Maternal serum metabolome and traffic-related air pollution exposure in pregnancy
Open accessAbstract
BACKGROUND: Maternal exposure to traffic-related air pollution during pregnancy has been shown to increase the risk of adverse birth outcomes and neurodevelopmental disorders. By utilizing high-resolution metabolomics (HRM), we investigated perturbations of the maternal serum metabolome in response to traffic-related air pollution to identify biological mechanisms. METHODS: We retrieved stored mid-pregnancy serum samples from 160 mothers who lived in the Central Valley of California known for high air particulate levels. We estimated prenatal traffic-related air pollution exposure (carbon monoxide, nitric oxides, and particulate matter <2.5 μm) during first-trimester using the California Line Source Dispersion Model, version 4 (CALINE4) based on residential addresses recorded at birth. We used liquid chromatography-high resolution mass spectrometry to obtain untargeted metabolic profiles and partial least squares discriminant analysis (PLS-DA) to select metabolic features associated with air pollution exposure. Pathway analyses were employed to identify biologic pathways related to air pollution exposure. As potential confounders we included maternal age, maternal race/ethnicity, and maternal education. RESULTS: In total we extracted 4038 and 4957 metabolic features from maternal serum samples in hydrophilic interaction (HILIC) chromatography (positive ion mode) and C18 (negative ion mode) columns, respectively. After controlling for confounding factors, PLS-DA (Variable Importance in Projection (VIP) ≥2) yielded 181 and 251 metabolic features (HILIC and C18, respectively) that discriminated between the high (n = 98) and low exposed (n = 62). Pathway enrichment analysis for discriminatory features associated with air pollution indicated that in maternal serum oxidative stress and inflammation related pathways were altered, including linoleate, leukotriene, and prostaglandin pathways. CONCLUSION: The metabolomic features and pathways we found to be associated with air pollution exposure suggest that maternal exposure during pregnancy induces oxidative stress and inflammation pathways previously implicated in pregnancy complications and adverse outcomes.
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The range of adverse health outcomes in children following early life fine and ultrafine PM exposure are understood to be caused through two broad mechanisms: directly crossing the placenta to reach fetal circulation, and/or indirectly through PM-driven maternal/placental oxidative stress, inflammation, epigenetic modifications in placental and offspring tissues, and potential endocrine disruption
“The range of adverse health outcomes in children following early life fine and ultrafine PM exposure are understood to be caused through two broad mechanisms, (1) directly crossing the placenta, hence, reaching fetal circulation and/or (2) indirectly through an interplay of PM-driven maternal/placental oxidative stress, inflammation, epigenetic modifications in placental and offspring tissues, and”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [132]
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Experimental — accuracy not yet measuredMaternal oxidative stress and inflammation-related pathways, including linoleate, leukotriene, and prostaglandin, were altered in response to traffic-related air pollution exposure.
“Using a metabolomics approach, Yan et al. [132] observed maternal oxidative stress and inflammation-related pathways, including linoleate, leukotriene, and prostaglandin, were altered in response to traffic-related air pollution exposure.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [132]
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Cites
PLS-regression: a basic tool of chemometrics
Wold, S., Sjöström, M., & Eriksson, L. (2001) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/s0169-7439(01)00155-1 · Cited by 10,084 · see citing works
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817 · see citing works
Protein Oxidation in Aging, Disease, and Oxidative Stress
Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,339 · see citing works
The role of antioxidants in the chemistry of oxidative stress: A review
Pisoschi, A. M., & Pop, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.040 · Cited by 2,844 · see citing works
Ford‐Hutchinson, A. W., Bray, M. A., Doig, M. V., Shipley, M., & Smith, M. J. H. (1980) · Nature · doi:10.1038/286264a0 · Cited by 2,060 · see citing works
Predicting Network Activity from High Throughput Metabolomics
Li, S., Park, Y. H., Duraisingham, S., Strobel, F. H., Khan, N., Soltow, Q. A., Jones, D. P., & Pulendran, B. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003123 · Cited by 931 · see citing works
Self-citationOxidative stress-induced DNA damage by particulate air pollution
Risom, L., Möller, P., & Loft, S. H. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.06.012 · Cited by 914 · see citing works
The Role of Inflammation and Infection in Preterm Birth
Romero, R. J., Espinoza, J., Gonçalves, L. F., Kusanovic, J. P., Friel, L. A., & Hassan, S. S. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2006-956773 · Cited by 913 · see citing works
Ambient air pollution, birth weight and preterm birth: A systematic review and meta-analysis
Stieb, D. M., Chen, L., Eshoul, M., & Judek, S. (2012) · Environmental Research · doi:10.1016/j.envres.2012.05.007 · Cited by 849 · see citing works
Oxidative stress: Its role in air pollution and adverse health effects
Kelly, F. J. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.8.612 · Cited by 817 · see citing works
Al-Gubory, K. H., Fowler, P., & Garrel, C. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.06.001 · Cited by 803 · see citing works
Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
Patterson, P. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.016 · Cited by 766 · see citing works
