Cardiovascular effects of partial sleep deprivation in healthy volunteers
Abstract
Sleep deprivation is common in Western societies and is associated with increased cardiovascular morbidity and mortality in epidemiological studies. However, the effects of partial sleep deprivation on the cardiovascular system are poorly understood. In the present study, we evaluated 13 healthy male volunteers (age: 31 ± 2 yr) monitoring sleep diary and wrist actigraphy during their daily routine for 12 nights. The subjects were randomized and crossover to 5 nights of control sleep (>7 h) or 5 nights of partial sleep deprivation (<5 h), interposed by 2 nights of unrestricted sleep. At the end of control and partial sleep deprivation periods, heart rate variability (HRV), blood pressure variability (BPV), serum norepinephrine, and venous endothelial function (dorsal hand vein technique) were measured at rest in a supine position. The subjects slept 8.0 ± 0.5 and 4.5 ± 0.3 h during control and partial sleep deprivation periods, respectively (P < 0.01). Compared with control, sleep deprivation caused significant increase in sympathetic activity as evidenced by increase in percent low-frequency (50 ± 15 vs. 59 ± 8) and a decrease in percent high-frequency (50 ± 10 vs. 41 ± 8) components of HRV, increase in low-frequency band of BPV, and increase in serum norepinephrine (119 ± 46 vs. 162 ± 58 ng/ml), as well as a reduction in maximum endothelial dependent venodilatation (100 ± 22 vs. 41 ± 20%; P < 0.05 for all comparisons). In conclusion, 5 nights of partial sleep deprivation is sufficient to cause significant increase in sympathetic activity and venous endothelial dysfunction. These results may help to explain the association between short sleep and increased cardiovascular risk in epidemiological studies.
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In a randomized crossover study of 18 healthy male participants, partial sleep deprivation (<5 hours) for 5 days compared to regular sleep (>7 hours) significantly reduced venous endothelial function.
“In another randomized crossover study of 18 healthy male participants, partial sleep deprivation (<5 hours) for 5 days was compared to regular sleep (>7 hours) and a significant reduction in venous endothelial function was observed [76].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [76]
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- Authors
- Dettoni, J. L., Consolim-Colombo, F. M., Drager, L. F., Rubira, M. C., Cavasin de Souza, S. B. P., Irigoyen, M. C., Mostarda, C., Borile, S., Krieger, E. M., Moreno, H., & Lorenzi-Filho, G.
- Affiliations
- Universidade Federal de Rondônia (BR)
- Hypertension Unit of Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Sleep Laboratory of Pulmonary Division of Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2012-07-15
- Volume
- 113
- Issue
- 2
- Pages
- 232-236
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1987176556
- Cited by
- 245
- References
- 36
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 11 · 2023: 23 · 2022: 30 · 2021: 20 · 2020: 15 · 2019: 17 · 2018: 18 · 2017: 13 · 2016: 14 · 2015: 22 · 2014: 18 · 2013: 14 · 2012: 3
- FWCI
- 24.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep restriction, cardiovascular effects, heart rate variability, blood pressure variability, norepinephrine, sympathetic activity, endothelial dysfunction, short sleep duration, cardiovascular risk
- MeSH terms
- Adult, Blood Pressure, Endothelium, Vascular, Heart Rate, Humans, Male, Motor Activity, Sleep Deprivation, Sympathetic Nervous System, Vasodilation
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