Effects of a contraceptive containing drospirenone and ethinyl estradiol on blood pressure and autonomic tone: a prospective controlled clinical trial.
Open accessAbstract
Background The use of combined oral contraceptives has been associated with an increased risk of adverse cardiovascular events. Whether these drugs alter cardiac autonomic nervous system control is not completely determined.Objective To evaluate the effect of a contraceptive containing 20mcg of ethinyl estradiol and 3mg of drospirenone on the heart rate variability, baroreflex sensitivity and blood pressure of healthy women.Study design Prospective controlled trial with 69 healthy women allocated in two groups: 36 volunteers under oral combined contraceptive use and 33 volunteers using of non-hormonal contraceptive methods. Subjects were tested before the introduction of the contraceptive method and 6 months after its use. For data acquisition, we used continuous non-invasive beat-to-beat blood pressure curve recordings. Multiple ANOVA was used to determine differences between groups and moments and p< 0.05 was considered statistically significant.Results At baseline, there were no differences in demographic and autonomic parameters between groups. Comparing cardiac sympatho-vagal modulation, baroreceptor sensitivity and blood pressure measurements between baseline and after 6 months, no significant difference was detected in each group or between groups.Conclusion A contraceptive containing 20mcg of ethinyl estradiol and 3mg of drospirenone causes no significant changes in clinical, hemodynamic and autonomic parameters of normal women.
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Cites
Everitt, B. S. (2001) · Psychology Press eBooks · doi:10.4324/9781410605542-11 · Cited by 6,877 · see citing works
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Circulation · doi:10.1161/01.cir.0000154900.76284.f6 · Cited by 3,985 · see citing works
Nonparametric Statistical Inference
(2012) · Springer eBooks · doi:10.1007/springerreference_205502 · Cited by 2,398 · see citing works
Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.543 · Cited by 2,276 · see citing works
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000150859.47929.8e · Cited by 2,051 · see citing works
Generalized Estimating Equations
Hardin, J. W., & Hilbe, J. M. (2002) · doi:10.1201/9781420035285 · Cited by 1,766 · see citing works
Medical-eligibility criteria for contraceptive use
Guillebaud, J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04615-8 · Cited by 1,095 · see citing works
Fifteen years experience with finger arterial pressure monitoring: assessment of the technology
Imholz, B. P. M. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00067-4 · Cited by 837 · see citing works
Stegeman, B. H., de Bastos, M., Rosendaal, F. R., Vlieg, A. V. H., Helmerhorst, F. M., Stijnen, T., & Dekkers, O. M. (2013) · BMJ · doi:10.1136/bmj.f5298 · Cited by 427 · see citing works
Nonparametric Statistical Inference
(2004) · Technometrics · doi:10.1198/tech.2004.s809 · Cited by 408 · see citing works
Reconstruction of Brachial Artery Pressure From Noninvasive Finger Pressure Measurements
Bos, W. J. W., van Goudoever, J., van Montfrans, G. A., et al. (1996) · Circulation · doi:10.1161/01.cir.94.8.1870 · Cited by 365 · see citing works
Contraceptive hormone use and cardiovascular disease
Shufelt, C. L., & Bairey Merz, C. N. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.042 · Cited by 287 · see citing works
Cardiovascular effects of partial sleep deprivation in healthy volunteers
Dettoni, J. L., Consolim-Colombo, F. M., Drager, L. F., Rubira, M. C., Cavasin de Souza, S. B. P., Irigoyen, M. C., Mostarda, C., Borile, S., Krieger, E. M., Moreno, H., et al. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01604.2011 · Cited by 245 · see citing works
Heart Rate Variability and Endogenous Sex Hormones During the Menstrual Cycle in Young Women
Leicht, A. S., Hirning, D. A., & Allen, G. D. (2003) · Experimental Physiology · doi:10.1113/eph8802535 · Cited by 201 · see citing works
The role of cardiac autonomic function in hypertension and cardiovascular disease
Palatini, P., & Julius, S. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0035-4 · Cited by 195 · see citing works
Sympathetic Activity and Baroreflex Sensitivity in Young Women Taking Oral Contraceptives
Minson, C. T., Halliwill, J. R., Young, T. M., & Joyner, M. J. (2000) · Circulation · doi:10.1161/01.cir.102.13.1473 · Cited by 139 · see citing works
Drospirenone, a progestogen with antimineralocorticoid properties: a short review
Oelkers, W. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.030 · Cited by 98 · see citing works
The Analysis of Longitudinal Data
Everitt, B. J., & Rabe‐Hesketh, S. (2001) · Statistics in the health sciences · doi:10.1007/978-1-4757-3285-6_7 · Cited by 87 · see citing works
Wu, C., Grandi, S. M., Filion, K. B., Abenhaim, H., Joseph, L., & Eisenberg, M. J. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12210 · Cited by 73 · see citing works
Parametric evaluation of heart rate variability during the menstrual cycle in young women.
