The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?
Open accessAbstract
While the hippocampal formation and the prefrontal cortex each have a well-established role in cognitive and mnemonic processes, the extent and manner in which these structures interact to achieve these functions has not been fully delineated. Recent research in rodents compellingly supports the idea that the projection of neurons extending from the CA1 region of the hippocampus and from the subiculum to the prefrontal cortex, referred to here as the H-PFC pathway, is critically involved in aspects of cognition related to executive function and to emotional regulation. Concurrently, it is becoming evident that persons suffering from schizophrenia, depression, and post-traumatic stress disorder display structural anomalies and aberrant functional coupling within the hippocampal-prefrontal circuit. Considering that these disorders involve varying degrees of cognitive impairment and emotional dysregulation, dysfunction in the H-PFC pathway might therefore be the common element of their pathophysiology. This overlap might also be intertwined with the pathway's evident susceptibility to stress and with its relationship to the amygdala. In consequence, the H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.
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Cites
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“Together, this profile of findings demonstrates the H-PFC pathway is highly sensitive to stress, an effect consistent with findings from a number of labs, namely that the hippocampus, mPFC, and amygdala all play critical roles in the brain’s stress response (McEwen, 2007).”
Deep Brain Stimulation for Treatment-Resistant Depression
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Cited by
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
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Prefrontal-Hippocampal Interactions in Memory and Emotion
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“…are associated with decreased mnemonic ability as well as disrupted emotional control, which are major symptoms of psychiatric disorders such as schizophrenia, depression, specific phobia, and post-traumatic stress disorder (PTSD; Sigurdsson et al., 2010; Godsil et al., 2013; Maren et al., 2013).”
BackgroundHippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease
Sigurdsson, T., & Duvarci, S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00190 · Cited by 309
Murray, E., Fernandes, M., Fazel, M., Kennedy, S., Villar, J., & Stein, A. (2015) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13435 · Cited by 273
Metadata
- Authors
- Godsil, B. P., Kiss, J. P., Spedding, M., & Jay, T. M.
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 23
- Issue
- 10
- Pages
- 1165-1181
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2088396693
- Cited by
- 434
- References
- 190
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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