Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats
Abstract
Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aging activates mitochondria-dependent apoptotic pathways in aged rats as result of down-regulated Bcl-2 and up-regulated Bax along with increased cleaved caspase-3.
“Similarly, aging activates the mitochondria-dependent apoptotic pathways in the aged rats as a result of down-regulated Bcl-2 and up-regulated Bax along with increased cleaved caspase-3 [38].”
From Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway (2021) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., & Giuffrida Stella, A. M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2214 · Cited by 1,543 · see citing works
Reid, K. F., & Fielding, R. A. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31823b5f13 · Cited by 858 · cited 1× · see citing works
“Ageassociated loss in function andmass of the skeletal muscle is well documented (Bijlsma et al., 2012; Reid and Fielding, 2012).”
Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Calabrese, E. J., & Mattson, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3074 · Cited by 803 · see citing works
Effects of Aging on Muscle Fibre Type and Size
Deschenes, M. R. (2004) · Sports Medicine · doi:10.2165/00007256-200434120-00002 · Cited by 671 · see citing works
Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585 · see citing works
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Iavicoli, I., Paola, R. D., Koverech, A., Cuzzocrea, S., Rizzarelli, E., & Calabrese, E. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.002 · Cited by 420 · see citing works
Exercise and hormesis: oxidative stress-related adaptation for successful aging
Radak, Z. O., Chung, H. Y., & Goto, S. (2005) · Biogerontology · doi:10.1007/s10522-004-7386-7 · Cited by 413 · see citing works
Reid, M. B., Lännergren, J., & Westerblad, H. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2202005 · Cited by 322 · see citing works
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
Koltai, E., Szabo, Z., Atalay, M., Boldogh, I., Naito, H., Goto, S., Nyakas, C., & Radak, Z. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.11.002 · Cited by 283 · see citing works
Radák, Z., Naito, H., Kaneko, T., Tahara, S., Nakamoto, H., Takahashi, R., Cardozo-Pelaez, F., & Goto, S. (2002) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-002-0918-6 · Cited by 269 · see citing works
Gilson, H., Schakman, O., Kalista, S., Lause, P., Tsuchida, K., & Thissen, J.-P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00193.2009 · Cited by 248 · see citing works
HIONA, A. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.001 · Cited by 247 · see citing works
Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA
Radak, Z. O., Zhao, Z., Goto, S., & Koltai, E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.010 · Cited by 226 · see citing works
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity
Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarelli, E., & Calabrese, E. J. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.007 · Cited by 225 · see citing works
Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB
Sriram, S., Subramanian, S., Sathiakumar, D., Venkatesh, R., Salerno, M. S., McFarlane, C. D., Kambadur, R., & Sharma, M. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00734.x · Cited by 189 · see citing works
The role of systemic inflammation in age‐related muscle weakness and wasting
Degens, H. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.01018.x · Cited by 188 · see citing works
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2
Witt, C. C., Witt, S. H., Lerche, S., Labeit, D., Back, W. E., & Labeit, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601952 · Cited by 186 · see citing works
Antioxidant signaling in skeletal muscle: A brief review
Ji, L. L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.002 · Cited by 184 · see citing works
Radak, Z. O., Chung, H. Y., Naıto, H., Takahashi, R., Jung, K. J., Kim, H., & Goto, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0509fje · Cited by 173 · see citing works
ROS in the local and systemic pathogenesis of COPD
LANGEN, R. C. J., Korn, S. H., & Wouters, E. F. �. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00316-2 · Cited by 153 · see citing works
Cellular and molecular events controlling skeletal muscle mass in response to altered use
Favier, F. B., Benoit, H., & Freyssenet, D. G. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0423-z · Cited by 149 · see citing works
Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle
Dickinson, J. M., Volpi, E., & Rasmussen, B. B. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182a4e699 · Cited by 139 · see citing works
