Cited by 139Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle

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Dickinson, Jared M., Volpi, Elena, Rasmussen, Blake B.·2013·Exercise and Sport Sciences Reviews

Abstract

In Brief The loss of skeletal muscle size and function with aging and sarcopenia may be related, in part, to an age-related muscle protein synthesis impairment. In this review, we discuss to what extent aging affects skeletal muscle protein synthesis and how nutrition and exercise can be used strategically to overcome age-related protein synthesis impairments and slow the progression of sarcopenia. This review discusses how aging affects the protein synthesis response of skeletal muscle to nutrition and exercise.

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Authors
Dickinson, J. M., Volpi, E., & Rasmussen, B. B.
Affiliations
The University of Texas Medical Branch at Galveston (US)
Corresponding author
Dickinson, Jared M.
Venue
Exercise and Sport Sciences Reviews
Published
2013-10
Volume
41
Issue
4
Pages
216-223
ISSN
0091-6331 (ISSN-L)
OpenAlex
W2120024598
Cited by
139
References
40
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 16 · 2021: 18 · 2020: 11 · 2019: 15 · 2018: 11 · 2017: 12 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 1
FWCI
1.19
Type
journal article
Language
en
Open access
Locations
  • Exercise and Sport Sciences Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000071)
  • National Institute on Aging (R01AG030070, R01AG018311, P30AG024832)
  • National Heart, Lung, and Blood Institute (R01HL130296, R01HL145055)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049877)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
sarcopenia, skeletal muscle aging, muscle protein synthesis, physical activity, nutrition, age-related muscle loss, muscle function decline
MeSH terms
Aging, Humans, Muscle Proteins, Nutritional Physiological Phenomena, Exercise, Muscle, Skeletal, Sarcopenia

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