Acute atorvastatin treatment exerts antidepressant-like effect in mice via the l-arginine–nitric oxide–cyclic guanosine monophosphate pathway and increases BDNF levels

A simplification of the protein assay method of Lowry et al. which is more generally applicable

Peterson, G. L. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90043-4 · Cited by 8,531 · see citing works

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394 · see citing works

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works

The tail suspension test: A new method for screening antidepressants in mice

Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534 · see citing works

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works

Rho GTPases and signaling networksPreprint

Aelst, L. V., & D’Souza‐Schorey, C. (1997) · Genes & Development · doi:10.1101/gad.11.18.2295 · Cited by 2,358 · see citing works

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works

New insights into BDNF function in depression and anxiety

Martinowich, K., Manji, H., & Lu, B. (2007) · Nature Neuroscience · doi:10.1038/nn1971 · Cited by 1,221 · see citing works

Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update

Schächter, M. (2004) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2004.00299.x · Cited by 1,216 · see citing works

Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies

Koolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

Sanacora, G., Zarate, C. A., Krystal, J. H., & Manji, H. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2462 · Cited by 894 · see citing works

Pathophysiology of depression: do we have any solid evidence of interest to clinicians?

HASLER, G. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00298.x · Cited by 604 · see citing works

Is mood chemistry?

Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works

NO as a signalling molecule in the nervous system

Esplugues, J. V. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704569 · Cited by 547 · see citing works

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.027 · Cited by 454 · see citing works

Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice

Chen, J., Zhang, C., Jiang, H., Li, Y., Zhang, L., Robin, A. M., Katakowski, M., Lü, M., & Chopp, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600034 · Cited by 451 · see citing works

[25] Nitric-oxide synthase assays

Hevel, J. M., & Marletta, M. A. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33028-x · Cited by 432 · see citing works

Glutamate and Depression: Clinical and Preclinical Studies

PAUL, I. A., & SKOLNICK, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.016 · Cited by 408 · see citing works

Emerging role of glutamate in the pathophysiology of major depressive disorder

Hashimoto, K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.005 · Cited by 381 · see citing works

Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients

Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0578-6 · Cited by 375 · see citing works

Correlation between plasma levels of glutamate, alanine and serine with severity of depression

Mitani, H., Shirayama, Y., Yamada, T., Maeda, K., Ashby, C. R., & Kawahara, R. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.036 · Cited by 332 · see citing works

Decreased plasma BDNF level in depressive patients

Lee, B.-H., Kim, H., Park, S., & Kim, Y. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.11.005 · Cited by 327 · see citing works

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

Wu, H., Lu, D., Jiang, H., Xiong, Y., Qu, C., Li, B., Mahmood, A., Zhou, D., & Chopp, M. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0369 · Cited by 304 · see citing works

Intra- and interstrain differences in models of “behavioral despair”

Bai, F., Li, X., Clay, M. P., Lindstrom, T. D., & Skolnick, P. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00599-8 · Cited by 250 · see citing works

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Protect Cortical Neurons from Excitotoxicity

Zacco, A., Togo, J. A., Spence, K., Ellis, A., Lloyd, D., Furlong, S., & Piser, T. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11104.2003 · Cited by 250 · see citing works

Neuroprotective effects of atorvastatin against glutamate‐induced excitotoxicity in primary cortical neurones

Bösel, J., Gandor, F., Harms, C., Synowitz, M., Harms, U., Djoufack, P. C., Megow, D., Dirnagl, U., Hörtnagl, H., Fink, K., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02980.x · Cited by 210 · see citing works

The NMDA Receptor as a Therapeutic Target in Major Depressive Disorder

Pittenger, C., Sanacora, G., & Krystal, J. H. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363267 · Cited by 203 · see citing works

Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Axonal Regeneration from Supraspinal Neurons Following Chronic Spinal Cord Injury

Jin, Y. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7980 · Cited by 193 · see citing works

Safety of atorvastatin derived from analysis of 44 completed trials in 9,416 patients

Newman, C. B., Palmer, G., Silbershatz, H., & Szarek, M. J. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00820-8 · Cited by 172 · see citing works

Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain

Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Ferraro, A. K., Vitto, M. F., Cesconetto, P. A., de Souza, C. T., & Quevedo, J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.024 · Cited by 159 · see citing works

Long-term statin use and psychological well-being

Young‐Xu, Y., Chan, K. A., Liao, J. K., Ravid, S., & Blatt, C. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00785-x · Cited by 139 · see citing works