Fuentes, E. N., Björnsson, B. T., Valdés, J. A., Einarsdottir, I. E., Lorca, B., Álvarez, M., & Molina, A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00535.2010 · Cited by 137 · see citing works
Cornelius, C., Perrotta, R. E., Graziano, A., Calabrese, E. J., & Calabrese, V. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-15 · Cited by 131 · see citing works
Myostatin signaling regulates Akt activity via the regulation of miR-486 expression
Hitachi, K., Nakatani, M., & Tsuchida, K. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.12.003 · Cited by 123 · see citing works
Redox-regulating sirtuins in aging, caloric restriction, and exercise
Radak, Z. O., Koltai, E., Taylor, A. W., Higuchi, M., Kumagai, S., Ohno, H., Goto, S., & Boldogh, I. R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.004 · Cited by 114 · see citing works
Görgens, S. W., Raschke, S., Holven, K. B., Jensen, J., Eckardt, K., & Eckel, J. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.768270 · Cited by 109 · see citing works
Chronology of age-related disease definitions: Osteoporosis and sarcopenia
Bijlsma, A. Y., Meskers, C. G. M., Westendorp, R. G. J., & Maier, A. B. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.001 · Cited by 101 · see citing works
Eley, H. L., Russell, S. T., & Tisdale, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90567.2008 · Cited by 100 · see citing works
The transcriptional role of Smads and FAST (FoxH1) in TGFβ and activin signalling
Attisano, L., Silvestri, C., Izzi, L., & Labbé, E. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00524-x · Cited by 97 · see citing works
Williamson, D. L., Kubica, N., Kimball, S. R., & Jefferson, L. S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.103481 · Cited by 96 · see citing works
Effects of Tumor Necrosis Factor- on Muscle-Protein Turnover in Female Wistar Rats
Llovera, M., López-Soriano, F. J., & Argilés, J. M. A. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.16.1334 · Cited by 92 · see citing works
Moriscot, A. S., Baptista, I. L., Bogomolovas, J., Witt, C. C., Hirner, S., Granzier, H. L. M., & Labeit, S. (2010) · Journal of Structural Biology · doi:10.1016/j.jsb.2010.02.001 · Cited by 85 · see citing works
Rosen, K. M., Wentworth, B. M., Rosenthal, N. A., & Villa‐Komaroff, L. (1993) · Endocrinology · doi:10.1210/endo.133.2.8393762 · Cited by 84 · see citing works
Hormetic effects of regular exercise in aging: correlation with oxidative stress
Goto, S., Naito, H., Kaneko, T., Chung, H. Y., & Radak, Z. O. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-092 · Cited by 82 · see citing works
Brioche, T., Kireev, R. A., Cuesta, S., Gratas‐Delamarche, A., Tresguerres, J. A. F., Gómez‐Cabrera, M. C., & Viña, J. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt187 · Cited by 76 · see citing works
Effects of the activin A–myostatin–follistatin system on aging bone and muscle progenitor cells
Bowser, M., Herberg, S., Arounleut, P., Shi, X., Fulzele, S., Hill, W., Isales, C. M., & Hamrick, M. W. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.004 · Cited by 75 · see citing works
Bonetto, A., Penna, F., Minero, V. G., Reffo, P., Bonelli, G., Baccino, F. M., & Costelli, P. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909789057015 · Cited by 69 · see citing works
Jayavelu, T., Jayaraman, G., Sivarajan, K., & Panneerselvam, C. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.028 · Cited by 54 · see citing works
Thomas, S. S., & Mitch, W. E. (2013) · Clinical and Experimental Nephrology · doi:10.1007/s10157-012-0729-9 · Cited by 54 · see citing works
Suryawan, A., Frank, J. W., Nguyen, H. V., & Davis, T. A. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000196718.47935.6e · Cited by 42 · see citing works
Molecular Responses to Moderate Endurance Exercise in Skeletal Muscle
Pasiakos, S. M., McClung, H. L., McClung, J. P., Urso, M. L., Pikosky, M. A., Cloutier, G. J., Fielding, R. A., & Young, A. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.4.282 · Cited by 33 · see citing works
Boonsong, T., Norton, L., Chokkalingam, K., Jewell, K., Macdonald, I. A., Bennett, A. J., & Tsintzas, K. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351310 · Cited by 26 · see citing works
Mattox, T. A., Young, M. E., Rubel, C. E., Spaniel, C., Rodriguez, J., Grevengoed, T. J., Gautel, M., Xu, Z., Anderson, E. J., & Willis, M. S. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9549-9 · Cited by 24 · see citing works
Living in a Box or Call of the Wild? Revisiting Lifetime Inactivity and Sarcopenia
Lawler, J. M., & Hindle, A. G. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3974 · Cited by 23 · see citing works
Nass, R. M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.001 · Cited by 16 · see citing works
TMEFF2 modulates the AKT and ERK signaling pathways.
