Differential effects of antipsychotic drugs on insight in first episode schizophrenia: Data from the European First-Episode Schizophrenia Trial (EUFEST)

Pijnenborg, G.H.M.; Timmerman, M.E.; Derks, E.M.; Fleischhacker, W.W.; Kahn, R.S.; Aleman, A.

doi:10.1016/j.euroneuro.2015.02.012

Cited by 35Schizophrenia research and treatmentMental Health and PsychiatryBipolar Disorder and Treatment

Differential effects of antipsychotic drugs on insight in first episode schizophrenia: Data from the European First-Episode Schizophrenia Trial (EUFEST)

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Pijnenborg, G.H.M., Timmerman, M.E., Derks, E.M., Fleischhacker, W.W., Kahn, R.S., Aleman, A.·2015·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2015.02.012

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Abstract

Although antipsychotics are widely prescribed, their effect of on improving poor illness insight in schizophrenia has seldom been investigated and therefore remains uncertain. This paper examines the effects of low dose haloperidol, amisulpride, olanzapine, quetiapine, and ziprasidone on insight in first-episode schizophrenia, schizoaffective disorder, or schizophreniform disorder. The effects of five antipsychotic drugs in first episode psychosis on insight were compared in a large scale open randomized controlled trial conducted in 14 European countries: the European First-Episode Schizophrenia Trial (EUFEST). Patients with at least minimal impairments in insight were included in the present study (n=455). Insight was assessed with item G12 of the Positive and Negative Syndrome Scale (PANSS), administered at baseline and at 1, 3, 6, 9, and 12 months after randomization. The use of antipsychotics was associated with clear improvements in insight over and above improvements in other symptoms. This effect was most pronounced in the first three months of treatment, with quetiapine being significantly less effective than other drugs. Effects of spontaneous improvement cannot be ruled out due to the lack of a placebo control group, although such a large spontaneous improvement of insight would seem unlikely.

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In first-episode psychosis, antipsychotic medications have a general effect of improving insight beyond symptom reduction, especially in the first three months of trials.
“Pijnenborg et al 173 analyzed the effects of various antipsychotic drugs across trials for first-episode psychosis and observed a general effect of medications in leading to improved insight above gains that could be accounted for by symptom reduction, especially in the first three months of the trials.”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [173]

