Laser‐evoked potentials as a tool for assessing the efficacy of antinociceptive drugs
Open accessAbstract
Laser‐evoked potentials (LEPs) are brain responses to laser radiant heat pulses and reflect the activation of Aδ nociceptors. LEPs are to date the reference standard technique for studying nociceptive pathway function in patients with neuropathic pain. To find out whether LEPs also provide a useful neurophysiological tool for assessing antinociceptive drug efficacy, in this double‐blind placebo‐controlled study we measured changes induced by the analgesic tramadol on LEPs in 12 healthy subjects. We found that tramadol decreased the amplitude of LEPs, whereas placebo left LEPs unchanged. The opioid antagonist naloxone partially reversed the tramadol‐induced LEP amplitude decrease. We conclude that LEPs may be reliably used in clinical practice and research for assessing the efficacy of antinociceptive drugs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LEPs reflect temporally distinct cortical processes specifically evoked by the activation of Aδ-fibres and are differentially modulated by cognitive and pharmacological interventions.
“LEPs reflect temporally distinct cortical processes specifically evoked by the activation of Aδ‐fibres 31 and are differentially modulated by cognitive 32, 33, 34 and pharmacological 35 interventions.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [35]
The study aimed to maintain a dataset of at least N > 11, comparable to other LEP studies including drug LEP studies with N = 12.
“We aimed to maintain a dataset of at least N > 11 [comparable to other LEP studies 47, including studies using LEPs to investigate the analgesic properties of drugs 35: N = 12]”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [35]
Cites
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263 · see citing works
EFNS guidelines on pharmacological treatment of neuropathic pain
Attal, N., Cruccu, G., Haanpää, M. L., Hansson, P. T., Jensen, T. S., Nurmikko, T. J., Sampaio, C., Sindrup, S. H., & Wiffen, P. J. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01511.x · Cited by 877 · see citing works
Self-citationBrain generators of laser-evoked potentials: from dipoles to functional significance
Garcia-Larrea, L., Frot, M., & Valeriani, M. (2003) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/j.neucli.2003.10.008 · Cited by 541 · see citing works
EFNS guidelines on neuropathic pain assessment
Cruccu, G., Anand, P., Attal, N., Garcı́a-Larrea, L., Haanpää, M. L., Jørum, E., Serra, J., & Jensen, T. S. (2004) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00791.x · Cited by 530 · see citing works
Self-citationThe hypoalgesic effect of tramadol in relation to CYP2D6*
Poulsen, L. K., Arendt‐Nielsen, L., Brøsen, K., & Sindrup, S. H. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90211-8 · Cited by 385 · see citing works
Duehmke, R. M., Hollingshead, J., & Cornblath, D. R. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003726.pub3 · Cited by 269 · see citing works
Reduced habituation to experimental pain in migraine patients: a CO2 laser evoked potential study
Valeriani, M., de Tommaso, M., Restuccia, D., Pera, D. L., Guido, M., Iannetti, G. D., Libro, G., Truini, A., Trapani, G. D., Puca, F., et al. (2003) · Pain · doi:10.1016/s0304-3959(03)00137-4 · Cited by 238 · see citing works
Self-citationContribution of monoaminergic modulation to the analgesic effect of tramadol
Desmeules, J. A., Piguet, V., Collart, L., & Dayer, P. (1996) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1996.tb00152.x · Cited by 238 · see citing works
Skarke, C., Darimont, J., Schmidt, H., Geißlinger, G., & Lötsch, J. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2003.5 · Cited by 226 · see citing works
High opiate receptor binding potential in the human lateral pain system
Baumgärtner, U., Buchholz, H., Bellosevich, A., Magerl, W., Siessmeier, T., Rolke, R., Höhnemann, S., Piel, M., Rösch, F., Wester, H., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.033 · Cited by 167 · see citing works
