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Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5mg and 10mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
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“Several recent studies have shown a significant treatment benefit from once-daily, low-dose tadalafil (McMahon 2004; McMahon 2005; Porst et al 2006; Rajfer et al 2007; Hatzichristou et al 2008; Porst et al 2008).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Porst et al 2006
In the citing paper
“The longer half-life provides a steady state of serum drug concentration with low dose, once-daily administration, a benefit not shared with the other two PDE5 inhibitors (McMahon 2004; McMahon 2005; Porst et al 2006; Porst et al 2008; Rajfer et al 2007).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Porst et al 2006
In the citing paper
“Successful intercourse was achieved in 67.2% and 72.8%, compared with 36.7% with placebo (p < 0.001).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Porst et al 2006
In the citing paper
“The mean IIEF-EF change from baseline at the endpoint was 9.7 and 9.4 for tadalafil 5 mg and tadalafil 10 mg, respectively, compared with 0.9 for placebo (p < 0.001).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Porst et al 2006
In the citing paper
“The authors concluded once-daily tadalafil 5 mg or 10 mg significantly improved erectile function in men with ED (Porst et al 2006).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Porst et al 2006
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Citations
Cites
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
Oral Sildenafil in the Treatment of Erectile Dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120
(1999) · doi:10.1016/s0090-4295(99)00099-0 · Cited by 1,051
Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., & Ignarro, L. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201093260203 · Cited by 1,006
Tadalafil pharmacokinetics in healthy subjects
Forgue, S. T., Patterson, B. E., Bedding, A. W., Payne, C. D., Phillips, D. L., Wrishko, R. E., & Mitchell, M. I. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02553.x · Cited by 284
Research works printed but not linked: 22
- Padma-Nathan, 2001, On-demand IC351 (Cialis(trademark)) enhances erectile function in patients with erectile dysfunction, Int J Impot Res, 13, 2, 10.1038/sj.ijir.3900631 · DOI
- Porst, 2001, a new highly selective PDE5 inhibitor, improves erectile function irrespective of the baseline severity and aetiology of ED or age of patient, Eur Urol, 39, 17
- Hanson-Divers, 1998, Health outcomes variables important to patients in the treatment of erectile dysfunction, J Urol, 159, 1541, 10.1097/00005392-199805000-00037 · DOI
- Carson, 2004, The efficacy and safety of tadalafil: an update, BJU Int, 93, 1276, 10.1111/j.1464-410X.2004.04819.x · DOI
- Young, 2005, Tadalafil improved erectile function at twenty-four and thirty-six hours after dosing in men with erectile dysfunction: US trial, J Androl, 26, 310, 10.2164/jandrol.04126 · DOI
- McMahon, 2005, Comparison of efficacy, safety, and tolerability of on-demand tadalafil and daily dosed tadalafil for the treatment of erectile dysfunction, J Sex Med, 2, 415, 10.1111/j.1743-6109.2005.20360.x · DOI · Paper page
- Mirone, 2005, An evaluation of an alternative dosing regimen with tadalafil, 3 times/week, for men with erectile dysfunction: SURE study in 14 European countries, Eur Urol, 47, 846, 10.1016/j.eururo.2005.02.019 · DOI
- Debusk, 2000, Management of sexual dysfunction in patients with cardiovascular disease: Recommendations of the Princeton consensus panel, Am J Cardiol, 86, 175, 10.1016/S0002-9149(00)00896-1 · DOI · Paper page
- Dunnett, 1955, A multiple comparison procedure for comparing several treatments with a control, J Amer Statist Assoc, 50, 1096, 10.1080/01621459.1955.10501294 · DOI