Ambient air pollution and low birthweight: a European cohort study (ESCAPE)
Pedersen, M., Giorgis-Allemand, L., Bernard, C., Aguilera, I., Andersen, A. N., Ballester, F., Beelen, R. M. J., Chatzi, L., Cirach, M., Danilevičiūtė, A., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70192-9 · Cited by 618 · see citing works
Eze, I. C., Hemkens, L. G., Bucher, H. C., Hoffmann, B. H., Schindler, C., Künzli, N., Schikowski, T., & Probst-Hensch, N. M. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1307823 · Cited by 545 · see citing works
Composition of Air Pollution Particles and Oxidative Stress in Cells, Tissues, and Living Systems
Ghio, A. J., Carraway, M. S., & Madden, M. C. (2011) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2012.632359 · Cited by 544 · see citing works
Particulate Matter Exposure and Stress Hormone Levels
Li, H., Cai, J., Chen, R., Zhao, Z., Ying, Z., Wang, L., Chen, J., Hao, K., Kinney, P. L., Chen, H., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.026796 · Cited by 521 · see citing works
Nutritional and medical importance of gamma-linolenic acid
Horrobin, D. F. (1992) · Progress in Lipid Research · doi:10.1016/0163-7827(92)90008-7 · Cited by 488 · see citing works
integrOmics: an R package to unravel relationships between two omics datasets
Cao, K. L., González, I., & Dejean, S. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp515 · Cited by 459 · see citing works
Vitamin E and oxidative stress
Chow, C. K. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90174-2 · Cited by 454 · see citing works
apLCMS—adaptive processing of high-resolution LC/MS data
Yu, T., Park, Y. H., Johnson, J. M., & Jones, D. P. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp291 · Cited by 402 · see citing works
Self-citationUppal, K., Soltow, Q. A., Strobel, F. H., Pittard, W. S., Gernert, K. M., Yu, T., & Jones, D. P. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-15 · Cited by 373 · see citing works
Self-citationParticulate Air Pollution and Fetal Health
Glinianaia, S. V., Rankin, J. M., Bell, R., Pless‐Mulloli, T., & Howel, D. (2004) · Epidemiology · doi:10.1097/01.ede.0000101023.41844.ac · Cited by 371 · see citing works
Ambient Air Pollution and Autism in Los Angeles County, California
Becerra, T. A., Wilhelm, M., Olsen, J., Cockburn, M., & Ritz, B. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205827 · Cited by 355 · see citing works
Self-citationAmbient Air Pollution and Pregnancy-Induced Hypertensive Disorders
Pedersen, M., Stayner, L. T., Slama, R., Sørensen, M., Figueras, F., Nieuwenhuijsen, M. J., Raaschou‐Nielsen, O., & Dadvand, P. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03545 · Cited by 328 · see citing works
xMSannotator: An R Package for Network-Based Annotation of High-Resolution Metabolomics Data
Uppal, K., Walker, D. I., & Jones, D. P. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b01214 · Cited by 299 · see citing works
Self-citationSimón‐Manso, Y., Lowenthal, M. S., Kilpatrick, L. E., Sampson, M. L., Telu, K. H., Rudnick, P. A., Mallard, W. G., Bearden, D. W., Schock, T. B., Tchekhovskoi, D. V., et al. (2013) · Analytical Chemistry · doi:10.1021/ac402503m · Cited by 295 · see citing works
Air Pollution and Neuropsychological Development: A Review of the Latest Evidence
Suades-González, E., Gascon, M., Guxens, M., & Sunyer, J. (2015) · Endocrinology · doi:10.1210/en.2015-1403 · Cited by 293 · see citing works
Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes
Sultana, Z., Maiti, K., Aitken, J., Morris, J., Dedman, L., & Smith, R. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12653 · Cited by 288 · see citing works
Metabolic Phenotypes of Response to Vaccination in Humans
Li, S., Sullivan, N., Rouphael, N., Yu, T., Banton, S., Maddur, M. S., McCausland, M. M., Chiu, C., Canniff, J. D., Dubey, S. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.026 · Cited by 277 · see citing works
Self-citationWu, J. Y., Ren, C., Delfino, R. J., Chung, J. M., Wilhelm, M. H., & Ritz, B. R. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800334 · Cited by 276 · see citing works
Self-citationWatanabe, M., Suliman, M. E., Qureshi, A. R., García‐López, E., Barany, P. F., Heimbürger, O., Stenvinkel, P., & Lindholm, B. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1860 · Cited by 276 · see citing works
The metabolomics of oxidative stress
Noctor, G., Lelarge‐Trouverie, C., & Mhamdi, A. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2014.09.002 · Cited by 253 · see citing works
Kaaja, R., Tikkanen, M., Viinikka, L. U., & Ylikorkala, O. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(94)00380-v · Cited by 245 · see citing works
Lipidomic Profiling of Influenza Infection Identifies Mediators that Induce and Resolve Inflammation
Tam, V. C., Quehenberger, O., Oshansky, C. M., Suen, R., Armando, A. M., Treuting, P. M., Thomas, P. G., Dennis, E. A., & Aderem, A. A. (2013) · Cell · doi:10.1016/j.cell.2013.05.052 · Cited by 243 · see citing works
Computational Metabolomics: A Framework for the Million Metabolome
Uppal, K., Walker, D. I., Liu, K., Li, S., Go, Y., & Jones, D. P. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00179 · Cited by 241 · see citing works
Self-citationOxidative stress in pregnancy and reproduction
Duhig, K. E., Chappell, L. C., & Shennan, A. H. (2016) · Obstetric Medicine · doi:10.1177/1753495x16648495 · Cited by 235 · see citing works
Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development
Guxens, M., García‐Esteban, R., Giorgis-Allemand, L., Forns, J., Badaloní, C., Ballester, F., Beelen, R. M. J., Cesaroni, G., Chatzi, L., Agostini, M. D., et al. (2014) · Epidemiology · doi:10.1097/ede.0000000000000133 · Cited by 228 · see citing works
CALINE4 - A DISPERSION MODEL FOR PREDICTING AIR POLLUTANT CONCENTRATIONS NEAR ROADWAYS. FINAL REPORT
Benson, P. E. (1984) · Cited by 199 · see citing works
Busse, W. W. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.mar-1 · Cited by 185 · see citing works
Histidine and lysine as targets of oxidative modification
