Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice
Abstract
Numerous studies have demonstrated that inflammation, oxidative stress and altered level of neurotrophins are involved in the pathogenesis of depressive illness. Mangiferin, a C-glucosylxanthone is abundant in the stem and bark of Mangifera indica L. The compound has been shown to possess antioxidant, anti-inflammatory and immunomodulatory activities. The present study was performed to investigate the effect of mangiferin pretreatment on lipopolysaccharide-induced increased proinflammatory cytokines, oxidative stress and neurobehavioural abnormalities. Mice were challenged with lipopolysaccharide (0.83 mg/kg, i.p.) after 14 days of mangiferin (20 and 40 mg/kg, p.o.) pretreatment. Mangiferin pretreatment significantly ameliorated the anxiety-like behaviour as evident from the results of an elevated plus maze, light-dark box and open field test. Mangiferin pretreatment also improved the anhedonic behaviour as revealed by sucrose preference test and increased social interaction time. It also prevented the lipopolysaccharide-evoked depressive-like effect by reducing the immobility time in forced swim and tail suspension test. Lipopolysaccharide-induced elevated oxidative stress was decreased with mangiferin pretreatment due to its potential to increase reduced glutathione concentration, Superoxide dismutase and catalase activity and decrease lipid peroxidation and nitrite level in the hippocampus as well as in the prefrontal cortex. Mangiferin pretreatment also attenuated neuroin…
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Mangiferin reduces LPS-induced IL-1beta expression and oxidative stress when used in depressive and anxiety disorders.
“Furthermore, mangiferin reduces LPS-induced IL-1β expression and oxidative stress when used in depressive and anxiety disorders (71).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [71]
In behavioral experiments, mice treated with LPS (0.83 mg/kg) intraperitoneal injection following oral pretreatment with mangiferin (20 and 40 mg/kg, 14 days) attenuated depressive and anxiety-like behaviors.
“Similarly, in behavioral experiments, mice were treated with LPS (0.83 mg/kg) intraperitoneal injection following oral pretreatment with mangiferin (20 and 40 mg/kg, 14 days), which subsequently attenuated depressive and anxiety-like behaviors (71).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [71]
Mangiferin increases glutathione concentration, SOD and catalase activity in mice, and decreases lipid peroxidation and nitrite level in the hippocampus and prefrontal cortex.
“Further research has ascertained that mangiferin increases glutathione concentration, superoxide dismutase (SOD) and catalase activity in mice; as well as decreasing lipid peroxidation and nitrite level in the hippocampus and prefrontal cortex (71).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [71]
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- Authors
- Jangra, A., Lukhi, M. M., Sulakhiya, K., Baruah, C. C., & Lahkar, M.
- Affiliations
- National Institute of Pharmaceutical Education and Research (IN)
- Assam Agricultural University (IN)
- Gauhati Medical College and Hospital (IN)
- Corresponding author
- Lahkar, Mangala
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 740
- Pages
- 337-345
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2028525373
- Cited by
- 122
- References
- 7
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 14 · 2022: 12 · 2021: 12 · 2020: 19 · 2019: 5 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 7 · 2014: 1 · 2013: 1
- FWCI
- 21.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Chemicals and Petrochemicals, Ministry of Chemicals and Fertilizers, India
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- mangiferin, lipopolysaccharide, depression, anxiety, neuroinflammation, oxidative stress, IL-1β, anhedonia, social interaction, hippocampus, prefrontal cortex, neuroprotection, antidepressant effects, anti-anxiety activity
- MeSH terms
- Animals, Antidepressive Agents, Antioxidants, Anxiety, Behavior, Animal, Catalase, Depression, Glutathione, Hippocampus, Lipopolysaccharides, Male, Malondialdehyde, Nitrites, Superoxide Dismutase, Anti-Anxiety Agents, Tumor Necrosis Factor-alpha, Thiobarbituric Acid Reactive Substances, Prefrontal Cortex, Oxidative Stress, Brain-Derived Neurotrophic Factor, Xanthones, Mice, Interleukin-1beta
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