Cited by 147Drug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsPharmaceutical studies and practices

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Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability

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Maderuelo, Cristina, Lanao, Jose M., Zarzuelo, Aránzazu·2019·European Journal of Pharmaceutical Sciences

DOI 10.1016/j.ejps.2019.105019

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Abstract

Enteric coating is a common procedure in the development of oral pharmaceutical dosage forms. The main advantage of enteric coating is that it protects the drug from acidic pH and enzymatic degradation in the stomach while protecting it from the undesirable effects of some drugs. There is certain controversy regarding the real influence of enteric coating on the bioavailability of many drugs. Various scientific articles have demonstrated an improvement in the extent of bioavailability of some drugs when enteric coating is used. In recent years, there have been many studies examining different formulation strategies for monolithic and multiparticulate systems, including different pharmaceutical oral dosage forms and delivery systems based on the combined use of enteric coating and other methods that improve the bioavailability of drugs administered orally. However, the real bioavailability, serum levels and therapeutic effect of these drugs may be influenced by gastrointestinal pH values, gastrointestinal environment, inter-individual or intra-individual variability in gastric emptying and gastrointestinal transit time, interpatient variability associated with the type of polymer used for enteric coating or other formulation variables. It deserves special attention to know the real influence of enteric coating on the bioavailability of new oral dosage forms.

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Authors: Maderuelo, C., Lanao, J. M., & Zarzuelo, A.
Affiliations: Universidad de Salamanca (ES)
ORCID: Maderuelo, Cristina
Lanao, Jose M.
Venue: European Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2019-10
Volume: 138
Pages: 105019
ISSN: 0928-0987 (ISSN-L)
DOI: 10.1016/j.ejps.2019.105019
OpenAlex: W2965827201
Cited by: 147
References: 157
Citations by year: 2026: 17 · 2025: 31 · 2024: 19 · 2023: 24 · 2022: 24 · 2021: 16 · 2020: 16
FWCI: 1.34
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: European Journal of Pharmaceutical Sciences (publishedVersion)
PubMed (publishedVersion)
Gredos (University of Salamanca) (publishedVersion, cc-by)
Hispana (submittedVersion, cc-by)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: enteric coating, oral solid dosage forms, drug bioavailability, gastrointestinal pH, gastroprotection, multiparticulate dosage forms, gastrointestinal transit time, gastric emptying, interindividual variability
MeSH terms: Administration, Oral, Biological Availability, Chemistry, Pharmaceutical, Dosage Forms, Pharmaceutical Preparations, Gastric Emptying, Gastrointestinal Transit, Humans, Drug Delivery Systems

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Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability

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