Uchida, K. (2003) · Amino Acids · doi:10.1007/s00726-003-0015-y · Cited by 164 · see citing works
Liang, D., Moutinho, J. L., Golan, R., Yu, T., Ladva, C. N., Niedzwiecki, M. M., Walker, D. I., Sarnat, S. E., Chang, H. H., Greenwald, R., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.07.044 · Cited by 159 · see citing works
Self-citationShort‐Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study
Li, W., Wilker, E. H., DORANS, K. S., Rice, M. B., Schwartz, J. D., Coull, B. A., Koutrakis, P., Gold, D. R., Keaney, J. F., Lin, H., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002742 · Cited by 154 · see citing works
Childhood Cancer and Traffic-Related Air Pollution Exposure in Pregnancy and Early Life
Heck, J. E., Wu, J. Y., Lombardi, C. A., Qiu, J., Meyers, T. J., Wilhelm, M. H., Cockburn, M., & Ritz, B. R. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306761 · Cited by 150 · see citing works
Self-citationOxidative stress early in pregnancy and pregnancy outcome
Stein, T. P., Scholl, T. O., Schluter, M. D., Leskiw, M. J., Chen, X., Spur, B. W., & Rodrı́guez, A. R. (2008) · Free Radical Research · doi:10.1080/10715760802510069 · Cited by 148 · see citing works
Ambient Air Pollution and Preeclampsia: A Spatiotemporal Analysis
Dadvand, P., Figueras, F., Basagaña, X., Beelen, R., Martinez, D., Cirach, M., Schembari, A., Hoek, G., Brunekreef, B., & Nieuwenhuijsen, M. J. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1206430 · Cited by 145 · see citing works
DAYAN, A. D. (2000) · Occupational and Environmental Medicine · doi:10.1136/oem.57.6.431c · Cited by 133 · see citing works
Hougaard, K. S., Jensen, K. A., Nordly, P., Taxvig, C., Vogel, U., Saber, A. T., & Wallin, H. (2008) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-5-3 · Cited by 132 · see citing works
Histidine and arginine are associated with inflammation and oxidative stress in obese women
Niu, Y., Feng, R., Hou, Y., Li, K., Kang, Z., Wang, J., Sun, C., & Li, Y. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005289 · Cited by 122 · see citing works
Rull, R. P., & Ritz, B. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6118 · Cited by 119 · see citing works
Self-citationAn effective and efficient approach for manually improving geocoded data
Goldberg, D. W., Wilson, J. P., Knoblock, C. A., Ritz, B., & Cockburn, M. G. (2008) · International Journal of Health Geographics · doi:10.1186/1476-072x-7-60 · Cited by 118 · see citing works
Self-citationGuerra, R., Vera‐Aguilar, E., Uribe-Ramírez, M., Gookin, G., Camacho, J., Osornio-Vargas, Á. R., Múgica-Álvarez, V., Angulo-Olais, R., Campbell, A., Froines, J. R., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.07.012 · Cited by 117 · see citing works
Air pollution in asthma: effect of pollutants on airway inflammation
Peden, D. B. (2001) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)62334-4 · Cited by 110 · see citing works
Daher, N., Saliba, N. A., Shihadeh, A., Jaafar, M., Baalbaki, R., Shafer, M. M., Schauer, J. J., & Sioutas, C. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.09.104 · Cited by 102 · see citing works
Cigarette smoking behaviour and blood metabolomics
Gu, F., Derkach, A., Freedman, N. D., Landi, M. T., Albanes, D., Weinstein, S. J., Mondul, A. M., Matthews, C. E., Guertin, K. A., Xiao, Q., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv330 · Cited by 102 · see citing works
Oxidized phospholipid signaling in traumatic brain injury
Anthonymuthu, T. S., Kenny, E., Lamade, A. M., Kagan, V. E., & Bayır, H. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.031 · Cited by 99 · see citing works
The impact of ambient air pollution on the human blood metabolome
Vlaanderen, J. J., Janssen, N., Hoek, G., Keski‐Rahkonen, P., Barupal, D. K., Cassee, F. R., Gosens, I., Strak, M., Steenhof, M., Qing Lan, B., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.03.042 · Cited by 95 · see citing works
Metabolomic assessment of exposure to near-highway ultrafine particles
Walker, D. I., Lane, K., Liu, K., Uppal, K., Patton, A. P., Durant, J. L., Jones, D. P., Brugge, D., & Pennell, K. D. (2018) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0102-5 · Cited by 94 · see citing works
Self-citationWang, Z., Zheng, Y., Zhao, B., Zhang, Y., Liu, Z., Xu, J., Chen, Y., Zhao, Y., Wang, F., Wang, H., et al. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00134 · Cited by 91 · see citing works
Yan, W., Yun, Y., Ku, T., Li, G., & Sang, N. (2016) · Scientific Reports · doi:10.1038/srep22429 · Cited by 88 · see citing works
Dick, C. A. J., Singh, P., Daniels, M. J., Evansky, P., Becker, S., & Gilmour, M. I. (2003) · Journal of Toxicology and Environmental Health · doi:10.1080/716100636 · Cited by 84 · see citing works
Blood transcriptomics and metabolomics for personalized medicine
Li, S., Todor, A., & Luo, R. (2015) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.10.005 · Cited by 84 · see citing works
Lavigne, É., Burnett, R. T., Stieb, D. M., Evans, G. J., Pollitt, K. J. G., Chen, H., van Rijswijk, D., & Weichenthal, S. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2535 · Cited by 77 · see citing works
Happo, M. S., Uski, O., Jalava, P., Kelz, J., Brunner, T., Hakulinen, P., Mäki‐Paakkanen, J., Kosma, V., Jokiniemi, J. K., Obernberger, I., et al. (2012) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2012.11.004 · Cited by 75 · see citing works
Evaluation of the CALINE4 and CAR-FMI models against measurements near a major road
Levitin, J., Härkönen, J., Kukkonen, J., & Nikmo, J. (2005) · Atmospheric Environment · doi:10.1016/j.atmosenv.2005.03.046 · Cited by 66 · see citing works
Oxidative stress and air pollution exposure during pregnancy: A molecular assessment
Nagiah, S., Phulukdaree, A., Naidoo, D., Ramcharan, K., Naidoo, R., Moodley, D., & Chuturgoon, A. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327114559992 · Cited by 65 · see citing works
