Central inhibitory effects on feeding induced by the adipo-myokine irisin
Abstract
Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of paraventricular nucleus, which receives NPY/AgRP projections from the arcuate nucleus, suggests a possible role of irisin in the central regulation of energy balance. In this context, in the present work we studied the effects of intra-hypothalamic irisin (1μl, 50-200nmol/l) administration on feeding and orexigenic [agouti-related peptide (AgRP), neuropeptide Y (NPY) and orexin-A] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides in male Sprague-Dawley rats. Furthermore, we evaluated the effects of irisin on hypothalamic dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) concentrations and plasma NE levels. Compared to vehicle, irisin injected rats showed decreased food intake, possibly mediated by stimulated CART and POMC and inhibited DA, NE and orexin-A, in the hypothalamus. We also found increased plasma NE levels, supporting a role for sympathetic nervous system stimulation in mediating increased oxygen consumption by irisin.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exercise-induced irisin may promote brain-derived neurotrophic factor (BDNF) synthesis in the CNS.
“Third, exercise-induced irisin may promote brain-derived neurotrophic factor (BDNF) synthesis in the CNS [7,67,68]; BDNF is a peptide known to possess central anorexigenic effects and to promote increased energy expenditure by increasing sympathetic outflow [246] (3).”
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
How to calculate sample size in animal studies?
Charan, J., & Kantharia, N. D. (2013) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.119726 · Cited by 1,881 · see citing works
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,556 · see citing works
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P. (1999) · Endocrine Reviews · doi:10.1210/er.20.1.68 · Cited by 1,554 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
Leptin enters the brain by a saturable system independent of insulin
Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222 · see citing works
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., & Reichardt, L. F. (2003) · Nature Neuroscience · doi:10.1038/nn1073 · Cited by 896 · see citing works
Leptin Signaling, Adiposity, and Energy Balance
Jéquier, E. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04293.x · Cited by 789 · see citing works
Neuroendocrine control of food intake
Valassi, E., Scacchi, M., & Cavagnini, F. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.06.004 · Cited by 649 · see citing works
FNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · see citing works
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
Cone, R. D., Cowley, M. A., Butler, A. A., Fan, W., Dl, M., & Low, M. J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801913 · Cited by 591 · see citing works
GLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems
Rellán‐Álvarez, R., Lobet, G., Lindner, H., Pradier, P., Sebastián, J., Yee, M., Geng, Y., Trontin, C., LaRue, T., Schrager‐Lavelle, A., et al. (2015) · eLife · doi:10.7554/elife.07597 · Cited by 305 · see citing works
A second look at the barriers of the medial basal hypothalamus
Peruzzo, B., Pastor, F., Blázquez, J. L., Schoebitz, K., Peláez, B., Amat, P., & Rodríguez, E. M. (2000) · Experimental Brain Research · doi:10.1007/s002219900289 · Cited by 273 · see citing works
Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss
Henry, F. E., Sugino, K., Tozer, A., Branco, T., & Sternson, S. M. (2015) · eLife · doi:10.7554/elife.09800 · Cited by 242 · see citing works
Irisin-immunoreactivity in neural and non-neural cells of the rodent
Dun, S. L., Lyu, R., Chen, Y., Chang, J. K., Luo, J. J., & Dun, N. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.050 · Cited by 236 · see citing works
Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity
Cason, A. M., Smith, R. J., Tahsili-Fahadan, P., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.009 · Cited by 229 · see citing works