Chen, X., & Ruiz-Echevarría, M. J. (2013) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
Low Levels of mtDNA Deletion Mutations in ETS Normal Fibers from Aged Rats
Pak, J. W., & Aiken, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.049 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 49 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Kalyanaraman, B.; Darley-Usmar, V.; Davies, K.J.A.; Dennery, P.; Forman, H.J.; Grisham, M.; Mann, G.; Moor; Roberts, J.L.J.I.; Ischiropoulos, H. The use of fluorescence probes to measure reactive oxygen and nitrogen species in cell: challenges, potentials and caveats. in press; 2011
Cited by
Sorted by citations
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works
Sarcopenia, frailty and their prevention by exercise
Nascimento, C. M., Ingles, M., Salvador-Pascual, A., Cominetti, M. R., Gomez-Cabrera, M. C., & Viña, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.035 · Cited by 396 · see citing works
Role of exercise in age-related sarcopenia
Yoo, S.-Z., No, M., Heo, J., Park, D., Kang, J., Kim, S. H., & Kwak, H. (2018) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1836268.134 · Cited by 243 · see citing works
The role of declining adaptive homeostasis in ageing
Pomatto, L. C. D., & Davies, K. J. A. (2017) · The Journal of Physiology · doi:10.1113/jp275072 · Cited by 223 · see citing works
Redox control of skeletal muscle atrophy.
Powers, S. K., Morton, A. B., Ahn, B., & Smuder, A. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.021 · Cited by 207 · see citing works
Zeng, Z., Liang, J., Wu, L., Zhang, H., Lv, J., & Chen, N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.583478 · Cited by 191 · see citing works
Fan, J., Yang, X., Li, J., Shu, Z., Dai, J., Liu, X., Li, B., Jia, S., Kou, X., Yang, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15728 · Cited by 179 · see citing works
Biochemical Pathways of Sarcopenia and Their Modulation by Physical Exercise: A Narrative Review
Ziaaldini, M. M., Marzetti, E., Picca, A., & Murlasits, Z. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00167 · Cited by 167 · see citing works
Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise
Vargas-Mendoza, N., Morales‐González, Á., Madrigal‐Santillán, E., Madrigal‐Bujaidar, E., Álvarez‐González, I., García-Melo, L. F., Anguiano‐Robledo, L., Fregoso-Aguilar, T. A., & Morales‐González, J. A. (2019) · Antioxidants · doi:10.3390/antiox8060196 · Cited by 163 · see citing works
Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
Kim, Y., Triolo, M., & Hood, D. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3165396 · Cited by 158 · see citing works
Carter, H. N., Kim, Y., Erlich, A. T., Zarrin‐khat, D., & Hood, D. A. (2018) · The Journal of Physiology · doi:10.1113/jp275998 · Cited by 136 · see citing works
Exercise effects on physiological function during aging
Radak, Z. O., Torma, F., Berkes, I., Goto, S., Mimura, T., Pósa, A., Balogh, L., Boldogh, I. R., Suzuki, K., Higuchi, M., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.444 · Cited by 112 · see citing works
Cordaro, M., Siracusa, R., Fusco, R., D’Amico, R., Peritore, A. F., Gugliandolo, E., Genovese, T., Scuto, M. C., Crupi, R., Mandalari, G., et al. (2020) · Antioxidants · doi:10.3390/antiox9080660 · Cited by 110 · see citing works
Hofmann, M., Schober-Halper, B., Oesen, S., Franzke, B., Tschan, H., Bachl, N., Strasser, E.-M., Quittan, M., Wagner, K., & Wessner, B. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3344-8 · Cited by 106 · see citing works
The systemic role of SIRT1 in exercise mediated adaptation
Radak, Z. O., Suzuki, K., Pósa, A., Petrovszki, Z., Koltai, E., & Boldogh, I. R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101467 · Cited by 90 · see citing works
