Cited by 122Glaucoma and retinal disordersDrug-Induced Ocular ToxicityConnexins and lens biology

Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain

Gupta, Neeru, Ly, Tina, Zhang, Qiang, Kaufman, Paul L., Weinreb, Robert N., Yücel, Yeni H.·2007·Experimental Eye Research

Abstract

In glaucoma, there is atrophy and loss of retinal ganglion cells (RGC), in addition to atrophy and loss of target neurons in the lateral geniculate nucleus (LGN) of the brain. To investigate possible changes to the dendrites of LGN neurons in glaucoma, a selective marker for dendrites called microtubule-associated protein-2 (MAP2) was used. The LGNs from five monkeys with varying degrees of optic nerve fiber loss were compared to those from five normal control monkeys. Dendrites in magno- and parvocellular layers connected to the glaucomatous eye were evaluated. In controls, long MAP2-positive dendrites with multiple fine branches were seen. However, chronic ocular hypertension induced striking disruption of dendrites with a thickened and shortened appearance. Dendrite field area was significantly reduced in the glaucoma group compared to controls. Sholl analysis revealed reduced dendrite complexity by 47% and 41% in magnocellular layer 1 and parvocellular layer 6, respectively in the glaucoma group compared to controls. The striking dendrite changes in the LGN following chronically elevated intraocular pressure may be relevant to early visual dysfunction in glaucoma.

Integrity signals

Registry

Crossref · 10.1016/j.exer.2006.09.013

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gupta, N., Ly, T., Zhang, Q., Kaufman, P. L., Weinreb, R. N., & Yücel, Y. H.
Affiliations
  • St. Michael's Hospital (CA)
  • University of Wisconsin–Madison (US)
  • University of California San Diego (US)
Corresponding author
Yücel, Yeni H.
Venue
Experimental Eye Research
Publisher
Elsevier BV
Published
2007-01
Volume
84
Issue
1
Pages
176-184
ISSN
0014-4835 (ISSN-L)
OpenAlex
W1973239499
Cited by
122
References
39
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 3 · 2015: 13 · 2014: 8 · 2013: 5 · 2012: 7
FWCI
3.70
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Eye Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of California, San Diego
  • Glaucoma Research Society of Canada
  • Canadian Institutes of Health Research
  • Research to Prevent Blindness
  • Glaucoma Foundation
  • National Eye Institute (EY02698)
Topics
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
  • Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords
glaucoma, chronic ocular hypertension, lateral geniculate nucleus, retinal ganglion cell death, MAP2, magnocellular layers, parvocellular layers, dendritic complexity, intraocular pressure, visual dysfunction
MeSH terms
Animals, Chronic Disease, Dendrites, Geniculate Bodies, Glaucoma, Intraocular Pressure, Macaca fascicularis, Microtubule-Associated Proteins, Nerve Fibers, Optic Nerve

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review