Adiposity signals and the control of energy homeostasis
Woods, S. C., & Seeley, R. J. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00454-8 · Cited by 221 · see citing works
Moon, H., Dincer, F., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.007 · Cited by 207 · see citing works
Piya, M. K., Harte, A. L., Sivakumar, K., Tripathi, G., Voyias, P. D., James, S. G., Sabico, S., Al‐Daghri, N. M., Saravanan, P., Barber, T. M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00308.2013 · Cited by 167 · see citing works
Peptides crossing the blood–brain barrier: some unusual observations
Kastin, A. J., Pan, W., Maness, L. M., & Banks, W. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01961-7 · Cited by 144 · see citing works
Harlan, S. M., Morgan, D. A., Agassandian, K., Guo, D.-F., Cassell, M. D., Sigmund, C. D., Mark, A. L., & Rahmouni, K. (2011) · Circulation Research · doi:10.1161/circresaha.111.240226 · Cited by 144 · see citing works
Leptin in the CNS: much more than a satiety signal
Harvey, J., & Ashford, M. L. J. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00076-5 · Cited by 131 · see citing works
Novelle, M. G., Contreras, C., Romero, A., López, M., & Diéguez, C. (2013) · International Journal of Endocrinology · doi:10.1155/2013/746281 · Cited by 117 · see citing works
Vazquez, M. J., González, C. R., Varela, L., Lage, R., Tovar, S. A., Sangiao‐Alvarellos, S., Williams, L. M., Vidal‐Puig, A., Nogueiras, R., López, M., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1708 · Cited by 116 · see citing works
Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk
Panagiotou, G., Mu, L., Na, B., Mukamal, K. J., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.06.001 · Cited by 111 · see citing works
Commins, S. P., Marsh, D. J., Thomas, S. A., Watson, P. M., Padgett, M. A., Palmiter, R., & Gettys, T. W. (1999) · Endocrinology · doi:10.1210/endo.140.10.7043 · Cited by 107 · see citing works
Brunetti, L., Nisio, C. D., Recinella, L., Chiavaroli, A., Leone, S., Ferrante, C., Orlando, G., & Vacca, M. (2011) · Peptides · doi:10.1016/j.peptides.2011.08.003 · Cited by 97 · see citing works
Palacios‐González, B., Vadillo‐Ortega, F., Polo‐Oteyza, E., Sánchez, T. S., Ancira‐Moreno, M., Romero‐Hidalgo, S., Meraz‐Cruz, N., & Antuna-Puente, B. P. (2015) · Obesity · doi:10.1002/oby.21029 · Cited by 93 · see citing works
Central and Peripheral Irisin Differentially Regulate Blood Pressure
Zhang, W.-Z., Chang, L., Zhang, C., Zhang, R., Li, Z.-R., Chai, B.-X., Li, J.-Y., Chen, E., & Mulholland, M. (2015) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-015-6580-y · Cited by 92 · see citing works
Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings
Brunetti, L., Michelotto, B., Orlando, G., & Vacca, M. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00255-1 · Cited by 86 · see citing works
Palou, M., Sánchez, J., Rodríguez, A. M., Priego, T., Picó, C., & Palou, A. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000204100 · Cited by 84 · see citing works
Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus
Brunetti, L., Orlando, G., Recinella, L., Michelotto, B., Ferrante, C., & Vacca, M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.04.020 · Cited by 75 · see citing works
Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats
Roberts, M. D., Bayless, D. S., Jenkins, N. T., Padilla, J., Childs, T. E., Martin, J. S., Dalbo, V. J., Booth, F. W., Rector, R. S., & Laughlin, M. H. (2013) · Metabolism · doi:10.1016/j.metabol.2013.02.002 · Cited by 73 · see citing works
Mode of leptin action in chicken hypothalamus
Dridi, S., Swennen, Q., Decuypere, E. M. P., & Buyse, J. G. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.034 · Cited by 71 · see citing works
Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice
Wu, Y., Tu, Q., Valverde, P., Zhang, J., Murray, D., Dong, L., Cheng, J. H., Jiang, H., Rios, M., Morgan, E. F., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00048.2014 · Cited by 61 · see citing works
Peripheral chemerin administration modulates hypothalamic control of feeding