Examination of behavioral deficits triggered by targeting BDNF in fetal or postnatal brains of mice

Chan, J., Unger, T. J., BYRNES, J. J., & Rios, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.002 · Cited by 125 · see citing works

Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care

Irwin, S. A., & Iglewicz, A. (2010) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.9808 · Cited by 123 · see citing works

Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder

Scarr, E., Pavey, G., Sundram, S., Mackinnon, A. J., & Dean, B. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00024.x · Cited by 121 · see citing works

Intercellular Glutamate Signaling in the Nervous System and Beyond

Featherstone, D. E. (2009) · ACS Chemical Neuroscience · doi:10.1021/cn900006n · Cited by 114 · see citing works

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

Piermartiri, T., Figueiredo, C. P., Rial, D., Duarte, F. S., Bezerra, S. C., Mancini, G., Bem, A. F. D., Prediger, R. D., & Tasca, C. I. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.08.030 · Cited by 106 · see citing works

Involvement of l-arginine–nitric oxide–cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice

Dhir, A., & Kulkarni, S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.008 · Cited by 100 · see citing works

Atorvastatin Prevents Hippocampal Cell Death due to Quinolinic Acid-Induced Seizures in Mice by Increasing Akt Phosphorylation and Glutamate Uptake

Piermartiri, T., Vandresen-Filho, S., Herculano, B., Martins, W. C., Dal’Agnolo, D., Stroeh, E., Carqueja, C. L., Boeck, C. R., & Tasca, C. I. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9057-6 · Cited by 100 · see citing works

Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test

Zomkowski, A. D. E., Engel, D., Gabilan, N. H., & Rodrigues, A. L. S. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.07.011 · Cited by 94 · see citing works

Glutamate-induced Toxicity in Hippocampal Slices Involves Apoptotic Features and p38MAPK Signaling

Molz, S., Decker, H., Dal-Cim, T. A., Cremonez, C., de Córdova, F. M., Leal, R. B., & Tasca, C. I. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9402-1 · Cited by 92 · see citing works

Involvement of nitric oxide–cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test

Kaster, M. P., Rosa, A. O., Santos, A. R. S., & Rodrigues, A. L. S. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005316 · Cited by 87 · see citing works

A controlled trial of methylene blue in severe depressive illness

Naylor, G. J., Smith, A. H. W., & Connelly, P. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90194-6 · Cited by 76 · see citing works

Involvement of nitric oxide–cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test

Moretti, M., Freitas, A. E., Budni, J., Fernandes, S. C. P., Balen, G. O., & Rodrigues, A. L. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.024 · Cited by 68 · see citing works

Statins may enhance the proteolytic cleavage of proBDNF: Implications for the treatment of depression

Tsai, S. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.09.043 · Cited by 55 · see citing works

Antidepressant-like and neuroprotective effects of Aloysia gratissima: Investigation of involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway

Zeni, A. L. B., Zomkowski, A. D. E., Dal-Cim, T. A., Maraschin, M., Rodrigues, A. L. S., & Tasca, C. I. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.07.009 · Cited by 52 · see citing works

Atorvastatin reduction of intracranial hematoma volume in rats subjected to controlled cortical impact

Lu, D., Mahmood, A., Qu, C., Goussev, A. V., Lü, M., & Chopp, M. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.5.0822 · Cited by 48 · see citing works

Inhibition of Neuronal Nitric Oxide Synthase and Soluble Guanylate Cyclase Prevents Depression‐Like Behaviour in Rats Exposed to Chronic Unpredictable Mild Stress

Yazır, Y., Utkan, T., & Arıcıoğlu, F. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2012.00877.x · Cited by 45 · see citing works

Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats

Renshaw, P. F., Parsegian, A., Yang, C. K., Novero, A., Yoon, S. J., Lyoo, I. K., Cohen, B. M., & Carlezon, W. A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.10.017 · Cited by 38 · see citing works

Cognitive remission: a novel objective for the treatment of major depression?

Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works

Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

McFarland, A. J., Anoopkumar‐Dukie, S., Arora, D. S., Grant, G. D., McDermott, C., Perkins, A. V., & Davey, A. K. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151120607 · Cited by 199 · see citing works

Therapeutic Strategies for Treatment of Inflammation-related Depression

Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 156 · see citing works

Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway

Pazini, F. L., Cunha, M. P., Rosa, J. M., Colla, A. R. D. S., Lieberknecht, V., Oliveira‐Giacomelli, Á., & Rodrigues, A. L. S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9580-9 · Cited by 132 · see citing works

Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets

Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works

Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice

Tomaz, V. D. S., Cordeiro, R. C., Costa, A. M. N., de Lucena, D. F., Júnior, H. V. N., de Sousa, F. C. F., Vasconcelos, S. M. M., Vale, M. L., Quevedo, J., & Macêdo, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.03.025 · Cited by 103 · see citing works

Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice

Taniguti, E. H., Ferreira, Y. S., Stupp, I. J. V., Fraga-Junior, E. B., Doneda, D. L., Lopes, L., Rios-Santos, F., Lima, E., Buss, Z. S., Viola, G. G., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.018 · Cited by 91 · see citing works

Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial

Gougol, A., Zareh-Mohammadi, N., Raheb, S., Farokhnia, M., Salimi, S., Iranpour, N., Yekehtaz, H., & Akhondzadeh, S. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115578160 · Cited by 77 · see citing works

Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?

Cartocci, V., Servadio, M., Trezza, V., & Pallottini, V. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25488 · Cited by 77 · see citing works

Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress

Lorigooini, Z., Boroujeni, S. N., Sayyadi-Shahraki, M., Rahimi‐Madiseh, M., Bijad, E., & Amini-Khoei, H. (2021) · Behavioural Neurology · doi:10.1155/2021/8817309 · Cited by 73 · see citing works

Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: a double-blind, placebo-controlled, randomized trial

Abbasi, S. H., Mohammadinejad, P., Shahmansouri, N., Salehiomran, A., Beglar, A. A., Zeinoddini, A., Forghani, S., & Akhondzadeh, S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.049 · Cited by 70 · see citing works

Involvement of PI3K/Akt/GSK-3β and mTOR in the antidepressant-like effect of atorvastatin in mice

Ludka, F. K., Constantino, L. C., Dal-Cim, T. A., Binder, L. B., Zomkowski, A. D. E., Rodrigues, A. L. S., & Tasca, C. I. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.004 · Cited by 66 · see citing works

In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder

Haghighi, M., Khodakarami, S., Jahangard, L., Ahmadpanah, M., Bajoghli, H., Holsboer-Trachsler, E., & Brand, S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.018 · Cited by 65 · see citing works

Atorvastatin improves cognitive, emotional and motor impairments induced by intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats, an experimental model of Parkinson's disease

de Castro, A. A., Wiemes, B. P., MATHEUS, F. C., Lapa, F. D. R., Viola, G. G., Santos, A. R. S., Tasca, C. I., & Prediger, R. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.029 · Cited by 62 · see citing works

Protective effects of some statins on epileptogenesis and depressive‐like behavior in WAG /Rij rats, a genetic animal model of absence epilepsy

Citraro, R., Chimirri, S., Aiello, R., Gallelli, L., Trimboli, F., Britti, D., Sarro, G. D., & Russo, E. (2014) · Epilepsia · doi:10.1111/epi.12686 · Cited by 62 · see citing works

Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice

Yu, X., Zhang, H., Dai, Y., Zhou, Z., Xu, R.-A., Hu, L., Zhang, C., Xu, H., An, Y., Tang, C., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.086 · Cited by 61 · see citing works

Biocatalyzed Synthesis of Statins: A Sustainable Strategy for the Preparation of Valuable Drugs

Hoyos, P., Pace, V., & Alcántara, A. R. (2019) · Catalysts · doi:10.3390/catal9030260 · Cited by 58 · see citing works

Estradiol reduces depressive-like behavior through inhibiting nitric oxide/cyclic GMP pathway in ovariectomized mice

Heydarpour, P., Salehi-Sadaghiani, M., Paydar, M. J., Rahimian, R., Fakhfouri, G., Khosravi, M., Khoshkish, S., Gharedaghi, M. H., Ghasemi, M., & Dehpour, A. R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.12.005 · Cited by 55 · see citing works

Brain‐derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide‐dependent contributor of brain‐derived neurotrophic factor in the brain

Monnier, A., Prigent‐Tessier, A., Quirié, A., Bertrand, N., Savary, S., Gondcaille, C., Garnier, P. E., Demougeot, C., & Marie, C. (2016) · Acta Physiologica · doi:10.1111/apha.12743 · Cited by 53 · see citing works

Statins for major depressive disorder: a systematic review and meta-analysis of randomized controlled trials

De Giorgi, R., De Crescenzo, F., Rizzo Pesci, N., Martens, M., Howard, W., Cowen, P. J., & Harmer, C. J. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249409 · Cited by 52 · see citing works

Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial

Brand, S., Farnia, V., Shakeri, J., Shirzadifar, M., Rezaei, M., Bajoghli, H., & Holsboer‐Trachsler, E. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s78696 · Cited by 52 · see citing works

Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice

Colla, A. R. D. S., Oliveira‐Giacomelli, Á., Pazini, F. L., Rosa, J. M., Manosso, L. M., Cunha, M. P., & Rodrigues, A. L. S. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.05.015 · Cited by 51 · see citing works

Guanosine Prevents Anhedonic-Like Behavior and Impairment in Hippocampal Glutamate Transport Following Amyloid-β1–40 Administration in Mice

Lanznaster, D., Mack, J. M., Coelho, V., Ganzella, M., Almeida, R. F., Dal-Cim, T. A., Hansel, G., Zimmer, E. R., Souza, D. O., Prediger, R. D., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0082-1 · Cited by 51 · see citing works

Statins in the treatment of depression: Hype or hope?

Köhler‐Forsberg, O., Otte, C., Gold, S. M., & Østergaard, S. D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107625 · Cited by 51 · see citing works

Atorvastatin prevents cell damage via modulation of oxidative stress, glutamate uptake and glutamine synthetase activity in hippocampal slices subjected to oxygen/glucose deprivation

Vandresen-Filho, S., Martins, W. C., Bertoldo, D. B., Mancini, G., Herculano, B., Bem, A. F. D., & Tasca, C. I. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.03.002 · Cited by 49 · see citing works

Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies

Giorgi, R. D., Pesci, N. R., Quinton, A. M. G., Crescenzo, F. D., Cowen, P. J., & Harmer, C. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.702617 · Cited by 49 · see citing works

GPR39 Zn2+-sensing receptor: A new target in antidepressant development?

Młyniec, K., Singewald, N., Holst, B., & Nowak, G. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.033 · Cited by 49 · see citing works

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Cunha, M. P., Pazini, F. L., Rosa, J. M., Ramos-Hryb, A. B., Oliveira‐Giacomelli, Á., Kaster, M. P., & Rodrigues, A. L. S. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9446-7 · Cited by 47 · see citing works

The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test

Cunha, M. P., Pazini, F. L., Ludka, F. K., Rosa, J. M., Oliveira‐Giacomelli, Á., Budni, J., Ramos-Hryb, A. B., Lieberknecht, V., Bettio, L. E. B., Martin‐de‐Saavedra, M. D., et al. (2015) · Amino Acids · doi:10.1007/s00726-014-1910-0 · Cited by 45 · see citing works

Augmentation effect of ketamine by guanosine in the novelty-suppressed feeding test is dependent on mTOR signaling pathway

Camargo, A., Pazini, F. L., Rosa, J. M., Wolin, I. A. V., Moretti, M., da Rosa, P. B., Neis, V. B., & Rodrigues, A. L. S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.017 · Cited by 44 · see citing works

Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress

Lin, P.-Y., Chang, A. Y. W., & Lin, T.-K. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.006 · Cited by 43 · see citing works

The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice

Yan, T., Xu, M., Wu, B., Liao, Z., Liu, Z., Zhao, X. D., Kai-shun, B., & Jia, Y. (2016) · Food & Function · doi:10.1039/c6fo00328a · Cited by 42 · see citing works

Atorvastatin Protects from Aβ1–40-Induced Cell Damage and Depressive-Like Behavior via ProBDNF Cleavage

Ludka, F. K., Cunha, M. P., Dal-Cim, T. A., Binder, L. B., Constantino, L. C., Massari, C. M., Martins, W. C., Rodrigues, A. L. S., & Tasca, C. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0134-6 · Cited by 42 · see citing works

Pharmacological profile of agmatine: An in-depth overview

Rafi, H., Rafiq, H., & Farhan, M. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102429 · Cited by 41 · see citing works

Antidepressant-like effect of atorvastatin in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway

Shahsavarian, A., Javadi, S., Jahanabadi, S., Khoshnoodi, M., Shamsaee, J., Shafaroodi, H., Mehr, S. E., & Dehpour, A. R. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.004 · Cited by 41 · see citing works

Atorvastatin and Fluoxetine Prevent Oxidative Stress and Mitochondrial Dysfunction Evoked by Glutamate Toxicity in Hippocampal Slices

Ludka, F. K., Dal-Cim, T. A., Binder, L. B., Constantino, L. C., Massari, C. M., & Tasca, C. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9882-6 · Cited by 38 · see citing works

