PEGylated Protein Drugs: Basic Science and Clinical Applications

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

Turecek, P. L., Bossard, M. J., Schoetens, F., & Ivens, I. A. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2015.11.015 · Cited by 733 · see citing works

State of the art in PEGylation: The great versatility achieved after forty years of research

Pasut, G., & Veronese, F. M. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.10.037 · Cited by 725 · see citing works

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval.

Hwang, D., Ramsey, J. D., & Kabanov, A. V. (2020) · Advanced drug delivery reviews · doi:10.1016/j.addr.2020.09.009 · Cited by 699 · see citing works

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

Kozma, G. T., Shimizu, T., Ishida, T., & Szebeni, J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.024 · Cited by 696 · see citing works

Polymer therapeutics-prospects for 21st century: The end of the beginning

Duncan, R., & Vicent, M. J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.012 · Cited by 411 · see citing works

Delivery strategies for sustained drug release in the lungs

Loira-Pastoriza, C., Todoroff, J., & Rita Vanbever, A. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.017 · Cited by 395 · see citing works

Polymer–drug conjugates: Origins, progress to date and future directions

Kopec̆ek, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.014 · Cited by 348 · see citing works

Green and Bio-Based Solvents

Calvo‐Flores, F. G., Monteagudo-Arrebola, M. J., Dobado, J. A., & Isac‐García, J. (2018) · Topics in Current Chemistry · doi:10.1007/s41061-018-0191-6 · Cited by 343 · see citing works

Surface Engineering of Liposomes for Stealth Behavior

Nag, O. K., & Awasthi, V. (2013) · Pharmaceutics · doi:10.3390/pharmaceutics5040542 · Cited by 322 · see citing works

Ph-responsive polymer–drug conjugates: design and progress

Pang, X., Jiang, Y., Xiao, Q., Leung, A. W., Hua, H., & Xu, C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.024 · Cited by 317 · see citing works

Administration, distribution, metabolism and elimination of polymer therapeutics

Markovsky, E., Baabur‐Cohen, H., Eldar‐Boock, A., Omer, L., Tiram, G., Ferber, S., Ofek, P., Polyak, D., Scomparin, A., & Satchi‐Fainaro, R. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.021 · Cited by 313 · see citing works

The enhanced permeability retention effect: a new paradigm for drug targeting in infection

Azzopardi, E., Ferguson, E. L., & Thomas, D. W. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks379 · Cited by 312 · see citing works

Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics

Verhoef, J. J. F., Carpenter, J. F., Anchordoquy, T. J., & Schellekens, H. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.08.015 · Cited by 267 · see citing works

Polymer therapeutics as nanomedicines: new perspectives

Duncan, R. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.05.507 · Cited by 252 · see citing works

Polysarcosine-containing copolymers: synthesis, characterization, self-assembly, and applications

Birke, A., Ling, J., & Barz, M. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.01.002 · Cited by 229 · see citing works

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

Doak, S. H., Manshian, B. B., Jenkins, G. J. S., & Singh, N. (2011) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2011.09.013 · Cited by 234 · see citing works

Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

Jeong, M., Lee, Y., Park, J., Jung, H., & Lee, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114990 · Cited by 227 · see citing works

Poly(2-oxazoline)s as materials for biomedical applications

de la Rosa, V. R. (2013) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-013-5034-y · Cited by 220 · see citing works

The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes

Kierstead, P. H., Okochi, H., Venditto, V. J., Chuong, T. C., Kivimae, S., Fréchet, J. M. J., & Szoka, F. C. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.023 · Cited by 210 · see citing works

Process for protein PEGylation

Pfister, D., & Morbidelli, M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.02.002 · Cited by 207 · see citing works

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

Sapuła, P., Bialik-Wąs, K., & Malarz, K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010253 · Cited by 203 · see citing works

Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials

Edwards‐Gayle, C. J. C., & Hamley, I. W. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob01092c · Cited by 195 · see citing works

Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A

Tiede, A., Brand, B., Fischer, R. J., Kavaklı, K., Lentz, S. R., Matsushita, T., Rea, C. J., Knobe, K. E., & Viuff, D. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12161 · Cited by 171 · see citing works

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

Baumann, A., Tuerck, D., Prabhu, S., Dickmann, L. J., & Sims, J. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.06.002 · Cited by 163 · see citing works

