Neurophysiological studies of pain pathways in peripheral and central nervous system disorders
Abstract
Standard clinical neurophysiological assessment of somatosensory pathways by sensory evoked potentials (SEPs) is limited to the tactile and proprioceptive systems consisting of large fibers in the peripheral nerve, the dorsal columns of the spinal cord and the medial lemniscus in the brainstem. This limitation means that about half of the lesions in the somatosensory system will not be detectable. In recent years, many clinical studies have confirmed that laser evoked potentials (LEPs) allow the assessment of the other half of the somatosensory system. Rapid heating of the skin by infrared laser pulses specifically activates the nociceptive and thermoreceptive pathways consisting of small fibers in the peripheral nerve and the anterolateral spinothalamic tract in the spinal cord and brainstem. Owing to the large degree of convergence of the somatosensory pathways on to common thalamic nuclei, the differential use of LEP vs. SEP is less evident for thalamocortical lesions. In contrast to standard SEPs, the LEP technique can be applied to non-glabrous skin in any dermatome. This review summarizes the principles of clinical neurophysiological studies of pain pathways and the findings obtained in patients with peripheral and central nervous system disorders. These data provide a rational basis for developing clinical indications for LEP testing.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LEPs reflect temporally distinct cortical processes specifically evoked by the activation of Aδ-fibres and are differentially modulated by cognitive and pharmacological interventions.
“LEPs reflect temporally distinct cortical processes specifically evoked by the activation of Aδ‐fibres 31 and are differentially modulated by cognitive 32, 33, 34 and pharmacological 35 interventions.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [31]
Cites
Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108 · see citing works
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · see citing works
Evoked-potential correlates of stimulus uncertainty
Sutton, S., Braren, M., Zubin, J., & John, E. R. (1965) · Science · doi:10.1126/science.150.3700.1187 · Cited by 3,061 · see citing works
The cortical representation of pain
Treede, R.-D., Kenshalo, D. R., Gracely, R. H., & Jones, A. K. P. (1999) · Pain · doi:10.1016/s0304-3959(98)00184-5 · Cited by 1,077 · see citing works
Self-citationPeripheral and central mechanisms of cutaneous hyperalgesia
Treede, R., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90027-c · Cited by 917 · see citing works
Self-citationTreede, R., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020619 · Cited by 440 · see citing works
Self-citationNeurophysiological evaluation of pain
Bromm, B., & Lorenz, J. (1998) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/s0013-4694(98)00075-3 · Cited by 410 · see citing works
Giblin, D. R. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1964.tb26744.x · Cited by 382 · see citing works
Kobal, G., & Hummel, C. (1988) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(88)90023-8 · Cited by 350 · see citing works
Neurophysiology and Functional Neuroanatomy of Pain Perception
Schnitzler, A., & Ploner, M. (2000) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200011000-00005 · Cited by 349 · see citing works
Gibson, S. J., Littlejohn, G. O., Gorman, M. M., Helme, R. D., & Granges, G. (1994) · Pain · doi:10.1016/0304-3959(94)90198-8 · Cited by 306 · cited 1× · see citing works
“Fibromyalgia is the only disease for which an increase in LEP amplitude has been documented in group comparisons with healthy subjects [26, 50].”
BackgroundPain sensitivity alterations as a function of lesion location in the parasylvian cortex
Greenspan, J. D., Lee, R. R., & Lenz, F. A. (1999) · Pain · doi:10.1016/s0304-3959(99)00021-4 · Cited by 297 · see citing works
Tarkka, I. M., & Treede, R.-D. (1993) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199310000-00009 · Cited by 289 · see citing works
Self-citationParallel Activation of Primary and Secondary Somatosensory Cortices in Human Pain Processing
Ploner, M., Schmitz, F., Freund, H., & Schnitzler, A. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.3100 · Cited by 283 · see citing works
C nociceptor activity in human nerve during painful and non painful skin stimulation.