Princi, T., Parco, S., Accardo, A., Radillo, O., Seta, F. D., & Guaschino, S. (2005) · PubMed · Cited by 67 · see citing works
Medical Eligibility Criteria for Contraceptive Use
Secor, R. M., & Stendig-Raskin, I. (2023) · Springer Publishing Company eBooks · doi:10.1891/9780826179630.0041 · Cited by 59 · see citing works
Effect of four combined oral contraceptives on blood pressure in the pill-free interval
Nichols, M., Robinson, G., Bounds, W., Newman, B., & Guillebaud, J. (1993) · Contraception · doi:10.1016/0010-7824(93)90034-5 · Cited by 57 · see citing works
Diagnostic techniques in generalized estimating equations
Venezuela, M. K., Botter, D. A., & Sandoval, M. C. (2007) · Journal of Statistical Computation and Simulation · doi:10.1080/10629360600780488 · Cited by 50 · see citing works
Middlekauff, H. R., Park, J., & Gornbein, J. A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00579.2011 · Cited by 44 · see citing works
Carter, J. R., Klein, J. C., & Schwartz, C. E. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00554.2009 · Cited by 40 · see citing works
Hormonal contraception: recent advances and controversies
(2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.093 · Cited by 36 · see citing works
Giribela, C. R. G., de Melo, N. R., Butcher, R. D. C. G. E. S., Hong, V. C., Guerra, G. M., Baracat, E. C., & Consolim‐Colombo, F. M. (2012) · Contraception · doi:10.1016/j.contraception.2011.08.017 · Cited by 34 · see citing works
Self-citationArias-Loza, P.-A., Hu, K., Schäfer, A., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000242482.57186.e8 · Cited by 30 · see citing works
Cagnacci, A., Ferrari, S., Napolitano, A., Piacenti, I., Arangino, S., & Volpe, A. (2012) · Contraception · doi:10.1016/j.contraception.2012.12.002 · Cited by 27 · see citing works
Moro, F., Morciano, A., Tropea, A., Sagnella, F., Palla, C., Scarinci, E., Ciardulli, A., Martínez, D., Familiari, A., Liuzzo, G., et al. (2013) · Reproductive Sciences · doi:10.1177/1933719113488444 · Cited by 26 · see citing works
Hurwitz, B. E., Henry, N., & Goldberg, R. B. (2009) · Gynecological Endocrinology · doi:10.1080/09513590902770149 · Cited by 20 · see citing works
Rebelo, A. C. S., Verlengia, R., Kunz, V. C., et al. (2012) · Contraception · doi:10.1016/j.contraception.2012.11.001 · Cited by 5 · see citing works
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Laborde, S., Mosley, E., & Thayer, J. F. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00213 · Cited by 2,336 · see citing works
“• Oral contraceptive intake for female participants, it might not influence HRV during rest conditions (Rebelo et al., 2011; Nisenbaum et al., 2014), but it may influence the response to stressful conditions (Kirschbaum et al., 1999).”
Background
- Authors
- Nisenbaum, M. G., Melo, N. R. D., Giribela, C. R. G., Morais, T. L. D., Guerra, G. M., de Angelis, K., Mostarda, C., Baracat, E. C., & Consolim-Colombo, F. M.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Nove de Julho (BR)
- Corresponding author
- Nisenbaum, Marcelo Gil
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 175
- Pages
- 62-66
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W2169543271
- Cited by
- 37
- References
- 32
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 6 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 2
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- FAPESP
- CNPq
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- drospirenone, ethinyl estradiol, combined oral contraceptives, blood pressure, heart rate variability, baroreflex sensitivity, cardiac autonomic nervous system, cardiovascular risk, healthy women
- MeSH terms
- Adult, Mineralocorticoid Receptor Antagonists, Androstenes, Autonomic Nervous System, Contraceptives, Oral, Combined, Estrogens, Ethinyl Estradiol, Female, Hemodynamics, Humans, Prospective Studies
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