The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
Untitled work
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Untitled work
(1998) · PubMed · Cited by 10,216 · see citing works
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,882 · see citing works
The UKU side effect rating scale: A new comprehensive rating scale for psychotropic drugs and a cross‐sectional study of side effects in neuroleptic‐treated patients
Lingjærde, O., Ahlfors, U. G., Bech, P., Dencker, S. J., & Elgen, K. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb10566.x · Cited by 1,705 · see citing works
Handbook of Psychiatric Measures
Salzman, C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1343 · Cited by 1,172 · see citing works
Insight and Psychosis
David, A. S. (1990) · The British Journal of Psychiatry · doi:10.1192/bjp.156.6.798 · Cited by 1,164 · see citing works
Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial
Kahn, R. S., Fleischhacker, W. W., Boter, H., Davidson, M., Vergouwe, Y., Keet, I. P., Gheorghe, M. D., Rybakowski, J. K., Galderisi, S., Libiger, J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60486-9 · Cited by 1,088 · see citing works
Application and Results of the Manchester Short Assessment of Quality of Life (Mansa)
Priebe, S., Huxley, P., Knight, S., & Evans, S. (1999) · International Journal of Social Psychiatry · doi:10.1177/002076409904500102 · Cited by 1,071 · see citing works
A Brief Mental Health Outcome Scale
Jones, S. H., Thornicroft, G., Coffey, M., & Dunn, G. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.166.5.654 · Cited by 1,019 · see citing works
Handbook of Psychiatric Measures
Rush, A. J., First, M. B., & Blacker, D. (2000) · Medical Entomology and Zoology · Cited by 846 · see citing works
Reliability and validity of a depression rating scale for schizophrenics
Addington, D., Addington, J., Maticka-Tyndale, E., & Joyce, J. (1992) · Schizophrenia Research · doi:10.1016/0920-9964(92)90003-n · Cited by 651 · see citing works
Insight in schizophrenia: a meta-analysis
Mintz, A. R., Dobson, K. S., & Romney, D. M. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00316-x · Cited by 563 · see citing works
Correlates and Long-Term Consequences of Poor Insight in Patients With Schizophrenia. A Systematic Review
Lincoln, T. M., Lullmann, E., & Rief, W. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm002 · Cited by 486 · see citing works
Descriptive Statistics
Woolson, R. F., & Clarke, W. R. (2002) · Wiley series in probability and statistics · doi:10.1002/9781118033050.ch2 · Cited by 347 · see citing works
A Randomized, Controlled Trial of Cognitive Behavioral Social Skills Training for Middle-Aged and Older Outpatients With Chronic Schizophrenia
Granholm, E. L., McQuaid, J. R., McClure, F. S., Auslander, L. A., Perivoliotis, D., Pedrelli, P., Patterson, T. L., & Jeste, D. V. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.3.520 · Cited by 339 · see citing works
A comparative study of insight scales and their relationship to psychopathological and clinical variables
Sanz, M. A. G., CONSTABLE, G., Lopez-Ibor, I., KEMP, R., & David, A. S. (1998) · Psychological Medicine · doi:10.1017/s0033291797006296 · Cited by 264 · see citing works
A User's Guide To Mlwin
Rasbash, J., Steele, F., Browne, W. J., Charlton, C., & Lang, I. C. (2015) · Cited by 255 · see citing works
Insight in Schizophrenia: Involvement of Self-Reflection Networks?
van der Meer, L., de Vos, A. E., Stiekema, A. P. M., Pijnenborg, G. H. M., van Tol, M., Nolen, W. A., David, A. S., & Aleman, A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs122 · Cited by 221 · see citing works
Early insight predicts depression and attempted suicide after 4 years in first‐episode schizophrenia and schizophreniform disorder
Crumlish, N., Whitty, P., Kamali, M., Clarke, M., Browne, S., McTigue, O., Lane, A., Kinsella, A., Larkin, C., & O’Callaghan, E. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00620.x · Cited by 190 · see citing works
The St. Hans Rating Scale for extrapyramidal syndromes: reliability and validity
Gerlach, J., Korsgaard, S., Clemmesen, P., Lauersen, A. ‐. L., Magelund, G., Noring, U., Povlsen, U. J., Bech, P., & Casey, D. E. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03366.x · Cited by 166 · see citing works
Evaluation of a psychoeducation program for Chinese clients with schizophrenia and their family caregivers
Chan, S. W., Yip, B., Tso, S., Cheng, B.-S., & Tam, W. (2008) · Patient Education and Counseling · doi:10.1016/j.pec.2008.08.028 · Cited by 162 · see citing works
Outcomes of an effectiveness trial of cognitive–behavioural intervention by mental health nurses in schizophrenia
Turkington, D., Kingdon, D., Rathod, S., Hammond, K., Pelton, J., & Mehta, R. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.bp.105.010884 · Cited by 151 · see citing works
Effect of Antipsychotic Medication Alone vs Combined With Psychosocial Intervention on Outcomes of Early-Stage Schizophrenia: A Randomized, 1-Year Study
Guo, X., Zhai, J., Liu, Z., Fang, M., Wang, B., Wang, C., Hu, B., Sun, X., Lv, L., Lu, Z., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.105 · Cited by 142 · see citing works
Insight in first-episode psychosis
McEvoy, J. P., Johnson, J. K., Perkins, D. O., Lieberman, J. A., Hamer, R. M., Keefe, R. S. E., Tohen, M. F., Glick, I. D., & Sharma, T. (2006) · Psychological Medicine · doi:10.1017/s0033291706007793 · Cited by 124 · see citing works
Patient and relative education in community psychiatry: a randomized controlled trial regarding its effectiveness
Merinder, L. B., Viuff, A. G., Laugesen, H., Clemmensen, K., Misfelt, S., & Espensen, B. (1999) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s001270050146 · Cited by 123 · see citing works
Insight as a Predictor of the Outcome of First-Episode Nonaffective Psychosis in a Prospective Cohort Study in England
Drake, R., Dunn, G., Tarrier, N., Bentall, R. P., Haddock, G., & Lewis, S. W. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0111 · Cited by 123 · see citing works
Insight and psychosis