Amphiphilic poly(l-amino acids) — New materials for drug delivery

Lalatsa, A., Schätzlein, A. G., Mazza, M., Le, T. B. H., & Uchegbu, I. F. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.046 · Cited by 163 · see citing works

Pharmacokinetics, pharmacodynamics and safety of aptamers

Kovacevic, K. D., Gilbert, J. C., & Jilma, B. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.008 · Cited by 162 · see citing works

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

Lu, D., Yan, Y., Avila, R. O., Kandela, I. K., Stepien, I., Seo, M., Bai, W., Yang, Q., Li, C., Haney, C. R., et al. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000942 · Cited by 153 · see citing works

Anti-PEG IgE in anaphylaxis associated with polyethylene glycol

Zhou, Z., Stone, C. A., Jakubovic, B. D., Phillips, E. J., Sussman, G., Park, J., Hoang, U., Kirshner, S., Levin, R. L., & Kozlowski, S. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.11.011 · Cited by 134 · see citing works

Effects of pharmaceutical PEGylation on drug metabolism and its clinical concerns

Zhang, X., Wang, H., Ma, Z., & Wu, B. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.967679 · Cited by 117 · see citing works

POxylation as an alternative stealth coating for biomedical applications

Bludau, H., Czapar, A. E., Pitek, A. S., Shukla, S., Jordan, R., & Steinmetz, N. F. (2017) · European Polymer Journal · doi:10.1016/j.eurpolymj.2016.10.041 · Cited by 112 · see citing works

Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins

Saifer, M. G. P., Williams, L. D., Sobczyk, M. A., Michaels, S. J., & Sherman, M. R. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.07.014 · Cited by 112 · see citing works

Sub-lethal toxicity of chlorpyrifos alone and in combination with polyethylene glycol to common carp (Cyprinus carpio)

Hatami, M., Banaee, M., & Haghi, B. N. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.12.077 · Cited by 105 · see citing works

Chemoenzymatic Reversible Immobilization and Labeling of Proteins without Prior Purification

Rashidian, M., Song, J. M., Pricer, R. E., & Distefano, M. D. (2012) · Journal of the American Chemical Society · doi:10.1021/ja211308s · Cited by 100 · see citing works

Targeting Peptides: The New Generation of Targeted Drug Delivery Systems

Todaro, B., Ottalagana, E., Luin, S., & Santi, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061648 · Cited by 100 · see citing works

Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

McSweeney, M. D., Price, L., Wessler, T., Ciociola, E. C., Herity, L. B., Piscitelli, J. A., DeWalle, A. C., Harris, T. N., Chan, A. K. P., Saw, R. S., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.08.017 · Cited by 99 · see citing works

Hydroxyethyl starch stabilized polydopamine nanoparticles for cancer chemotherapy

Wu, H., Hu, H., Wan, J., Li, Y., Wu, Y., Tang, Y., Xiao, C., Xu, H., Yang, X., & Li, Z. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.05.082 · Cited by 97 · see citing works

From design to the clinic: practical guidelines for translating cardiovascular nanomedicine

Cicha, I., Chauvierre, C., Texier, I., Cabella, C., Metselaar, J. M., Szebeni, J., Dézsi, L., Alexiou, C., Rouzet, F., Storm, G., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy219 · Cited by 97 · see citing works

Low-energy-consumption electrochemical CO2 capture driven by biomimetic phenazine derivatives redox medium

Xie, H., Wu, Y., Liu, T., Wang, F., Chen, B., & Liang, B. (2019) · Applied Energy · doi:10.1016/j.apenergy.2019.114119 · Cited by 96 · see citing works

Oral inhalation for delivery of proteins and peptides to the lungs

Fröhlich, E., & Salar-Behzadi, S. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.04.003 · Cited by 92 · see citing works

Fast separation of large biomolecules using short monolithic columns

Podgornik, A., Yamamoto, S., Peterka, M., & Krajnc, N. L. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.02.004 · Cited by 91 · see citing works

Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice

Emam, S. E., Elsadek, N. E., Lila, A. S. A., Takata, H., Kawaguchi, Y., Shimizu, T., Ando, H., Ishima, Y., & Ishida, T. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.001 · Cited by 91 · see citing works