Inoue, A., Cheng, X. W., Huang, Z., Hu, L., Kikuchi, R., Jiang, H., Piao, L., Sasaki, T., Itakura, K., Wu, H., et al. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12166 · Cited by 89 · see citing works
Liang, J., Zhang, H., Zeng, Z., Wu, L., Zhang, Y., Guo, Y., Lv, J., Wang, C., Fan, J., & Chen, N. (2021) · Metabolites · doi:10.3390/metabo11050323 · Cited by 84 · see citing works
Roland, N., Koltai, E., Taylor, A. W., Suzuki, K., Győri, F. J., & Radak, Z. O. (2018) · Antioxidants · doi:10.3390/antiox7070085 · Cited by 77 · see citing works
Dethlefsen, M. M., Halling, J. F., Møller, H. D., Plomgaard, P., Regenberg, B., Ringholm, S., & Pilegaard, H. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.011 · Cited by 54 · see citing works
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46 · see citing works
Huang, H., Zheng, J., Shen, N., Wang, G., Zhou, G., Fang, Y., Lin, J., & Zhao, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-28280-6 · Cited by 49 · see citing works
Sarcopenia: Tilting the Balance of Protein Homeostasis
Tan, K. T., Ang, S. T., & Tsai, S. (2019) · PROTEOMICS · doi:10.1002/pmic.201800411 · Cited by 49 · see citing works
Ubiquitin Ligases in Longevity and Aging Skeletal Muscle
Hughes, D. C., Baehr, L. M., Waddell, D. S., Sharples, A. P., & Bodine, S. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147602 · Cited by 45 · see citing works
Exercise training as a drug to treat age associated frailty
Viña, J., Salvador‐Pascual, A., Tarazona‐Santabalbina, F. J., Rodríguez‐Mañas, L., & Gómez‐Cabrera, M. C. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.024 · Cited by 45 · see citing works
SIRT1 may play a crucial role in overload‐induced hypertrophy of skeletal muscle
Koltai, E., Bori, Z., Chabert, C., Dubouchaud, H., Naıto, H., Machida, S., Davies, K. J. A., Murlasits, Z., Fry, A. C., Boldogh, I. R., et al. (2017) · The Journal of Physiology · doi:10.1113/jp273774 · Cited by 45 · see citing works
The emerging role of follistatin under stresses and its implications in diseases
Zhang, L., Liu, K., Han, B., Xu, Z., & Gao, X. (2017) · Gene · doi:10.1016/j.gene.2017.10.017 · Cited by 44 · see citing works
Ribeiro, M. B. T., Guzzoni, V., Hord, J. M., Lopes, G. N., Marqueti, R. D. C., de Andrade, R. V., Selistre-de-Araújo, H. S., & Durigan, J. L. Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-09343-6 · Cited by 40 · see citing works
Takahashi, H., Suzuki, Y., Mohamed, J. S., Gotoh, T., Pereira, S. L., & Alway, S. E. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.02.075 · Cited by 37 · see citing works
Advances in exercise to alleviate sarcopenia in older adults by improving mitochondrial dysfunction
Zhu, Y., Zhou, X., Zhu, A., Xiong, S., Xie, J., & Bai, Z. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1196426 · Cited by 33 · see citing works
Shabani, R., & Izaddoust, F. (2018) · Acta Gymnica · doi:10.5507/ag.2018.007 · Cited by 23 · see citing works
Intermittent bout exercise training down-regulates age-associated inflammation in skeletal muscles
Kim, J., & Yi, H. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.11.001 · Cited by 23 · see citing works
Seo, D. Y., Lee, S. R., Kwak, H. B., Park, H., Seo, K. W., Noh, Y. H., Song, K., Ryu, J., Ko, K. S., Rhee, B. D., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.04.003 · Cited by 23 · see citing works
Molecular mechanisms and potential interventions during aging-associated sarcopenia
Luo, X., Wang, J., Ju, Q., Li, T., & Bi, X. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.112020 · Cited by 21 · see citing works
Li, F., Yu, H., Lin, X., & Liu, Y. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-38810-6_38 · Cited by 20 · see citing works