Statin Function as an Anti-inflammation Therapy for Depression in Patients With Coronary Artery Disease by Downregulating Interleukin-1β

Ma, W., Shen, D., Liu, J., Pan, J., Yu, L., Shi, W., Deng, L. H., Zhu, L., Yang, F., Liu, J., et al. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000323 · Cited by 35 · see citing works

Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis

de Oliveira, C. V., Grigoletto, J., Canzian, J., Duarte, M. M. M. F., Duarte, T., Furian, A. F., & Oliveira, M. S. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2017.10.021 · Cited by 35 · see citing works

Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine

Neis, V. B., Bettio, L. E. B., Moretti, M., da Rosa, P. B., Olescowicz, G., Fraga, D. B., Gonçalves, F. M., Freitas, A. E., Heinrich, I. A., Lopes, M. W., et al. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.08.005 · Cited by 33 · see citing works

Digestion behavior and antidepressant-like effect promoted by acute administration of blueberry extract on mice

Gapsky, A., Gomes, T. M., Bredun, M. A., Lima, N. S., Ludka, F. K., Bordignon-Luiz, M. T., & Burin, V. M. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108618 · Cited by 32 · see citing works

Antidepressant-like effect of Canavalia brasiliensis (ConBr) lectin in mice: Evidence for the involvement of the glutamatergic system

Rieger, D. K., Costa, A. P., Budni, J., Moretti, M., Barbosa, S. G. R., Nascimento, K. S., Teixeira, E. H., Cavada, B. S., Rodrigues, A. L. S., & Leal, R. B. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.03.008 · Cited by 32 · see citing works

Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice

Hai-Na, Z., Xu-Ben, Y., Cong-Rong, T., Yan-Cheng, C., Fan, Y., Lei-Mei, X., Ruo-Lan, S., Ye-Zi, Ye-Xuan, W., & Jing, L. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05406-w · Cited by 29 · see citing works

The pharmacological bases for repurposing statins in depression: a review of mechanistic studies

Giorgi, R. D., Pesci, N. R., Rosso, G., Maina, G., Cowen, P. J., & Harmer, C. J. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02533-z · Cited by 29 · see citing works

The antidepressant-like effects of biperiden may involve BDNF/TrkB signaling-mediated BICC1 expression in the hippocampus and prefrontal cortex of mice

Zhou, D., Zhang, Z., Liu, L., Li, C., Li, M., Yu, H., Cai, X., Sun, X., Shen, X., Wang, J., et al. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.02.004 · Cited by 28 · see citing works

Atorvastatin evokes a serotonergic system-dependent antidepressant-like effect in mice

Ludka, F. K., Constantino, L. C., Kuminek, G., Binder, L. B., Zomkowski, A. D. E., Cunha, M. P., Dal-Cim, T. A., Rodrigues, A. L. S., & Tasca, C. I. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.04.005 · Cited by 27 · see citing works

Simvastatin exerts antidepressant-like activity in mouse forced swimming test: Role of NO-cGMP-KATP channels pathway and PPAR-gamma receptors

Naserzadeh, R., Abad, N., Ghorbanzadeh, B., Dolatshahi, M., & Mansouri, M. T. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.03.002 · Cited by 27 · see citing works

In vitro 6-hydroxydopamine-induced toxicity in striatal, cerebrocortical and hippocampal slices is attenuated by atorvastatin and MK-801

Massari, C. M., de Castro, A. A., Dal-Cim, T. A., Lanznaster, D., & Tasca, C. I. (2016) · Toxicology in Vitro · doi:10.1016/j.tiv.2016.09.015 · Cited by 26 · see citing works

Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling

da Rosa, P. B., Bettio, L. E. B., Neis, V. B., Moretti, M., Kaufmann, F. N., Tavares, M. K., Werle, I., Dalsenter, Y. D. O., Platt, N., Rosado, A. F., et al. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09779-6 · Cited by 26 · see citing works

Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases

Lashgari, N., Roudsari, N. M., Zadeh, S. S. T., Momtaz, S., Abbasifard, M., Reiner, Ž., Abdolghaffari, A. H., & Sahebkar, A. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01077-w · Cited by 23 · see citing works

Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test

Gonçalves, F. M., Neis, V. B., Rieger, D. K., Peres, T. V., Lopes, M. W., Heinrich, I. A., Costa, A. P., Rodrigues, A. L. S., Kaster, M. P., & Leal, R. B. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1753-4 · Cited by 23 · see citing works

Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway

Camargo, A., Dalmagro, A. P., Fraga, D. B., Rosa, J. M., Zeni, A. L. B., Kaster, M. P., & Rodrigues, A. L. S. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05879-8 · Cited by 20 · see citing works

Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling

Camargo, A., Dalmagro, A. P., Rosa, J. M., Zeni, A. L. B., Kaster, M. P., Tasca, C. I., & Rodrigues, A. L. S. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104797 · Cited by 19 · see citing works

Involvement of agmatine in antidepressant-like effect of HMG-CoA reductase inhibitors in mice

Rahangdale, S. R., Fating, R., Gajbhiye, M., Kapse, M., Inamdar, N., Kotagale, N. R., Umekar, M. J., & Taksande, B. G. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173739 · Cited by 19 · see citing works

A low-dose combination of ketamine and guanosine counteracts corticosterone-induced depressive-like behavior and hippocampal synaptic impairments via mTORC1 signaling

Camargo, A., Dalmagro, A. P., Wolin, I. A. V., Siteneski, A., Zeni, A. L. B., & Rodrigues, A. L. S. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110371 · Cited by 17 · see citing works

Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders

Tarai, S., Mukherjee, R., Gupta, S., Rizvanov, A. A., Palotás, A., Pammi, V. S. C., & Bit, A. (2019) · Cognitive Neurodynamics · doi:10.1007/s11571-019-09522-3 · Cited by 16 · see citing works

Guanosine potentiates the antidepressant-like effect of subthreshold doses of ketamine: Possible role of pro-synaptogenic signaling pathway

Camargo, A., Dalmagro, A. P., Zeni, A. L. B., & Rodrigues, A. L. S. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.186 · Cited by 16 · see citing works

Effects of First High-Dose Atorvastatin Loading in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Li, Q., Zhao, Y., Wang, Z., Jiang, H., Liu, W., & Cao, B. (2016) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000370 · Cited by 15 · see citing works

Ilex paraguariensis hydroalcoholic extract exerts antidepressant-like and neuroprotective effects: involvement of the NMDA receptor and the l-arginine-NO pathway

Ludka, F. K., Tandler, L. D. F., Kuminek, G., Olescowicz, G., Jacobsen, J., & Molz, S. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000211 · Cited by 15 · see citing works

High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin

Okudan, N., & Belviranlı, M. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.09.019 · Cited by 14 · see citing works

Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of simvastatin in mice: Without tolerance and withdrawal syndrome

Dolatshahi, M., Davoudi, S., Paridar, Y., Naserzadeh, R., & Ghorbanzadeh, B. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134578 · Cited by 13 · see citing works

The Anti-Depressant Effects of Statins in Patients With Major Depression Post-Myocardial Infarction: An Updated Review 2022

Gutlapalli, S. D., Farhat, H., Irfan, H., Muthiah, K., Pallipamu, N., Taheri, S., Thiagaraj, S. S., Shukla, T. S., Giva, S., & Penumetcha, S. S. (2022) · Cureus · doi:10.7759/cureus.32323 · Cited by 13 · see citing works

17α-ethinyl estradiol attenuates depressive-like behavior through GABAA receptor activation/nitrergic pathway blockade in ovariectomized mice

Saravi, S. S. S., Arefidoust, A., Yaftian, R., Saravi, S. S. S., & Dehpour, A. R. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4242-9 · Cited by 13 · see citing works

Mammalian target of rapamycin (mTOR)/nitric oxide system possibly modulate antidepressant-like effect of 17α-ethinyl estradiol in ovariectomized mice

Saravi, S. S. S., Arefidoust, A., Saravi, S. S. S., Yaftian, R., Bayati, M., Salehi, M., & Dehpour, A. R. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.078 · Cited by 13 · see citing works

Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems

Lin, M., Li, H., Zhao, Y. H., Cai, E., Zhu, H., Gao, Y., Liu, S., Yang, H., Zhang, L., Tang, G., et al. (2017) · Molecules · doi:10.3390/molecules22040565 · Cited by 13 · see citing works

Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors

Vandresen-Filho, S., França, L. M., Alcantara-Junior, J., Nogueira, L. C., Brito, T. M., Lopes, L., Júnior, F. M., Vanzeler, M. L. A., Bertoldo, D. B., Dias, P. G., et al. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.024 · Cited by 13 · see citing works