A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse

McSweeney, M. D., Wessler, T., Price, L., Ciociola, E. C., Herity, L. B., Piscitelli, J. A., Zamboni, W. C., Forest, M. G., Cao, Y., & Lai, S. K. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.06.002 · Cited by 86 · see citing works

Hematopoietic Stem and Progenitor Cell Mobilization in Mice and Humans by a First-in-Class Mirror-Image Oligonucleotide Inhibitor of CXCL12

Vater, A., Sahlmann, J., Kröger, N., Zöllner, S. K., Lioznov, M. V., Maasch, C., Buchner, K., Vossmeyer, D., Schwoebel, F., Purschke, W. G., et al. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.58 · Cited by 84 · see citing works

Aqueous phase polymeric corrosion inhibitors: Recent advancements and future opportunities

Verma, C., Quraishi, M. A., & Rhee, K. Y. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.118387 · Cited by 81 · see citing works

Macromolecular therapeutics

Yang, J., & Kopec̆ek, J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.013 · Cited by 79 · see citing works

Chemical Approaches to Synthetic Drug Delivery Systems for Systemic Applications

Braatz, D., Cherri, M., Tully, M., Dimde, M., Ma, G., Mohammadifar, E., Reisbeck, F., Ahmadi, V., Schirner, M., & Haag, R. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202203942 · Cited by 78 · see citing works

Recommendations for the characterization of immunogenicity response to multiple domain biotherapeutics

Gorovits, B., Wakshull, E., Pillutla, R. C., Xu, Y., Manning, M. S., & Goyal, J. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.05.010 · Cited by 78 · see citing works

Protein HESylation for half-life extension: Synthesis, characterization and pharmacokinetics of HESylated anakinra

Liebner, R., Mathaes, R., Meyer, M., Hey, T., Winter, G., & Besheer, A. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.03.010 · Cited by 75 · see citing works

Design Rationale and Development Approach for Pegfilgrastim as a Long-Acting Granulocyte Colony-Stimulating Factor

Arvedson, T., O’Kelly, J., & Yang, B. (2015) · BioDrugs · doi:10.1007/s40259-015-0127-4 · Cited by 74 · see citing works

Protein Engineering Strategies for Improved Pharmacokinetics

Rondon, A., Mahri, S., Morales-Yánez, F., Dumoulin, M., & Rita Vanbever, A. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202101633 · Cited by 71 · see citing works

Polysarcosine brush stabilized gold nanorods for in vivo near-infrared photothermal tumor therapy

Zhu, H., Chen, Y., Yan, F., Chen, J., Tao, X., Ling, J., Yang, B., He, Q., & Mao, Z. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.12.050 · Cited by 70 · see citing works

Pharmacokinetic, Biodistribution, and Biophysical Profiles of TNF Nanobodies Conjugated to Linear or Branched Poly(ethylene glycol)

Vugmeyster, Y., Entrican, C., Joyce, A. P., Lawrence-Henderson, R. F., Leary, B. A., Mahoney, C. S., Patel, H. K., Raso, S. W., Olland, S., Hegen, M., et al. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300066a · Cited by 67 · see citing works

Comparative Binding of Disulfide-Bridged PEG-Fabs

Khalili, H., Godwin, A., Choi, J.-W., Lever, R., & Brocchini, S. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300372r · Cited by 65 · see citing works

TGFβ functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation

Watarai, A., Schirmer, L., Thönes, S., Freudenberg, U., Werner, C., Simon, J. C., & Anderegg, U. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.07.036 · Cited by 65 · see citing works

Emerging Challenges and Innovations in Surfactant-mediated Stabilization of Biologic Formulations

Katz, J. S., Chou, D. K., Christian, T. R., Das, T. K., Patel, M., Singh, S. N., & Wen, Y. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.12.002 · Cited by 63 · see citing works

Luminescent quantum-dot-sized conjugated polymernanoparticles—nanoparticle formation in a miniemulsion system

Hashim, Z., Howes, P. D., & Green, M. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm02935a · Cited by 62 · see citing works

Criteria for Selecting PEGylation Sites on Proteins for Higher Thermodynamic and Proteolytic Stability