van Veldhoven, K., Kiss, A., Keski‐Rahkonen, P., Robinot, N. R., Scalbert, A., Cullinan, P., Chung, K. F., Collins, P. D., Sinharay, R., Barratt, B., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.11.034 · Cited by 65 · see citing works
Cost and effectiveness of the California triple marker prenatal screening program
Cunningham, G. C., & Tompkinson, D. G. (1999) · Genetics in Medicine · doi:10.1097/00125817-199907000-00006 · Cited by 64 · see citing works
Serum arachidonic acid levels in normal and preeclamptic pregnancies
Ogburn, P. L., Williams, P. P., Johnson, S. B., & Holman, R. T. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(84)80023-x · Cited by 63 · see citing works
Multi-platform metabolomics assays for human lung lavage fluids in an air pollution exposure study
Surowiec, I., Karimpour, M., Gouveia-Figueira, S. C., Wu, J., Unosson, J., Bosson, J. A., Blomberg, A., Pourazar, J., Sandström, T., Behndig, A., et al. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9566-0 · Cited by 60 · see citing works
Self-citationWainwright, S., & Powell, W. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54795-5 · Cited by 54 · see citing works
Environmental metabolomics: Biological markers for metal toxicity
García-Sevillano, M. Á., García‐Barrera, T., & Gómez‐Ariza, J. L. (2015) · Electrophoresis · doi:10.1002/elps.201500052 · Cited by 54 · see citing works
Metabolic regulation by secreted phospholipase A2
Sato, H., Taketomi, Y., & Murakami, M. (2016) · Inflammation and Regeneration · doi:10.1186/s41232-016-0012-7 · Cited by 54 · see citing works
Wu, J. Y., Laurent, O., Li, L., Hu, J., & Kleeman, M. J. (2016) · PubMed Central · Cited by 51 · see citing works
Self-citationMetabolome-wide association study of anti-epileptic drug treatment during pregnancy
Walker, D. I., Perry‐Walker, K., Finnell, R. H., Pennell, K. D., Tran, V., May, R., McElrath, T. F., Meador, K. J., Pennell, P. B., & Jones, D. P. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.12.001 · Cited by 49 · see citing works
Self-citationDellaPenna, D., & Mène‐Saffrané, L. (2011) · Advances in botanical research · doi:10.1016/b978-0-12-385853-5.00002-7 · Cited by 48 · see citing works
Menni, C., Metrustry, S., Mohney, R. P., Beevers, S. D., Barratt, B., Spector, T. D., Kelly, F. J., & Valdes, A. M. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201411-2059le · Cited by 47 · see citing works
Particulate metal exposures induce plasma metabolome changes in a commuter panel study
Ladva, C. N., Golan, R., Liang, D., Greenwald, R., Walker, D. I., Uppal, K., Raysoni, A. U., Tran, V., Yu, T., Flanders, W. D., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203468 · Cited by 46 · see citing works
Self-citationHoggatt, K. J., Flores, M. E. S., Solorio, R., Wilhelm, M. H., & Ritz, B. R. (2011) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-011-9556-4 · Cited by 45 · see citing works
Self-citationProtein oxidation and degradation caused by particulate matter
Lai, C., Lee, C.-N., Bai, K., Yang, Y.-L., Chuang, K.-J., Wu, S., & Chuang, H. (2016) · Scientific Reports · doi:10.1038/srep33727 · Cited by 42 · see citing works
Li, S., Dunlop, A. L., Jones, D. P., & Corwin, E. J. (2015) · Biological Research For Nursing · doi:10.1177/1099800415595463 · Cited by 36 · see citing works
Self-citationWard-Caviness, C. K., Breitner, S., Wolf, K., Cyrys, J., Kastenmüller, G., Wang‐Sattler, R., Schneider, A. E., & Peters, A. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw247 · Cited by 36 · see citing works
Martens, D. S., Gouveia, S. C., Madhloum, N., Janssen, B. G., Plusquin, M., Vanpoucke, C., Lefebvre, W., Forsberg, B., Nording, M. L., & Nawrot, T. S. (2016) · Environmental Health Perspectives · doi:10.1289/ehp291 · Cited by 35 · see citing works
Comparison and evaluation of several mobile-source and line-source models in Israel
Marmur, A., & Mamane, Y. (2003) · Transportation Research Part D Transport and Environment · doi:10.1016/s1361-9209(03)00002-6 · Cited by 31 · see citing works
Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study
Lee, K., Wong, C. K. C., Chuang, K.-J., Bien, M.-Y., Cao, J.-J., Han, Y., Tian, L., Chang, C.-C., Feng, P., Ho, K., et al. (2014) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2014.04.029 · Cited by 30 · see citing works
Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel
Jones, D. P., Walker, D. I., Uppal, K., Rohrbeck, P., Mallon, T. M., & Go, Y. (2016) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000763 · Cited by 29 · see citing works
Self-citationEffects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels.
Powell, W. S., Rokach, J., KHANAPURE, S. P., Manna, S., Hashefi, M., Gravel, S., Macleod, J., Falck, J. R., & BHATT, R. K. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12349-5 · Cited by 24 · see citing works
Measurement of 8-Iso-Prostaglandin F2α in Biological Fluids as a Measure of Lipid Peroxidation
Tacconelli, S., Capone, M. L., & Patrignani, P. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-364-6_14 · Cited by 23 · see citing works
Broderick, B., Budd, U., Misstear, B. D. R., Čeburnis, D., & Jennings, S. G. (2005) · International Journal of Environment and Pollution · doi:10.1504/ijep.2005.007388 · Cited by 21 · see citing works
Controlled Exposures of Asthmatics to Air Pollutants
Peden, D. B. (1999) · Air Pollution and Health · doi:10.1016/b978-012352335-8/50112-5 · Cited by 18 · see citing works
Anderson, S. M., Naidoo, R. N., Ramkaran, P., Phulukdaree, A., Muttoo, S., Asharam, K., & Chuturgoon, A. A. (2017) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-017-0465-y · Cited by 13 · see citing works
Increased placental production of leukotriene B4 in gestational hypertension
Biagi, G., Rosa, V. D., Pelusi, G., Scagliarini, G., Sani, G., & COCCHERI, S. (1990) · Thrombosis Research · doi:10.1016/0049-3848(90)90220-7 · Cited by 12 · see citing works
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- DellaPenna D, Mène-Saffrané L. 2011 Chapter 5 - vitamin e. In: Advances in botanical research, Vol. 59, (Rébeillé F, Douce R, eds): Academic Press, 179– 227.