- McMahon, 2004, Efficacy and safety daily tadalafil in men with erectile dysfunction previously unresponsive to on-demand tadalafil, J Sex Med, 1, 292, 10.1111/j.1743-6109.04042.x · DOI · Paper page
- Montorsi, 2004, Tadalafil in the treatment of erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy: A randomized, double-blind, placebo controlled trial, J Urol, 172, 1036, 10.1097/01.ju.0000136448.71773.2b · DOI · Paper page
- Brock, 2002, Efficacy and safety of tadalafil for the treatment of erectile dysfunction: Results of integrated analyses, J Urol, 168, 1332, 10.1016/S0022-5347(05)64442-4 · DOI · Paper page
- Saenz de Tejada, 2002, Effects of tadalafil on erectile dysfunction in men with diabetes, Diabetes Care, 25, 2159, 10.2337/diacare.25.12.2159 · DOI · Paper page
- Skoumal, 2004, Efficacy and treatment satisfaction with on-demand tadalafil (Cialis) in men with erectile dysfunction, Eur Urol, 46, 362, 10.1016/j.eururo.2004.04.026 · DOI
- Montorsi, 2004, Long-term safety and tolerability of tadalafil in the treatment of erectile dysfunction, Eur Urol, 45, 339, 10.1016/j.eururo.2003.11.010 · DOI
- Jackson, 2004, Update on clinical trials of tadalafil demonstrates no increased risk of cardiovascular adverse events, J Sex Med, 1, 161, 10.1111/j.1743-6109.2004.04024.x · DOI
- Chockalingam, 2005, Efficacy and optimal dose of sildenafil in primary pulmonary hypertension, Int J Cardiol, 99, 91, 10.1016/j.ijcard.2003.12.023 · DOI
- Kukreja, 2004, Cardioprotection with phosphodiesterase-5 inhibition - A novel preconditioning strategy, J Mol Cell Cardiol, 36, 165, 10.1016/j.yjmcc.2003.11.001 · DOI
- Behr-Roussel, 2005, Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats: Lack of tachyphylaxis, Eur Urol, 47, 87, 10.1016/j.eururo.2004.09.005 · DOI
- Caretta, 2005, Resumption of spontaneous erections in selected patients affected by erectile dysfunction and various degrees of carotid wall alteration: Role of tadalafil, Eur Urol, 48, 326, 10.1016/j.eururo.2005.01.013 · DOI
- Desouza, 2002, Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes, Diabetes Care, 25, 1336, 10.2337/diacare.25.8.1336 · DOI
- Rosano, 2005, Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk, Eur Urol, 47, 214, 10.1016/j.eururo.2004.10.002 · DOI · Paper page
Cited by
Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
Hatzimouratidis, K., Amar, E., Eardley, I., Giuliano, F., Hatzichristou, D., Montorsi, F., Vardi, Y., & Wespes, E. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.020 · Cited by 1,223
Self-citationShamloul, R., & Ghanem, H. (2013) · The Lancet · doi:10.1016/s0140-6736(12)60520-0 · Cited by 1,091
Tadalafil in the treatment of erectile dysfunction
Coward, R., & Carson, C. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3336 · Cited by 138
Evaluation and Management of Erectile Dysfunction
Burnett, A. L. (2012) · Campbell-Walsh Urology · doi:10.1016/b978-1-4160-6911-9.00024-4 · Cited by 28
Metadata
- Authors
- Porst, H., Giuliano, F., Glina, S., Ralph, D., Casabé, A. R., Elion-Mboussa, A., Shen, W., & Whitaker, J. S.
- Venue
- European Urology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 50
- Issue
- 2
- Pages
- 351-359
- ISSN
- 0302-2838
- Cited by
- 152
- References
- 5
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- CoChat. (2026). Citation check: Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5mg and 10mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. https://app.cochat.ai/papers/10.1016/j.eururo.2006.02.052
- The paper
- Porst, H., Giuliano, F., Glina, S., Ralph, D., Casabé, A. R., Elion-Mboussa, A., Shen, W., & Whitaker, J. S. (2006). Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5mg and 10mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. European Urology. https://doi.org/10.1016/j.eururo.2006.02.052
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