Study on antidepressant activity of sesquiterpenoids from ginseng root

Ge, W., Li, H., Zhao, Y. H., Cai, E., Zhu, H., Gao, Y., Liu, S., Yang, H., & Zhang, L. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.057 · Cited by 12 · see citing works

Neuropharmacological and antiproliferative activity of Tetrastigma leucostaphyllum (Dennst.) Alston: Evidence from in-vivo, in-vitro and in-silico approaches

Rudra, S., Faruque, M. O., Tahamina, A., Emon, N. U., Haidar, I. K. A., & Uddin, S. B. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.04.027 · Cited by 11 · see citing works

Antidepressant-like Effect of Merazin Hydrate Depends on NO/ERK by Suppressing Its Downstream NF-κB or Nonactivating CREB/BDNF in Mouse Hippocampus

Wu, L., Liu, X., Huang, Y., Lu, C., Zhou, J., Ren, P., & Huang, X. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00246 · Cited by 10 · see citing works

Statins in depression: a repurposed medical treatment can provide novel insights in mental health

Giorgi, R. D., Cowen, P. J., & Harmer, C. J. (2022) · International Review of Psychiatry · doi:10.1080/09540261.2022.2113369 · Cited by 9 · see citing works

Pharmacological evaluation of NO/cGMP/KATP channels pathway in the antidepressant-like effect of carbamazepine in mice

Ajaman, M., Naserzadeh, R., & Ghorbanzadeh, B. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000600 · Cited by 9 · see citing works

Depression and Obesity

Schweinfurth, N., Walter, M., Borgwardt, S., & Lang, U. E. (2015) · Springer eBooks · doi:10.1007/978-3-319-19821-7_18 · Cited by 8 · see citing works

Multiple cellular targets involved in the antidepressant-like effect of glutathione

Dafré, A. L., Rosa, J. M., Rodrigues, A. L. S., & Cunha, M. P. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109195 · Cited by 8 · see citing works

Paradoxical effect of statin medication on depressive disorder in first-ever ischemic stroke patients: possible antidepressant-like effect prestroke and the opposite in continuous medication poststroke

Li, Y., Guo, Y., Zhou, M., Ma, M., Fang, J., & He, L. (2021) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000352 · Cited by 8 · see citing works

Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades

Pereira, V. S., Suavinha, A. C. D. R., Wegener, G., & Joca, S. R. L. (2019) · Acta Neuropsychiatrica · doi:10.1017/neu.2018.39 · Cited by 8 · see citing works

Latent Sex Differences in CaMKII-nNOS Signaling That Underlie Antidepressant-Like Effects of Yueju-Ganmaidazao Decoction in the Hippocampus

Yin, Y., Qian, S., Chen, Y., Sun, Y., Li, Y., Yu, Y., Li, J., Wu, Z., Yu, X., Ge, R., et al. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.640258 · Cited by 7 · see citing works

Guanosine boosts the fast, but not sustained, antidepressant-like and pro-synaptogenic effects of ketamine by stimulating mTORC1-driven signaling pathway

Camargo, A., Dalmagro, A. P., Delanogare, E., Fraga, D. B., Wolin, I. A. V., Zeni, A. L. B., Brocardo, P. S., & Rodrigues, A. L. S. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.12.010 · Cited by 7 · see citing works

NMDA receptor-mediated modulation on glutamine synthetase and glial glutamate transporter GLT-1 is involved in the antidepressant-like and neuroprotective effects of guanosine

Camargo, A., Dalmagro, A. P., Altê, G. A., Zeni, A. L. B., Tasca, C. I., & Rodrigues, A. L. S. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110440 · Cited by 6 · see citing works

Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl)benzofuran in male Swiss mice

Rech, T. D. S. T., Strelow, D. N., Krüger, L. D., Neto, J. S. S., Blödorn, G. B., Alves, D. A. C., Brüning, C. A., & Bortolatto, C. F. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02508-3 · Cited by 5 · see citing works

Neurotrophin levels at admission did not change significantly upon alcohol deprivation and were positively correlated with the BMI and LDL levels

Popa‐Wagner, A., Furczyk, K., Richter, J., Irmisch, G., & Thome, J. (2013) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-1-20 · Cited by 5 · see citing works

Engineering NO delivery system renormalizes the excitability of inhibitory interneurons after spinal cord injury via chloride extrusion

Wu, S., Qian, Y., Fan, Z., Lin, Q., Zhang, Q., Chen, Z., Pu, X., Chen, X., Guo, Q., Mao, N., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.07.022 · Cited by 4 · see citing works