Enggaard, T. P., Poulsen, L. K., Arendt‐Nielsen, L., Brøsen, K., Ossig, J., & Sindrup, S. H. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000189613.61910.32 · Cited by 126 · see citing works
Duehmke, R. M., Cornblath, D. R., & Hollingshead, J. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003726.pub2 · Cited by 99 · see citing works
Pharmacodynamics of Orally Administered Sustained- release Hydromorphone in Humans
Angst, M. S., Drover, D. R., Lötsch, J., Ramaswamy, B., Naidu, S., Wada, D., & Stanski, D. R. (2001) · Anesthesiology · doi:10.1097/00000542-200101000-00014 · Cited by 93 · see citing works
Neurophysiological studies of pain pathways in peripheral and central nervous system disorders
Treede, R.-D. (2003) · Journal of Neurology · doi:10.1007/s00415-003-0237-7 · Cited by 83 · see citing works
Petersen‐Felix, S., Arendt‐Nielsen, L., Bak, P., Fischer, M., & Zbinden, A. M. (1996) · British Journal of Anaesthesia · doi:10.1093/bja/77.2.165 · Cited by 75 · see citing works
The hypoalgesic effect of imipramine in different human experimental pain models
Poulsen, L. K., Arendt‐Nielsen, L., Brøsen, K., Nielsen, K. K., & Gram, L. F. (1995) · Pain · doi:10.1016/0304-3959(94)00142-2 · Cited by 74 · see citing works
Berrocoso, E., de Benito, M., & Micó, J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0761-8 · Cited by 58 · see citing works
Role of 5-HT1A and 5-HT1B receptors in the antinociceptive effect of tramadol
Rojas-Corrales, M. O., Berrocoso, E., & Micó, J. A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.02.006 · Cited by 40 · see citing works
Lorenz, J., Beck, H., & Bromm, B. (1997) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/s0168-5597(97)00064-6 · Cited by 40 · see citing works
Epileptiform synchronization in the cingulate cortex
Panuccio, G., Curia, G., Colosimo, A., Cruccu, G., & Avoli, M. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2008.01779.x · Cited by 32 · see citing works
Self-citationEpileptiform synchronization in the rat insular and perirhinal cortices in vitro
Sudbury, J. R., & Avoli, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05962.x · Cited by 28 · see citing works
Self-citationTruini, A., & Cruccu, G. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.04.006 · Cited by 17 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Slater, R., Cornelissen, L., Lorenzo Fabrizi, D., Patten, D., Yoxen, J., Worley, A., Boyd, S. G., Meek, J. H., & Fitzgerald, M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61303-7 · Cited by 356 · see citing works
Vadalouca, A., Raptis, E., Μoka, Ε., Zis, P., Sykioti, P., & Siafaka, I. (2011) · Pain Practice · doi:10.1111/j.1533-2500.2011.00485.x · Cited by 116 · see citing works
Transcutaneous Spinal Direct Current Stimulation
Cogiamanian, F. M., Ardolino, G., Vergari, M., Ferrucci, R., Ciocca, M., Scelzo, E., Barbieri, S., & Priori, A. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00063 · Cited by 102 · see citing works
Truini, A., Vergari, M., Biasiotta, A., Cesa, S. L., Gabriele, M., Stefano, G. D., Cambieri, C., Cruccu, G., Inghilleri, M., & Priori, A. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.04.009 · Cited by 99 · see citing works
Self-citationNociceptive brain activity as a measure of analgesic efficacy in infants
Hartley, C., Duff, E. P., Green, G., Mellado, G. S., Worley, A., Rogers, R., & Slater, R. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah6122 · Cited by 94 · see citing works
Electroencephalography and analgesics
Malver, L. P., Brokjær, A., Staahl, C., Graversen, C., Andresen, T., & Drewes, A. M. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12137 · Cited by 89 · see citing works
Attachment style moderates partner presence effects on pain: a laser-evoked potentials study
Krahé, C., Paloyelis, Y., Condon, H., Jenkinson, P. M., Williams, S. C. R., & Fotopoulou, A. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu156 · Cited by 69 · see citing works