Hees, J. V., & Gybels, J. (1981) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.44.7.600 · Cited by 269 · see citing works
Bromm, B., & Treede, R. (1991) · PubMed · Cited by 267 · see citing works
Self-citationVariability of laser-evoked potentials: attention, arousal and lateralized differences
Beydoun, A. A., Morrow, T. J., Shen, J. F., & Casey, K. L. (1993) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(93)90002-7 · Cited by 259 · see citing works
Cerebral evoked potentials in patients with dissociated sensory loss
Halliday, A. M., & Wakefield, G. S. (1963) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.26.3.211 · Cited by 250 · see citing works
PATHOGENESIS OF GIANT SOMATOSENSORY EVOKED POTENTIALS IN PROGRESSIVE MYOCLONIC EPILEPSY
Shibasaki, H., Yamashita, Y., Neshige, R., Tobimatsu, S., & Fukui, R. (1985) · Brain · doi:10.1093/brain/108.1.225 · Cited by 249 · see citing works
Valeriani, M., Rambaud, L., & Mauguı̀ere, F. (1996) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(96)95625-7 · Cited by 241 · see citing works
Painful Stimuli Evoke Potentials Recorded Over the Human Anterior Cingulate Gyrus
Lenz, F. A., Rios, M., Zirh, A. T., Chau, D. T., Krauss, G., & Lesser, R. P. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2231 · Cited by 236 · see citing works
Garcı́a-Larrea, L. (2002) · Brain · doi:10.1093/brain/awf275 · Cited by 222 · see citing works
The intracutaneous stimulus: a new pain model for algesimetric studies.
Bromm, B., & Meier, W. (1984) · PubMed · Cited by 220 · see citing works
Late somatosensory evoked cerebral potentials in response to cutaneous heat stimuli
Treede, R., Kief, S., Hölzer, T., & Bromm, B. (1988) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(88)90020-x · Cited by 216 · see citing works
Self-citationResponses of human cutaneous afferents to CO2 laser stimuli causing pain
Bromm, B., Jahnke, M. T., & Treede, R. (1984) · Experimental Brain Research · doi:10.1007/bf00240510 · Cited by 207 · see citing works
Self-citationLorenz, J., Grasedyck, K., & Bromm, B. (1996) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0013-4694(95)00259-6 · Cited by 203 · see citing works
C- and Aδ-fiber components of heat-evoked cerebral potentials in healthy human subjects
Magerl, W., Ali, Z., Ellrich, J., Meyer, R. A., & Treede, R. (1999) · Pain · doi:10.1016/s0304-3959(99)00061-5 · Cited by 185 · see citing works
Self-citationKenshalo, D. R., Iwata, K., Sholas, M., & Thomas, D. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.2.719 · Cited by 184 · see citing works
Pain-Related Somatosensory Evoked Potentials Following CO2 Laser Stimulation in Man
Kakigi, R., Shibasaki, H., & Ikeda, A. (1988) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-198810000-00107 · Cited by 175 · see citing works
Bragard, D., Chen, A. C. N., & Plaghki, L. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12604-5 · Cited by 171 · see citing works
Bowsher, D. R., Leijon, G., & Thuomas, K. (1998) · Neurology · doi:10.1212/wnl.51.5.1352 · Cited by 160 · see citing works
Laser emitted radiant heat for pain research
Mor, J., & Carmon, A. (1975) · Pain · doi:10.1016/0304-3959(75)90040-8 · Cited by 156 · see citing works
Kunde, V., & Treede, R. (1993) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(93)90052-q · Cited by 154 · see citing works
Self-citationBaron, R., & Saguer, M. (1993) · Brain · doi:10.1093/brain/116.6.1477 · Cited by 154 · see citing works
SOMATOSENSORY CEREBRAL EVOKED POTENTIALS AFTER VASCULAR LESIONS OF THE BRAIN-STEM AND DIENCEPHALON
Noël, P., & Desmedt, J. E. (1975) · Brain · doi:10.1093/brain/98.1.113 · Cited by 144 · see citing works
SOMATOSENSORY EVOKED POTENTIALS IN CERVICAL SPONDYLOSIS
Yu, Y. L., & Jones, S. J. (1985) · Brain · doi:10.1093/brain/108.2.273 · Cited by 140 · see citing works
Evidence of a Specific Spinal Pathway for the Sense of Warmth in Humans
Iannetti, G. D., Truini, A., Romaniello, A., Galeotti, F., Rizzo, C., Manfredi, M., & Cruccu, G. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00393.2002 · Cited by 137 · see citing works
Left-hemisphere dominance in early nociceptive processing in the human parasylvian cortex