Lawrence, P. B., Gavrilov, Y., Matthews, S. S., Langlois, M. I., Shental-Bechor, D., Greenblatt, H. M., Pandey, B. K., Smith, M. S., Paxman, R. J., Torgerson, C. D., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5095183 · Cited by 62 · see citing works

Polymer-drug conjugates: recent progress on administration routes

Pang, X., Yang, X., & Zhai, G. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.912779 · Cited by 55 · see citing works

PEGylation: Posttranslational bioengineering of protein biotherapeutics

Veronese, F. M., & Pasut, G. (2008) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2009.02.002 · Cited by 54 · see citing works

Neutron reflectometry from poly (ethylene-glycol) brushes binding anti-PEG antibodies: Evidence of ternary adsorption

Schneck, E., Berts, I., Halperin, A., Daillant, J., & Fragneto, G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.041 · Cited by 54 · see citing works

Treatment-induced and Pre-existing Anti-peg Antibodies: Prevalence, Clinical Implications, and Future Perspectives

Gaballa, S. A., Shimizu, T., Ando, H., Takata, H., Emam, S. E., Ramadan, E., Naguib, Y. W., Mady, F. M., Khaled, K. A., & Ishida, T. (2023) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.11.001 · Cited by 58 · see citing works

Enabling sublingual peptide immunization with molecular self-assemblies

Kelly, S. H., Wu, Y., Varadhan, A. K., Curvino, E. J., Chong, A. S., & Collier, J. H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119903 · Cited by 53 · see citing works

Emerging well-tailored nanoparticulate delivery system based on in situ regulation of the protein corona

Li, Z., Wang, Y., Zhu, J., Zhang, Y., Zhang, W., Zhou, M., Luo, C., Li, Z. J., Cai, B., Gui, S., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.007 · Cited by 52 · see citing works

Polymeric Nanomaterials

Raja, M. M., Lim, P. Q., Wong, Y. S., Xiong, G. M., Zhang, Y., Venkatraman, S. S., & Huang, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814033-8.00018-7 · Cited by 50 · see citing works

Isoform separation and binding site determination of mono-PEGylated lysozyme with pH gradient chromatography

Maiser, B., Kröner, F., Dismer, F., Brenner‐Weiß, G., & Hubbuch, J. J. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.10.047 · Cited by 49 · see citing works

The Impact of Product and Process Related Critical Quality Attributes on Immunogenicity and Adverse Immunological Effects of Biotherapeutics

Wen, Y., & Jawa, V. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.12.003 · Cited by 47 · see citing works

Aldehyde PEGylation Kinetics: A Standard Protein versus a Pharmaceutically Relevant Single Chain Variable Fragment

Moosmann, A., Blath, J., Lindner, R. M., Müller, E., & Böttinger, H. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200090x · Cited by 46 · see citing works

PEG‐Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response

Özer, İ., Pitoc, G. A., Layzer, J. M., Moreno, A., Olson, L. B., Layzer, K. D., Hucknall, A., Sullenger, B. A., & Chilkoti, A. (2022) · Advanced Materials · doi:10.1002/adma.202107852 · Cited by 45 · see citing works

Site-Specific PEGylation of Therapeutic Proteins via Optimization of Both Accessible Reactive Amino Acid Residues and PEG Derivatives

Zhang, C., Yang, X., Yuan, Y., Pu, J., & Liao, F. (2012) · BioDrugs · doi:10.1007/bf03261880 · Cited by 46 · see citing works

Characterization of protein release from poly(ethylene glycol) hydrogels with crosslink density gradients

Bal, T., Kepsutlu, B., & Kızılel, S. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34701 · Cited by 44 · see citing works

Dynamic Covalent Bond‐Assisted Programmed and Traceless Protein Release: High Loading Nanogel for Systemic and Cytosolic Delivery

Su, S., Wang, Y., Du, F., Lu, H., & Li, Z. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201805287 · Cited by 44 · see citing works

Polyethylene glycol: Properties, applications, and challenges

Gaballa, S. A., Naguib, Y. W., Mady, F. M., & Khaled, K. (2023) · Journal of advanced Biomedical and Pharmaceutical Sciences · doi:10.21608/jabps.2023.241685.1205 · Cited by 43 · see citing works

Cleaner approach for improving the papermaking from agro and hardwood blended pulps using biopolymers