X. F. Amador, A. S. D. (1999) · Nordic Journal of Psychiatry · doi:10.1080/080394899427737 · Cited by 122 · see citing works
A prospective evaluation of adherence to medication in first episode schizophrenia
Kamali, M., Kelly, B. D., Clarke, M., Browne, S., Gervin, M., Kinsella, A., Lane, A., Larkin, C., & O’Callaghan, E. (2006) · European Psychiatry · doi:10.1016/j.eurpsy.2005.05.015 · Cited by 119 · see citing works
Cannabis use in children and adolescents with first episode psychosis: Influence on psychopathology and short-term outcome (CAFEPS study)
Baeza, I., Graell, M., Moreno, D. M., Castro‐Fornieles, J., Parellada, M., González-Pinto, A. M., Payá, B., Soutullo, C. A., de la Serna, E., & Arango, C. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.04.005 · Cited by 116 · see citing works
Insight and Psychosocial Treatment Compliance in Schizophrenia
Lysaker, P. H., Bell, M. D., Milstein, R., BRYSON, G. J., & Goulet, J. L. (1994) · Psychiatry · doi:10.1080/00332747.1994.11024695 · Cited by 111 · see citing works
Trait and State Attributes of Insight in First Episodes of Early-Onset Schizophrenia and Other Psychoses: A 2-Year Longitudinal Study
Parellada, M., Boada, L., Fraguas, D., Reig, S., Castro‐Fornieles, J., Moreno, D. M., González-Pinto, A. M., Otero, S., Rapado‐Castro, M., Graell, M., et al. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq109 · Cited by 111 · see citing works
Changes in insight during treatment for psychotic disorders: A meta-analysis
Pijnenborg, G. H. M., van Donkersgoed, R. J. M., David, A. S., & Aleman, A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.018 · Cited by 106 · see citing works
Insight in Psychosis: Relationship With Neurocognition, Social Cognition and Clinical Symptoms Depends on Phase of Illness
Quee, P. J., van der Meer, L., Bruggeman, R., de Haan, L., A, L. K. M., Cahn, W., Mulder, N. C. L., Wiersma, D., & Aleman, A. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq133 · Cited by 105 · see citing works
The association of insight with psychotic symptoms, depression, and cognition in early psychosis: A 3-year follow-up
Saeedi, H., Addington, J., & Addington, D. E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.09.018 · Cited by 102 · see citing works
The European First Episode Schizophrenia Trial (EUFEST): Rationale and design of the trial
Fleischhacker, W. W., Keet, I. P. M., & Kahn, R. S. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.06.004 · Cited by 100 · see citing works
A randomised controlled trial of cognitive behaviour therapy for psychosis in a routine clinical service
Peters, E., Landau, S., McCrone, P., Cooke, M. A., Fisher, P., Steel, C., Evans, R., Carswell, K., Dawson, K., Williams, S., et al. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01572.x · Cited by 91 · see citing works
Insight in schizophrenia: associations with empathy
Pijnenborg, G. H. M., Spikman, J. M., Jeronimus, B. F., & Aleman, A. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0373-0 · Cited by 65 · see citing works
Insight, global functioning and psychopathology amongst in-patient clients with schizophrenia
Stefanopoulou, E., Lafuente, A. R., Saez Fonseca, J. A., & Huxley, A. (2009) · Psychiatric Quarterly · doi:10.1007/s11126-009-9103-9 · Cited by 51 · see citing works
Insight correlates in child- and adolescent-onset first episodes of psychosis: results from the CAFEPS study
Parellada, M., Fraguas, D., Bombín, I., Otero, S., Castro‐Fornieles, J., Baeza, I., González-Pinto, A. M., Graell, M., Soutullo, C. A., Payá, B., et al. (2008) · Psychological Medicine · doi:10.1017/s0033291708004868 · Cited by 49 · see citing works
Effects of clozapine on awareness of illness and cognition in schizophrenia
Pallanti, S., Quercioli, L., & Pazzagli, A. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00033-5 · Cited by 46 · see citing works
TRIP: a psycho‐educational programme in Hong Kong for people with schizophrenia
Chan, S. H., Lee, S. W., & Chan, I. W. M. (2007) · Occupational Therapy International · doi:10.1002/oti.226 · Cited by 40 · see citing works
Insight: Demographic Differences and Associations with One-Year Outcome in Schizophrenia and Schizoaffective Disorder
Wiffen, B. D. R., Rabinowitz, J., Fleischhacker, W. W., & David, A. S. (2010) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.4.3.3 · Cited by 36 · see citing works
Insight in schizophrenia–course and predictors during the acute treatment phase of patients suffering from a schizophrenia spectrum disorder
Schennach, R., Meyer, S., Seemüller, F., Jäger, M., Schmauss, M., Laux, G., Pfeiffer, H., Naber, D., Schmidt, L. G., Gaebel, W., et al. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2012.01.001 · Cited by 32 · see citing works
Effects of Aripiprazole on Insight and Subjective Experience in Individuals With an At-Risk Mental State
Kobayashi, H., Morita, K., Takeshi, K., Koshikawa, H., Yamazawa, R., Kashima, H., & Mizuno, M. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181b2fe22 · Cited by 29 · see citing works
Insight change in psychosis: relationship with neurocognition, social cognition, clinical symptoms and phase of illness
Quee, P. J., van der Meer, L., Krabbendam, L., de Haan, L., Cahn, W., Wiersma, D., van Beveren, N., Pijnenborg, G. H. M., Mulder, C. L., Bruggeman, R., et al. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12138 · Cited by 29 · see citing works
The nature and evolution of insight in schizophrenia: A multi-informant longitudinal study of first-episode versus chronic patients
Koren, D., Viksman, P., Giuliano, A. J., & Seidman, L. J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.10.013 · Cited by 29 · see citing works
Effects of antipsychotic drugs on insight in schizophrenia
Bianchini, O., Porcelli, S., Nespeca, C., Cannavò, D., Trappoli, A., Aguglia, E., De Ronchi, D., & Serretti, A. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.03.022 · Cited by 16 · see citing works
Insight change and its relationship to subjective well-being during acute atypical antipsychotic treatment in schizophrenia
Kim, J., Ann, J.-H., & Lee, J. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2010.01230.x · Cited by 8 · see citing works

