Venue
- European Journal of Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 166
- Pages
- 502-513
- ISSN
- 0223-5234 (ISSN-L)
- OpenAlex
- W2914645254
- Cited by
- 544
- References
- 119
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mirza, A. Z., Althagafi, I. I., & Shamshad, H. (2019). Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications. European Journal of Medicinal Chemistry. https://doi.org/10.1016/j.ejmech.2019.01.067
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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