Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy
Open accessAbstract
For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising nanocarriers, some of which have already been applied in different stages of clinical trials. The successful advantages of polymeric micelles from bench to bedside are due to their special core/shell structures, which can carry specific drugs in certain disease conditions. Particularly, poly(ethylene glycol)-polylactide (PEG-PLA) micelles have been considered as one of the most promising platforms for drug delivery. The PEG shell effectively prevents the adsorption of proteins and phagocytes, thereby evidently extending the blood circulation period. Meanwhile, the hydrophobic PLA core can effectively encapsulate many therapeutic agents. This review summarizes recent advances in PEG-PLA micelles for the treatment of malignancy. In addition, future perspectives for the development of PEG-PLA micelles as drug delivery systems are also presented.
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Polymeric nanomicelles possess the merit of the EPR effect due to their small size, where they passively diffuse through the endothelial lining and remain at the site of inflammation owing to poor lymphatic drainage, thus releasing their payload at the specific site.
“The polymeric nanomicelles possess the merit of the EPR effect due to their small size [92] where they passively diffuse through the endothelial lining and remain at the site of inflammation owing to poor lymphatic drainage, thus releasing their payload at the specific site.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [92]
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- Authors
- Wang, J., Li, S., Han, Y., Guan, J., Chung, S., Wang, C., & Li, D.
- Affiliations
- Chinese Academy of Sciences (CN)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- University of Waterloo (CA)
- Corresponding author
- Han, Yuping
- Guan, Jingjing
- Li, Di
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2018-03-08
- Volume
- 9
- Pages
- 202-202
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC5890116
- OpenAlex
- W2792803144
- Cited by
- 155
- References
- 115
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 26 · 2023: 21 · 2022: 22 · 2021: 20 · 2020: 24 · 2019: 16 · 2018: 5
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (51673190, 51603204, 51303174, 51473165, 51390484, 51520105004)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polymeric micelles, cancer therapy, drug delivery systems, nanocarriers, core-shell structure, PEGylation, blood circulation, protein adsorption resistance, photosensitizers, gene delivery, clinical translation
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