A folate modified pH sensitive targeted polymeric micelle alleviated systemic toxicity of doxorubicin (DOX) in multi-drug resistant tumor bearing mice
Abstract
Purpose The purpose of this work was to demonstrate the advantages of a folate modified pH sensitive micelle system (HPPF) on reducing the systemic toxicity of antitumor drug doxorubicin (DOX) as well as increasing the antitumor efficacy on multi-drug resistant tumor.Methods The micelle HPPF was fabricated by PHIS-PEG and Fol-PEG-PLA using dialysis method. Multi-drug resistant human breast-cancer cell (MCF-7Adr) was used to test the therapeutic effect of DOX loaded HPPF micelles (HPPF/DOX). Nude mice bearing MCF-7Adr tumor was used to evaluate the systemic toxicity of HPPF/DOX.Results The micelle HPPF was successfully prepared with good size uniformity and pH sensitivity. The in vitro experiments showed that HPPF significantly increased the intracellular level and cytotoxicity of DOX. The in vivo experiments demonstrated that HPPF had largely reduced the mortality and body weight loss, improved the animal status and decreased damages on heart and lung tissues comparing to free DOX.Conclusions The HPPF/DOX could significantly increase the antitumor efficacy of DOX and largely alleviate the systemic side effects induced by high dose DOX in the treatment of multi-drug resistant tumor.
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The combination of folate-modified pH-sensitive system micelle loaded with doxorubicin can effectively reduce the systemic toxicity of doxorubicin, reduce the damage to heart and lung tissues, and improve its anti-tumor efficacy.
“The combination of folate-modified pH-sensitive system micelle loaded the anti-tumor drug doxorubicin can effectively reduce the systemic toxicity of doxorubicin, reduce the damage to heart and lung tissues, and improve its anti-tumor efficacy.42”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [42]
Cites
Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J. M., Wang, A. Z., Langer, R., & Farokhzad, O. C. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,685 · see citing works
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
Schinkel, A. H., & Jonker, J. W. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00169-2 · Cited by 1,427 · see citing works
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
Schinkel, A. H., & Jonker, J. W. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.027 · Cited by 1,236 · see citing works
Parker, N. L., Turk, M. J., Westrick, E. M., Lewis, J. D., Low, P. S., & Leamon, C. P. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2004.12.026 · Cited by 1,199 · see citing works
Recent progress in tumor pH targeting nanotechnology
Lee, E. S., Gao, Z., & Bae, Y. H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.003 · Cited by 866 · see citing works
Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention
Albini, A., Pennesi, G., Donatelli, F., Cammarota, R., Flora, S. D., & Noonan, D. M. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp440 · Cited by 840 · see citing works
Polymeric micelle for tumor pH and folate-mediated targeting
Lee, E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00239-6 · Cited by 620 · see citing works
Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor
Lee, E. S., Na, K., & Bae, Y. H. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.018 · Cited by 577 · see citing works
Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance
Shapira, A., Livney, Y. D., Broxterman, H. J., & Assaraf, Y. G. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.01.003 · Cited by 509 · see citing works
Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis.
Arola, O., Saraste, A., Pulkki, K. J., Kallajoki, M. A., Parvinen, M., & Voipio-Pulkki, L. M. (2000) · PubMed · Cited by 490 · see citing works
Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
Yin, Q., Shen, J., Zhang, Z., Yu, H., & Li, Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.04.011 · Cited by 366 · see citing works
Kim, D., Lee, E. S., Oh, K. T., Gao, Z. G., & Bae, Y. H. (2008) · Small · doi:10.1002/smll.200701275 · Cited by 313 · see citing works
Multidrug resistance: Physiological principles and nanomedical solutions
Kunjachan, S., Rychlik, B., Storm, G., Kiessling, F. M., & Lammers, T. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.018 · Cited by 259 · see citing works
Kim, D., Gao, Z. G., Lee, E. S., & Bae, Y. H. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900021q · Cited by 182 · see citing works