Bhardwaj, S., Bhardwaj, N. K., & Negi, Y. S. (2018) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2018.12.143 · Cited by 43 · see citing works

Hydrophobic interaction chromatography for purification of monoPEGylated RNase A

Mayolo‐Deloisa, K., Lienqueo, M. E., Andrews, B. A., Rito‐Palomares, M., & Asenjo, J. A. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.03.079 · Cited by 42 · see citing works

Advances and trends in the design, analysis, and characterization of polymer–protein conjugates for “PEGylaided” bioprocesses

González‐Valdez, J., Rito‐Palomares, M., & Benavides, J. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-5845-6 · Cited by 42 · see citing works

Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma

Fang, J., Beland, F. A., Tang, Y., & Roffler, S. R. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.12.022 · Cited by 43 · see citing works

PEGylated Human Serum Albumin: Review of PEGylation, Purification and Characterization Methods

Akbarzadehlaleh, P., Mirzaei, M., Mashahdi-keshtiban, M., Shamsasenjan, K., & Heidari, H. R. (2016) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2016.043 · Cited by 41 · see citing works

Accelerated clearance by antibodies against methoxy PEG depends on pegylation architecture

Lin, Y., Chen, B., Tran, T. T. M., Chang, T.-C., Al‐Qaisi, T. S., & Roffler, S. R. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.021 · Cited by 40 · see citing works

PEGylation and pharmacological characterization of a potential anti-tumor drug, an engineered arginine deiminase originated from Pseudomonas plecoglossicida

Zhang, L., Liu, M., Jamil, S., Han, R., Xu, G., & Ni, Y. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.11.042 · Cited by 40 · see citing works

Purification of PEGylated Proteins

Fee, C. J., & Alstine, J. M. V. (2011) · Methods of biochemical analysis · doi:10.1002/9780470939932.ch14 · Cited by 40 · see citing works

Gold nanostructures in melanoma: Advances in treatment, diagnosis, and theranostic applications

Dastgheib, Z. S., Abolmaali, S. S., Farahavar, G., Salmanpour, M., & Tamaddon, A. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35655 · Cited by 40 · see citing works

Poly(ethylene glycol)-Radix Ophiopogonis polysaccharide conjugates: Preparation, characterization, pharmacokinetics and in vitro bioactivity

Lin, X., Wang, S., Jiang, Y., Wang, Z.-J., Sun, G., De-sheng, X., Feng, Y., & Shen, L. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.07.003 · Cited by 38 · see citing works

P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency

Barz, M., Armiñán, A., Canal, F., Wolf, F. K., Koynov, K., Frey, H., Zentel, R., & Vicent, M. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.024 · Cited by 37 · see citing works

Pushing the science forward: chitosan nanoparticles and functional repair of CNS tissue after spinal cord injury

Chen, B., Bohnert, D. M., Borgens, R. B., & Cho, Y. (2013) · Journal of Biological Engineering · doi:10.1186/1754-1611-7-15 · Cited by 36 · see citing works

Oligo(ethylene glycol)-sidechain microgels prepared in absence of cross-linking agent: Polymerization, characterization and variation of particle deformability

Welsch, N., & Lyon, L. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181369 · Cited by 35 · see citing works

Polyvinyl Alcohol as a Biocompatible Alternative for the Passivation of Gold Nanorods

Kinnear, C., Burnand, D., Clift, M. J. D., Kilbinger, A. F. M., Rothen‐Rutishauser, B., & Petri‐Fink, A. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201404100 · Cited by 35 · see citing works

Head to Head Comparison of the Formulation and Stability of Concentrated Solutions of HESylated versus PEGylated Anakinra

Liebner, R., Meyer, M., Hey, T., Winter, G., & Besheer, A. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24253 · Cited by 33 · see citing works

Pharmacokinetics, excretion, distribution, and metabolism of 60-kDa polyethylene glycol used in BAY 94-9027 in rats and its value for human prediction

Baumann, A., Piel, I., Hucke, F., Sandmann, S., Hetzel, T., & Schwarz, T. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.01.015 · Cited by 33 · see citing works

Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light–dark toxicity ratio toward an effective photodynamic cancer therapy

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Pharmacokinetics, tissue distribution and excretion of 40kDa PEG and PEGylated rFVIII (N8-GP) in rats

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