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The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation

Iannotti, Fabio Arturo, Vitale, Rosa Maria·2021·Cells
DOI 10.3390/cells10030586PMC PMC8001692
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Abstract

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the expression of a plethora of target genes involved in metabolism, immune reaction, cell differentiation, and a variety of other cellular changes and adaptive responses. PPARs are activated by a large number of both endogenous and exogenous lipid molecules, including phyto- and endo-cannabinoids, as well as endocannabinoid-like compounds. In this view, they can be considered an extension of the endocannabinoid system. Besides being directly activated by cannabinoids, PPARs are also indirectly modulated by receptors and enzymes regulating the activity and metabolism of endocannabinoids, and, vice versa, the expression of these receptors and enzymes may be regulated by PPARs. In this review, we provide an overview of the crosstalk between cannabinoids and PPARs, and the importance of their reciprocal regulation and modulation by common ligands, including those belonging to the extended endocannabinoid system (or “endocannabinoidome”) in the control of major physiological and pathophysiological functions.

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Metadata

Authors
Iannotti, F. A., & Vitale, R. M.
Affiliations
Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2021-03-07
Volume
10
Issue
3
Pages
586
ISSN
2073-4409
DOI
10.3390/cells10030586
PMC
PMC8001692
Cited by
130
References
11
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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