Cited by
Sorted by citations
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
“offspring tissues, and potential endocrine disruption [131, 132].”
BackgroundGu, J., Shi, Y., Zhu, Y., Chen, N., Wang, H., Zhang, Z., & Chen, T. (2020) · PLOS Medicine · doi:10.1371/journal.pmed.1003188 · Cited by 184 · see citing works
Toxicity of airborne particles—established evidence, knowledge gaps and emerging areas of importance
Kelly, F. J., & Fussell, J. C. (2020) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2019.0322 · Cited by 128 · see citing works
Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms
Fussell, J. C., Jauniaux, E. R. M., Smith, R. B., & Burton, G. J. (2023) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17727 · Cited by 102 · see citing works
Liang, D., Li, Z., Vlaanderen, J. J., Tang, Z., Jones, D. P., Vermeulen, R. C. H., & Sarnat, J. A. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11851 · Cited by 92 · see citing works
Self-citationMetabolomic signatures of the long-term exposure to air pollution and temperature
Nassan, F. L., Kelly, R. S., Kosheleva, A., Koutrakis, P., Vokonas, P., Lasky-Su, J. A., & Schwartz, J. D. (2021) · Environmental Health · doi:10.1186/s12940-020-00683-x · Cited by 90 · see citing works
Ambient PM2.5 species and ultrafine particle exposure and their differential metabolomic signatures
Nassan, F. L., Wang, C., Kelly, R. S., Lasky-Su, J. A., Vokonas, P., Koutrakis, P., & Schwartz, J. D. (2021) · Environment International · doi:10.1016/j.envint.2021.106447 · Cited by 83 · see citing works
Gaskins, A. J., Tang, Z., Hood, R. B., Ford, J. B., Schwartz, J. D., Jones, D. P., Laden, F., & Liang, D. (2021) · Environment International · doi:10.1016/j.envint.2021.106666 · Cited by 74 · see citing works
Self-citationZhang, J., Liang, S., Ning, R., Jiang, J., Zhang, J., Shen, H., Chen, R., Duan, J., & Sun, Z. (2020) · Environment International · doi:10.1016/j.envint.2019.105444 · Cited by 71 · see citing works
Dai, Y., Huo, X., Cheng, Z., Faas, M. M., & Xu, X. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139626 · Cited by 66 · see citing works
Inoue, K., Yan, Q. J., Arah, O. A., Paul, K. C., Walker, D. I., Jones, D. P., & Ritz, B. R. (2020) · Current Environmental Health Reports · doi:10.1007/s40572-020-00284-3 · Cited by 66 · see citing works
Self-citationGrossklaus, R., Liesenkötter, K., Doubek, K. J., Völzke, H., & Gaertner, R. (2023) · Nutrients · doi:10.3390/nu15102249 · Cited by 57 · see citing works
Morris, R. H., Counsell, S. J., McGonnell, I. M., & Thornton, C. (2021) · BioEssays · doi:10.1002/bies.202000288 · Cited by 54 · see citing works
Meng, Q., Liu, J. Z., Shen, J., Rosario, I. D., Lakey, P. S. J., Shiraiwa, M., Su, J. G., Weichenthal, S., Zhu, Y., Oroumiyeh, F., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12196 · Cited by 48 · see citing works
Self-citationCellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy
Chiarello, D. I., Ustáriz, J., Marı́n, R., Carrasco‐Wong, I., Farías, M., Giordano, A., Gallardo, F. S., Illanes, S. E., & Gutiérrez, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1084986 · Cited by 45 · see citing works
Haghani, A., Johnson, R. G., Woodward, N. C., Feinberg, J. I., Lewis, K., Ladd‐Acosta, C., Safi, N., Jaffe, A. E., Sioutas, C., Allayee, H., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00907-1 · Cited by 44 · see citing works
Assessing How Social Exposures Are Integrated in Exposome Research: A Scoping Review
Neufcourt, L., Castagné, R., Mabile, L., Khalatbari‐Soltani, S., Delpierre, C., & Kelly‐Irving, M. (2022) · Environmental Health Perspectives · doi:10.1289/ehp11015 · Cited by 43 · see citing works
Wang, T., Han, Y., Li, H., Wang, Y., Xue, T., Chen, X., Wu, C. H., Fan, Y., Qiu, X., Gong, J., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.106314 · Cited by 42 · see citing works
Prenatal exposure to air pollution is associated with structural changes in the neonatal brain
Bos, B., Barratt, B., Batallé, D., Gale‐Grant, O., Hughes, E., Beevers, S. D., Cordero‐Grande, L., Price, A. N., Hutter, J. M., Hajnal, J. V., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.107921 · Cited by 41 · see citing works
Zhang, Y., Wang, J., Gong, X., Chen, L., Zhang, B., Wang, Q., Han, B., Zhang, N., Xue, F., Vedal, S., et al. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115301 · Cited by 41 · see citing works
Wei, S., Wei, Y., Gong, Y., Chen, Y., Cui, J., Li, L., Yan, H., Yu, Y., Lin, X., Li, G., et al. (2022) · Metabolomics · doi:10.1007/s11306-022-01895-7 · Cited by 40 · see citing works
Untargeted Metabolomics Screen of Mid‐pregnancy Maternal Serum and Autism in Offspring
Ritz, B. R., Yan, Q. J., Uppal, K., Liew, Z., Cui, X., Ling, C., Inoue, K., von Ehrenstein, O., Walker, D. I., & Jones, D. P. (2020) · Autism Research · doi:10.1002/aur.2311 · Cited by 39 · see citing works
Self-citationUse of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum
Jin, L., Pollitt, K. J. G., Liew, Z., Vollmar, A. K. R., Vasiliou, V., Johnson, C. H., & Zhang, Y. (2021) · Current Environmental Health Reports · doi:10.1007/s40572-020-00298-x · Cited by 39 · see citing works
Self-citationAmbient PM2.5 exposures and systemic inflammation in women with early pregnancy