Brunetti, L., Orlando, G., Ferrante, C., Recinella, L., Leone, S., Chiavaroli, A., Nisio, C. D., Shohreh, R., Manippa, F., Ricciuti, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.11.007 · Cited by 60 · see citing works
LHA dopaminergic activity in obese and lean Zucker rats
Yang, Z., & Meguid, M. M. (1995) · Neuroreport · doi:10.1097/00001756-199505300-00029 · Cited by 59 · see citing works
Clark, K. A., MohanKumar, S. M. J., Kasturi, B. S., & MohanKumar, P. S. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00350.2005 · Cited by 53 · see citing works
Brunetti, L., Orlando, G., Ferrante, C., Recinella, L., Leone, S., Chiavaroli, A., Nisio, C. D., Shohreh, R., Manippa, F., Ricciuti, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.03.019 · Cited by 50 · see citing works
Irisin: A myokine with locomotor activity
Zhang, W., Chang, L., Zhang, C., Zhang, R., Li, Z., Chai, B., Li, J., Chen, E., & Mulholland, M. T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.069 · Cited by 44 · see citing works
Effects of central irisin administration on the uncoupling proteins in rat brain
Erden, Y., Tekin, S., Sandal, S., Etem, E. Ö., Tektemur, A., & Kırbağ, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.046 · Cited by 41 · see citing works
Kutlu, S., Aydın, M., Alçin, E., Özcan, M., Bakoš, J., Ježová, D., & Yılmaz, B. (2009) · Brain Research · doi:10.1016/j.brainres.2009.12.044 · Cited by 40 · see citing works
Brunetti, L., Ferrante, C., Orlando, G., Recinella, L., Leone, S., Chiavaroli, A., Nisio, C. D., Shohreh, R., Manippa, F., Ricciuti, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.07.021 · Cited by 20 · see citing works
Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response
Dey, S., Li, X., Teng, R., Alnaeeli, M., Chen, Z., Rogers, H. M., & Noguchi, C. T. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0171 · Cited by 19 · see citing works
Schlögl, M., Piaggi, P., Votruba, S. B., Walter, M. F., Krakoff, J. A., & Thearle, M. S. (2015) · Appetite · doi:10.1016/j.appet.2015.03.003 · Cited by 17 · see citing works
Ganguly, P. K. (2010) · International Journal of General Medicine · doi:10.2147/ijgm.s7749 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
“Irisin Ob: ↑ [39]+; T2DM: ↓ [39]+ AE: ↑ (aerobic or resistance) [40]+ CE: ↓? (aerobic or resistance) [41]+ ↑ (via PGC-1α): cold-induced shivering [42], ↑AMP:ATP ratio (via AMPK-PGC-1α pathway), FGF21* [43], and METRNL (via ↑PGC-1α4)* [44] ↓: proinflammatory cytokines [45] (possibly via NF-kB-mediated inhibition of PGC…”
BackgroundInfluentialRoles of myokines in exercise-induced improvement of neuropsychiatric function
Kim, S., Choi, J., Moon, S., Park, D., Kwak, H., & Kang, J. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02253-8 · Cited by 168 · see citing works
An update on the role of irisin in the regulation of endocrine and metabolic functions
Mahgoub, M., D’Souza, C. M., Darmaki, R. S. A., Baniyas, M. M. Y. H., & Adeghate, E. A. (2018) · Peptides · doi:10.1016/j.peptides.2018.03.018 · Cited by 109 · see citing works
Irisin, a fascinating field in our times
Bao, J., She, Q.-Y., Hu, P., Jia, N., & Li, A. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.06.003 · Cited by 102 · see citing works
Ferrante, C., Recinella, L., Ronci, M., Menghini, L., Brunetti, L., Chiavaroli, A., Leone, S., Di Iorio, L., Carradori, S., Tirillini, B., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.01.035 · Cited by 99 · see citing works
Self-citationIs irisin the new player in exercise-induced adaptations or not? A 2017 update
Fatouros, I. G. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0674 · Cited by 91 · see citing works
Zengin, G., Ferrante, C., Orlando, G., Zheleva‐Dimitrova, D., Gevrenova, R., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Aumeeruddy, M. Z., et al. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.13003 · Cited by 78 · see citing works
Nutraceutical potential of Corylus avellana daily supplements for obesity and related dysmetabolism