Schlereth, T., Baumgärtner, U., Magerl, W., Stoeter, P., & Treede, R. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00345-8 · Cited by 136 · see citing works
Self-citationHeart involvement in muscular dystrophies due to sarcoglycan gene mutations
Melacini, P., Fanin, M., Duggan, D. J., Freda, M. P., Berardinelli, A. L., Danieli, G. A., Barchitta, A., Hoffman, E. P., Volta, S. D., & Angelini, C. I. (1999) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199904)22:4 · Cited by 136 · see citing works
Evoked cerebral potential correlates of C-fibre activity in man
Bromm, B., Neitzel, H., Tecklenburg, A., & Treede, R. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90137-4 · Cited by 134 · see citing works
Self-citationCEREBRAL POTENTIALS EVOKED BY PAINFUL LASER STIMULI IN PATIENTS WITH SYRINGOMYELIA
Treede, R., Lankers, J., Frieling, A., Zangemeister, W. H., Kunze, K., & Bromm, B. (1991) · Brain · doi:10.1093/brain/114.4.1595 · Cited by 129 · see citing works
Self-citationLaser-evoked potentials: exogenous and endogenous components
Siedenberg, R., & Treede, R. (1996) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(95)00255-3 · Cited by 127 · see citing works
Self-citationPAIN-RELATED SOMATOSENSORY EVOKED POTENTIALS IN SYRINGOMYELIA
Kakigi, R., Shibasaki, H., Kuroda, Y., Neshige, R., Endo, C., Tabuchi, K., & Kishikawa, T. (1991) · Brain · doi:10.1093/brain/114.4.1871 · Cited by 123 · see citing works
Spiegel, J., Hansen, C., & Treede, R. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00297-7 · Cited by 123 · see citing works
Self-citationThe P300 in pain evoked potentials
Zaslansky, R., Sprecher, E., Tenke, C. E., Hemli, A. J., & Yarnitsky, D. (1996) · Pain · doi:10.1016/0304-3959(96)03020-5 · Cited by 118 · see citing works
Kakigi, R., Shibasaki, H., Tanaka, K., Ikeda, T., Oda, K., Endo, C., Ikeda, A., Neshige, R., Kuroda, Y., Miyata, K., et al. (1991) · Muscle & Nerve · doi:10.1002/mus.880140510 · Cited by 117 · see citing works
Estimation of conduction velocity of Aδ fibers in humans
Kakigi, R., Endo, C., Neshige, R., Kuroda, Y., & Shibasaki, H. (1991) · Muscle & Nerve · doi:10.1002/mus.880141209 · Cited by 115 · see citing works
Vogel, H., Port, J. D., Lenz, F. A., Solaiyappan, M., Krauss, G., & Treede, R. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00772.2002 · Cited by 109 · see citing works
Self-citationKanda, M., Fujiwara, N., Xu, X., Shindo, K., Nagamine, T., Ikeda, A., & Shibasaki, H. (1996) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0013-4694(95)00190-5 · Cited by 88 · see citing works
Peripheral fiber correlates to noxious thermal stimulation in humans
Kenton, B., Coger, R. W., Crue, B. L., Pinsky, J., Friedman, Y., & Carmon, A. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90040-3 · Cited by 88 · see citing works
Mechanisms and predictors of chronic facial pain in lateral medullary infarction
Fitzek, S., Baumgärtner, U., Fitzek, C., Magerl, W., Urban, P. P., Thömke, F., Marx, J., Treede, R., Stoeter, P., & Hopf, H. C. (2001) · Annals of Neurology · doi:10.1002/ana.99 · Cited by 88 · see citing works
Self-citationDissociated secondary hyperalgesia in a subject with a large-fibre sensory neuropathy
Treede, R., & Cole, J. D. (1993) · Pain · doi:10.1016/0304-3959(93)90077-3 · Cited by 85 · see citing works
Self-citationLaser-evoked cerebral potentials and sensory function in patients with central pain
Casey, K. L., Beydoun, A. A., Boivie, J., Sjölund, B. H., Holmgren, H., Leijon, G., Morrow, T., & Rosén, I. (1996) · Pain · doi:10.1016/0304-3959(95)00143-3 · Cited by 84 · see citing works
Legrain, V., Bruyer, R., Guérit, J., & Plaghki, L. (2003) · Pain · doi:10.1016/s0304-3959(02)00451-7 · Cited by 83 · see citing works
Towell, A., Purves, A. M., & Boyd, S. (1996) · Pain · doi:10.1016/0304-3959(96)03016-3 · Cited by 83 · see citing works
Opsommer, E., Masquelier, É., & Plaghki, L. (1999) · Neurophysiologie Clinique · doi:10.1016/s0987-7053(00)87265-2 · Cited by 78 · see citing works
Agostino, R., Cruccu, G., Romaniello, A., Innocenti, P., Inghilleri, M., & Manfredi, M. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00247-3 · Cited by 77 · see citing works
Quantitative objective assessment of peripheral nociceptive C fibre function.