Kaminskas, L. M., McLeod, V. M., Kelly, B. D., Sberna, G., Boyd, B. J., Williamson, M., Owen, D. J., & Porter, C. J. H. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.05.013 · Cited by 178 · see citing works
Susa, M., Iyer, A. K., Ryu, K., Hornicek, F. J., Mankin, H. J., Amiji, M. M., & Duan, Z. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-399 · Cited by 162 · see citing works
Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein Inhibitors
Coley, H. M. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-416-6_15 · Cited by 159 · see citing works
Bansal, T., Akhtar, N., Jaggi, M., Khar, R. K., & Talegaonkar, S. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.07.010 · Cited by 157 · see citing works
Qiu, L., Qiao, M., Chen, Q., Tian, C., Long, M., Wang, M., Li, Z., Hu, W. S., Li, G., Cheng, L., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.008 · Cited by 153 · see citing works
Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes
Wang, C. Y., & Huang, L. (1984) · Biochemistry · doi:10.1021/bi00314a026 · Cited by 139 · see citing works
Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor
Kim, D., Lee, E. S., Park, K., Kwon, I. C., & Bae, Y. H. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9603-6 · Cited by 114 · see citing works
Anthracyclines in haematology: preclinical studies, toxicity and delivery systems
Richardson, D. S., & Johnson, S. A. (1997) · Blood Reviews · doi:10.1016/s0268-960x(97)90020-5 · Cited by 96 · see citing works
Mohajer, G., Lee, E. S., & Bae, Y. H. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9277-5 · Cited by 73 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Polylactic acid (PLA) controlled delivery carriers for biomedical applications
Tyler, B., Gullotti, D., Mangraviti, A., Utsuki, T., & Brem, H. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.018 · Cited by 1,050 · see citing works
Recent advances in polymeric micelles for anti-cancer drug delivery
Biswas, S., Kumari, P., Lakhani, P. M., & Ghosh, B. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.12.031 · Cited by 475 · see citing works
Ramasamy, T., Ruttala, H. B., Gupta, B., Poudel, B. K., Choi, H., Yong, C. S., & Kim, J. O. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.043 · Cited by 373 · see citing works
Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors
Dallavalle, S., Dobričić, V., Lazzarato, L., Gazzano, E., Machuqueiro, M., Pajeva, I. K., Tsakovska, I., Zidar, N., & Fruttero, R. (2020) · Drug Resistance Updates · doi:10.1016/j.drup.2020.100682 · Cited by 320 · see citing works
Targeted nanomedicine for cancer therapeutics: Towards precision medicine overcoming drug resistance
Bar-Zeev, M., Livney, Y. D., & Assaraf, Y. G. (2017) · Drug Resistance Updates · doi:10.1016/j.drup.2017.05.002 · Cited by 316 · see citing works
Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue
Gote, V., Nookala, A. R., Bolla, P. K., & Pal, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094673 · Cited by 173 · see citing works
Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy
Wang, J., Li, S., Han, Y., Guan, J., Chung, S., Wang, C., & Li, D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00202 · Cited by 155 · see citing works
Li, R., & Xie, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.020 · Cited by 127 · see citing works
Zhang, Y., Cai, L., Li, D., Lao, Y., Liu, D., Li, M., Ding, J., & Chen, X. (2018) · Nano Research · doi:10.1007/s12274-018-2066-0 · Cited by 114 · see citing works
Sodeifian, G., Sajadian, S. A., & Daneshyan, S. (2018) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2018.06.009 · Cited by 113 · see citing works
Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System
Zhang, G., Du, R., Zhang, L., Cai, D., Sun, X. J., Zhou, Y., Zhou, J., Qian, J., Zhong, K., Zheng, K., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201502868 · Cited by 79 · see citing works
Liu, J., Zhang, J., Song, K., Du, J., Wang, X., Liu, J., Li, B., Ouyang, R., Miao, Y., Sun, Y., et al. (2021) · Small · doi:10.1002/smll.202101015 · Cited by 76 · see citing works
Self-citationFluorescent silicon nanomaterials: from synthesis to functionalization and application
Song, B., & He, Y. (2019) · Nano Today · doi:10.1016/j.nantod.2019.03.005 · Cited by 73 · see citing works
Zhang, J., Liu, Y., Wang, X., Du, J., Song, K., Li, B., Chang, H., Ouyang, R., Miao, Y., Sun, Y., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c18853 · Cited by 72 · see citing works
