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Cited by 35Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementEstrogen and related hormone effects

Changes in glandular and stromal estrogen and progesterone receptor isoform expression in eutopic and ectopic endometrium following treatment with the levonorgestrel-releasing intrauterine system

Engemise, Samuel L., Willets, Jonathon M., Taylor, Anthony H., Emembolu, Joseph O., Konje, Justin C.·2011·European Journal of Obstetrics & Gynecology and Reproductive Biology
DOI 10.1016/j.ejogrb.2011.02.013
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Abstract

Objectives The levonorgestrel (LNG) intrauterine system (LNG-IUS) has been shown to improve symptoms in women with minimal to moderate endometriosis. The precise mechanism for this is unknown. We hypothesized that this involves alteration in the expression of estrogen receptors (ER) and progesterone receptors (PR).Study design A prospective study of tissues obtained prospectively from 28 women with laparoscopically confirmed minimal to moderate endometriosis treated with LNG-IUS for 6 months. Endometrial and endometriotic biopsies obtained before and 6 months after treatment were processed and stained for ER-α, ER-β and PR expression by immunohistochemistry. Photographs were obtained and the receptors quantified.Results The mean (±SD) age of the 28 women was 31±7.2 (range 18-42) years. Eight of them at initial biopsy were in the proliferative phase and 20 in the secretory phase. ER-α, ER-β and PR expression decreased significantly in the glandular (P<0.0001) and stromal (P<0.0001) compartments of the eutopic endometrium after treatment with LNG-IUS. Similarly, ER-α, ER-β and PR were significantly decreased in the stromal compartment of ectopic endometrium (P<0.0001), and significantly decreased in the ectopic glands of ER-α (P<0.0001), ER-β (P=0.0002) and PR (P=0.0064) expression.Conclusion The ameliorative effect of LNG-IUS on the symptoms of minimal to moderate endometriosis is likely modulated through a decrease in the expression of glandular and stromal ER-α, ER-β and PR in the ectopic endometrium.

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Crossref · 10.1016/j.ejogrb.2011.02.013

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  • The ameliorative effects of LNG-IUS on endometriosis symptoms are likely modulated through a decrease in expression of glandular and stromal estrogen (α and β) and progesterone receptors in the ectopic endometrium.

    “Moreover, the ameliorative effects of LNG-IUS on endometriosis' symptoms are likely modulated through a decrease in the expression of glandular and stromal estrogen ( α and β ) and progesterone receptors in the ectopic endometrium [76, 77].”

    From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [77]

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Authors
Engemise, S. L., Willets, J. M., Taylor, A. H., Emembolu, J. O., & Konje, J. C.
Affiliations
  • University of Leicester (GB)
  • Leicester Royal Infirmary (GB)
Corresponding author
Konje, Justin C.
ORCID
Venue
European Journal of Obstetrics & Gynecology and Reproductive Biology
Publisher
Elsevier BV
Published
2011-07
Volume
157
Issue
1
Pages
101-106
ISSN
  • 0028-2243 (ISSN-L)
  • 0301-2115
DOI
10.1016/j.ejogrb.2011.02.013
OpenAlex
W2162323283
Cited by
35
References
32
Citations by year
2026: 2 · 2024: 2 · 2023: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 4
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
levonorgestrel-releasing intrauterine system, endometriosis, estrogen receptor alpha, estrogen receptor beta, progesterone receptor, ectopic endometrium, eutopic endometrium, endometrial stroma, endometrial glands
MeSH terms
Adolescent, Adult, Biopsy, Endometriosis, Endometrium, Female, Follicular Phase, Humans, Immunohistochemistry, Luteal Phase, Receptors, Estrogen, Receptors, Progesterone, Severity of Illness Index, Down-Regulation, Drug Delivery Systems, Levonorgestrel, Protein Isoforms, Young Adult

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