Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain
Abstract
In glaucoma, there is atrophy and loss of retinal ganglion cells (RGC), in addition to atrophy and loss of target neurons in the lateral geniculate nucleus (LGN) of the brain. To investigate possible changes to the dendrites of LGN neurons in glaucoma, a selective marker for dendrites called microtubule-associated protein-2 (MAP2) was used. The LGNs from five monkeys with varying degrees of optic nerve fiber loss were compared to those from five normal control monkeys. Dendrites in magno- and parvocellular layers connected to the glaucomatous eye were evaluated. In controls, long MAP2-positive dendrites with multiple fine branches were seen. However, chronic ocular hypertension induced striking disruption of dendrites with a thickened and shortened appearance. Dendrite field area was significantly reduced in the glaucoma group compared to controls. Sholl analysis revealed reduced dendrite complexity by 47% and 41% in magnocellular layer 1 and parvocellular layer 6, respectively in the glaucoma group compared to controls. The striking dendrite changes in the LGN following chronically elevated intraocular pressure may be relevant to early visual dysfunction in glaucoma.
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There is dendritic atrophy of the lateral geniculate nucleus in glaucoma.
“In addition, there is a dendritic atrophy of the lateral geniculate nucleus, the site to which the RGC axons project (Gupta et al., 2007; Park and Ou, 2013).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Gupta et al., 2007
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- Authors
- Gupta, N., Ly, T., Zhang, Q., Kaufman, P. L., Weinreb, R. N., & Yücel, Y. H.
- Affiliations
- St. Michael's Hospital (CA)
- University of Wisconsin–Madison (US)
- University of California San Diego (US)
- Corresponding author
- Yücel, Yeni H.
- Venue
- Experimental Eye Research
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 84
- Issue
- 1
- Pages
- 176-184
- ISSN
- 0014-4835 (ISSN-L)
- OpenAlex
- W1973239499
- Cited by
- 122
- References
- 39
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 3 · 2015: 13 · 2014: 8 · 2013: 5 · 2012: 7
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Diego
- Glaucoma Research Society of Canada
- Canadian Institutes of Health Research
- Research to Prevent Blindness
- Glaucoma Foundation
- National Eye Institute (EY02698)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- glaucoma, chronic ocular hypertension, lateral geniculate nucleus, retinal ganglion cell death, MAP2, magnocellular layers, parvocellular layers, dendritic complexity, intraocular pressure, visual dysfunction
- MeSH terms
- Animals, Chronic Disease, Dendrites, Geniculate Bodies, Glaucoma, Intraocular Pressure, Macaca fascicularis, Microtubule-Associated Proteins, Nerve Fibers, Optic Nerve
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