Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105

Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881

Atg8: an autophagy-related ubiquitin-like protein family.

Shpilka, T., Weidberg, H., Pietrokovski, S., & Elazar, Z. (2011) · Genome biology · doi:10.1186/gb-2011-12-7-226 · Cited by 543

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López‐Aranda, M. F., Silva, A. J., & Oddo, S. (2013) · Aging Cell · doi:10.1111/acel.12057 · Cited by 362

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin

Sarkar, S., Krishna, G., Imarisio, S., Saiki, S., O’Kane, C. J., & Rubinsztein, D. C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm294 · Cited by 353

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

Cheng, K. K., Yeung, C. F., Ho, S. W., Chow, S. F., Chow, A. H. L., & Baum, L. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9444-4 · Cited by 329

Autophagy and disease: always two sides to a problem

Sridhar, S., Botbol, Y. M., Macián, F., & Cuervo, A. M. (2011) · The Journal of Pathology · doi:10.1002/path.3025 · Cited by 298

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

Ghosh, S., Banerjee, S., & Sil, P. C. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.05.022 · Cited by 501

Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives

Zhang, Z., Yang, X., Song, Y., & Tu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101464 · Cited by 387

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170512 · Cited by 354

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth, H., & Lee, H.-K. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00428-5 · Cited by 288

Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Fu, Y., Chen, T., Weng, L., Huang, L., Lai, D., & Weng, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111888 · Cited by 280

The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans

Stoiber, W., Obermayer, A., Steinbacher, P., & Krautgartner, W.-D. (2015) · Biomolecules · doi:10.3390/biom5020702 · Cited by 262

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146476 · Cited by 243

Neuroprotective Herbs for the Management of Alzheimer’s Disease

Gregory, J., Vengalasetti, Y. V., Bredesen, D. E., & Rao, R. V. (2021) · Biomolecules · doi:10.3390/biom11040543 · Cited by 264

Curcumin: A naturally occurring autophagy modulator

Shakeri, A., Cicero, A. F. G., Panahi, Y., Mohajeri, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27404 · Cited by 231

The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

Razani, E., Pourbagheri‐Sigaroodi, A., Safaroghli‐Azar, A., Zoghi, A., Bavarsad, M. S., & Bashash, D. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01231-3 · Cited by 232

Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates

Park, H., Kang, J., & Lee, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093369 · Cited by 217

The metal ion hypothesis of Alzheimer’s disease and the anti-neuroinflammatory effect of metal chelators

Chen, L.-L., Fan, Y.-G., Zhao, L.-X., Zhang, Q., & Wang, Z.-Y. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106301 · Cited by 200

Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure

Naoi, M., Wu, Y., Shamoto‐Nagai, M., & Maruyama, W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102451 · Cited by 177

Proteome‐Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents

Abegg, D., Frei, R., Cerato, L., Hari, D. P., Wang, C., Waser, J., & Adibekian, A. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201505641 · Cited by 158

Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine

Ding, M.-R., Qu, Y.-J., Hu, B., & An, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113208 · Cited by 145

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

Zhang, J., Wang, J., Xu, J., Lu, Y., Jiang, J.-K., Wang, L., Shen, H., & Xia, D. (2016) · Oncotarget · doi:10.18632/oncotarget.12318 · Cited by 137

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

Kang, L., Xiang, Q., Zhan, S., Song, Y., Wang, K., Zhao, K., Li, S., Shao, Z., Cao, Y., & Zhang, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7810320 · Cited by 127

Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

Giampieri, F., Afrin, S., Forbes-Hernández, T. Y., Gasparrini, M., Cianciosi, D., Reboredo‐Rodríguez, P., Varela‐López, A., Quiles, J. L., & Battino, M. A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7234 · Cited by 117

Autophagy and Tau Protein

Hamano, T., Enomoto, S., Shirafuji, N., Ikawa, M., Yamamura, O., Yen, S.-H. C., & Nakamoto, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147475 · Cited by 122

Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment

Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108

Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies

Sarker, M. R., & Franks, S. F. (2018) · GeroScience · doi:10.1007/s11357-018-0017-z · Cited by 110

Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview

Libro, R., Giacoppo, S., Soundara Rajan, T., Bramanti, P., & Mazzon, E. (2016) · Molecules · doi:10.3390/molecules21040518 · Cited by 107

