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Timing Requirements for Insulin/IGF-1 Signaling in C. elegans
Abstract
The insulin/IGF-1 (where IGF-1 is insulin-like growth factor–1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We find that in Caenorhabditis elegans , the pathway acts during adulthood, to relatively advanced ages, to influence aging. In contrast, it regulates diapause during development. In addition, the pathway controls longevity and reproduction independently of one another. Together our findings show that life-span regulation can be dissociated temporally from phenotypes that might seem to decrease the quality of life.
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Hormonal pathways, particularly those involving insulin and insulin-like growth factor 1, have long been associated with the trade-off between reproduction and longevity in model organisms.
“Hormonal pathways, particularly those involving insulin and insulin-like growth factor 1, have long been associated with the trade-off between reproduction and longevity in model organisms52,53.”
From Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans (2026) · cites this paper as [52]
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- We thank all members of the Kenyon lab for critical review and discussion of this work. A.D. was supported by the Cancer Research Fund of the Damon Runyon Foundation Fellowship grant DRG-1525. D.K.C. was supported by a Howard Hughes Medical Institute Predoctoral Fellowship. Supported by a grant from the NIH (grant 5RO1AG11816) to C.K.
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Metadata
- Authors
- Dillin, A., Crawford, D. K., & Kenyon, C.
- Affiliations
- Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143–0448, USA.
- Venue
- Science
- Published
- 2002-10-25
- Volume
- 298
- Issue
- 5594
- Pages
- 830-834
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 443
- References
- 0
- Language
- en
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