Mollica, A., Zengin, G., Stefanucci, A., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Locatelli, M., Dimmito, M. P., Novellino, E., et al. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.06.016 · Cited by 72 · see citing works
Locatelli, M., Macchione, N., Ferrante, C., Chiavaroli, A., Recinella, L., Carradori, S., Zengin, G., Cesa, S., Leporini, L., Leone, S., et al. (2018) · Molecules · doi:10.3390/molecules23051145 · Cited by 71 · see citing works
Detection and quantitation of irisin in human cerebrospinal fluid by tandem mass spectrometry
Ruan, Q., Zhang, L.-M., Ruan, J., Zhang, X.-X., Chen, J., Ma, C., & Yu, Z. (2018) · Peptides · doi:10.1016/j.peptides.2018.03.013 · Cited by 62 · see citing works
Marrano, N., Biondi, G., Borrelli, A., Cignarelli, A., Perrini, S., Laviola, L., Giorgino, F., & Natalicchio, A. (2021) · Biomolecules · doi:10.3390/biom11020286 · Cited by 56 · see citing works
Zengin, G., Ferrante, C., Gnapi, D. E., Sinan, K. I., Orlando, G., Recinella, L., Diuzheva, A., Jekő, J., Cziáky, Z., Chiavaroli, A., et al. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108610 · Cited by 49 · see citing works
The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons
Rodrigues, K. C. D. C., Pereira, R. M., de Campos, T. D. P., de Moura, R. F., da Silva, A. S. R., Cintra, D. E., Ropelle, E. R., Pauli, J. R., de Araújo, M. B., & de Moura, L. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00088 · Cited by 48 · see citing works
Orlando, G., Leone, S., Ferrante, C., Chiavaroli, A., Mollica, A., Stefanucci, A., Macedonio, G., Dimmito, M. P., Leporini, L., Menghini, L., et al. (2018) · Molecules · doi:10.3390/molecules23123071 · Cited by 48 · see citing works
Irisin, Energy Homeostasis and Male Reproduction
Sengupta, P., Dutta, S., Karkada, I. R., Akhigbe, R. E., & Chinni, S. V. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746049 · Cited by 46 · see citing works
Irisin may have a role in pubertal development and regulation of reproductive function in rats
Ülker, N., Yardımcı, A., Tektemur, N. K., Bulmuş, Ö., Kaya, Ş. Ö., Bulmuş, F. G., Türk, G., Özcan, M., & Canpolat, S. (2020) · Reproduction · doi:10.1530/rep-20-0072 · Cited by 45 · see citing works
Hormones, Metabolism and the Benefits of Exercise
(2017) · Research and Perspectives in Endocrine Interactions · doi:10.1007/978-3-319-72790-5 · Cited by 44 · see citing works
Butt, Z. D., Hackett, J. D., & Volkoff, H. (2017) · Peptides · doi:10.1016/j.peptides.2017.02.003 · Cited by 44 · see citing works
The role of irisin in metabolic flexibility: beyond adipose tissue browning.
Shen, S.-N., Liao, Q., Chen, X.-P., Peng, C., & Lin, L.-G. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.03.019 · Cited by 36 · see citing works
Orlando, G., Zengin, G., Ferrante, C., Ronci, M., Recinella, L., Şenkardeş, İ., Gevrenova, R., Zheleva‐Dimitrova, D., Chiavaroli, A., Leone, S., et al. (2019) · Molecules · doi:10.3390/molecules24142582 · Cited by 37 · see citing works
Guglielmi, P., Secci, D., Petzer, A., Bagetta, D., Chimenti, P., Rotondi, G., Ferrante, C., Recinella, L., Leone, S., Alcaro, S., et al. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1653864 · Cited by 33 · see citing works
Islam, M. R., Young, M. F., & Wrann, C. D. (2017) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-72790-5_8 · Cited by 32 · see citing works
Ferrante, C., Recinella, L., Ronci, M., Orlando, G., Simone, S. C. D., Brunetti, L., Chiavaroli, A., Leone, S., Politi, M., Tirillini, B. B., et al. (2019) · Phytotherapy Research · doi:10.1002/ptr.6429 · Cited by 31 · see citing works
Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain
Natalicchio, A., Marrano, N., Biondi, G., Dipaola, L., Spagnuolo, R., Cignarelli, A., Perrini, S., Laviola, L., & Giorgino, F. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3238 · Cited by 31 · see citing works
Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome
Aladag, T., Moğulkoç, R., & Baltacı, A. K. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230411105506 · Cited by 30 · see citing works