Analyzing the genes related to Alzheimer’s disease via a network and pathway-based approach

Hu, Y.-S., Xin, J., Hu, Y. C., Zhang, L., & Wang, J. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0252-z · Cited by 117

The impact of curcumin and its modified formulations on Alzheimer's disease

Farkhondeh, T., Samarghandian, S., Pourbagher‐Shahri, A. M., & Sedaghat, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28411 · Cited by 110

Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review

Wang, Z., Liu, J., Zhu, Z., Su, C.-F., Sreenivasmurthy, S. G., Iyaswamy, A., Lu, J., Chen, G., Song, J., & Li, M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110968 · Cited by 109

Antiaging agents: safe interventions to slow aging and healthy life span extension

Liu, J. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00339-y · Cited by 112

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Stacchiotti, A., & Corsetti, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.555409 · Cited by 106

Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease

Bustamante, H. A., González, A., Cerda‐Troncoso, C., Shaughnessy, R., Carola Otth, L., Soza, A., & Burgos, P. V. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00126 · Cited by 102

The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer’s disease

Zhang, Y., Chen, X., Zhao, Y., Ponnusamy, M., & Liu, Y. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0013 · Cited by 99

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Ferreira, C., Vieira, P., Sá, H., Malva, J. O., Castelo-Branco, M. S., Reis, F., & Viana, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1360065 · Cited by 110

Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats

Chen, Q., Mo, R., Wu, N., Zou, X., Shi, C., Gong, J., Li, J., Fang, K., Wang, D., De-shen, Y., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00334 · Cited by 92

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Ege, D. (2021) · Materials · doi:10.3390/ma14123332 · Cited by 97

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

Dhakal, S., Kushairi, N., Phan, C., Adhikari, B., Sabaratnam, V., & Macreadie, I. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205090 · Cited by 92

Neuroprotective effects of curcumin through autophagy modulation

Forouzanfar, F., Read, M. I., Barreto, G. E., & Sahebkar, A. (2019) · IUBMB Life · doi:10.1002/iub.2209 · Cited by 90

Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway

Zhao, Z., YU, Z.-Y., Li, J., & OUYANG, X.-N. (2016) · Oncology Letters · doi:10.3892/ol.2016.4606 · Cited by 88

Exploring the multimodal role of phytochemicals in the modulation of cellular signaling pathways to combat age-related neurodegeneration

Uddin, M. S., Hossain, M. F., Mamun, A. A., Shah, M. A., Hasana, S., Bulbul, I. J., Sarwar, M. S., Mansouri, R. A., Ashraf, G. M., Rauf, A., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138313 · Cited by 89

Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells

Feng, X., Chen, L., Guo, W., Zhang, Y., Lai, X., Shao, L., & Li, Y. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.057 · Cited by 84

Neuroprotection of Multifunctional Phytochemicals as Novel Therapeutic Strategy for Neurodegenerative Disorders: Antiapoptotic and Antiamyloidogenic Activities by Modulation of Cellular Signal Pathways

Naoi, M., Shamoto‐Nagai, M., & Maruyama, W. (2019) · Future Neurology · doi:10.2217/fnl-2018-0028 · Cited by 84

Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression

Tizabi, Y., Hurley, L. L., Qualls, Z., & Akinfiresoye, L. R. (2014) · Molecules · doi:10.3390/molecules191220864 · Cited by 84

Curcumin promotes functional recovery and inhibits neuronal apoptosis after spinal cord injury through the modulation of autophagy

Li, W., Yao, S., Li, H., Meng, Z., & Sun, X. (2019) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2019.1616147 · Cited by 81

Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases

Heras-Sandoval, D., Pérez‐Rojas, J. M., & Pedraza‐Chaverrí, J. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109442 · Cited by 79

Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis

Rainey, N. E., Moustapha, A., & Petit, P. X. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3656419 · Cited by 81

Bakuchiol: A newly discovered warrior against organ damage

Xin, Z., Wu, X., Ji, T., Xu, B., Han, Y., Sun, M., Jiang, S., Li, T. X., Hu, W., Deng, C., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.001 · Cited by 75

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Zhang, Z., Wang, X., Zhang, D., Liu, Y., & Lin, L. (2019) · Aging · doi:10.18632/aging.101759 · Cited by 76

MiR-361-5p suppresses chemoresistance of gastric cancer cells by targeting FOXM1 via the PI3K/Akt/mTOR pathway

Tian, L., Zhao, Z., Xie, L., & Zhu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.23513 · Cited by 71

The interplay between oxidative stress and autophagy: focus on the development of neurological diseases

Talebi, M., Vadoud, S. A. M., Haratian, A., Talebi, M., Farkhondeh, T., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2022) · Behavioral and Brain Functions · doi:10.1186/s12993-022-00187-3 · Cited by 72

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.