de Tommaso, M., Nolano, M., Iannone, F., Vecchio, E., Ricci, K., Lorenzo, M., Delussi, M., Girolamo, F., Lavolpe, V., Provitera, V., et al. (2014) · Journal of Neurology · doi:10.1007/s00415-013-7211-9 · Cited by 73 · see citing works
Cerebellar direct current stimulation modulates pain perception in humans
Bocci, T., Santarcangelo, E. L., Vannini, B., Torzini, A., Carli, G., Ferrucci, R., Priori, A., Valeriani, M., & Sartucci, F. (2015) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-140453 · Cited by 64 · see citing works
Self-citationPaloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works
Mouraux, A., Bannister, K., Becker, S., Finn, D. P., Pickering, G. P., Pogatzki-Zahn, E. M., & Graven‐Nielsen, T. (2021) · European Journal of Pain · doi:10.1002/ejp.1730 · Cited by 61 · see citing works
Noninvasive Spinal Cord Stimulation: Technical Aspects and Therapeutic Applications
Nardone, R., Höller, Y., Taylor, A. C., Thomschewski, A. C., Orioli, A., Frey, V., Trinka, E., & Brigo, F. (2015) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12332 · Cited by 56 · see citing works
Bocci, T., Carolis, G. D., Paroli, M., Barloscio, D., Parenti, L., Tollapi, L., Valeriani, M., & Sartucci, F. (2018) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12747 · Cited by 56 · see citing works
Self-citationBocci, T., Carolis, G. D., Ferrucci, R., Paroli, M., Mansani, F., Priori, A., Valeriani, M., & Sartucci, F. (2019) · The Cerebellum · doi:10.1007/s12311-019-01020-w · Cited by 53 · see citing works
Self-citationCesa, S. L., Stefano, G. D., Leone, C. M., Pepe, A., Galosi, E., Alù, F., Fasolino, A., Cruccu, G., Valeriani, M., & Truini, A. (2017) · European Journal of Pain · doi:10.1002/ejp.1112 · Cited by 51 · see citing works
Self-citationClinical neurophysiology of pain
Lefaucheur, J. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64142-7.00045-x · Cited by 51 · see citing works
Pazzaglia, C., Vollono, C., Ferraro, D., Virdis, D., Lupi, V., Pera, D. L., Tonali, P. A., Padua, L., & Valeriani, M. (2010) · Pain · doi:10.1016/j.pain.2010.03.001 · Cited by 46 · see citing works
Nociception and the neonatal brain
Gursul, D., Hartley, C., & Slater, R. (2019) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2019.05.008 · Cited by 47 · see citing works
Peripheral and central nervous system correlates in fibromyalgia
Vecchio, E., Lombardi, R., Paolini, M., Libro, G., Delussi, M. D., Ricci, K., Quitadamo, S. G., Gentile, E., Girolamo, F., Iannone, F., et al. (2020) · European Journal of Pain · doi:10.1002/ejp.1607 · Cited by 47 · see citing works
Habituation to Pain in “Medication Overuse Headache”: A CO 2 Laser‐Evoked Potential Study
Ferraro, D., Vollono, C., Miliucci, R., Virdis, D., Armas, L. D., Pazzaglia, C., Pera, D. L., Tarantino, S., Balestri, M., Trapani, G. D., et al. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2012.02151.x · Cited by 45 · see citing works
Turri, M., Teatini, F., Donato, F., Zanette, G., Tugnoli, V., Deotto, L., Bonetti, B., & Squintani, G. M. (2018) · Medicines · doi:10.3390/medicines5030059 · Cited by 43 · see citing works
High Hypnotizability Impairs the Cerebellar Control of Pain
Bocci, T., Barloscio, D., Parenti, L., Sartucci, F., Carli, G., & Santarcangelo, E. L. (2017) · The Cerebellum · doi:10.1007/s12311-016-0764-2 · Cited by 44 · see citing works
Self-citationRütgen, M., Seidel, E., Pletti, C., Riečanský, I., Gartus, A., Eisenegger, C., & Lamm, C. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.04.023 · Cited by 40 · see citing works
Truini, A., Piroso, S., Pasquale, E. D., Notartomaso, S., Stefano, G. D., Lattanzi, R., Battaglia, G., Nicoletti, F., & Cruccu, G. (2015) · Molecular Pain · doi:10.1186/s12990-015-0009-2 · Cited by 39 · see citing works
Self-citationde Tommaso, M., Ricci, K., Libro, G., Vecchio, E., Delussi, M. D., Montemurno, A., Lopalco, G., & Iannone, F. (2017) · Pain Research and Treatment · doi:10.1155/2017/9747148 · Cited by 39 · see citing works
de Tommaso, M., Brighina, F., Fierro, B., Francesco, V. D. V., Santostasi, R., Sciruicchio, V., Vecchio, E., Serpino, C., Lamberti, P., & Livrea, P. (2010) · The Journal of Headache and Pain · doi:10.1007/s10194-010-0247-7 · Cited by 31 · see citing works
