Cited by 517Antioxidant Activity and Oxidative StressRedox biology and oxidative stressTryptophan and brain disorders

Oxidative Stress and Anxiety: Relationship and Cellular Pathways

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Bouayed, Jaouad, Rammal, Hassan, Soulimani, Rachid·2009·Oxidative Medicine and Cellular Longevity

Abstract

High O 2 consumption, modest antioxidant defenses and a lipid‐rich constitution make the brain highly vulnerable to redox imbalances. Oxidative damage in the brain causes nervous system impairment. Recently, oxidative stress has also been implicated in depression, anxiety disorders and high anxiety levels. The findings which establish a link between oxidative stress and pathological anxiety have inspired a number of other recent studies focusing on the link between oxidative status and normal anxiety and also on a possible causal relationship between cellular oxidative stress and emotional stress. This review examines the recent discoveries made on the link between oxidative status and normal anxiety levels and the putative role of oxidative stress in genesis of anxiety. We discuss the different opinions and questions that exist in the field and review the methodological approaches that are being used to determine a causal relationship between oxidative and emotional stress.

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  1. [2]Leman S Le Guisquet A Belzung C Ferreri M Liens anxiété-mémoire: Études expérimentales Dans: “Anxiété, anxiolytiques et troubles cognitifs” 2004 Paris Elsevier 71 79
  2. [6]Alonso J Lépine JP Overview of key data from the European Study of Epidemiology of Mental Disorders (ESEMeD) J Clin Psychiatry 2007 68 3 9 17288501

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Authors
Bouayed, J., Rammal, H., & Soulimani, R.
Affiliations
Laboratoire Animal et Agroécosystèmes (FR)
Corresponding author
Bouayed, Jaouad
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2009-01
Volume
2
Issue
2
Pages
63-67
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2056266253
Cited by
517
References
57
Citations by year
2026: 21 · 2025: 40 · 2024: 30 · 2023: 44 · 2022: 41 · 2021: 49 · 2020: 43 · 2019: 36 · 2018: 24 · 2017: 43 · 2016: 37 · 2015: 25 · 2014: 26 · 2013: 15 · 2012: 16
FWCI
1.27
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
oxidative stress, anxiety, emotional stress, antioxidant defense, lipid peroxidation, anxiety disorders, depression
MeSH terms
Animals, Antioxidants, Anxiety, Reactive Oxygen Species, Oxidative Stress, Mice

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