Tramutola, A., Lanzillotta, C., & Di Domenico, F. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1244482 · Cited by 69

Trilateral association of autophagy, mTOR and Alzheimer’s disease: Potential pathway in the development for Alzheimer’s disease therapy

Subramanian, A., Tamilanban, T., Alsayari, A., Ramachawolran, G., Wong, L. S., Sekar, M., Gan, S. H., Subramaniyan, V., Chinni, S. V., Rani, N. N. I. M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1094351 · Cited by 70

Curcumin, Cardiometabolic Health and Dementia

Kim, Y., & Clifton, P. M. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15102093 · Cited by 68

Exercise-Induced Benefits for Alzheimer’s Disease by Stimulating Mitophagy and Improving Mitochondrial Function

Liang, J., Wang, C., Zhang, H., Huang, J., Xie, J., & Chen, N. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.755665 · Cited by 70

Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine

Zeng, Q., Siu, W. S., Li, L., Yu, J., Liang, S., Cao, M., Ma, M., & Wu, Z. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.027 · Cited by 64

Autophagy in neuroinflammatory diseases

Muller, S., Brun, S., René, F., Seze, J. D., Loeffler, J., & Jeltsch‐David, H. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.05.015 · Cited by 66

TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implications

Gu, Z., Cao, H., Zuo, C., Huang, Y., Miao, J., Song, Y., Yang, Y., Zhu, L., & Wang, F. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105855 · Cited by 69

Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer’s Disease

Rahman, M. A., Rahman, M. S., Rahman, M. H., Rasheduzzaman, M., Mamun-Or-Rashid, A. N. M., Uddin, M. J., Rahman, M. R., Hwang, H., Pang, M., & Rhim, H. (2020) · Biomedicines · doi:10.3390/biomedicines9010005 · Cited by 68

Targeting Aggrephagy for the Treatment of Alzheimer’s Disease

Malampati, S., Song, J., Tong, B. C., Nalluri, A., Yang, C., Wang, Z., Sreenivasmurthy, S. G., Zhu, Z., Liu, J., Su, C.-F., et al. (2020) · Cells · doi:10.3390/cells9020311 · Cited by 60

Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles

Deng, Z., Dong, Y., Zhou, X., Lu, J.-H., & Yue, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.009 · Cited by 58

Transcription factor EB: an emerging drug target for neurodegenerative disorders

Song, J., Liu, J., Jiang, Y., Wang, Z., & Li, M. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.10.013 · Cited by 59

The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

Yang, Y., & Zhang, L. (2020) · Food & Function · doi:10.1039/c9fo02611h · Cited by 57

Hippocampal Endosomal, Lysosomal, and Autophagic Dysregulation in Mild Cognitive Impairment

Perez, S. E., He, B., Nadeem, M., Wuu, J., Ginsberg, S. D., Ikonomović, M. D., & Mufson, E. J. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000179 · Cited by 57

Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway

Wang, J., Wang, C., & Bu, G. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5805 · Cited by 57

Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3β in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer’s Disease Mice

Sun, J., Zhang, X., Wang, C., Teng, Z., & Li, Y. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x17500902 · Cited by 54

Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice

Spinelli, K. J., Osterberg, V. R., Meshul, C. K., Soumyanath, A., & Unni, V. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128510 · Cited by 56

The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases

Perrone, L., Squillaro, T., Napolitano, F., Terracciano, C., Sampaolo, S., & Melone, M. A. B. (2019) · Nutrients · doi:10.3390/nu11081881 · Cited by 51

Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation

Ratano, P., Petrella, C., Forti, F., Passeri, P. P., Morena, M., Palmery, M., Trezza, V., Severini, C., & Campolongo, P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.030 · Cited by 51