Zhang, B., Gong, X., Han, B., Chu, M., Gong, C., Yang, J., Chen, L., Wang, J., Bai, Z., & Zhang, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154564 · Cited by 39 · see citing works
Metabolomic signatures of the short-term exposure to air pollution and temperature
Nassan, F. L., Kelly, R. S., Koutrakis, P., Vokonas, P., Lasky-Su, J. A., & Schwartz, J. D. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111553 · Cited by 38 · see citing works
Child serum metabolome and traffic-related air pollution exposure in pregnancy
Ritz, B. R., Yan, Q. J., He, D., Wu, J. Y., Walker, D. I., Uppal, K., Jones, D. P., & Heck, J. E. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111907 · Cited by 36 · see citing works
Self-citationMetabolomic signatures of lead exposure in the VA Normative Aging Study
Kelly, R. S., Bayne, H. N., Spiro, A., Vokonas, P., Sparrow, D., Weiss, S. T., Schwartz, J. D., Nassan, F. L., Lee‐Sarwar, K. A., Huang, M., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110022 · Cited by 35 · see citing works
Li, A., Mei, Y., Zhao, M., Xu, J., Li, R., Zhao, J., Zhou, Q., Ge, X., & Xu, Q. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116750 · Cited by 36 · see citing works
High-Resolution Metabolomic Assessment of Pesticide Exposure in Central Valley, California
Yan, Q. J., Paul, K. C., Walker, D. I., Furlong, M., Rosario, I. D., Yu, Y., Zhang, K., Cockburn, M., Jones, D. P., & Ritz, B. R. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00523 · Cited by 34 · see citing works
Self-citationLiao, J., Goodrich, J. A., Walker, D. I., Lin, Y., Lurmann, F. W., Qiu, C., Jones, D. P., Gilliland, F. D., Chazi, L., & Chen, Z. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121522 · Cited by 32 · see citing works
Self-citationXu, J., Liu, Y., Zhang, Q., Su, Z., Yan, T., Zhou, S., Wang, T., Wei, X., Chen, Z., Hu, G., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2021.118763 · Cited by 32 · see citing works
Banoei, M. M., Iupe, I., Bazaz, R. D., Campos, M., Vogel, H. J., Winston, B. W., & Mirsaeidi, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-56174-8 · Cited by 31 · see citing works
Zhu, K., Browne, R. W., Blair, R. H., Bonner, M. R., Tian, M., Niu, Z., Deng, F., Farhat, Z., & Mu, L. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111401 · Cited by 28 · see citing works
Hu, X., Yan, M., He, L., Qiu, X., Zhang, J. J., Zhang, Y., Mo, J., Day, D. B., Xiang, J., & Gong, J. (2021) · Environment International · doi:10.1016/j.envint.2021.106623 · Cited by 27 · see citing works
Hood, R. B., Liang, D., Tang, Z., Kloog, I., Schwartz, J. D., Laden, F., Jones, D., & Gaskins, A. J. (2022) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000191 · Cited by 27 · see citing works
Self-citationKim, J. H., Yan, Q. J., Uppal, K., Cui, X., Ling, C., Walker, D. I., Heck, J. E., Ehrenstein, O. S. V., Jones, D. P., & Ritz, B. R. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110823 · Cited by 27 · see citing works
Self-citationChen, G., Qian, Z. M., Zhang, J., Wang, X., Zhang, Z., Cai, M., Arnold, L. D., Abresch, C., Wang, C., Liu, Y., et al. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14367 · Cited by 25 · see citing works
Yao, Y., Schneider, A. E., Wolf, K., Zhang, S., Wang‐Sattler, R., Peters, A., & Breitner, S. (2022) · Environment International · doi:10.1016/j.envint.2022.107632 · Cited by 22 · see citing works
Wing, S. E., Larson, T. V., Hudda, N., Boonyarattaphan, S., Rosario, I. D., Fruin, S. A., & Ritz, B. R. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154678 · Cited by 20 · see citing works
Self-citationLi, Z., Sarnat, J. A., Liu, K., Hood, R. B., Chang, C.-J., Hu, X. Y., Tran, V., Greenwald, R., Chang, H. H., Russell, A. G., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c00064 · Cited by 19 · see citing works
Self-citationLi, Z., Zhang, M., Hong, X., Wang, G., Choi, G., Nadeau, K. C., Buckley, J. P., & Wang, X. (2024) · Environment International · doi:10.1016/j.envint.2024.109144 · Cited by 20 · see citing works
Su, Z., Bai, X., Wang, H., Wang, S., Chen, C., Xiao, F., Guo, H., Gao, H., Leng, L., & Li, H. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00775-3 · Cited by 19 · see citing works
Song, J., Liu, Q., Hao, M., Zhai, X., & Chen, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1078593 · Cited by 19 · see citing works
Shu, H., Jin, S., Liu, H., Xia, W., Liang, G., Xu, S., Fang, X., Li, C., Wang, Q., Sun, X., et al. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130102 · Cited by 19 · see citing works
Efficient ammonia production from food by-products by engineered Escherichia coli
Tatemichi, Y., Kuroda, K., Nakahara, T., & Ueda, M. (2020) · AMB Express · doi:10.1186/s13568-020-01083-7 · Cited by 18 · see citing works
Dong, J., Ma, Y., Leng, K., Wei, L., Wang, Y., Su, C., Liu, M., & Chen, J. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135671 · Cited by 17 · see citing works
Tao, S., Yang, M., Pan, B., Wang, Y., Tian, F., Han, D., Shao, W., Yang, W., Xie, Y., Fang, X., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114648 · Cited by 16 · see citing works
Meng, Q., Liu, J. Z., Shen, J., Rosario, I. D., Janzen, C., Devaskar, S. U., Lakey, P. S. J., Shiraiwa, M., Weichenthal, S., Zhu, Y., et al. (2024) · American Journal of Epidemiology · doi:10.1093/aje/kwae152 · Cited by 16 · see citing works
