Cited by 60Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCancer, Lipids, and Metabolism

Effects of statin therapy on glycemic control and insulin resistance: a systematic review and meta-analysis

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Alvarez-Jimenez, Laura, Morales-Palomo, Felix, Moreno-Cabañas, Alfonso, Ortega, Juan F., Mora-Rodríguez, Ricardo·2023·European Journal of Pharmacology

Abstract

AIMS: To update the evidence about the diabetogenic effect of statins. METHODS: We searched for randomized-controlled trials reporting the effects of statin therapy on glycosylated hemoglobin (HbA1c) and/or homeostatic model insulin resistance (i.e., HOMA-IR) as indexes of diabetes. Studies were classified between the ones testing normal vs individuals with already altered glycemic control (HbA1c ≥ 6.5%; and HOMA-IR ≥ 2.15). Furthermore, studies were separated by statin type and dosage prescribed. Data are presented as mean difference (MD) and 95% confidence intervals. RESULTS: A total of 67 studies were included in the analysis (>25,000 individuals). In individuals with altered glycemic control, statins increased HbA1c levels (MD 0.21%, 95% CI 0.16-to-0.25) and HOMA-IR index (MD 0.31, 95% CI 0.24-to-0.38). In individuals with normal glycemic control, statin increased HbA1c (MD 1.33%, 95% CI 1.31-to-1.35) and HOMA-IR (MD 0.49, 95% CI 0.41-to-0.58) in comparison to the placebo groups. The dose or type of statins did not modulate the diabetogenic effect. CONCLUSIONS: Statins, slightly but significantly raise indexes of diabetes in individuals with adequate or altered glycemic control. The diabetogenic effect does not seem to be influenced by the type or dosage of statin prescribed.

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Crossref · 10.1016/j.ejphar.2023.175672

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  • Statin exposure possibly exacerbates the risk to develop diabetes in individuals with TS, who are already at high risk for metabolic derangement.

    “Statin exposure possibly exacerbates the risk to develop diabetes in individuals with TS, who are already at high risk for metabolic derangement.479,480”

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Authors
Alvarez-Jimenez, L., Morales-Palomo, F., Moreno-Cabañas, A., Ortega, J. F., & Mora-Rodríguez, R.
Affiliations
University of Castilla-La Mancha (ES)
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2023-05
Volume
947
Pages
175672
ISSN
0014-2999 (ISSN-L)
OpenAlex
W4360604542
Cited by
60
References
120
Citations by year
2026: 11 · 2025: 19 · 2024: 19 · 2023: 11
FWCI
3.90
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmacology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • RUIdeRA - Institutional University Repository (University of Castilla-La Mancha) (submittedVersion, cc-by-nc-nd)
Funders
  • Ministerio de Ciencia e Innovación
  • España Ministerio de Ciencia e Innovación (PID2020-116159RB-IOO MCIN/AEI/10.13039/501100011033)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
statins, diabetogenic effect, glycemic control, insulin resistance, HbA1c, HOMA-IR, type 2 diabetes
MeSH terms
Glycemic Control, Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Type 2, Glycated Hemoglobin, Humans, Insulin, Insulin Resistance, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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