Radak, Z. O., & Taylor, A. W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00005-x · Cited by 20 · see citing works
Cui, X., Zhang, Y., Wang, Z., Yu, J., Kong, Z., & Ružić, L. (2019) · Experimental Physiology · doi:10.1113/ep087601 · Cited by 21 · see citing works
Puchert, M., Adams, V., Linke, A. H.-P., & Engele, J. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.05.019 · Cited by 19 · see citing works
Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle
Navas‐Enamorado, I., Bernier, M., Brea‐Calvo, G., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.04.005 · Cited by 19 · see citing works
The Role of Sirtuins in Sarcopenia and Frailty
Anwar, M., Pradhan, R., Dey, S., & Kumar, R. (2023) · Aging and disease · doi:10.14336/ad.2022.0622 · Cited by 19 · see citing works
Wang, C., Liang, J., Ren, Y., Huang, J., Jin, B., Wang, G., & Chen, N. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.930185 · Cited by 18 · see citing works
Aoki, K., Konno, M., Honda, K., Abe, T., Nagata, T., Takehara, M., Sugasawa, T., Takekoshi, K., & Ohmori, H. (2020) · Geriatrics · doi:10.3390/geriatrics5030048 · Cited by 17 · see citing works
Exercise-induced muscle damage: multi-parametric MRI quantitative assessment
Lyu, X., Gao, Y., Liu, Q., Zhao, H., Zhou, H., & Pan, S. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04085-z · Cited by 18 · see citing works
Xia, Z., Cholewa, J. M., Zhao, Y., Yang, Y., Shang, H., Guimarães‐Ferreira, L., Naimo, M. A., Su, Q., & Zanchi, N. E. (2016) · Nutrients · doi:10.3390/nu8050246 · Cited by 17 · see citing works
Mitochondrial Adaptations in Aged Skeletal Muscle: Effect of Exercise Training
Ziaaldini, M. M., Hosseini, S. R. A., & Fathi, M. (2017) · Physiological Research · doi:10.33549/physiolres.933329 · Cited by 16 · see citing works
Effects of treadmill with different intensities on bone quality and muscle properties in adult rats
Liu, Z., Gao, J., & Gong, H. (2019) · BioMedical Engineering OnLine · doi:10.1186/s12938-019-0728-0 · Cited by 16 · see citing works
Study on the comorbid mechanisms of sarcopenia and late-life depression
Wu, J., Tang, J., Huang, D., Wang, Y., Zhou, E., Ru, Q., Xu, G., Chen, L., & Wu, Y. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115538 · Cited by 12 · see citing works
Khemraj, P., Kuznyetsova, A., & Hood, D. A. (2025) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2025.101049 · Cited by 11 · see citing works
Natsume, T., Yoshihara, T., & Naıto, H. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0384 · Cited by 10 · see citing works
Su, H., Wen, T., Liu, D., Shao, J., Zhao, L., & Gao, Q. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.811369 · Cited by 10 · see citing works
Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury
Zhu, L., Yu, L., Zhang, W.-H., Deng, J., Liu, S., Huang, W., Zhang, M., Lu, Y., Han, X., & Liu, Y. (2020) · Stem Cells International · doi:10.1155/2020/8412598 · Cited by 10 · see citing works
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
Ji, F., Lee, H. S., Lee, H., & Kim, J. (2025) · FEBS Open Bio · doi:10.1002/2211-5463.70049 · Cited by 10 · see citing works
Dashtiyan, A. A., Sepehrimanesh, M., Tanideh, N., & Afzalpour, M. E. (2017) · Biochimie Open · doi:10.1016/j.biopen.2017.03.005 · Cited by 8 · see citing works
Plant-derived compounds, vitagens, vitagenes and mitochondrial function
Franco, R., Navarro, G., & Martínez‐Pinilla, E. (2022) · PharmaNutrition · doi:10.1016/j.phanu.2021.100287 · Cited by 8 · see citing works
Aoki, K., Konno, M., Tokinoya, K., Honda, K., Abe, T., Nagata, T., Takehara, M., Sugasawa, T., Takekoshi, K., & Ohmori, H. (2022) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.68.39 · Cited by 8 · see citing works
Zolfaghari, M., Faramarzi, M., Hedayati, M., & Ghaffari, M. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14202 · Cited by 7 · see citing works