Parkhouse, N., & Quesne, P. M. L. (1988) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.1.28 · Cited by 77 · see citing works
Generator Mechanism of Pain-Related Evoked Potentials Following CO2 Laser Stimulation of the Hand
Miyazaki, M., Shibasaki, H., Kanda, M., Xu, X., Shindo, K., Honda, M., Ikeda, A., Nagamine, T., Kaji, R., & Kimura, J. (1994) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199403000-00010 · Cited by 75 · see citing works
Laser-evoked brain potentials in patients with dissociated loss of pain and temperature sensibility
Bromm, B., Frieling, A., & Lankers, J. (1991) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(91)90111-a · Cited by 73 · see citing works
Spiegel, J., Hansen, C., Baumgärtner, U., Hopf, H. C., & Treede, R. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00069-5 · Cited by 58 · see citing works
Self-citationSpiegel, J., Hansen, C., & Treede, R. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13025-1 · Cited by 57 · see citing works
Self-citationLangsame Rindenpotentiale bei Schmerzreizung am Menschen
Spreng, M., & Ichioka, M. (1964) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00412773 · Cited by 57 · see citing works
Conduction velocity of the human spinothalamic tract as assessed by laser evoked potentials
Cruccu, G., Iannetti, G. D., Agostino, R., Romaniello, A., Truini, A., & Manfredi, M. (2000) · Neuroreport · doi:10.1097/00001756-200009110-00040 · Cited by 55 · see citing works
Hyperalgesia with reduced laser evoked potentials in neuropathic pain
Wu, Q., Garcı́a-Larrea, L., Mertens, P., Beschet, A., Sindou, M., & Mauguı̀ere, F. (1999) · Pain · doi:10.1016/s0304-3959(98)00206-1 · Cited by 54 · see citing works
Assessment of pain in the elderly using event-related cerebral potentials
Gibson, S. J., Gorman, M., & Helms, R. (1990) · Pain · doi:10.1016/0304-3959(90)92179-t · Cited by 53 · see citing works
Physiological study of the spinothalamic tract conduction in multiple sclerosis
Kakigi, R., Kuroda, Y., Neshige, R., Endo, C., & Shibasaki, H. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90290-2 · Cited by 48 · see citing works
Arendt‐Nielsen, L., Gregersen, H., Toft, E. S., & Bjerring, P. (1991) · Muscle & Nerve · doi:10.1002/mus.880140604 · Cited by 48 · see citing works
Lankers, J., Frieling, A., Kunze, K., & Bromm, B. (1991) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.7.650 · Cited by 47 · see citing works
Iannetti, G. D. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.6.792 · Cited by 44 · see citing works
The intracutaneous pain model in the assessment of analgesic efficacy
Scharein, E., & Bromm, B. (1998) · Pain Reviews · doi:10.1191/096813098674115417 · Cited by 42 · see citing works
Lorenz, J., Hansen, H.-C., Kunze, K., & Bromm, B. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.1.107 · Cited by 39 · see citing works
Hansen, H. C., Treede, R., Lorenz, J., Kunze, K., & Bromm, B. (1996) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199607000-00007 · Cited by 39 · see citing works
Self-citationPain-related somatosensory evoked potentials in cortical reflex myoclonus.
Kakigi, R., Shibasaki, H., Neshige, R., Ikeda, A., Mamiya, K., & Kuroda, Y. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.1.44 · Cited by 35 · see citing works
Treede, R., Meier, W., Kunze, K., & Bromm, B. (1988) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.10.1330 · Cited by 34 · see citing works
Self-citationAgostino, R., Cruccu, G., Iannetti, G. D., Innocenti, P., Romaniello, A., Truini, A., & Manfredi, M. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00477-6 · Cited by 28 · see citing works
Pain-Related and Electrically Stimulated Somatosensory Evoked Potentials in Patients With Stroke
Yamamoto, M., Kachi, T., & Igata, A. (1995) · Stroke · doi:10.1161/01.str.26.3.426 · Cited by 28 · see citing works
Unmasking of an early laser evoked potential by a point localization task
Valeriani, M., Restuccia, D., Pera, D. L., Fiaschetti, L., Tonali, P. A., & Arendt‐Nielsen, L. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00439-9 · Cited by 27 · see citing works
Kanda, M., Mima, T., Xu, X., Fujiwara, N., Shindo, K., Nagamine, T., Ikeda, A., & Shibasaki, H. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb07043.x · Cited by 26 · see citing works
Physiological functions of the ascending spinal tracts in HTLV-I-associated myelopathy (HAM)
Kakigi, R., Kuroda, Y., Takashima, H., Endo, C., Neshige, R., & Shibasaki, H. (1992) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(92)90015-4 · Cited by 26 · see citing works
Rousseaux, M., Cassim, F., Bayle, B., & Laureau, E. (1999) · Stroke · doi:10.1161/01.str.30.10.2223 · Cited by 23 · see citing works
Somatosensory evoked responses following cervical cordotomy.
