Epigenetic genes and epilepsy — emerging mechanisms and clinical applications

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A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

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The epigenotype

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Non-coding RNAs as regulators in epigenetics

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Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.

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An estimate of the total number of true human miRNAs

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15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.

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Double chromodomains cooperate to recognize the methylated histone H3 tail

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DNA methylation and memory formation

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MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells

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Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

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Epilepsy-associated genes

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Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

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Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons.

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Epigenetic mechanisms in neurological disease

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Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease

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Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy

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G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

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The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

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The cartilage specific microRNA‐140 targets histone deacetylase 4 in mouse cells

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Epigenetic Regulation in Neurodegenerative Diseases

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Sequential phases of cortical specification involve Neurogenin‐dependent and ‐independent pathways

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Mutations in the JARID1C Gene, Which Is Involved in Transcriptional Regulation and Chromatin Remodeling, Cause X-Linked Mental Retardation

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Non-coding RNAs, epigenetics and complexity

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Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex

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Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies

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DNA methylation models histone acetylation

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Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

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Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes

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SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS

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MicroRNAs in epilepsy: pathophysiology and clinical utility

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Epigenetics: The origins and evolution of a fashionable topic

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Malformations of cortical development and epilepsy

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The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis

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Coupling of cell migration with neurogenesis by proneural bHLH factors

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Ultra-rare genetic variation in common epilepsies: a case-control sequencing study

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De Novo Loss-of-Function Mutations in CHD2 Cause a Fever-Sensitive Myoclonic Epileptic Encephalopathy Sharing Features with Dravet Syndrome

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Epileptogenesis in pediatric cortical dysplasia: The dysmature cerebral developmental hypothesis

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Mechanisms of human inherited epilepsies

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ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

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The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation

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Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response

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Molecular Complexes at Euchromatin, Heterochromatin and Centromeric Chromatin

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The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma

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Mutations in the chromatin-associated protein ATRX

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ATRX Partners with Cohesin and MeCP2 and Contributes to Developmental Silencing of Imprinted Genes in the Brain

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Advances in understanding of Rett syndrome and MECP2 duplication syndrome: prospects for future therapies

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NeuroD2 Is Necessary for Development and Survival of Central Nervous System Neurons

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Maintenance of Epigenetic InformationPreprint

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