Yang, L., Wang, M., Mo, L., Yang, Y., Cui, Y., & Wu, Y. (2024) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-024-07835-x · Cited by 5 · see citing works
Antioxidants and Polyphenols Mediate Mitochondrial Mediated Muscle Death Signaling in Sarcopenia
Alway, S. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00026-9 · Cited by 6 · see citing works
Aoki, K., Suzuki, T., Hui, F., Nakano, T., Yanazawa, K., Yonamine, M., Fujita, S.-I., Sugasawa, T., Yoshida, Y., Omi, N., et al. (2021) · Nutrients · doi:10.3390/nu13051735 · Cited by 5 · see citing works
Jabeen, S., & Qazi, J. I. (2023) · Nutrition · doi:10.1016/j.nut.2023.112110 · Cited by 3 · see citing works
Radak, Z. O. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-815137-2.00010-3 · Cited by 2 · see citing works
Linking mitochondrial dysfunction to sarcopenia
Alway, S. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00004-1 · Cited by 1 · see citing works
Zeng, Z., Zhang, H., Liang, J., Lv, J., Wu, L., & Chen, N. (2024) · Advanced Exercise and Health Science · doi:10.1016/j.aehs.2024.03.001 · Cited by 1 · see citing works
roostaei, M., Pirani, H., & Rashidlamir, A. (2020) · Medical Laboratory Journal · doi:10.29252/mlj.14.5.48 · Cited by 1 · see citing works
Aoki, K., Konno, M., Tokinoya, K., Honda, K., Abe, T., Nagata, T., Takehara, M., Sugasawa, T., Takekoshi, K., & Ohmori, H. (2020) · Preprints.org · doi:10.20944/preprints202008.0118.v1 · Cited by 1 · see citing works
اثر تمرین تداومی با شدت متوسط بر شاخصهای اتوفاژی عضله اسکلتی در رت های نر سالمند نژاد ویستار
دلشاد, س., یعقوبی, ع., & رضائیان, ن. (2021) · Journal of North Khorasan University of Medical Sciences · doi:10.29252/nkjmd-120413
Delshad, S., Yaghoubi, A., & Rezaeian, N. (2021) · Journal of North Khorasan University of Medical Sciences · doi:10.52547/nkums.12.4.94
Mekrungruangwong, T., Patumraj, S., & Viboolvorakul, S. (2019) · doi:10.58837/chula.the.2019.368
Establishment and Evaluation of a Rat Model of lipopolysaccharide-high-fat diet Induced SarcopeniaPreprint
Gao, Y., Li, M., Wang, Y., Chen, B., Chen, S., Wang, S., & Lin, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3416539/v1
A novel rat model of sarcopenia based on lipopolysaccharide and high-fat dietPreprint
Gao, Y., Li, M., Wang, Y., Fu, R., Chen, B., Chen, S., Wang, S., & Lin, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4236764/v1
Asadpour, S. M., Daryanoosh, F., & Zarifkar, A. H. (2025) · Biogerontology · doi:10.1007/s10522-025-10363-3
Constans, A. (2019) · theses.fr (ABES) · doi:10.70675/93486891z6065z449cz992az7390677dca22
- Authors
- Ziaaldini, M. M., Koltai, E., Csende, Z., Goto, S., Boldogh, I., Taylor, A. W., & Radak, Z.
- Affiliations
- Semmelweis University (HU)
- Juntendo University (JP)
- The University of Texas Medical Branch at Galveston (US)
- Western University (CA)
- Corresponding author
- Radak, Zsolt
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 67
- Pages
- 9-14
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2068554185
- Cited by
- 72
- References
- 49
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 13 · 2017: 11 · 2016: 8 · 2015: 2
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Funders
- OTKA (K 112810)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- exercise training, skeletal muscle aging, sarcopenia, cachexia, anabolic signaling, catabolic pathways, apoptosis, follistatin, myostatin, proteasome, ubiquitination, TNF-α, reactive oxygen species, p53, Bax, Bcl-2, muscle mass loss
- MeSH terms
- Aging, Animals, Male, Physical Conditioning, Animal, Signal Transduction, Rats, Wistar, Apoptosis, Reactive Oxygen Species, Muscle, Skeletal, Follistatin, Myostatin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