Self-citationMultifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors
Kesharwani, S. S., Kaur, S., Tummala, H., & Sangamwar, A. T. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.10.022 · Cited by 71 · see citing works
Yang, Y., Hu, D., Lu, Y., Chu, B., He, X., Chen, Y., Xiao, Y., Yang, C., Zhou, K., Yuan, L., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.021 · Cited by 64 · see citing works
Yi, X., Zhang, Q., Zhao, D., Xu, J.-Q., Zhong, Z., Zhuo, R., & Li, F. (2016) · Polymer Chemistry · doi:10.1039/c5py01783a · Cited by 60 · see citing works
Self-citationGao, W., Ye, G., Duan, X., Yang, X., & Yang, V. C. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s115215 · Cited by 57 · see citing works
Self-citationOvercoming multiple drug resistance in cancer using polymeric micelles
Kesharwani, S. S., Kaur, S., Tummala, H., & Sangamwar, A. T. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1537261 · Cited by 57 · see citing works
Wang, M., Li, J., Li, X., Mu, H., Zhang, X., Shi, Y., Chu, Y., Wang, A., Wu, Z., & Sun, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.04.015 · Cited by 51 · see citing works
Self-citationZwitterionic pH-responsive hyaluronic acid polymer micelles for delivery of doxorubicin
Gao, Q.-Q., Zhang, C., Zhang, E. X., Chen, H., Zhen, Y., Zhang, S., & Zhang, S. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.03.007 · Cited by 50 · see citing works
Folate-targeting redox hyperbranched poly(amido amine)s delivering MMP-9 siRNA for cancer therapy
Li, M., Zhou, X., Zeng, X., Wang, C., Xu, J., Ma, D., & Xue, W. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01964h · Cited by 48 · see citing works
Li, J., Wang, F., Sun, D., & Wang, R. (2016) · Journal of drug targeting · doi:10.3109/1061186x.2016.1154561 · Cited by 45 · see citing works
Zhu, Y., Liu, R., Huang, H., & Zhu, Q. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00243 · Cited by 45 · see citing works
Han, K., Zhang, W., Zhang, J., Ma, Z., & Han, H. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700470 · Cited by 44 · see citing works
Qiu, J., Zhang, H., Wang, Z., Liu, D., Liu, S., Han, W., Regenstein, J. M., & Geng, L. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.10.087 · Cited by 42 · see citing works
Sun, J., Song, Y., Lu, M., Lin, X., Liu, Y., Zhou, S., Su, Y., & Deng, Y. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.08.029 · Cited by 40 · see citing works
Reddy, L. H., & Bazile, D. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.08.012 · Cited by 38 · see citing works
Ye, G., Jiang, Y., Yang, X., Hu, H., Wang, B., Sun, L., Yang, V. C.-M., Sun, D., & Gao, W. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b15978 · Cited by 37 · see citing works
Self-citationRecent advances in biomedical applications of smart nanomaterials: a comprehensive review
Goshisht, M. K., Goshisht, A., Bajpai, A., & Bajpai, A. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00137d · Cited by 35 · see citing works
Lee, W., Loo, C., Leong, C. R., Young, P. M., Traini, D., & Rohanizadeh, R. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2017.1247804 · Cited by 35 · see citing works
Li, L., Tian, L., Wang, Y., Zhao, W., Cheng, F., Li, Y., & Yang, B. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00266h · Cited by 32 · see citing works
Yang, C., Liu, W., Xiao, J., Yuan, C., Chen, Y., Guo, J., Yue, H., Zhu, D., Lin, W., Tang, S.-Q., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020170 · Cited by 31 · see citing works
Thapa, R. K., Byeon, J. H., Ku, S., Yong, C. S., & Kim, J. O. (2017) · NPG Asia Materials · doi:10.1038/am.2017.141 · Cited by 27 · see citing works
Zhan, W., Li, H., Guo, Y., Lü, Y., Pang, L., & Zhang, C. (2021) · Nanotechnology · doi:10.1088/1361-6528/abda74 · Cited by 23 · see citing works
Zhao, Y., Shi, D., Shang, M., Sun, X. Y., Guo, L., Meng, D., Liu, X., Zhou, X., & Li, J. (2022) · Drug Delivery · doi:10.1080/10717544.2021.2023698 · Cited by 21 · see citing works
Ji, X., Guo, D., Song, B., Wu, S., Chu, B., Su, Y., & He, Y. (2018) · Nano Research · doi:10.1007/s12274-018-1976-1 · Cited by 19 · see citing works
Octenyl-succinylated inulins for the delivery of hydrophobic drug
Han, L., Sun, J., Williams, P. A., Yang, J., & Zhang, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.068 · Cited by 18 · see citing works
Emerging nano-delivery systems for targeting mitochondria
Burska, A. N., Raish, K., Bayandy, D., & Paunov, V. N. (2025) · Nanoscale · doi:10.1039/d5nr03935e · Cited by 17 · see citing works
