Oxidative Stress and Anxiety: Relationship and Cellular Pathways
Open accessAbstract
High O 2 consumption, modest antioxidant defenses and a lipid‐rich constitution make the brain highly vulnerable to redox imbalances. Oxidative damage in the brain causes nervous system impairment. Recently, oxidative stress has also been implicated in depression, anxiety disorders and high anxiety levels. The findings which establish a link between oxidative stress and pathological anxiety have inspired a number of other recent studies focusing on the link between oxidative status and normal anxiety and also on a possible causal relationship between cellular oxidative stress and emotional stress. This review examines the recent discoveries made on the link between oxidative status and normal anxiety levels and the putative role of oxidative stress in genesis of anxiety. We discuss the different opinions and questions that exist in the field and review the methodological approaches that are being used to determine a causal relationship between oxidative and emotional stress.
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Increased oxidative damage occurs quite often in anxiety.
“anxiety [9, 10]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [10]
Increased oxidative damage occurs quite often in bipolar disorder.
“bipolar disorder (BD) [10–14]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [10]
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- Authors
- Bouayed, J., Rammal, H., & Soulimani, R.
- Affiliations
- Laboratoire Animal et Agroécosystèmes (FR)
- Corresponding author
- Bouayed, Jaouad
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 2
- Issue
- 2
- Pages
- 63-67
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC2763246
- OpenAlex
- W2056266253
- Cited by
- 517
- References
- 57
- Citations by year
- 2026: 21 · 2025: 40 · 2024: 30 · 2023: 44 · 2022: 41 · 2021: 49 · 2020: 43 · 2019: 36 · 2018: 24 · 2017: 43 · 2016: 37 · 2015: 25 · 2014: 26 · 2013: 15 · 2012: 16
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- oxidative stress, anxiety, emotional stress, antioxidant defense, lipid peroxidation, anxiety disorders, depression
- MeSH terms
- Animals, Antioxidants, Anxiety, Reactive Oxygen Species, Oxidative Stress, Mice
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