Research progress in traditional Chinese medicine in the treatment of Alzheimer’s disease and related dementias

Tan, W., Qi, L., Hu, X., & Tan, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.921794 · Cited by 55

Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic challenges, target specificity, clinical trials and future perspectives

Ayaz, M., Mosa, O. F., Nawaz, A., Hamdoon, A. A. E., Elkhalifa, M. E. M., Sadiq, A., Ullah, F., Ahmed, A., Kabra, A., Khan, H. Z., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155272 · Cited by 53

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model

Sohrabi, M., Floden, A. M., Manocha, G. D., Klug, M. G., & Combs, C. K. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00200 · Cited by 50

Graphene Oxide Ameliorates the Cognitive Impairment Through Inhibiting PI3K/Akt/mTOR Pathway to Induce Autophagy in AD Mouse Model

Chu, F., Li, K., Li, X., Xu, L., Huang, J., & Yang, Z. R. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03167-z · Cited by 50

Alzheimer's disease genes and autophagy

Yoon, S.-Y., & Kim, D.-H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.018 · Cited by 42

Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway

Zhu, X., & Zhu, R. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s159236 · Cited by 44

The neuroprotective effects of Berberine against amyloid β-protein-induced apoptosis in primary cultured hippocampal neurons via mitochondria-related caspase pathway

Liang, Y., Huang, M., Jiang, X., Liu, Q., Chang, X., & Guo, Y. C. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.048 · Cited by 43

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

Casasampere, M., Ordóñez, Y. F., Pou, A., & Casas, J. (2015) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2015.07.025 · Cited by 42

Curcumin ameliorates insulin signalling pathway in brain of Alzheimer’s disease transgenic mice

Feng, H., Dang, H.-Z., Fan, H. J., Chen, X., Rao, Y., Ren, Y., Yang, J.-D., Shi, J., Wang, P., & Tian, J. (2016) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632016659494 · Cited by 42

Brain-derived neurotrophic factor: a mediator of inflammation-associated neurogenesis in Alzheimer’s disease

Chen, J.-J., Wang, T., An, C.-D., Jiang, C., Zhao, J., & Li, S. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0017 · Cited by 40

Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer’s Disease

Zhao, Y., Zhang, Y., Zhang, J., Zhang, X., & Yang, G. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200114163636 · Cited by 40

Proteome‐Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents

Abegg, D., Frei, R., Cerato, L., Hari, D. P., Wang, C., Waser, J., & Adibekian, A. (2015) · Angewandte Chemie · doi:10.1002/ange.201505641 · Cited by 40

Effects of curcumin on synapses in APPswe/PS1dE9 mice

He, Y., Wang, P., Wei, P., Feng, H., Ren, Y., Yang, J.-D., Rao, Y., Shi, J., & Tian, J. (2016) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632016638099 · Cited by 38

Autophagy: The missing link in diabetic neuropathy?

Yerra, V. G., Gundu, C., Bachewal, P., & Kumar, A. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.11.004 · Cited by 37

The Potential Protective Effect of Curcumin on Amyloid- β -42 Induced Cytotoxicity in HT-22 Cells

Zhang, L., Fang, Y., Cheng, X., Lian, Y., Zeng, Z., Wu, C., Zhu, H., & Xu, H. (2018) · BioMed Research International · doi:10.1155/2018/8134902 · Cited by 36

Schizandrol A protects against Aβ1–42-induced autophagy via activation of PI3K/AKT/mTOR pathway in SH-SY5Y cells and primary hippocampal neurons

Song, L., Yao, L., Zhang, L., Piao, Z., & Lu, Y. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01792-2 · Cited by 36

Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis

Xue, Y., Li, M., Xue, Y., Jin, W., Han, X., Zhang, J., Chu, X., Li, Z., & Chu, L. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11586 · Cited by 34

Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease

Yang, S., Du, Y., Zhao, X., Wu, C., & Yu, P. (2022) · Cells · doi:10.3390/cells11111735 · Cited by 38

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Hoppe, J. B., Frozza, R. L., Meneghetti, A., Bernardi, A., da Silva, T., Gerhardt, D., & Salbego, C. G. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.1099 · Cited by 1

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