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Phahladira, L. S., Asmal, L., Kilian, S., Chiliza, B., Scheffler, F., Luckhoff, H. K., du Plessis, S., & Emsley, R. A. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.10.013 · Cited by 34 · see citing works
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Leucht, S., Arango, C., & López-Moríñigo, J.-D. (2022) · Pharmacopsychiatry · doi:10.1055/a-1854-0185 · Cited by 33 · see citing works
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Dondé, C., Laprévote, V., Lavallé, L., Haesebaert, F., Fakra, É., & Brunelin, J. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12993 · Cited by 25 · see citing works
Social cognitive group treatment for impaired insight in psychosis: A multicenter randomized controlled trial
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The impact of second generation antipsychotics on insight in schizophrenia: results from 14 randomized, placebo controlled trials
Mattila, T., Koeter, M., Wohlfarth, T., Storosum, J., van den Brink, W., Derks, E., Leufkens, H., & Denys, D. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.10.004 · Cited by 18 · see citing works
Modeling the Longitudinal Effects of Insight on Depression, Quality of Life and Suicidality in Schizophrenia Spectrum Disorders: Results from the FACE-SZ Cohort
Ehrminger, M., Urbach, M., Passerieux, C., Aouizerate, B., Berna, F. S., Bohec, A.-L., Capdevielle, D., Chéreau, I., Clauss, J. M. E., Dubertret, C., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081196 · Cited by 18 · see citing works
Effects of antipsychotics on insight in schizophrenia: results from independent samples of first-episode and acutely relapsed patients
Misiak, B., Frydecka, D., Beszłej, J. A., Moustafa, A. A., Tybura, P., Kucharska-Mazur, J., Samochowiec, A., Bieńkowski, P., & Samochowiec, J. (2016) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000120 · Cited by 14 · see citing works
Insight into illness and its relationship to illness severity, cognition and estimated antipsychotic dopamine receptor occupancy in schizophrenia: An antipsychotic dose reduction study
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Clarifying associations between cortical thickness, subcortical structures, and a comprehensive assessment of clinical insight in enduring schizophrenia
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Yun, J., Lee, J. S., Kang, S. H., Nam, B., Lee, S. J., Lee, S., Choi, J., Kim, C., & Chung, Y. (2019) · Korean Journal of Schizophrenia Research · doi:10.16946/kjsr.2019.22.2.21 · Cited by 5 · see citing works
El abordaje temprano y tratamiento mixto en el manejo de la esquizofrenia
Salcedo, L. A. V., Arévalo, E. T., Marín, R. Á. V., Valenzuela, C. A. S., de la Cruz, M. S., Clavijo, G. M. C., Huamán, K., Bonilla, C., Puma, N. R., & Caballero, P. (2019) · Anales de la Facultad de Medicina · doi:10.15381/anales.803.16869 · Cited by 4 · see citing works
Brexpiprazole in the Management of Schizophrenia: A Consensus Report of Best Practices From Acute to Maintenance Treatment
Correll, C. U., Mafi, C. E., Fagiolini, A. M., Seerden, P., Seifritz, E., Tiihonen, J., Vita, A., & Citrome, L. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s539306 · Cited by 3 · see citing works
Levels of and changes in psychosis symptoms and clinical insight: Exploring the impact of differential antipsychotic mechanisms
Stabell, L. A., Johnsen, E., Kroken, R. A., Løberg, E., Kjelby, E., Joa, I., Reitan, S. K., Rettenbacher, M. A., Hugdahl, K., & Gjestad, R. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.116948 · Cited by 3 · see citing works
Evaluation of anti-liver cancer activity and anticancer mechanism of one novel small molecule compound (THY-10A62) targeting FAK pathway
Huang, W., Zou, R., Xu, J., Deng, Y., Zhang, D., Hu, Y., Zhang, Q., Huang, J., & Zhang, Z. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1498005 · Cited by 1 · see citing works
Ziprasidone, Zuclopenthixole, and Fluspirilene in the Treatment of Psychosis
Rodrígues-Amorím, D., & Olivares, J. M. (2021) · Springer eBooks · doi:10.1007/978-3-319-56015-1_415-1
Verbetering ziekte-inzicht door antipsychotica
van Loghum, B. S. (2015) · Psychopraktijk · doi:10.1007/s13170-015-0076-0
Ziprasidone, Zuclopenthixole, and Fluspirilene in the Treatment of Psychosis
Rodrígues-Amorím, D., & Olivares, J. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_415
Changes in insight and outcome over the early course of first-episode psychosis. The OPTiMiSE trial
López-Moríñigo, J.-D., Díaz‐Caneja, C. M., Galvañ, J., Fraguas, D., Moreno, C., Berger, G., Leucht, S., Rossum, I. W.-V., David, A. L., & Arango, C. (2026) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2026.100441
Clinical insight in schizophrenia: Time-specific associations with symptoms, cognition and antipsychotic mechanisms
Stabell, L. A., Johnsen, E., Kroken, R. A., Løberg, E., Joa, I., Reitan, S. K., Rettenbacker, M., & Gjestad, R. (2026) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2026.100463

