Cited by 246Anesthesia and Pain ManagementPain Mechanisms and TreatmentsPain Management and Treatment

Preventing chronic pain following acute pain: Risk factors, preventive strategies, and their efficacy

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McGreevy, Kai, Bottros, Michael M., Raja, Srinivasa N.·2011·European Journal of Pain Supplements

Abstract

Chronic pain is the leading cause of disability in the United States. The transition from acute to persistent pain is thought to arise from maladaptive neuroplastic mechanisms involving three intertwined processes, peripheral sensitization, central sensitization, and descending modulation. Strategies aimed at preventing persistent pain may target such processes. Models for studying preventive strategies include persistent post-surgical pain (PPP), persistent post-trauma pain (PTP) and post-herpetic neuralgia (PHN). Such entities allow a more defined acute onset of tissue injury after which study of the long-term effects is more easily examined. In this review, we examine the pathophysiology, epidemiology, risk factors, and treatment strategies for the prevention of chronic pain using these models. Both pharmacological and interventional approaches are described, as well as a discussion of preventive strategies on the horizon.

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Crossref · 10.1016/j.eujps.2011.08.013

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  • The benefits of perioperative use of a subanesthetic dose of ketamine for prevention of various types of CPSP, including phantom limb pain, have been demonstrated in different studies.

    “The benefits of the perioperative use of a subanesthetic dose of ketamine for the prevention of various types of CPSP, including phantom limb pain, has been demonstrated in different studies [39].”

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Authors
McGreevy, K., Bottros, M. M., & Raja, S. N.
Affiliations
Johns Hopkins University (US)
Corresponding author
Raja, Srinivasa N.
Venue
European Journal of Pain Supplements
Publisher
Wiley
Published
2011-11
Volume
5
Issue
S2
Pages
365-376
ISSN
1754-3207 (ISSN-L)
OpenAlex
W2097740018
Cited by
246
References
128
Citations by year
2026: 11 · 2025: 16 · 2024: 16 · 2023: 25 · 2022: 19 · 2021: 17 · 2020: 28 · 2019: 24 · 2018: 17 · 2017: 18 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 9 · 2012: 7
FWCI
8.52
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pain Supplements (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS026363)
Topics
  • Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
chronic pain prevention, acute pain, persistent post-surgical pain, postherpetic neuralgia, peripheral sensitization, central sensitization, descending pain modulation, neuroplasticity, risk factors, pharmacological prophylaxis

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