Self-citationLi, Z., Dunlop, A. L., Sarnat, J. A., Hüls, A., Eick, S. M., Gaskins, A. J., Chang, H. H., Russell, A. G., Tan, Y., Cheng, H., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c02071 · Cited by 15 · see citing works
Self-citationRamírez, V., Bautista, R. J., Frausto-González, O., Rodríguez‐Peña, N., Tena‐Betancourt, E., & Bautista, C. J. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00999-8 · Cited by 14 · see citing works
Integrated molecular response of exposure to traffic-related pollutants in the US trucking industry
Walker, D. I., Hart, J. E., Patel, C. J., Rudel, R. A., Chu, J., Garshick, E., Pennell, K. D., Laden, F., & Jones, D. P. (2021) · Environment International · doi:10.1016/j.envint.2021.106957 · Cited by 13 · see citing works
Self-citationKang, N., Sargsyan, S., Chough, I., Petrick, L. M., Liao, J., Wu, C., Pavlovic, N., Lurmann, F., Martinez, M. P., McConnell, R., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124729 · Cited by 12 · see citing works
Xiao, H., Yao, C., Qi, Z., Liu, J., Liu, X., Zhou, Y., Tang, E., Hu, Y.-G., Jiang, Y., Li, D., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.160438 · Cited by 10 · see citing works
Yao, Y., Schneider, A. E., Wolf, K., Zhang, S., Wang‐Sattler, R., Peters, A., & Breitner, S. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165780 · Cited by 10 · see citing works
Pizent, A. (2025) · Antioxidants · doi:10.3390/antiox14121442 · Cited by 9 · see citing works
Chung, M. K., Smith, M. R., Lin, Y., Walker, D. I., Jones, D. P., Patel, C. J., & Kong, S. W. (2021) · Exposome · doi:10.1093/exposome/osab004 · Cited by 9 · see citing works
Self-citationGalindo‐Prieto, B., & Mudway, I. S. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.344826 · Cited by 9 · see citing works
Metabolomics profiling of tobacco exposure in children with cystic fibrosis
Wisniewski, B. L., Shrestha, C. L., Zhang, S., Thompson, R., Gross, M. D., Groner, J. A., Uppal, K., Ramilo, O., Mejías, A., & Kopp, B. T. (2020) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.05.003 · Cited by 8 · see citing works
Self-citationAldana, S. I., Petrick, L. M., Niedzwiecki, M. M., Valvi, D., Just, A. C., Gutiérrez-Ávila, I., Kloog, I., Barupal, D. K., Téllez‐Rojo, M. M., Wright, R. O., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c10717 · Cited by 7 · see citing works
Rodríguez, L. S., Gálvez-Fernández, M., Rojas‐Benedicto, A., Domingo‐Relloso, A., Amigó, N., Redón, J., Monleón, D., Sáez, G. T., Téllez-Plaza, M., Martı́n-Escudero, J. C., et al. (2023) · Antioxidants · doi:10.3390/antiox12122122 · Cited by 8 · see citing works
The neonatal blood spot metabolome in retinoblastoma
Yan, Q. J., He, D., Walker, D. I., Uppal, K., Wang, X., Orimoloye, H. T., Jones, D. P., Ritz, B. R., & Heck, J. E. (2023) · EJC Paediatric Oncology · doi:10.1016/j.ejcped.2023.100123 · Cited by 6 · see citing works
Self-citationXu, Z., Li, D., Liu, Q., Li, S., Li, Y., Li, S., Bian, Y., Kan, X., Wang, Y., & Liu, J. (2025) · Environment International · doi:10.1016/j.envint.2025.109638 · Cited by 5 · see citing works
Dai, Y., Cheng, Z., Zeng, Z., Hylkema, M. N., Faas, M. M., & Huo, X. (2022) · Exposure and Health · doi:10.1007/s12403-022-00503-2 · Cited by 4 · see citing works
A metabolome-wide case-control study of african american breast cancer patients
Luo, J., Kibriya, M. G., Chen, H., Kim, K. C., Ahsan, H., Olopade, O. I., Olopade, C. O., Aschebrook‐Kilfoy, B., & Huo, D. (2023) · BMC Cancer · doi:10.1186/s12885-023-10656-1 · Cited by 4 · see citing works
Coumans, J. V. F., & Al‐Jaaidi, S. (2023) · Environmental Research Health · doi:10.1088/2752-5309/acdd18 · Cited by 4 · see citing works
Jiang, Y., Liu, P., Zeng, M., Zhuang, G., Qiu, C., Wang, L., Liu, W., & Liu, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-87955-z · Cited by 4 · see citing works
A Long Way from Steubenville: Environmental Epidemiology in a Rapidly Changing World
Ritz, B. R. (2022) · American Journal of Epidemiology · doi:10.1093/aje/kwac031 · Cited by 4 · see citing works
Self-citationRoad Traffic Pollution, Motor Driving Occupation and Human Reproductive Health- An Overview
Kumar, S. (2024) · Advances in Environmental and Engineering Research · doi:10.21926/aeer.2401004 · Cited by 3 · see citing works
Hughes, M. L., Kuiper, G., Hoskovec, L., WeMott, S., Young, B. N., Benka-Coker, W. O., Quinn, C. W., Erlandson, G., Martínez, N. M., Mendoza, J., et al. (2024) · Environmental Research Health · doi:10.1088/2752-5309/ad52ba · Cited by 3 · see citing works
Jorge, B. C., da Silva, J. B. F., dos Santos, S. T. C., Barbosa, F., Sandrim, V. C., & Arena, A. C. (2025) · Reproductive Toxicology · doi:10.1016/j.reprotox.2025.109029 · Cited by 3 · see citing works
Morris, R. H., Chabrier, G., Counsell, S. J., McGonnell, I. M., & Thornton, C. (2022) · Developmental Neuroscience · doi:10.1159/000524829 · Cited by 3 · see citing works
Kang, N., Petrick, L. M., Liao, J., Chen, W., Rahman, M. M., Carter, S., Pavlovic, N., Lurmann, F., Chow, T., Martinez, M. P., et al. (2022) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-026-00897-0 · Cited by 2 · see citing works