Do Antipsychotics Affect Insight in Psychosis Differentially? Data From the EUFEST Trial.
Pijnenborg, G. H. M., Timmerman, M. E., Derks, E. M., Fleischhacker, W. W., Kahn, R. S., & Aleman, A. (2015) · European Psychiatry · doi:10.1016/s0924-9338(15)30194-2
A meta-analysis of randomised clinical trials comparing olanzapine with other antipsychotic agents used in the treatment of schizophrenia
Croker, V., Coleman, K. A., Mudge, M., Aldridge, G., Davey, P., & Castle, D. J. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)80448-6
Clinical insight among persons with schizophrenia spectrum disorders treated with amisulpride, aripiprazole or olanzapine: a semi-randomised trial
Stabell, L. A., Johnsen, E., Kroken, R. A., Løberg, E., Blindheim, A. A., Joa, I., Reitan, S. K., Rettenbacher, M. A., Munk‐Jørgensen, P., & Gjestad, R. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04981-9 · Cited by 5 · see citing works
T206. ANTIPSYCHOTIC EFFECTIVENESS FOCUSING ON INSIGHT
Stabell, L. A., Johnsen, E., Kroken, R. A., Løberg, E., Joa, I., Reitan, S. K., Rettenbacher, M. A., & Gjestad, R. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa029.766
Effects of antipsychotics on insight in schizophrenia: results from independent samples of first-episode and acutely relapsed patients
Misiak, B., Frydecka, D., Beszłej, J. A., Moustafa, A. A., Tybura, P., Kucharska-Mazur, J., Samochowiec, A., Bieńkowski, P., & Samochowiec, J. (2016) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000120 · Cited by 14 · see citing works