de Tommaso, M., Betti, V., Bocci, T., Bolognini, N., Russo, F. D., Fattapposta, F., Ferri, R., Invitto, S., Koch, G., Miniussi, C., et al. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04420-7 · Cited by 30 · see citing works
Self-citationBrain Plasticity in Patients with Spinal Cord Injuries: A Systematic Review
Calderone, A., Cardile, D., Luca, R. D., Quartarone, A., Corallo, F., & Calabrò, R. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042224 · Cited by 30 · see citing works
Benromano, T., Pick, C. G., Granovsky, Y., & Defrin, R. (2016) · Pain Medicine · doi:10.1093/pm/pnw349 · Cited by 27 · see citing works
Morgalla, M. H., Filho, M. F. D. B., Chander, B. S., Soekadar, S. R., Tatagiba, M. S., & Lepski, G. A. (2018) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12900 · Cited by 26 · see citing works
Effects of OnabotulintoxinA on Habituation of Laser Evoked Responses in Chronic Migraine
de Tommaso, M., Delussi, M. D., Ricci, K., Montemurno, A., Carbone, I., & Vecchio, E. (2016) · Toxins · doi:10.3390/toxins8060163 · Cited by 26 · see citing works
Differential processing of laser stimuli by Aδ and C fibres in major depression
Terhaar, J., Viola, F. C., Franz, M., Berger, S., Bär, K., & Weiß, T. (2011) · Pain · doi:10.1016/j.pain.2011.03.027 · Cited by 23 · see citing works
Schaffler, K., Nicolas, L. B., Borta, A., Brand, T., Reitmeir, P., Roebling, R., & Scholpp, J. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13247 · Cited by 23 · see citing works
de Tommaso, M., Betti, V., Bocci, T., Bolognini, N., Russo, F. D., Fattapposta, F., Ferri, R., Invitto, S., Koch, G., Miniussi, C., et al. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04527-x · Cited by 20 · see citing works
Self-citationObjective methods for the assessment of the spinal and supraspinal effects of opioids
Fischer, I. W. D., Hansen, T. M., Lelic, D., Brokjær, A., Frøkjær, J. B., Christrup, L. L., & Olesen, A. E. (2016) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2016.10.001 · Cited by 18 · see citing works
Cortical integration of bilateral nociceptive signals: when more is less
Northon, S., Rustamov, N., & Piché, M. (2018) · Pain · doi:10.1097/j.pain.0000000000001451 · Cited by 17 · see citing works
The new micropatterned interdigitated electrode for selective assessment of the nociceptive system
Stefano, G. D., Lionardo, A. D., Cesa, S. L., Pietro, G. D., Fasolino, A., Galosi, E., Leone, C. M., Cruccu, G., Marinelli, L., Leandri, M., et al. (2020) · European Journal of Pain · doi:10.1002/ejp.1545 · Cited by 17 · see citing works
Self-citationMorphine modifies the cingulate–operculum network underlying painful rectal evoked potentials
Lelic, D., Olesen, A. E., Gregersen, H. N., Dahan, A., Kolesnikov, Y. A., & Drewes, A. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.020 · Cited by 16 · see citing works
Dangers, L., Laviolette, L., Similowski, T., & Morélot‐Panzini, C. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00358 · Cited by 15 · see citing works
Landmann, G., Berger, M. F., Stockinger, L., & Opsommer, E. (2017) · Spinal Cord · doi:10.1038/sc.2016.191 · Cited by 16 · see citing works
Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes
Papagianni, A. E., Siedler, G., Sommer, C., & Üçeyler, N. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000644 · Cited by 14 · see citing works
Advanced Pharmaco-EEG Reveals Morphine Induced Changes in the Brain's Pain Network
Lelic, D., Olesen, A. E., Brock, C., Staahl, C., & Drewes, A. M. (2012) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0b013e3182570fd3 · Cited by 13 · see citing works
Monk, V., Moultrie, F., Hartley, C., Hoskin, A., Green, G., Bell, J. L., Stokes, C., Juszczak, E., Norman, J. E., Rogers, R., et al. (2019) · Efficacy and Mechanism Evaluation · doi:10.3310/eme06090 · Cited by 12 · see citing works
Laser evoked potentials in fibromyalgia with peripheral small fiber involvement
