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Cited by 126Wound Healing and TreatmentsBurn Injury Management and OutcomesPhytochemistry and biological activity of medicinal plants

The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.

Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism

Kimura, Yoshiyuki, Sumiyoshi, Maho, Samukawa, Kei-ichi, Satake, Noriko, Sakanaka, Masahiro·2008·European Journal of Pharmacology
DOI 10.1016/j.ejphar.2008.02.036
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Abstract

Some reports published from 1967 to 1999 describe the use of ointments containing high doses (0.1 to 0.2%, w/w) C. asiataica herb extracts to enhance wound repair. Lower doses at which burn wound repair is enhanced by such topical applications have not been established yet. We found that the application of asiaticoside at low doses of 10(-8) to 10(-12)% (w/w) facilitated burn wound repair. To clarify the accelerating mechanisms of asiaticoside on burn wound repair, we examined the effects of asiaticoside on the levels of various cytokines produced at the site of the burn wound. The topical application of a low dose (10 pg, 1 ng, or 100 ng/wound area) of asiaticoside increased monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and interleukin (IL)-1beta levels in burn wound exudates. Asiaticoside (10 pg to 100 ng/ml) enhanced MCP-1 production in HaCaT cells, but it had no direct effect on VEGF production. Furthermore, asiaticoside (10 pg to 100 ng/ml) increased the IL-1beta production in THP-1 macrophages with MCP-1, but it had no effect on IL-1beta production without MCP-1 or with lipopolysaccharide (LPS). These findings suggest that the enhancement of burn wound healing by asiaticoside might be due to the promotion of angiogenesis during skin wound repair as a result of the stimulation of VEGF production caused by the increase in MCP-1 expression in keratinocytes and the increase in IL-1beta expression in macrophages induced cooperatively…

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Metadata

Authors
Kimura, Y., Sumiyoshi, M., Samukawa, K.-I., Satake, N., & Sakanaka, M.
Affiliations
  • Ehime University (JP)
  • Kobe Gakuin University (JP)
Corresponding author
Kimura, Yoshiyuki
ORCID
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2008-04
Volume
584
Issue
2-3
Pages
415-423
ISSN
0014-2999 (ISSN-L)
DOI
10.1016/j.ejphar.2008.02.036
OpenAlex
W2031014053
Cited by
126
References
56
Citations by year
2026: 7 · 2025: 7 · 2024: 3 · 2023: 15 · 2022: 9 · 2021: 10 · 2020: 3 · 2019: 10 · 2018: 10 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 14 · 2012: 4
FWCI
4.28
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology (19590694)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
Keywords
asiaticoside, burn wound healing, wound healing, angiogenesis, vascular endothelial growth factor, MCP-1, IL-1β, macrophages, keratinocytes, cytokine production
MeSH terms
Administration, Cutaneous, Animals, Burns, Cell Line, Cell Survival, Dermatologic Agents, Disease Models, Animal, Dose-Response Relationship, Drug, Exudates and Transudates, Humans, Macrophages, Male, Mice, Inbred BALB C, Plant Extracts, Time Factors, Triterpenes, Wound Healing, Signal Transduction, Keratinocytes, Cytokines, Neovascularization, Physiologic, Chemokine CCL2, Centella, Vascular Endothelial Growth Factor A, Cell Proliferation, Mice, Interleukin-1beta

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