EFFECT OF DIFFERENT STATINS IN ANIMAL MODEL OF ANXIETY IN WISTAR RATS

Vc, J., Ommurugan, B., & Chogtu, B. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i10.24222 · Cited by 4 · see citing works

A Call for Drug Therapies for the Treatment of Social Behavior Disorders in Dementia: Systematic Review of Evidence and State of the Art

Cerami, C., Perini, G., Panzavolta, A., Ramusino, M. C., & Costa, A. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911550 · Cited by 3 · see citing works

Brain derived neurotrophic factor has a role in the antidepressant effect of atorvastatin and fenofibrate in Wistar rats

Ali, E., & Abouelella, A. (2022) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2022.177123.1188 · Cited by 2 · see citing works

Novel strategy for treating neurotropic viral infections using hypolipidemic drug AtorvastatinPreprint

Mallick, S., Chakraborty, S., Hazra, B., Dev, S., Mukherjee, S., Wani, M. A., & Basu, A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/639096 · Cited by 2 · see citing works

Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development

Alcántara, A. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-709-0 · Cited by 1 · see citing works

The antidepressant effects of Atorvastatin are mediated by reduction of nitric oxide pathway in ovariectomized micePreprint

Jahanabadi, S., Safshekan, P. S., & Moradi, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1589414/v1 · Cited by 1 · see citing works

UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS BIOLÓGICAS PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS

Cunha, M. P. (2013)

Participação da via NMDA-NO do córtex pré-frontal medial ventral na modulação das consequências comportamentais do estresse de nado forçado: mecanismos intracelulares

Pereira, V. S. (2015) · doi:10.11606/t.17.2015.tde-07072015-084140

MLR-1023 Improves Cognition Deficiency and Oxidative Stress in Lipopolysaccharide-Induced Mice Model of Alzheimer’s Disease: Role of PPAR-gamma Receptors and NO-cGMP-KATP Channels Pathway

Dolatshahi, M., Hayay, Y., Mard‐Soltani, M., Paridar, Y., & Nazarinia, D. (2024) · Journal of Advanced Immunopharmacology · doi:10.5812/jai-149170

Associations between statin use and depressive disorders and suicidal behaviour

Roztocka, A., Radziszewski, K., Osiński, P., Szlęzak, Z. A., Kulinek, A. J., & Stefaniak, I. (2025) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2025.0017

In vivo Administration of Atorvastatin Does Not Impair Mitochondrial Function or Cellular Viability in the Prefrontal Cortex of Mice

Gessler, K. B., Rescaroli, J., Pires, S. M., Lippert, F. G. W., Spanamberg, E. S., Bernardes, G., Zavorne, I. M., Tasca, C. I., & Mancini, G. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00805-2

Exploring the antidepressant-like effects of atorvastatin in ovariectomized mice: involvement of the nitric oxide pathway

Jahanabadi, S., Safshekan, P. S., & Moradi, A. (2025) · Physiology and Pharmacology · doi:10.66224/phypha.29.4.464

Antidepressant-like effect of atorvastatin in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway

Shahsavarian, A., Javadi, S., Jahanabadi, S., Khoshnoodi, M., Shamsaee, J., Shafaroodi, H., Mehr, S. E., & Dehpour, A. R. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.004 · Cited by 41 · see citing works

Simvastatin exerts antidepressant-like activity in mouse forced swimming test: Role of NO-cGMP-KATP channels pathway and PPAR-gamma receptors

Naserzadeh, R., Abad, N., Ghorbanzadeh, B., Dolatshahi, M., & Mansouri, M. T. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.03.002 · Cited by 27 · see citing works

Exploring the antidepressant-like effects of atorvastatin in ovariectomized mice: involvement of the nitric oxide pathway

Jahanabadi, S., Safshekan, P. S., & Moradi, A. (2025) · Physiology and Pharmacology · doi:10.66224/phypha.29.4.464

Atorvastatin evokes a serotonergic system-dependent antidepressant-like effect in mice

Ludka, F. K., Constantino, L. C., Kuminek, G., Binder, L. B., Zomkowski, A. D. E., Cunha, M. P., Dal-Cim, T. A., Rodrigues, A. L. S., & Tasca, C. I. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.04.005 · Cited by 27 · see citing works

Brain derived neurotrophic factor has a role in the antidepressant effect of atorvastatin and fenofibrate in Wistar rats

Ali, E., & Abouelella, A. (2022) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2022.177123.1188 · Cited by 2 · see citing works