Namerow, N. S. (1969) · PubMed · Cited by 21 · see citing works
Roth, E. J., & McGuire, J. R. (1996) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.1996.11754096 · Cited by 10 · see citing works
Funktionsprüfung der nozizeptiven Bahnen durch SEP nach schmerzhaften Laser-Hitzereizen
Treede, R. (2005) · Springer eBooks · doi:10.1007/3-540-26659-3_9 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Determinants of Laser-Evoked EEG Responses: Pain Perception or Stimulus Saliency?
Iannetti, G. D., Hughes, N. P., Lee, M., & Mouraux, A. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00097.2008 · Cited by 400 · see citing works
Clinical usefulness of laser-evoked potentials
Treede, R., Lorenz, J., & Baumgärtner, U. (2003) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2003.10.009 · Cited by 388 · see citing works
Self-citationPleger, B., Ragert, P., Schwenkreis, P., Förster, A., Wilimzig, C., Dinse, H. R., Nicolas, V., Maier, C., & Tegenthoff, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.045 · Cited by 299 · see citing works
Antal, A., Brepohl, N., Poreisz, C., Boros, K., Csifcsák, G., & Paulus, W. (2008) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e318157233b · Cited by 179 · see citing works
Characterizing the Cortical Activity through Which Pain Emerges from Nociception
Lee, M. C., Mouraux, A., & Iannetti, G. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0014-09.2009 · Cited by 169 · see citing works
Pathophysiology of pain in postherpetic neuralgia: A clinical and neurophysiological study
Truini, A., Galeotti, F., Haanpää, M., Zucchi, R., Albanesi, A., Biasiotta, A., Gatti, A., & Cruccu, G. (2008) · Pain · doi:10.1016/j.pain.2008.08.018 · Cited by 137 · see citing works
Valentini, E., Hu, L., Chakrabarti, B., Hu, Y. S., Aglioti, S. M., & Iannetti, G. D. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.069 · Cited by 127 · see citing works
Neurophysiological Coding of Traits and States in the Perception of Pain
Schulz, E., Tiemann, L., Schuster, T., Groß, J., & Ploner, M. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr027 · Cited by 116 · see citing works
Truini, A., Vergari, M., Biasiotta, A., Cesa, S. L., Gabriele, M., Stefano, G. D., Cambieri, C., Cruccu, G., Inghilleri, M., & Priori, A. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.04.009 · Cited by 99 · see citing works
Legon, W., Rowlands, A., Opitz, A., Sato, T. F., & Tyler, W. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051177 · Cited by 99 · see citing works
Churyukanov, M., Plaghki, L., Legrain, V., & Mouraux, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035817 · Cited by 97 · see citing works
Ploner, M., & May, E. S. (2017) · Pain · doi:10.1097/j.pain.0000000000001087 · Cited by 90 · see citing works
Mechanisms of pain in multiple sclerosis: A combined clinical and neurophysiological study
Truini, A., Galeotti, F., Cesa, S. L., Rezze, S. D., Biasiotta, A., Stefano, G. D., Tinelli, E., Millefiorini, E., Gatti, A., & Cruccu, G. (2012) · Pain · doi:10.1016/j.pain.2012.05.024 · Cited by 82 · see citing works
Laser‐evoked potentials as a tool for assessing the efficacy of antinociceptive drugs
Truini, A., Panuccio, G., Galeotti, F., Maluccio, M. R., Sartucci, F., Avoli, M., & Cruccu, G. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2009.05.001 · Cited by 80 · see citing works
Normative data for Aδ contact heat evoked potentials in adult population
Granovsky, Y., Anand, P., Nakae, A., Nascimento, O. J. M., Smith, B. E., Sprecher, E., & Valls‐Solé, J. (2016) · Pain · doi:10.1097/j.pain.0000000000000495 · Cited by 74 · see citing works
May, E. S., Butz, M., Kahlbrock, N., Hoogenboom, N., Brenner, M., & Schnitzler, A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.05.071 · Cited by 75 · see citing works
Valentini, E., Torta, D. M. E., Mouraux, A., & Iannetti, G. D. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2011.21609 · Cited by 66 · see citing works
Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works
Trigeminal small-fibre function assessed with contact heat evoked potentials in humans
Truini, A., Galeotti, F., Pennisi, E. M., Casa, F., Biasiotta, A., & Cruccu, G. (2007) · Pain · doi:10.1016/j.pain.2007.01.030 · Cited by 61 · see citing works
