Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates

Di Florio, A.; Craddock, N.; van den Bree, M.

doi:10.1016/j.eurpsy.2013.07.004

Cited by 117Bipolar Disorder and TreatmentSubstance Abuse Treatment and OutcomesPersonality Disorders and Psychopathology

Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates

Di Florio, A., Craddock, N., van den Bree, M.·2014·European Psychiatry

DOI 10.1016/j.eurpsy.2013.07.004

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Abstract

AIMS: To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity. METHODS: Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias. RESULTS: In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men. CONCLUSION: AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.

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Authors: Di Florio, A., Craddock, N., & van den Bree, M.
Affiliations: Cardiff University (GB)
ORCID: Craddock, N.
Venue: European Psychiatry
Publisher: Cambridge University Press (CUP)
Published: 2014-03
Volume: 29
Issue: 3
Pages: 117-124
ISSN: 0924-9338 (ISSN-L)
1778-3585
DOI: 10.1016/j.eurpsy.2013.07.004
OpenAlex: W1974477361
Cited by: 117
References: 71
Citations by year: 2026: 6 · 2025: 9 · 2024: 6 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 2
FWCI: 1.19
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 2237 d)
Locations: European Psychiatry (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders: Medical Research Council (MR/L010305/1, MR/K023233/1)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: bipolar disorder, alcoholism, alcohol abuse, psychiatric comorbidity, lifetime prevalence, sex differences, publication bias, heterogeneity sources
MeSH terms: Alcoholism, Bipolar Disorder, Humans, Comorbidity

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Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates

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