The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice
Abstract
Autophagy is a lysosomal degradation pathway, which is essential for cell survival, proliferation, differentiation and homeostasis. It is well known that beta-amyloid (Aβ) aggregation is one of key characteristics for Alzheimer's disease (AD), which triggers a complex pathological cascade, leading to neurodegeneration. Recent studies have shown that Aβ peptide is generated from amyloid β precursor protein (APP) during autophagic turnover of APP-rich organelles by autophagy. Aβ generation during normal autophagy is subsequently degraded by lysosomes. Curcumin, a nature plant extraction, has been reported to inhibit the generation and deposition of Aβ; however, the underlying mechanisms are not fully understood yet. In the present study, we reported that curcumin treatment not only attenuated cognitive impairment detected by Morris water maze test, but also inhibited the generation of Aβ investigated by immunohistochemistry in APP/PS1 double transgenic AD mice. Moreover, curcumin induced autophagy in the mice, evidenced by LC3 immunofluorescence analysis and western blot assays on LC3. Furthermore, we found that curcumin significantly decreased the expression of Phosphatidylinositol 3-Kinase (PI3K), phosphorylated Akt and rapamycin (mTOR) at protein levels, respectively. Taken together, our data suggests that curcumin inhibits Aβ generation and induces of autophagy by downregulating PI3K/Akt/mTOR signaling pathway, and further shows a neuroprotective effect. Meanwhile curcumin might be a candidate neuroprotective agent for AD patients treatment by inducing autophagy.
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“Significant cognitive improvement was documented at low (160 ppm) and high (1000 ppm) doses of curcumin after administration for the 6-month period in the double transgenic AD model (APP/PS1) [110].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [110]
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Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078
Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881
Atg8: an autophagy-related ubiquitin-like protein family.
Shpilka, T., Weidberg, H., Pietrokovski, S., & Elazar, Z. (2011) · Genome biology · doi:10.1186/gb-2011-12-7-226 · Cited by 543
Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López‐Aranda, M. F., Silva, A. J., & Oddo, S. (2013) · Aging Cell · doi:10.1111/acel.12057 · Cited by 362
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
Sarkar, S., Krishna, G., Imarisio, S., Saiki, S., O’Kane, C. J., & Rubinsztein, D. C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm294 · Cited by 353
Cheng, K. K., Yeung, C. F., Ho, S. W., Chow, S. F., Chow, A. H. L., & Baum, L. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9444-4 · Cited by 329
Autophagy and disease: always two sides to a problem
Sridhar, S., Botbol, Y. M., Macián, F., & Cuervo, A. M. (2011) · The Journal of Pathology · doi:10.1002/path.3025 · Cited by 298
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Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives
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Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease
Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170512 · Cited by 354
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Metadata
- Authors
- Wang, C., Zhang, X., Teng, Z., Zhang, T., & Li, Y.
- Affiliations
- Chongqing Medical University (CN)
- Corresponding author
- Li, Yu
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 740
- Pages
- 312-320
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2008391194
- Cited by
- 233
- References
- 32
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 16 · 2023: 12 · 2022: 29 · 2021: 24 · 2020: 29 · 2019: 22 · 2018: 18 · 2017: 20 · 2016: 15 · 2015: 11 · 2014: 1
- FWCI
- 10.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81100948, 81271426)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- curcumin, autophagy, PI3K/AKT/mTOR pathway, Alzheimer's disease, APP/PS1 double transgenic mice, cognitive impairment, neuroprotection, LC3, rapamycin, amyloid precursor protein
- MeSH terms
- Beclin-1, Alzheimer Disease, Animals, Autophagy, Cognition, Curcumin, Disease Models, Animal, Female, Hippocampus, Male, Memory, Mice, Transgenic, Peptide Fragments, Signal Transduction, Down-Regulation, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Neuroprotective Agents, Maze Learning, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt, Presenilin-1, Phosphatidylinositol 3-Kinase, TOR Serine-Threonine Kinases
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