Hu, L., Valentini, E., Zhang, Z. G., Liang, M., & Iannetti, G. D. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.057 · Cited by 54 · see citing works
Poreisz, C., Antal, A., Boros, K., Brepohl, N., Csifcsák, G., & Paulus, W. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-1188-5 · Cited by 53 · see citing works
Hansen, N., Obermann, M., Poitz, F., Holle, D., Diener, H., Antal, A., Paulus, W., & Katsarava, Z. (2011) · Cephalalgia · doi:10.1177/0333102410390394 · Cited by 49 · see citing works
Neurobiology of estrogen status in deep craniofacial pain
Bereiter, D. A., & Okamoto, K. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-385198-7.00010-2 · Cited by 46 · see citing works
Wydenkeller, S., Wirz, R., & Halder, P. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.12.007 · Cited by 45 · see citing works
Functional integration within the human pain system as revealed by Granger causality
Ploner, M., Schoffelen, J., Schnitzler, A., & Groß, J. (2009) · Human Brain Mapping · doi:10.1002/hbm.20826 · Cited by 42 · see citing works
Torta, D. M., Liang, M., Valentini, E., Mouraux, A., & Iannetti, G. D. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3019-6 · Cited by 41 · see citing works
Pain Related Cortical Oscillations: Methodological Advances and Potential Applications
Peng, W., & Tang, D. (2016) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2016.00009 · Cited by 41 · see citing works
Improved diagnosis of spinal cord disorders with contact heat evoked potentials
Ulrich, A., Haefeli, J., Blum, J., Min, K., & Curt, A. E. P. (2013) · Neurology · doi:10.1212/wnl.0b013e31828c2ed1 · Cited by 40 · see citing works
Tashiro, S., Mizuno, K., Kawakami, M., Takahashi, O., Nakamura, T., Suda, M., Haruyama, K., Otaka, Y., Tsuji, T., & Liu, M. (2019) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622319889259 · Cited by 39 · see citing works
Biasiotta, A., Casato, M., Cesa, S. L., Colantuono, S., Stefano, G. D., Leone, C. M., Carlesimo, M., Piroso, S., Cruccu, G., & Truini, A. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7261-7 · Cited by 38 · see citing works
Clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury
Curt, A. E. P., & ELLAWAY, P. H. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52137-8.00004-8 · Cited by 34 · see citing works
Hashmi, J. A., & Davis, K. D. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90500.2008 · Cited by 28 · see citing works
Neuropathic pain and its assessment
Cruccu, G., & Truini, A. (2010) · Surgical Oncology · doi:10.1016/j.suronc.2009.11.012 · Cited by 28 · see citing works
Truini, A., Galeotti, F., Biasiotta, A., Gabriele, M., Inghilleri, M., Petrucci, M., & Cruccu, G. (2008) · Muscle & Nerve · doi:10.1002/mus.21162 · Cited by 27 · see citing works
Weiß, T., Hesse, W., Ungureanu, M., Hecht, H., Leistritz, L., Witte, H., & Miltner, W. H. R. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00912.2007 · Cited by 27 · see citing works
McKune, C. M., Murrell, J. C., Nolan, A. M., White, K., & Wright, B. D. (2015) · doi:10.1002/9781119421375.ch29 · Cited by 27 · see citing works
Truini, A., Biasiotta, A., Stefano, G. D., Cesa, S. L., Leone, C. M., Cartoni, C., Leonetti, F., Casato, M., Pergolini, M., Petrucci, M., et al. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6698-9 · Cited by 26 · see citing works
Cutaneous silent period recordings in demyelinating and axonal polyneuropathies
Lopergolo, D., Isak, B., Gabriele, M., Onesti, E., Ceccanti, M., Capua, G., Fionda, L., Biasiotta, A., Stefano, G. D., Cesa, S. L., et al. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.11.013 · Cited by 23 · see citing works
Differential processing of laser stimuli by Aδ and C fibres in major depression
Terhaar, J., Viola, F. C., Franz, M., Berger, S., Bär, K., & Weiß, T. (2011) · Pain · doi:10.1016/j.pain.2011.03.027 · Cited by 23 · see citing works
Laser evoked potentials in amyotrophic lateral sclerosis
Simone, I. L., Tortelli, R., Samarelli, V., D’Errico, E., Sardaro, M., Difruscolo, O., Calabrese, R., Francesco, V. D. V., Livrea, P., & de Tommaso, M. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.09.023 · Cited by 23 · see citing works
What do general neurologists need to know about neuropathic pain?
