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The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation
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“there are now numerous studies showing that rapamycin can extend the lifespan not only of model organisms including yeast, worms, and flies 20–22, but also as we detail below, in both wild-type mice and in many disease models.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [20]
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Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671
Two neurons mediate diet-restriction-induced longevity in C. elegans
Bishop, N. A., & Guarente, L. (2007) · Nature · doi:10.1038/nature05904 · Cited by 643
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705028200 · Cited by 202
Self-citationCristina, D., Cary, M., Lunceford, A., Clarke, C., & Kenyon, C. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000450 · Cited by 166
Sobenin, I. A., Nedosugova, L. V., Filatova, L. V., Balabolkin, M. I., Gorchakova, T. V., & Orekhov, A. N. (2008) · Acta Diabetologica · doi:10.1007/s00592-007-0011-x · Cited by 119
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Research works printed but not linked: 75
- Abramoff, 2004, Image processing with ImageJ, Biophotonics Int., 11, 36
- Ali, 2000, Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet, Prostaglandins Leukot. Essent. Fatty Acids, 62, 253, 10.1054/plef.2000.0152 · DOI
- An, 2003, SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response, Genes Dev., 17, 1882, 10.1101/gad.1107803 · DOI
- An, 2005, Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3, Proc. Natl Acad. Sci. USA, 102, 16275, 10.1073/pnas.0508105102 · DOI
- Bargmann, 1990, Chemosensory cell function in the behavior and development of Caenorhabditis elegans, Cold Spring Harb. Symp. Quant. Biol., 55, 529, 10.1101/SQB.1990.055.01.051 · DOI
- Block, 1985, The chemistry of garlic and onions, Sci. Am., 252, 114, 10.1038/scientificamerican0385-114 · DOI
- Bordia, 1998, Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease, Prostaglandins Leukot. Essent. Fatty Acids, 58, 257, 10.1016/S0952-3278(98)90034-5 · DOI
- Breithaupt-Grogler, 1997, Protective effect of chronic garlic intake on elastic properties of aorta in the elderly, Circulation, 96, 2649, 10.1161/01.CIR.96.8.2649 · DOI
- Chen, 2004, Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals, Free Radic. Biol. Med., 37, 1578, 10.1016/j.freeradbiomed.2004.07.021 · DOI
- Choe, 2009, The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans, Mol. Cell. Biol., 29, 2704, 10.1128/MCB.01811-08 · DOI
- Collins, 2009, Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes, Circ. Res., 104, e42, 10.1161/CIRCRESAHA.108.188771 · DOI
- Dillin, 2002, Timing requirements for insulin/IGF-1 signaling in C. elegans, Science, 298, 830, 10.1126/science.1074240 · DOI · Paper page
- Durak, 2002, Effects of garlic extract on oxidant/antioxidant status and atherosclerotic plaque formation in rabbit aorta, Nutr. Metab. Cardiovasc. Dis., 12, 141
- El-Sabban, 2008, Effect of garlic on atherosclerosis and its factors, East. Mediterr. Health J., 14, 195
- Fabian, 1995, Identification genes that are differentially expressed during aging in Caenorhabditis elegans, J. Gerontol. Biol. Sci. Med. Sci., 50, B245, 10.1093/gerona/50A.5.B245 · DOI
- Fisher, 2006, The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms, Aging Cell, 5, 127, 10.1111/j.1474-9726.2006.00203.x · DOI
- Fisher, 2008, The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia, J. Biol. Chem., 283, 9127, 10.1074/jbc.M708341200 · DOI
- Gao, 1999, Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China, Jpn J. Cancer Res., 90, 614, 10.1111/j.1349-7006.1999.tb00791.x · DOI
- Gardner, 2001, The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults, Atherosclerosis, 154, 213, 10.1016/S0021-9150(00)00466-4 · DOI
- Gardner, 2007, Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial, Arch. Intern. Med., 167, 346, 10.1001/archinte.167.4.346 · DOI
- Garigan, 2002, Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation, Genetics, 161, 1101, 10.1093/genetics/161.3.1101 · DOI · Paper page
