The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway
Abstract
The environmental pollution from microplastics has caused concern from the whole society due to its harm to organisms. However, the effect of microplastics on liver damage and fibrosis remains unclear in the case of long-term accumulation. The present study demonstrated that the 0.1 μm microplastic could enter hepatocytes from circulation and result liver damage even at a low concentration. Microplastic exposure could induce DNA damage in both nucleus and mitochondria, by which the dsDNA fragment was translocated into cytoplasm and triggered the DNA sensing adaptor STING. The activation of cGAS/STING pathway initiated the downstream cascade reaction, the NFκB translocated into nucleus and upregulated pro-inflammatory cytokines expression, and thus facilitating liver fibrosis eventually. Furthermore, inhibition of STING could alleviate the liver fibrosis via blocking the NFκB translocation and fibronectin expression. This study provided a valuable insight to elucidate the potential risk and mechanism of hepatic toxicity and fibrosis induced by microplastics.
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Cites
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Molecular mechanisms and cellular functions of cGAS–STING signalling
Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052
Molecular and cellular mechanisms of liver fibrosis and its regression
Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024
Deng, Y., Zhang, Y., Lemos, B., & Ren, H. (2017) · Scientific Reports · doi:10.1038/srep46687 · Cited by 1,471
DNA sensing by the cGAS–STING pathway in health and disease
Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0151-1 · Cited by 1,467
Liver Macrophages in Tissue Homeostasis and Disease
Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424
Pollutants bioavailability and toxicological risk from microplastics to marine mussels
Avio, C. G., Gorbi, S., Milan, M., Benedetti, M., Fattorini, D., d'Errico, G., Pauletto, M., Bargelloni, L., & Regoli, F. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2014.12.021 · Cited by 1,413
Targeting STING with covalent small-molecule inhibitors
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Crossing the blood-brain barrier with nanoparticles
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Cited by
Microplastics and Oxidative Stress—Current Problems and Prospects
Kadac-Czapska, K., Ośko, J., Knez, E., & Grembecka, M. (2024) · Antioxidants · doi:10.3390/antiox13050579 · Cited by 341
Novel regulators of hepatic macrophages in liver fibrosis
Tang, X., Bai, M., Du, X., Wang, H., Liu, M., Fu, X., Zhang, H., Liang, S., & Wang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1705503 · Cited by 12
Lee, S. (2026) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2025.2584495 · Cited by 8
Pulmonary toxicity of polymethyl methacrylate nanoplastics via intratracheal intubation in mice
Youn, C., Jo, Y.-J., Kwon, J., Yoon, S.-B., You, H.-J., & Kim, J.-S. (2026) · Scientific Reports · doi:10.1038/s41598-025-31615-9 · Cited by 3
Metadata
- Authors
- Shen, R., Yang, K., Cheng, X., Guo, C., Xing, X., Sun, H., Liu, D., Liu, X., & Wang, D.
- Venue
- Environmental Pollution
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 300
- Pages
- 118986
- ISSN
- 0269-7491 (ISSN-L)
- OpenAlex
- W4211020476
- Cited by
- 264
- References
- 49
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shen, R., Yang, K., Cheng, X., Guo, C., Xing, X., Sun, H., Liu, D., Liu, X., & Wang, D. (2022). Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway. Environmental Pollution. https://doi.org/10.1016/j.envpol.2022.118986
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
