Cited by 62Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Central inhibitory effects on feeding induced by the adipo-myokine irisin

Ferrante, Claudio, Orlando, Giustino, Recinella, Lucia, Leone, Sheila, Chiavaroli, Annalisa, Di Nisio, Chiara, Shohreh, Rugia, Manippa, Fabio +3 more·2016·European Journal of Pharmacology

Abstract

Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of paraventricular nucleus, which receives NPY/AgRP projections from the arcuate nucleus, suggests a possible role of irisin in the central regulation of energy balance. In this context, in the present work we studied the effects of intra-hypothalamic irisin (1μl, 50-200nmol/l) administration on feeding and orexigenic [agouti-related peptide (AgRP), neuropeptide Y (NPY) and orexin-A] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides in male Sprague-Dawley rats. Furthermore, we evaluated the effects of irisin on hypothalamic dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) concentrations and plasma NE levels. Compared to vehicle, irisin injected rats showed decreased food intake, possibly mediated by stimulated CART and POMC and inhibited DA, NE and orexin-A, in the hypothalamus. We also found increased plasma NE levels, supporting a role for sympathetic nervous system stimulation in mediating increased oxygen consumption by irisin.

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Crossref · 10.1016/j.ejphar.2016.09.011

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Authors
Ferrante, C., Orlando, G., Recinella, L., Leone, S., Chiavaroli, A., Di Nisio, C., Shohreh, R., Manippa, F., Ricciuti, A., Vacca, M., & Brunetti, L.
Affiliations
University of Chieti-Pescara (IT)
Corresponding author
Brunetti, Luigi
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2016-11
Volume
791
Pages
389-394
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2508257164
Cited by
62
References
51
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 17 · 2018: 11 · 2017: 9
FWCI
7.84
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
irisin, FNDC5, feeding behavior, hypothalamus, paraventricular nucleus, neuropeptide Y, agouti-related protein, orexin-A, cocaine- and amphetamine-regulated transcript, proopiomelanocortin, dopamine, norepinephrine, serotonin, plasma norepinephrine, sympathetic nervous system, energy homeostasis, physical activity
MeSH terms
Animals, Dopamine, Eating, Feeding Behavior, Fibronectins, Hypothalamus, Male, Neuropeptides, Norepinephrine, Serotonin, Rats, Sprague-Dawley, Rats

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