Zhang, X., Hu, C., Wu, H., Ma, Z., & Tang, Q. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00557-5 · Cited by 30 · see citing works
Tekin, S., Erden, Y., Özyalın, F., Etem, E. Ö., Çiğremiş, Y., Çolak, C., Tekedereli, İ., & Sandal, S. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.046 · Cited by 28 · see citing works
Yardımcı, A., Ülker, N., Özgen, A., Ozbeg, G., Ozdede, M. R., Ercan, E. Ç., & Canpolat, S. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137245 · Cited by 30 · see citing works
Neuroprotective Effects of Testosterone in the Hypothalamus of an Animal Model of Metabolic Syndrome
Sarchielli, E., Comeglio, P., Filippi, S., Cellai, I., Guarnieri, G., Marzoppi, A., Cipriani, S., Vignozzi, L., Morelli, A., & Maggi, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041589 · Cited by 26 · see citing works
Myokines in Appetite Control and Energy Balance
Grannell, A., Kokkinos, A. D., & le Roux, C. W. (2022) · Muscles · doi:10.3390/muscles1010003 · Cited by 23 · see citing works
Zengin, G., Ferrante, C., Şenkardeş, İ., Gevrenova, R., Zheleva‐Dimitrova, D., Menghini, L., Orlando, G., Recinella, L., Chiavaroli, A., Leone, S., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.03.041 · Cited by 22 · see citing works
Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
Hue, I., Capilla, E., Rosell-Moll, E., Balbuena-Pecino, S., Goffette, V., Gabillard, J., & Navarro, I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1155202 · Cited by 21 · see citing works
Anorexigenic effects induced by RVD-hemopressin(α) administration
Ferrante, C., Recinella, L., Leone, S., Chiavaroli, A., Nisio, C. D., Martinotti, S., Mollica, A., Macedonio, G., Stefanucci, A., Dvorácskó, S., et al. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.05.015 · Cited by 19 · see citing works
Mandic, S., & Volkoff, H. (2018) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2018.04.017 · Cited by 19 · see citing works
Orlando, G., Ferrante, C., Zengin, G., Sinan, K. I., Béné, K., Diuzheva, A., Jekő, J., Cziáky, Z., Simone, S. C. D., Recinella, L., et al. (2019) · Antioxidants · doi:10.3390/antiox8090343 · Cited by 20 · see citing works
Shaw, A., Tóth, B. B., Király, R., Arianti, R., Csomós, I., Póliska, S., Vámos, A., Korponay-Szabo, I. R., Bacsó, Z., Győry, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.737872 · Cited by 19 · see citing works
Sundarrajan, L., & Unniappan, S. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.06.027 · Cited by 17 · see citing works
Ferrante, C., Zengin, G., Menghini, L., Diuzheva, A., Jekő, J., Cziáky, Z., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., et al. (2019) · Processes · doi:10.3390/pr7080522 · Cited by 17 · see citing works
Mohammadi, S., Oryan, S., Komaki, A., Eidi, A., & Zarei, M. (2019) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-019-09842-2 · Cited by 16 · see citing works
Effects of growth hormone-releasing hormone gene targeted ablation on ghrelin-induced feeding
Recinella, L., Leone, S., Ferrante, C., Chiavaroli, A., Shohreh, R., Nisio, C. D., Vacca, M., Orlando, G., Salvatori, R., & Brunetti, L. (2017) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2017.10.007 · Cited by 15 · see citing works
Miazgowski, T., Kaczmarkiewicz, A., Miazgowski, B., & Kopeć, J. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01415-1 · Cited by 12 · see citing works
Parkin, R., & Murray, A. J. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1355922 · Cited by 12 · see citing works
Marrelli, M., Araniti, F., Statti, G. A., & Conforti, F. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.01.006 · Cited by 11 · see citing works
Auricular acupuncture induces FNDC5/irisin and attenuates obese inflammation in mice
Lu, Y., & Li, G. (2020) · Acupuncture in Medicine · doi:10.1136/acupmed-2017-011405 · Cited by 11 · see citing works
Bernardes-Ribeiro, M., Patrone, L. G. A., Cristina-Silva, C., Bícego, K. C., & Gargaglioni, L. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-62650-7 · Cited by 10 · see citing works
Ligand Bias and Its Association With Pro-resolving Actions of Melanocortin Drugs
