Investigation of diagnostic potentials of nine different biomarkers in endometriosis
Abstract
Objective To investigate the diagnostic potentials of the serum levels of nine different biomarkers in endometriosis.Study design In this case-controlled, prospective clinical study, 80 women underwent laparoscopy or laparotomy with a preliminary diagnosis of chronic pelvic pain, severe secondary dysmenorrhea, infertility, pelvic endometriosis or pelvic mass. The 60 women with confirmed pelvic endometriosis constituted the endometriosis group, and the other 20 women without endometriosis constituted the control group. Preoperative blood samples were obtained for serum biomarker measurements. Serum levels of nine different serum biomarkers including α-enolase, macrophage migration inhibitory factor, leptin, interleukin-8, anti-endometrial antibody, phosphoinositide dependent protein kinase 1, CA125, syntaxin-5, and laminin-1 were measured concurrently and compared between the control and endometriosis groups, and among control group and endometriosis subgroups including stage I, stage II, stage III and stage IV endometriosis.Results The serum levels of α-enolase, macrophage migration inhibitory factor, leptin, interleukin-8 and antiendometrial antibodies showed a statistically significant difference neither between control and endometriosis groups nor among control group and endometriosis subgroups. The serum levels of CA125, syntaxin-5 and laminin-1 showed a statistically significant difference both between the control and endometriosis groups (p<0.01) and among control group and endometriosis subgroups (p<0.01). Serum levels of laminin-1 in stage II and IV endometriosis; syntaxin-5 in stage I and II endometriosis; and CA125 in stage III and IV endometriosis were found to have the different levels compared to control group.Conclusions These findings show that the concurrent measurement of CA125, syntaxin-5 and laminin-1 might be a useful non-invasive test in strengthening the diagnosis of endometriosis and in predicting its severity.
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Ozhan et al. stated that a panel of CA-125, syntaxin-5, and laminin-1 had 90% sensitivity, 70% specificity, and 88.7% accuracy to distinguish endometriosis patients (n=60) from controls (n=20).
“Ozhan et al. stated that a panel consisting of CA-125, syntaxin-5, and laminin-1 had 90% sensitivity, 70% specificity, and 88.7% accuracy to distinguish endometriosis patients (n = 60) from controls (n = 20) [41].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [41]
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- Authors
- Ozhan, E., Kokcu, A., Yanik, K., & Gunaydin, M.
- Affiliations
- Ondokuz Mayıs University (TR)
- ORCID
- Gunaydin, Murat
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 178
- Pages
- 128-133
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W2169935875
- Cited by
- 44
- References
- 33
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 3
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, serum biomarkers, CA125, syntaxin 5, laminin-1, non-invasive diagnosis, endometriosis severity, endometriosis staging, alpha-enolase, macrophage migration inhibitory factor, leptin, interleukin-8, anti-endometrial antibodies, phosphoinositide-dependent protein kinase 1
- MeSH terms
- Adult, Endometriosis, Female, Humans, Laminin, Prospective Studies, Biomarkers, Case-Control Studies, CA-125 Antigen, Qa-SNARE Proteins
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