The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Hazardous effects of chemical pesticides on human health–Cancer and other associated disorders
Abstract
Poisoning from pesticides is a global public health problem and accounts for nearly 300,000 deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes through which humans get exposed to pesticides. The mode of exposure is an important factor as it also signifies the concentration of pesticides exposure. Pesticides are used extensively in agricultural and domestic settings. These chemicals are believed to cause many disorders in humans and wildlife. Research from past few decades has tried to answer the associated mechanism of action of pesticides in conjunction with their harmful effects. This perspective considers the past and present research in the field of pesticides and associated disorders. We have reviewed the most common diseases including cancer which are associated with pesticides. Pesticides have shown to be involved in the pathogenesis of Parkinson's and Alzheimer's diseases as well as various disorders of the respiratory and reproductive tracts. Oxidative stress caused by pesticides is an important mechanism through which many of the pesticides exert their harmful effects. Oxidative stress is known to cause DNA damage which in turn may cause malignancies and other disorders. Many pesticides have shown to modulate the gene expression at the level of non-coding RNAs, histone deacetylases, DNA methylation patterns suggesting their role in epigenetics.
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Cites
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Cited by
Alengebawy, A., Abdelkhalek, S. T., Qureshi, S. R., & Wang, M.-Q. (2021) · Toxics · doi:10.3390/toxics9030042 · Cited by 2,339
Towards better representation of organic agriculture in life cycle assessment
van der Werf, H. M. G., Knudsen, M. T., & Cederberg, C. (2020) · Nature Sustainability · doi:10.1038/s41893-020-0489-6 · Cited by 394
Alzheimer’s Disease: An Updated Overview of Its Genetics
Andrade-Guerrero, J., Santiago-Balmaseda, A., Jeronimo-Aguilar, P., Vargas-Rodríguez, I., Cadena-Suárez, A. R., Sánchez-Garibay, C., Pozo-Molina, G., Méndez-Catalá, C. F., Cardenas-Aguayo, M.-D.-C., Diaz-Cintra, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043754 · Cited by 336
Khursheed, A., Rather, M. A., Jain, V., Wani, A. R., Rasool, S., Nazir, R., Malik, N. A., & Majid, S. A. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105854 · Cited by 322
Kaur, H., Devi, N., Siwal, S. S., Alsanie, W. F., Thakur, M. K., & Thakur, V. K. (2023) · ACS Omega · doi:10.1021/acsomega.2c07719 · Cited by 273
Metadata
- Authors
- Sabarwal, A., Kumar, K., & Singh, R. P.
- Venue
- Environmental Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 63
- Pages
- 103-114
- ISSN
- 1382-6689 (ISSN-L)
- OpenAlex
- W2889414204
- Cited by
- 658
- References
- 122
- FWCI
- 35.40
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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