- Gerisch, 2001, A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span, Dev. Cell, 1, 841, 10.1016/S1534-5807(01)00085-5 · DOI
- Gorinstein, 2007, The atherosclerotic heart disease and protecting properties of garlic: contemporary data, Mol. Nutr. Food Res., 51, 1365, 10.1002/mnfr.200700064 · DOI
- Greer, 2009, Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans, Aging Cell, 8, 113, 10.1111/j.1474-9726.2009.00459.x · DOI
- Henderson, 2001, daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans, Curr. Biol., 11, 1975, 10.1016/S0960-9822(01)00594-2 · DOI
- Horikawa, 2008, Elongation and desaturation of fatty acids are critical in growth, lipid metabolism and ontogeny of Caenorhabditis elegans, J. Biochem., 144, 149, 10.1093/jb/mvn055 · DOI
- Hsing, 2002, Allium vegetables and risk of prostate cancer: a population-based study, J. Natl Cancer Inst., 94, 1648, 10.1093/jnci/94.21.1648 · DOI
- Inoue, 2005, The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response, Genes Dev., 19, 2278, 10.1101/gad.1324805 · DOI
- Jia, 2002, DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity, Development, 129, 221, 10.1242/dev.129.1.221 · DOI
- Kalayarasan, 2008, Chromium (VI)-induced oxidative stress and apoptosis is reduced by garlic and its derivative S-allylcysteine through the activation of Nrf2 in the hepatocytes of Wistar rats, J. Appl. Toxicol., 28, 908, 10.1002/jat.1355 · DOI
- Katane, 2007, Caenorhabditis elegans has two genes encoding functional d-aspartate oxidases, FEBS J., 274, 137, 10.1111/j.1742-4658.2006.05571.x · DOI
- Kell, 2007, Activation of SKN-1 by novel kinases in Caenorhabditis elegans, Free Radic. Biol. Med., 43, 1560, 10.1016/j.freeradbiomed.2007.08.025 · DOI
- Kenyon, 1993, A C. elegans mutant that lives twice as long as wild type, Nature, 366, 461, 10.1038/366461a0 · DOI · Paper page
- Kniazeva, 2003, Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans, Genetics, 163, 159, 10.1093/genetics/163.1.159 · DOI
- Kniazeva, 2004, Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development, PLoS Biol., 2, E257, 10.1371/journal.pbio.0020257 · DOI
- Kwak, 2004, Chemoprevention through the Keap1–Nrf2 signaling pathway by phase 2 enzyme inducers, Mutat. Res., 555, 133, 10.1016/j.mrfmmm.2004.06.041 · DOI
- Lakowski, 1998, The genetics of caloric restriction in Caenorhabditis elegans, Proc. Natl. Acad. Sci. U. S. A., 95, 13091, 10.1073/pnas.95.22.13091 · DOI
- Lau, 2006, Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit, J. Nutr., 136, 765S, 10.1093/jn/136.3.765S · DOI
- Lee, 2001, Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway, Curr. Biol., 11, 1950, 10.1016/S0960-9822(01)00595-4 · DOI
- Leiers, 2003, A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans, Free Radic. Biol. Med., 34, 1405, 10.1016/S0891-5849(03)00102-3 · DOI
- Lin, 1997, daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans, Science, 278, 1319, 10.1126/science.278.5341.1319 · DOI
- Lin, 2001, Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling, Nat. Genet., 28, 139, 10.1038/88850 · DOI
- Link, 2002, Reporter transgenes for study of oxidant stress in Caenorhabditis elegans, Meth. Enzymol., 353, 497, 10.1016/S0076-6879(02)53072-X · DOI
- Mair, 2009, Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans, PLoS ONE, 4, e4535, 10.1371/journal.pone.0004535 · DOI
- McElwee, 2003, Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16, Aging Cell, 2, 111, 10.1046/j.1474-9728.2003.00043.x · DOI · Paper page
- McElwee, 2004, Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance, J. Biol. Chem., 279, 44533, 10.1074/jbc.M406207200 · DOI
- Minniti, 2009, Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans, Aging Cell, 8, 690, 10.1111/j.1474-9726.2009.00521.x · DOI
- Murphy, 2003, Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans, Nature, 424, 277, 10.1038/nature01789 · DOI · Paper page
- O'Gara, 2000, Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori, Appl. Environ. Microbiol., 66, 2269, 10.1128/AEM.66.5.2269-2273.2000 · DOI
- Oh, 2006, Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation, Nat. Genet., 38, 251, 10.1038/ng1723 · DOI