The Effects of Climate Change on Children’s Health
Bonthrone, A. F., Piyasena, C., & Counsell, S. J. (2025) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2025.05.010 · Cited by 2 · see citing works
Puvvula, J., Chen, A., Simmons, R. A., Leite, R., & Lien, Y. (2025) · Placenta · doi:10.1016/j.placenta.2025.09.012 · Cited by 2 · see citing works
Shi, H., Han, C., Hou, J., Chen, C. J., Ma, N., Liang, Y., & Guo, Y. (2025) · Environmental Science Processes & Impacts · doi:10.1039/d5em00316d · Cited by 2 · see citing works
Untargeted serum metabolomics and air pollution in Parkinson’s disease
Kwon, D., Paul, K. C., Lin, Y., Thordarson, D., Wu, J., Su, J., Jones, D. P., Bronstein, J. M., & Ritz, B. R. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01451-3 · Cited by 1 · see citing works
Self-citationApplication of Biomarkers in Assessing Human Health Impacts of Air Pollution
Niyogi, S., & Hecker, M. (2024) · Springer eBooks · doi:10.1007/978-981-97-1363-9_11 · Cited by 1 · see citing works
Holzhausen, E. A., Tan, Y., Young, N., Jones, R. B., Tang, Z., Sarnat, J. A., Lurmann, F., Chang, H. H., Tran, V., Jones, D. P., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c04955 · Cited by 1 · see citing works
Self-citationPengaruh Paparan Pencemar Udara Terhadap Stres Oksidatif: Sistematik Review
Kusmiyati, K., Kambuno, N. T., Selasa, P., & Waangsir, F. W. (2022) · Jurnal Ilmu Lingkungan · doi:10.14710/jil.20.3.628-636 · Cited by 1 · see citing works
Additional file 1 of A metabolome-wide case-control study of african american breast cancer patients
Luo, J., Kibriya, M. G., Chen, H., Kim, K. C., Ahsan, H., Olopade, O. I., Olopade, C. O., Aschebrook‐Kilfoy, B., & Huo, D. (2023) · Figshare · doi:10.6084/m9.figshare.22616558
Using Exposomics to Advance Neurotoxicology
Duarte-Hospital, C., & Miller, G. W. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00290-4
Li, X., Zhu, X., Chen, D., Zhao, Y., Deng, X., Zhan, Y., Guo, B., Xu, T., & Wang, X. (2025) · Atmospheric Environment · doi:10.1016/j.atmosenv.2025.121511
Kumar, S., Salafia, C. M., Shah, R., Girardi, T., Miller, R. K., Thurston, S. W., Hopke, P. K., Skrill, D., Brunner, J., Harrington, D. K., et al. (2025) · Environmental Research · doi:10.1016/j.envres.2025.122880
Nassan, F. L., Kelly, R. S., Kosheleva, A., Koutrakis, P., Vokonas, P., Lasky-Su, J. A., & Schwartz, J. D. (2021) · Figshare · doi:10.6084/m9.figshare.13543789
Tatemichi, Y., Kuroda, K., Nakahara, T., & Ueda, M. (2020) · Figshare · doi:10.6084/m9.figshare.12825290
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C. H., Pendleton, D., Harvey, N., Shore, R. A., Li, Y., Chen, J., Tian, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966363
Residential Greenness and Subtypes of Gestational Diabetes Mellitus: A Metabolomic Investigation
Cao, J., Jiang, W., Zhang, T., Yuan, Z., Yang, D., Liu, L., Zhang, Q., & Zhang, J. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119667
Li, N., Jin, M. S., Lan, C., Xu, J., Han, B., Liu, X. P., Pan, B., & Wang, B. (2026) · Environment & Health · doi:10.1021/envhealth.5c00186
Osborne, K., Liew, Z., Cui, X., Walker, D. I., Jones, D. P., Lin, Y., O’Sharkey, K., Heck, J. E., Paul, K. C., & Ritz, B. R. (2026) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000464
Self-citationShen, J., Wei, Q., Wang, L., Jin, Y., Qin, Y., Meng, R., Hu, Z., Hu, Q., Han, Z., Wei, Q., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c16521
Kessler, B. R., Dunlop, A. L., Hood, R. B., Eick, S. M., Zhan, J. J., Hoffman, S., Jin, Z., Tan, Y., Ferranti, E. P., Sarnat, J. A., et al. (2026) · Environment & Health · doi:10.1021/envhealth.5c00490
Wang, X., Zhang, L. P., Peng, X., Pan, R., Guo, M., Yin, X., Hu, H., Wei, J. N., Chen, J., & Zhu, P. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120371
- Authors
- Yan, Q., Liew, Z., Uppal, K., Cui, X., Ling, C., Heck, J. E., von Ehrenstein, O. S., Wu, J., Walker, D. I., Jones, D. P., & Ritz, B.
- Affiliations
- University of California, Los Angeles (US)
- Yale University (US)
- Emory University (US)
- Lucile Packard Children's Hospital (US)
- University of California, Irvine (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Ritz, Beate
- ORCID
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 130
- Pages
- 104872
- ISSN
- 0160-4120 (ISSN-L)
- PMC
- PMC7017857
- OpenAlex
- W2950162098
- Cited by
- 91
- References
- 95
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 7 · 2023: 13 · 2022: 17 · 2021: 18 · 2020: 13 · 2019: 2
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Environment International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Environmental Health Sciences (R21ES25573)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- traffic-related air pollution, prenatal exposure, pregnancy, oxidative stress, inflammation, leukotriene pathway, prostaglandin pathway, particulate matter, carbon monoxide, nitric oxide, birth outcomes, Central Valley
- MeSH terms
- Traffic-Related Pollution, Adolescent, Adult, Air Pollutants, Air Pollution, Vehicle Emissions, California, Carbon Monoxide, Female, Humans, Maternal-Fetal Exchange, Nitrogen Oxides, Pregnancy, Maternal Exposure, Particulate Matter, Metabolomics, Metabolome, Young Adult
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