Schestatsky, P., & Nascimento, O. J. M. (2009) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2009000400039 · Cited by 23 · see citing works
Optimizing the Measurement of Contact Heat Evoked Potentials
Warbrick, T., Derbyshire, S. W. G., & Bagshaw, A. P. (2009) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0b013e31819d8016 · Cited by 21 · see citing works
Empathy for pain in fibromyalgia patients: An EEG study
de Tommaso, M., Ricci, K., Conca, G., Vecchio, E., Delussi, M. D., & Invitto, S. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.09.007 · Cited by 18 · see citing works
Cortical integration of bilateral nociceptive signals: when more is less
Northon, S., Rustamov, N., & Piché, M. (2018) · Pain · doi:10.1097/j.pain.0000000000001451 · Cited by 17 · see citing works
Truini, A., Romaniello, A., Svensson, P. J., Galeotti, F., Graven‐Nielsen, T., Wang, K., Cruccu, G., & Arendt‐Nielsen, L. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0508-5 · Cited by 16 · see citing works
Abnormal sudomotor skin responses to temperature and pain stimuli in syringomyelia
Heras, M. V. D. L., Valls‐Solé, J., Schestatsky, P., Montero, J., & Casado, V. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0422-6 · Cited by 16 · see citing works
Jensen‐Dahm, C., Madsen, C. S., Waldemar, G., Ballegaard, M., Hejl, A., Johnsen, B., & Jensen, T. S. (2015) · Pain Medicine · doi:10.1093/pm/pnv012 · Cited by 16 · see citing works
Laser evoked potential recording from intracerebral deep electrodes
Valeriani, M., Truini, A., Pera, D. L., Insola, A., Galeotti, F., Petrachi, C., Mazzone, P. A. M., & Cruccu, G. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.02.162 · Cited by 15 · see citing works
Laboratory tools for assessing neuropathic pain
Stefano, G. D., Cesa, S. L., Biasiotta, A., Leone, C. M., Pepe, A., Cruccu, G., & Truini, A. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1033-x · Cited by 13 · see citing works
Naro, A., Bramanti, P., Bramanti, A., & Calabrò, R. S. (2017) · Consciousness and Cognition · doi:10.1016/j.concog.2017.08.009 · Cited by 12 · see citing works
ORIGINS OF TACTILE VULNERABILITY IN HIGH-RISK INFANTS
Weiss, S. J., & Wilson, P. (2006) · Advances in Neonatal Care · doi:10.1016/j.adnc.2005.11.006 · Cited by 12 · see citing works
Miltner, W. H. R., Franz, M., & Naumann, E. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1371636 · Cited by 11 · see citing works
Schmerzmessung und klinische Diagnostik
Kröner‐Herwig, B., & Lautenbacher, S. (2010) · Springer eBooks · doi:10.1007/978-3-642-12783-0_17 · Cited by 11 · see citing works
Lütolf, R., Rösner, J., Curt, A. E. P., & Hubli, M. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2021.0280 · Cited by 10 · see citing works
Valls‐Solé, J. (2016) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2016.02.002 · Cited by 10 · see citing works
Neuropathies sensitives des petites fibres : intérêt des potentiels évoqués laser
Créac’h, C., Convers, P., Robert, F., Antoine, J.-C. G., & Camdessanché, J. (2010) · Revue Neurologique · doi:10.1016/j.neurol.2010.08.011 · Cited by 10 · see citing works
Hansen, T. M., Graversen, C., Frøkjær, J. B., Olesen, A. E., Valeriani, M., & Drewes, A. M. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12579 · Cited by 8 · see citing works
Kontakthitzeevozierte Potenziale
Seifert, C. L., Nitzsche, D., Valet, M., Tölle, T. R., & Sprenger, T. (2008) · Der Nervenarzt · doi:10.1007/s00115-008-2465-7 · Cited by 8 · see citing works
Selektive C-Faser-Stimulation durch Stimulation winziger Hautareale
Weiß, T., & Miltner, W. H. R. (2005) · Der Schmerz · doi:10.1007/s00482-005-0416-9 · Cited by 8 · see citing works
Fuseya, H., Tashiro, S., Takahashi, O., Kobayashi, Y., Tsuji, T., & Mizuno, K. (2025) · Neural Plasticity · doi:10.1155/np/7939662 · Cited by 7 · see citing works
Gobbelé, R., Halboni, P., Büchner, H., & Waberski, T. D. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.08.008 · Cited by 7 · see citing works
Evaluation of afferent pain pathways in adrenomyeloneuropathic patients
Yagüe, S., Heras, M. V. D. L., Casasnovas, C., Ruíz, M., Pedro, J., Valls‐Solé, J., & Pujol, A. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.12.011 · Cited by 6 · see citing works