- Oliveira, 2009, Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf, Aging Cell, 8, 524, 10.1111/j.1474-9726.2009.00501.x · DOI
- Park, 2009, Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1, Aging Cell, 8, 258, 10.1111/j.1474-9726.2009.00473.x · DOI
- Patel, 2008, Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs, Free Radic. Biol. Med., 44, 1897, 10.1016/j.freeradbiomed.2008.02.006 · DOI
- Powolny, 2008, Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds, Cancer Lett., 269, 305, 10.1016/j.canlet.2008.05.027 · DOI
- Raizen, 1995, Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans, Genetics, 141, 1365, 10.1093/genetics/141.4.1365 · DOI
- Rea, 2007, Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans, PLoS Biol., 5, e259, 10.1371/journal.pbio.0050259 · DOI · Paper page
- Ried, 2008, Effect of garlic on blood pressure: a systematic review and meta-analysis, BMC Cardiovasc. Disord., 8, 13, 10.1186/1471-2261-8-13 · DOI
- Rivlin, 2001, Historical perspective on the use of garlic, J. Nutr., 131, 951S, 10.1093/jn/131.3.951S · DOI
- Rottiers, 2006, Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase, Dev. Cell, 10, 473, 10.1016/j.devcel.2006.02.008 · DOI
- Shukla, 2007, Cancer chemoprevention with garlic and its constituents, Cancer Lett., 247, 167, 10.1016/j.canlet.2006.05.009 · DOI
- Slowing, 2001, Study of garlic extracts and fractions on cholesterol plasma levels and vascular reactivity in cholesterol-fed rats, J. Nutr., 131, 994S, 10.1093/jn/131.3.994S · DOI
- Sun, 2006, Determination of the concentration of diallyl trisulfide in rat whole blood using gas chromatography with electron-capture detection and identification of its major metabolite with gas chromatography mass spectrometry, Yakugaku Zasshi, 126, 521, 10.1248/yakushi.126.521 · DOI
- Sutphin, 2009, Measuring Caenorhabditis elegans life span on solid media, J. Vis. Exp., May 12;(27)
- Tanaka, 2004, Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study, Hiroshima J. Med. Sci., 53, 39
- Tanaka, 2008, NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet, J. Pharmacol. Exp. Ther., 325, 655, 10.1124/jpet.107.135822 · DOI
- Tawe, 1998, Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display, Nucleic Acids Res., 26, 1621, 10.1093/nar/26.7.1621 · DOI
- Tsao, 2001, In vitro activity of garlic oil and four diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae, J. Antimicrob. Chemother., 47, 665, 10.1093/jac/47.5.665 · DOI
- Tsao, 2001, In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils, J. Med. Microbiol., 50, 646, 10.1099/0022-1317-50-7-646 · DOI
- Tsao, 2003, Garlic extract and two diallyl sulphides inhibit methicillin-resistant Staphylococcus aureus infection in BALB/cA mice, J. Antimicrob. Chemother., 52, 974, 10.1093/jac/dkg476 · DOI
- Tullet, 2008, Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans, Cell, 132, 1025, 10.1016/j.cell.2008.01.030 · DOI · Paper page
- Van Gilst, 2005, A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49, Proc. Natl Acad. Sci. USA, 102, 13496, 10.1073/pnas.0506234102 · DOI
- Viswanathan, 2005, A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span, Dev. Cell, 9, 605, 10.1016/j.devcel.2005.09.017 · DOI
- Yeh, 2006, Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract, J. Nutr., 136, 745S, 10.1093/jn/136.3.745S · DOI
- You, 1989, Allium vegetables and reduced risk of stomach cancer, J. Natl Cancer Inst., 81, 162, 10.1093/jnci/81.2.162 · DOI
- Zhang, 2001, A randomized trial of the effects of garlic oil upon coronary heart disease risk factors in trained male runners, Blood Coagul. Fibrinolysis, 12, 67, 10.1097/00001721-200101000-00010 · DOI
Cited by
Sorted by citations
Targeting the biology of aging with mTOR inhibitors
Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372
Wang, Z., Ma, X., Li, J., & Cui, X. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.001 · Cited by 39
Metadata
- Authors
- Powolny, A. A., Singh, S. V., Melov, S., Hubbard, A., & Fisher, A. L.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 46
- Issue
- 6
- Pages
- 441-452
- ISSN
- 0531-5565
- PMC
- PMC3104016
- Cited by
- 68
- References
- 5
- Language
- en
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