Authors: Pijnenborg, G. H. M., Timmerman, M. E., Derks, E. M., Fleischhacker, W. W., Kahn, R. S., & Aleman, A.
Affiliations: University Medical Center Groningen (NL)
University of Groningen (NL)
Amsterdam UMC Location University of Amsterdam (NL)
Innsbruck Medical University (AT)
University Medical Center Utrecht (NL)
Corresponding author: Pijnenborg, G.H.M.
ORCID: Pijnenborg, G.H.M.
Timmerman, M.E.
Derks, E.M.
Kahn, R.S.
Aleman, A.
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2015-06
Volume: 25
Issue: 6
Pages: 808-816
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2015.02.012
OpenAlex: W2154444128
Cited by: 35
References: 49
Citations by year: 2026: 3 · 2025: 2 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 8 · 2018: 7 · 2017: 1 · 2016: 2 · 2015: 1
FWCI: 2.97
Type: journal article
Language: en
Open access: green
dspace.library.uu.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Pure Amsterdam UMC (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: AstraZeneca
Sanofi
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords: antipsychotic drugs, insight, first-episode schizophrenia, first-episode psychosis, haloperidol, amisulpride, olanzapine, quetiapine, ziprasidone, schizoaffective disorder, schizophreniform disorder, spontaneous improvement
MeSH terms: Adolescent, Adult, Analysis of Variance, Dose-Response Relationship, Drug, Europe, Female, Humans, Longitudinal Studies, Male, Psychiatric Status Rating Scales, Retrospective Studies, Schizophrenia, Antipsychotic Agents, Treatment Outcome, Young Adult

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Differential effects of antipsychotic drugs on insight in first episode schizophrenia: Data from the European First-Episode Schizophrenia Trial (EUFEST)

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