Vecchio, E., Quitadamo, S. G., Ricci, K., Libro, G., Delussi, M. D., Lombardi, R., Lauria, G., & de Tommaso, M. (2022) · Clinical Neurophysiology · doi:10.1016/j.clinph.2022.01.001 · Cited by 13 · see citing works
Campbell-Yeo, M. L., Benoit, B., Newman, A. J., Johnston, C. C., Bardouille, T., Stevens, B., & Jiang, A. (2022) · Trials · doi:10.1186/s13063-022-06424-4 · Cited by 12 · see citing works
Slater, R., Hartley, C., Moultrie, F., Adams, E., Juszczak, E., Rogers, R., Norman, J. E., Patel, C. K., Stanbury, K., Hoskin, A., et al. (2017) · Wellcome Open Research · doi:10.12688/wellcomeopenres.10005.2 · Cited by 12 · see citing works
Shiroshita, Y., Kirimoto, H., Ozawa, M., Watanabe, T., Uematsu, H., Yunoki, K., & Sobue, I. (2021) · Children · doi:10.3390/children8020058 · Cited by 9 · see citing works
Slater, R., Hartley, C., Moultrie, F., Adams, E., Juszczak, E., Rogers, R., Norman, J. E., Patel, C. K., Stanbury, K., Hoskin, A., et al. (2016) · Wellcome Open Research · doi:10.12688/wellcomeopenres.10005.1 · Cited by 9 · see citing works
Dangers, L., Laviolette, L., Charbit, B., Similowski, T., & Morélot‐Panzini, C. (2016) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2016.06.007 · Cited by 7 · see citing works
Neural variability reliably encodes interindividual differences in the perception of pain intensity
Zhang, L., Geng, X.-Y., & Hu, L. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003470 · Cited by 6 · see citing works
Mouraux, A., Bloms‐Funke, P., Boesl, I., Caspani, O., Chapman, S. C., Stefano, G. D., Finnerup, N. B., Garcı́a-Larrea, L., Goetz, M. H., Kostenko, A. V., et al. (2021) · Trials · doi:10.1186/s13063-021-05272-y · Cited by 6 · see citing works
Self-citationPain-motor integration in chronic pain: A neurophysiological study
Asci, F., Stefano, G. D., Santo, A. D., Bianchini, E., Leone, C. M., Cesa, S. L., Zampogna, A., Cruccu, G., & Suppa, A. (2023) · Clinical Neurophysiology · doi:10.1016/j.clinph.2023.07.010 · Cited by 6 · see citing works
Self-citationPsychophysics of Pain: A Methodological Introduction
McDaniel, A. L., Dimitrov, T., Bruehl, S. P., Monroe, T. B., Failla, M. D., Cowan, R. L., Ryan, C., & Anderson, A. R. (2023) · Pain Management Nursing · doi:10.1016/j.pmn.2023.02.006 · Cited by 5 · see citing works
Neurophysiological methods in examination of patients with chronic postoperative pain
Tsedinova, Y. B., Churuykanov, M. V., Medvedeva, L. A., & Zagorulko, O. I. (2020) · Russian Journal of Pain · doi:10.17116/pain20201804160 · Cited by 5 · see citing works
Revealing the time course of laser‐evoked potential habituation by high temporal resolution analysis
Kersebaum, D., Fabig, S., Sendel, M., Muntean, A. C., Baron, R., & Hüllemann, P. (2021) · European Journal of Pain · doi:10.1002/ejp.1823 · Cited by 4 · see citing works
Morgalla, M. H., Zhang, Y., Filho, M. F. D. B., Lepski, G. A., & Chander, B. S. (2021) · Pain Practice · doi:10.1111/papr.13094 · Cited by 3 · see citing works
Wicht, C. A., Mouthon, M., Chabwine, J. N., Gaab, J., & Spierer, L. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15645 · Cited by 2 · see citing works
Changes in Parameters of Laser-Induced Potentials After Transcutaneous Electroneurostimulation
Timofeeva, M. A., Arkov, V. V., Andreev, R. A., Trushkin, E. V., & Tonevitsky, A. (2011) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-011-1173-7 · Cited by 2 · see citing works
Laser-Evoked Potentials to Pudendal Stimulation in Healthy Subjects: A Pilot Study
Frasson, E., Tozzi, M. C., Bordignon, M., Motti, L., Ferrari, F., Torre, G., Graziottin, A., Monaco, S., & Bertolasi, L. (2020) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000694 · Cited by 2 · see citing works
Neuroimaging of Paediatric Pain
Hartley, C., & Slater, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-48046-6_18 · Cited by 1 · see citing works
Goudman, L., Mouraux, A., Daenen, L., Nijs, J., Cras, P. P., Roussel, N. A., Moens, M., Lenoir, D., Coppieters, I., Huysmans, E., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051520 · Cited by 1 · see citing works