Patruno, S., Garrido‐Mesa, J., Romano, M., Perretti, M., & Montero‐Melendez, T. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00919 · Cited by 10 · see citing works
Hypothalamic pathways regulate the anorectic action of p-chloro-diphenyl diselenide in rats
Bortolatto, C. F., Nogueira, C. W., Porteiro, B., Imbernón, M., & Nogueiras, R. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.09.032 · Cited by 8 · see citing works
Zengin, G., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Recinella, L., Chiavaroli, A., Leone, S., Ronci, M., Aumeeruddy, M. Z., et al. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12766 · Cited by 8 · see citing works
Moslehi, E., Moslehi, Z., & Khalvati, B. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.100104 · Cited by 7 · see citing works
Nadermann, N., & Volkoff, H. (2019) · Peptides · doi:10.1016/j.peptides.2019.170182 · Cited by 7 · see citing works
Zengin, G., Locatelli, M., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Recinella, L., Chiavaroli, A., Leone, S., Leporini, L., et al. (2018) · International Journal of Environmental Health Research · doi:10.1080/09603123.2018.1552930 · Cited by 6 · see citing works
Irisin, the Myokine: Guardian and Mediator in Cardiovascular System
Lan, T., Yan, X., Li, J., Gu, H., Hou, Q., He, E., & Yang, Q. (2025) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70097 · Cited by 5 · see citing works
Neuroendocrinology of the Hypothalamus and Pituitary Axes
Tran, T. N., Sosa-Pagan, M., & Uwaifo, G. I. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-62187-2_5 · Cited by 5 · see citing works
Moslehi, E., Minasian, V., & Sadeghi, H. (2021) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_110_19 · Cited by 5 · see citing works
Shamas, S. (2019) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2019.283 · Cited by 4 · see citing works
Effect of the Myokine Irisin on Circadian Rhythm of Voluntary Locomotor Activity in Rats
Inyushkin, A. N., Павленко, С. И., Isakova, T. S., Konashenkova, A., Inyushkin, A. A., & Inyushkin, A. A. (2025) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093025020164 · Cited by 2 · see citing works
Irisin Signaling Pathway is up Regulated by Resistance Training in Ovariectomized Rats
Magosso, N. S. S. (2017) · Obesity & Control Therapies Open Access · doi:10.15226/2374-8354/4/2/00136 · Cited by 1 · see citing works
Moslehi, E., Minasian, V., & Sadeghi, H. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Rodríguez, A. M., Bonet, M. L., & Ribot, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00026-2
Pereira, K. C., Talpo, T. C., Nogueira, G. A. S., Zanesco, A. M., Sidarta-Oliveira, D., junior, J. A. D. S., Boschero, A. C., Velloso, L. A., & Barbosa, H. C. L. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05729-8
Irisin as a metabolic regulator of male reproduction
Batool, I., Pessoa, E. R., Pereira, E. S., Guerreiro, D. D., & Moura, A. A. (2026) · Biology of Reproduction · doi:10.1093/biolre/ioag183
- Authors
- Ferrante, C., Orlando, G., Recinella, L., Leone, S., Chiavaroli, A., Di Nisio, C., Shohreh, R., Manippa, F., Ricciuti, A., Vacca, M., & Brunetti, L.
- Affiliations
- University of Chieti-Pescara (IT)
- Corresponding author
- Brunetti, Luigi
- ORCID
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 791
- Pages
- 389-394
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2508257164
- Cited by
- 62
- References
- 51
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 17 · 2018: 11 · 2017: 9
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- irisin, FNDC5, feeding behavior, hypothalamus, paraventricular nucleus, neuropeptide Y, agouti-related protein, orexin-A, cocaine- and amphetamine-regulated transcript, proopiomelanocortin, dopamine, norepinephrine, serotonin, plasma norepinephrine, sympathetic nervous system, energy homeostasis, physical activity
- MeSH terms
- Animals, Dopamine, Eating, Feeding Behavior, Fibronectins, Hypothalamus, Male, Neuropeptides, Norepinephrine, Serotonin, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review