Novel folated Pluronic/poly(lactic acid) nanoparticles for targeted delivery of paclitaxel
Xiong, X. Y., Long, T., Qin, X., Li, Z. L., Gong, Y., Li, Y. P., Yang, Y., & Liu, Z. Y. (2016) · RSC Advances · doi:10.1039/c6ra09271c · Cited by 17 · see citing works
Di, Y., Li, T., Zhu, Z., Chen, F., Jia, L., Liu, W., Gai, X., Wang, Y., Pan, W., & Yang, X. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s141982 · Cited by 16 · see citing works
Self-citationDevelopment of stimuli-responsive intelligent polymer micelles for the delivery of doxorubicin
Yang, F., Xu, J., Fu, M., Ji, J., Chi, L., & Zhai, G. (2020) · Journal of drug targeting · doi:10.1080/1061186x.2020.1766474 · Cited by 14 · see citing works
Hu, C., Gu, F., Gong, C., Xia, Q., Gao, Y., & Gao, S. (2021) · Journal of Biomaterials Applications · doi:10.1177/08853282211060252 · Cited by 14 · see citing works
Pasban, S., & Raissi, . (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111402 · Cited by 12 · see citing works
Fluorescent nanodiamond for nanotheranostic applications
Pramanik, G., Bag, S., & Chakrabortty, S. (2022) · Microchimica Acta · doi:10.1007/s00604-022-05545-6 · Cited by 12 · see citing works
Advances in Polymeric Colloids for Cancer Treatment
Ali, I., Althakfi, S. H., Suhail, M., Locatelli, M., Hsieh, M., Alsehli, M., & Hameed, A. M. (2022) · Polymers · doi:10.3390/polym14245445 · Cited by 11 · see citing works
Glutathione-dependent micelles based on carboxymethyl chitosan for delivery of doxorubicin
Zhang, X., Li, C., Zheng, H. S., Song, H., Li, L., Xiong, F., Yang, J. P., & Qiu, T. (2016) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2016.1238128 · Cited by 8 · see citing works
Bayram, N. N., Topuzoğulları, M., İşoğlu, İ. A., & Dinçer, S. (2021) · Polymer Bulletin · doi:10.1007/s00289-021-03964-8 · Cited by 7 · see citing works
Potential of nanoparticles as drug delivery system for cancer treatment
Pelissari, F. M., Neri-Numa, I. A., Molina, G., Ferreira, D., & Pastore, G. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813741-3.00019-4 · Cited by 6 · see citing works
Marković, M. D., Panić, V. V., & Pjanović, R. (2025) · Biopolymers · doi:10.1002/bip.70012 · Cited by 5 · see citing works
Recent Updates on Folate Targeted Drug Delivery Systems in Cancer: A Mini Review
Bisht, G. S., Sharma, D., & Sharma, M. (2022) · Current Cancer Therapy Reviews · doi:10.2174/1573394718666220508181053 · Cited by 3 · see citing works
The Development and Achievement of Polymeric Nanoparticles for Cancer Drug Treatment
Lee, W., Loo, C., Young, P. M., Traini, D., & Rohanizadeh, R. (2017) · Springer eBooks · doi:10.1007/978-981-10-3647-7_2 · Cited by 3 · see citing works
Robust fluorescent amphiphilic polymer micelle for drug carrier application
Shi, L., Lu, S., Sun, T., Xi, G., Chen, Z., Xu, K., Zhao, X., Shen, M., Jia, T., & Zhao, X. (2021) · New Journal of Chemistry · doi:10.1039/d1nj01473k · Cited by 1 · see citing works
Purnamasari, E. S., Septiana, L., Hardianto, A., Soedjanaatmadja, U. M. S., Anggraeni, A., & Bahti, H. H. (2022) · Indonesian Journal of Chemistry · doi:10.22146/ijc.68313
Lee, E., Lee, J., Park, S. C., Lee, H., Hwang, D., & Kim, D. W. (2026) · Pharmaceuticals · doi:10.3390/ph19091491
- Authors
- Li, X., Yang, X., Lin, Z., Wang, D., Mei, D., He, B., Wang, X., Wang, X., Zhang, Q., & Gao, W.
- Affiliations
- Peking University (CN)
- Corresponding author
- Gao, Wei
- Venue
- European Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 76
- Pages
- 95-101
- ISSN
- 0928-0987 (ISSN-L)
- OpenAlex
- W2084578790
- Cited by
- 56
- References
- 23
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 3
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation of China (81402857)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- doxorubicin, folic acid, pH-responsive micelles, polymeric micelles, multidrug resistance, breast cancer, systemic toxicity, targeted drug delivery, PEG-PLA, cardiotoxicity, pulmonary toxicity
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Chemistry, Pharmaceutical, Dose-Response Relationship, Drug, Doxorubicin, Drug Carriers, Female, Folic Acid, Heart Diseases, Humans, Hydrogen-Ion Concentration, Mice, Inbred BALB C, Mice, Nude, Micelles, Particle Size, Polymers, Technology, Pharmaceutical, Time Factors, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Xenograft Model Antitumor Assays, Tumor Burden, Lung Injury, MCF-7 Cells
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