Scheuren, P. S., Nauer, N., Rösner, J., Curt, A. E. P., & Hubli, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07967-x · Cited by 6 · see citing works
Park, J., & Lee, K. H. (2020) · Journal of Men s Health · doi:10.31083/jomh.v16i3.285 · Cited by 10 · see citing works
Multimodal Integrative Perception : Biological correlates and qualitative experiences
Maldonato, N. M., Sperandeo, R., Coco, M., Cioffi, V., de Lucia, S., Mosca, L. L., & Esposito, A. A. (2020) · IEEE International Conference on Cognitive Infocommunications · doi:10.1109/coginfocom50765.2020.9237912 · Cited by 4 · see citing works
The Skin and the Nervous System
Archer, C. B., & Eedy, D. J. (2004) · doi:10.1002/9780470750520.ch60 · Cited by 4 · see citing works
The Skin and the Nervous System
Archer, C. B., & Eedy, D. J. (2010) · doi:10.1002/9781444317633.ch63 · Cited by 4 · see citing works
Júlio, S. U., Schneuwly, M., Scheuren, P. S., Hubli, M., & Schubert, M. J. W. (2025) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2025.110382 · Cited by 3 · see citing works
Schmerzmess ung und klinische Diagnostik
Kröner‐Herwig, B., & Lautenbacher, S. (2016) · Springer eBooks · doi:10.1007/978-3-662-50512-0_12 · Cited by 3 · see citing works
Agostini, T., Scisciolo, G. D., Lazzeri, D., Almesberger, D., Mori, A., Cassardo, A., Li, A. Q., Zhang, Y. X., & Dini, M. (2013) · European Journal of Plastic Surgery · doi:10.1007/s00238-012-0803-2 · Cited by 3 · see citing works
A comprehensive EEG dataset of laser-evoked potentials for pain research
Zhao, X., Zhou, J., Zhang, L., Zhuang, Y., Duan, H., Wei, S., Yao, S., Lu, X., Bi, Y., & Hu, L. (2025) · Scientific Data · doi:10.1038/s41597-025-05900-1 · Cited by 3 · see citing works
Évaluation fonctionnelle des douleurs neuropathiques
Hatem, S. M., Attal, N., & Plaghki, L. (2010) · Douleur et Analgésie · doi:10.1007/s11724-010-0190-z · Cited by 2 · see citing works
Brain plasticity: dynamic changes of the cerebral activity as effect of pain modulation
Wang, L. (2007) · Cited by 2 · see citing works
Physiology and Pathophysiology of Pain
White, K. (2024) · Wiley eBooks · doi:10.1002/9781119830306.ch46 · Cited by 2 · see citing works
Indications des potentiels lasers dans l’exploration de la douleur neuropathique
Créac’h, C. (2014) · Pratique Neurologique - FMC · doi:10.1016/j.praneu.2014.09.002 · Cited by 1 · see citing works
May, E. S. (2012) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver · Cited by 1 · see citing works
Electrophysiological Markers for Neuropathic Pain in Spinal Cord Injured Subjects
Wydenkeller, S. (2009) · Zurich Open Repository and Archive (University of Zurich) · doi:10.3929/ethz-a-005773226
Simultane EEG - fMRT Untersuchung von schmerzevozierten Reaktionen
Falkai, P. (2013)
Neurophysiological Assessments in Small Fiber Neuropathy: Evoked Potentials
Privitera, R., & Anand, P. (2019) · Springer eBooks · doi:10.1007/978-981-13-3546-4_3
Nociception and pain in the electroencephalogram
Anders, M. (2022) · doi:10.21248/gups.73753
Badr, L., Gagné-Pelletier, L., Massé‐Alarie, H., & Mercier, C. (2024) · Brain Sciences · doi:10.3390/brainsci14090851
Cambier, J., Masson, M., Masson, C., & Dehen, H. (2012) · Elsevier eBooks · doi:10.1016/b978-2-294-71451-1.00001-7
Normative data of laser evoked potentials using Nd:YAP laser
Sukockienė, E., Perchet, C., Créac’h, C., Garcı́a-Larrea, L., & Lascano, A. M. (2026) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2026.10.002
- Authors
- Treede, R.-D.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Treede, Rolf-Detlef
- ORCID
- Treede, Rolf-Detlef
- Venue
- Journal of Neurology
- Published
- 2003-10-01
- Volume
- 250
- Issue
- 10
- Pages
- 1152-1161
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2007507727
- Cited by
- 83
- References
- 84
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 10
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Keywords
- laser-evoked potentials, sensory evoked potentials, pain pathways, somatosensory pathways, nociceptive pathways, small fiber neuropathy, peripheral nerve disorders, central nervous system disorders, infrared laser stimulation
- MeSH terms
- Central Nervous System Diseases, Evoked Potentials, Somatosensory, Humans, Lasers, Pain, Peripheral Nervous System Diseases, Temperature, Touch
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review