Bocci, T., Ferrucci, R., Priori, A., Valeriani, M., & Sartucci, F. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.89805 · Cited by 1 · see citing works
Self-citationNeuropathic Pain: Mechanisms, Clinical Aspects and Treatment Options
Kersebaum, D., Sachau, J., Fabig, S., & Baron, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.24257-0 · Cited by 1 · see citing works
Attenuated Laser Evoked Potentials in Sarcoidosis Patients in Clinical Remission
Korenromp, I. H. E., Krabbenbos, I. P., van Swol, C. F. P., van Dongen, E. P., Vogels, O. J. M., Grutters, J. C., & Boezeman, E. H. J. F. (2012) · Journal of Neurology Research · doi:10.4021/jnr.v2i5.150
Laboratory Investigations, Imaging and Neurological Assessment in Pain Management
Squire, P., Walk, D., Irving, G. A., & Backonja, M. M. (2010) · doi:10.1002/9781444329711.ch9
Zanville, N. (2018) · ProQuest Demo Repository · doi:10.7912/c2qh1h
Stouffs, A., Lebrun, L., & Mouraux, A. (2018) · Douleur et Analgésie · doi:10.3166/dea-2018-0041
Attenuated Laser Evoked Potentials in Sarcoidosis Patients in Clinical Remission
Korenromp (2012) · Journal of Neurology Research · doi:10.4021/jnr150w
Hartley, C., & Slater, R. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198818762.003.0040
Laboratory investigations, imaging and neurological assessment in pain management
Squire, P., & Backonja, M. M. (2022) · doi:10.1002/9781119701170.ch10
The Neural Correlates of Expectations Effects
Wicht, C. A. (2022) · doi:10.51363/unifr.sth.2022.003
Supraspinal facilitation to repetitive painful stimulation: a laser-evoked potential study
Archibald, J., Ortiz, O., Enzler, A., Rösner, J., & Kramer, J. L. K. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00283.2022
Pomelova, E. D., Popyvanova, A., Bredikhin, D., Koriakina, M. M., Ilyukina, N., Шестакова, А. Н., & Blagovechtchenski, E. (2023) · Research Square · doi:10.21203/rs.3.rs-2813634/v1
Pomelova, E. D., Popyvanova, A., Bredikhin, D., Koriakina, M. M., Шестакова, А. Н., & Blagovechtchenski, E. (2023) · Genes and Cells · doi:10.23868/gc545830
Neural variability reliably and selectively encodes pain discriminabilityPreprint
Zhang, L., Geng, X.-Y., & Hu, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.26.640289
C-fiber-related brain responses evoked by laser heat pulses applied to the back
Provencher, B., & Piché, M. (2025) · The Journal of Physiological Sciences · doi:10.1016/j.jphyss.2025.100018
Clemente, L., Rocca, M. L., Stramaglia, S., Marinazzo, D., Lombardi, R., Lauria, G., & de Tommaso, M. (2025) · Frontiers in Network Physiology · doi:10.3389/fnetp.2025.1592518
Kim, H. S., & Woo, S. H. (2025) · Korean Intraoperative Neuromonitoring Society · doi:10.54441/jnn.2025.5.2.119
How the Brain Interprets Pain in Autistic People: Does Sex Matter?
Granovsky, Y., Weissman‐Fogel, I., Hoffman, T., Levi, M. K., Gal, E., Sprecher, E., Shor, M., & Bar‐Shalita, T. (2026) · European Journal of Pain · doi:10.1002/ejp.70411
- Authors
- Truini, A., Panuccio, G., Galeotti, F., Maluccio, M. R., Sartucci, F., Avoli, M., & Cruccu, G.
- Affiliations
- IRCCS San Raffaele Roma (IT)
- Montreal Neurological Institute and Hospital (CA)
- Istituto Superiore di Sanità (IT)
- University of Pisa (IT)
- Corresponding author
- Cruccu, G.
- Venue
- European Journal of Pain
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 14
- Issue
- 2
- Pages
- 222-225
- ISSN
- 1090-3801 (ISSN-L)
- 1532-2149
- PMC
- PMC4878893
- OpenAlex
- W1997666775
- Cited by
- 80
- References
- 22
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 6 · 2013: 3 · 2012: 5
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- Sapienza Università di Roma
- Canadian Institutes of Health Research (8109_6, MT 8109)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- laser-evoked potentials, tramadol, naloxone, opioid antagonists, nociceptive pathways, drug efficacy evaluation
- MeSH terms
- Adult, Analgesics, Analgesics, Opioid, Double-Blind Method, Electroencephalography, Evoked Potentials, Female, Humans, Lasers, Male, Naloxone, Narcotic Antagonists, Pain, Pain Measurement, Tramadol, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
