Muscarinic acetylcholine receptors in the nucleus accumbens core and shell contribute to cocaine priming-induced reinstatement of drug seeking

Yee, Judy; Famous, Katie R.; Hopkins, Thomas J.; McMullen, Michael C.; Pierce, R. Christopher; Schmidt, Heath D.

doi:10.1016/j.ejphar.2010.10.045

Cited by 34Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study

Muscarinic acetylcholine receptors in the nucleus accumbens core and shell contribute to cocaine priming-induced reinstatement of drug seeking

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Yee, Judy, Famous, Katie R., Hopkins, Thomas J., McMullen, Michael C., Pierce, R. Christopher, Schmidt, Heath D.·2011·European Journal of Pharmacology

DOI 10.1016/j.ejphar.2010.10.045PMC PMC3033040

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Abstract

Muscarinic acetylcholine receptors in the nucleus accumbens play an important role in mediating the reinforcing effects of cocaine. However, there is a paucity of data regarding the role of accumbal muscarinic acetylcholine receptors in the reinstatement of cocaine-seeking behavior. The goal of these experiments was to assess the role of muscarinic acetylcholine receptors in the nucleus accumbens core and shell in cocaine and sucrose priming-induced reinstatement. Rats were initially trained to self-administer cocaine or sucrose on a fixed-ratio schedule of reinforcement. Lever-pressing behavior was then extinguished and followed by a subsequent reinstatement phase during which operant responding was induced by either a systemic injection of cocaine in cocaine-experienced rats or non-contingent delivery of sucrose pellets in subjects with a history of sucrose self-administration. Results indicated that systemic administration of the muscarinic acetylcholine receptor antagonist scopolamine (5.0 mg/kg, i.p.) dose-dependently attenuated cocaine, but not sucrose, reinstatement. Furthermore, administration of scopolamine (36.0 μg) directly into the nucleus accumbens shell or core attenuated cocaine priming-induced reinstatement. In contrast, infusion of scopolamine (36.0 μg) directly into the accumbens core, but not shell, attenuated sucrose reinstatement, which suggests that muscarinic acetylcholine receptors in these two subregions of the nucleus accumbens have differential roles in sucrose seeking. Taken together, these results indicate that cocaine priming-induced reinstatement is mediated, in part, by increased signaling through muscarinic acetylcholine receptors in the shell subregion of the nucleus accumbens. Muscarinic acetylcholine receptors in the core of the accumbens, in contrast, appear to play a more general (i.e. not cocaine specific) role in motivated behaviors.

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Blockade of muscarinic acetylcholine receptors using scopolamine decreases reinstatement of cocaine seeking.
“Less intuitively, blockade of mAChRs using scopolamine decreases reinstatement of cocaine seeking (Yee et al., 2011), but this may be due to increased ACh release through blockade of inhibitory autoreceptors (Douglas et al., 2001).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Yee et al., 2011

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Self-citation
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Self-citation

Authors: Yee, J., Famous, K. R., Hopkins, T. J., McMullen, M. C., Pierce, R. C., & Schmidt, H. D.
Affiliations: Boston University (US)
University of Pennsylvania (US)
Corresponding author: Schmidt, Heath D.
ORCID: Famous, Katie R.
Hopkins, Thomas J.
Pierce, R. Christopher
Schmidt, Heath D.
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2011-01
Volume: 650
Issue: 2-3
Pages: 596-604
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/j.ejphar.2010.10.045
PMC: PMC3033040
OpenAlex: W2024305001
Cited by: 34
References: 59
Citations by year: 2026: 1 · 2025: 2 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 3
FWCI: 1.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: School of Medicine, Boston University
National Institutes of Health
National Institute on Drug Abuse (R01DA015214, R01DA15214, K02 DA18678, K01DA030445, F30 DA19304, F30DA019304, DA 16824, F31DA016824, K02DA018678)
National Institute of General Medical Sciences (T32GM008541, T32 GM008541-7)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: muscarinic receptors, nucleus accumbens, cocaine priming, reinstatement, cocaine self-administration, sucrose self-administration, scopolamine, motivated behavior, drug-seeking behavior
MeSH terms: Animals, Behavior, Animal, Cocaine, Conditioning, Operant, Dose-Response Relationship, Drug, Extinction, Psychological, Male, Nucleus Accumbens, Receptors, Muscarinic, Reinforcement Schedule, Scopolamine, Self Administration, Rats, Sprague-Dawley, Muscarinic Antagonists, Rats, Drug-Seeking Behavior

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Muscarinic acetylcholine receptors in the nucleus accumbens core and shell contribute to cocaine priming-induced reinstatement of drug seeking

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